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Repurposing Anthelmintics: Effects of Rafoxanide and Copper-Functionalized SBA-15 Carriers Against Methicillin-Resistant Staphylococcus aureus
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Invention Summary:
Due to the rise in bacterial resistance to conventional antibiotics, materials that can administer antimicrobial drugs in a regulated manner more effectively are critically needed. While new antibiotic classes are created and widely used, existing,...
Published: 12/22/2022
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Inventor(s): Maricely Ramírez-Hernández, Javiera Norambuena-Morales, Tewodros Asefa, Jeffrey Boyd
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Animal Health & Care, Technology Classifications > Biomaterials, Technology Classifications > Nanotechnology
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New method for biosynthesis of hydroxylated polymethoxyflavones
The potential benefits of hydroxylated polymethoxyflavones
Invention Summary:
Hydroxylated polymethoxyflavones (OH-PMFs), are a class of novel flavonoid compounds found in citrus plants with very low abundance. OH-PMFs could be produced through semi-chemical or semi-bio synthesis from their PMF counterparts, but the technique to...
Published: 8/25/2022
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Inventor(s): Qingrong Huang, Chi-Tang Ho, Shiwei Su
Keywords(s): Food preservatives/additives, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Physical Sciences & Engineering
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Novel ChABC formulation with machine learning-guided automation
Invention Summary:
Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 10/12/2022
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Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
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Cellularized Nerve Regeneration Graft to Remediate Peripheral Nerve Injury
Invention Summary:
Peripheral Nerve Injuries (PNI) arising from physical trauma, cancers, or other nervous system pathologies are associated with higher costs and socioeconomic impact globally. Currently available technologies to remediate nerve injury are often unsuccessful in restoring nerve functions to its original capacity and cost of managing...
Published: 11/2/2022
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Inventor(s): Sanjeeva Murthy, Zhiping Pang, Jeremy Perrelle, Jasmine Gamboa, Andrew Boreland, Amir McCormick
Keywords(s): Bioengineering scaffolds, Biomaterials, Neuropathic Pain
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences
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Improved Nerve Conduits for Treatment of Peripheral Nerve Injuries
Scanning electron microscope image of conduits
Invention Summary:
Nerve conduits are used for treatment of peripheral nerve injuries. However, the current conduits are associated with poor healing resulting from swelling and reduction of luminal volume, suture pull-out, collapse, kinking, compression, and lack of mechanical strength to withstand...
Published: 12/2/2022
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Inventor(s): Joachim Kohn
Keywords(s): Biomaterials, Neurological disorder & neuropathic pain, Polymers & Composites, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials
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PEG Nanocarriers, Nanogels
and Synthesis Methods
Invention Summary:
A novel platform of PEG-only nanocarriers and nanogels has been developed by Rutgers scientists. The nanocarriers can be used from 100Da-100- kDa and are capable of forming stable nanogels and nanogel aggregates in a variety of sizes from 20-30nm up to >1000nm. The carriers and gels have improved solubility over existing technologies...
Published: 9/1/2022
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Inventor(s): Patrick Sinko, Manjeet Deshmukh, Hilliard Kutscher, Stanley Stein, Simi Gunaseelan, Anupa Menjoge
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Film Forming Foam (FFF) for Burn Wounds/Burnflex
Invention Summary:
Many available dressings on the market use latex, PVC, or polyurethane as barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may be coated in silver sulfadiazine,...
Published: 12/23/2022
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Inventor(s): Maricely Ramírez-Hernández, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
Keywords(s): Antibacterial, Drug Delivery, Nanoparticles, Nanotechnology, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Consumer & Household Goods
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Biocompatible and Biodegradable Films for Effective Prevention of Postoperative Adhesions
Shear modulus of polyelectrolyte complex (PEC) films (red) compared to soft tissue and competing materials (blue).
Invention Summary:
Adhesions often form after surgery, causing chronic abdominal or pelvic pain. Currently available adhesion prevention products form only a physical barrier against adhesions and have undesirable properties, such as...
Published: 10/12/2022
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Inventor(s): Noshir Langrana, Devendra Verma, Michelle Previtera
Keywords(s): Biomaterials
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Medical Devices
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Type-I Collagen Methacrylamide-Derivatized Hydrogels
Invention Summary:
Natural material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties....
Published: 9/8/2022
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Inventor(s): David Shreiber, Ian Gaudet
Keywords(s): Bioengineering scaffolds, Wound healing
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Nanotechnology-based Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases
Two-in-one: Combined nanocarrier based targeted chemo and gene therapy
1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human...
Published: 9/8/2022
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Inventor(s): Tamara Minko, Olga Garbuzenko, Oleh Taratula, Lorna Rodriguez-Rust, Vatsal Shah
Keywords(s): Anti-cancer, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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