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Novel ChABC formulation with machine learning-guided automation
​ ​ Invention Summary: Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 8/2/2022   |   Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
Anti-Viral Facial Masks
­​ Testing of the anti-viral activity of an exemplary mask against a human coronavirus (HCoV229E) similar to the one causing COVID-19. Note that small bars are better than big ones. See text for more details. pfu=plaque forming unità indicating the quantity of viruses; “+ 5min” indicates that masks were washed for 5 min. ​...
Published: 3/31/2022   |   Inventor(s): David Devore, Joachim Kohn, Yong Mao, Sanjeeva Murthy, Kim-phuong Le
Keywords(s): Antiviral, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
Biodegradable and Biocompatible Polymers for Controlled NSAID Delivery
­ ​ A. Drug delivery system hydrolysis – composed of 1 (Ibuprofen), 2 (naproxen) and 3 (tartatic acid) into polymer backbones. B. Hydrolytic degradation of the ibuprofen-based polyester. Invention Summary: Ibuprofen and naproxen are commonly used to treat pain and swelling associated with rheumatoid arthritis and osteoarthritis....
Published: 3/17/2022   |   Inventor(s): Kathryn Uhrich, Roselin Rosario-Melendez
Keywords(s): Biomaterials, Inflammation, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Antioxidant-based poly(anhydride-esters)
­ ​ ​ Invention Summary: Free radicals have been identified as major sources of oxidative stress in cells leading to DNA damage. This increased oxidative stress has been implicated in various deleterious conditions including cardiovascular diseases, neurodegenerative diseases, and cancer, while also contributing to the physiology of...
Published: 3/17/2022   |   Inventor(s): Kathryn Uhrich, Michelle Morano
Keywords(s): Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
Amphiphilic macromolecules with novel hydrophobic segments
­ ​ ​ Invention Summary: Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 3/17/2022   |   Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu
Keywords(s): Antibacterial, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Amphiphilic Polymer Stabilized Nanoparticles with Enhanced Biological Stability and Activity
­ ​ Experimental oxLDL macrophage cellular uptake results after 24-hr incubation with AM micelle or NP configurations under serum free conditions (white bars), 5% FBS (gray bars) and 20% FBS (black bars). Invention Summary: According to Centers for Disease Control and Prevention nearly 25% of deaths in the US is due to cardiovascular...
Published: 3/17/2022   |   Inventor(s): Kathryn Uhrich, Prabhas Moghe, Adam York, Robert Prud'homme
Keywords(s): Biomaterials, Cardiovascular, Drug Delivery, Nanoparticles, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Cellularized Nerve Regeneration Graft to Remediate Peripheral Nerve Injury
Invention Summary: Peripheral Nerve Injuries (PNI) arising from physical trauma, cancers, or other nervous system pathologies are associated with higher costs and socioeconomic impact globally. Currently available technologies to remediate nerve injury are often unsuccessful in restoring nerve functions to its original capacity and cost of managing...
Published: 2/18/2022   |   Inventor(s): Sanjeeva Murthy, Zhiping Pang, Jeremy Perrelle, Jasmine Gamboa, Andrew Boreland, Amir McCormick
Keywords(s): Bioengineering scaffolds, Biomaterials, Neuropathic Pain
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences
Biodegradable and Biocompatible Salicylic Acid Releasing Polymer to Enhance Diabetic Bone Regeneration
­ ​ ​​​​​​​pCT images of control and polyaspirin treated defects after 4 weeks. Graph shows average percent bone fill in defects after 4 weeks Invention Summary: Nearly 300 million people suffer from diabetes mellitus worldwide, with 25 million diabetics in the U.S. alone. Patients with diabetes are more prone to fractures, periodontitis,...
Published: 2/11/2022   |   Inventor(s): Kathryn Uhrich, Roselin Rosario-Melendez, Michelle Morano, Sabrina Snyder, Joseph Fiorellini (UPENN), Dana Graves (UPENN), Keisuke Wada (UPENN)
Keywords(s): Biomaterials, Diabetes & Metabolic Disorders, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV. Cationic Amphiphile Concentration (μM) Invention Summary: Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion,...
Published: 12/1/2021   |   Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Biodegradable and Versatile Copolymers to Promote Wound Healing
Invention Summary: Wound healing is a complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers and thus there is a need for a biodegradable and versatile copolymers to promote wound healing. Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise...
Published: 12/1/2021   |   Inventor(s): Kathryn Uhrich, Sabrina Snyder
Keywords(s): Biomaterials, Drug Delivery, Neurological disorder & neuropathic pain, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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