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Negative Pressure-Assisted DNA Delivery
Fig.1. Dermal suction induces long-lasting antigen expression and T-cell response. (A) Dermal suction via a small hand-held device with a 6-mm orifice against the skin. Inset: immune response is 100 times stronger when compared with injection alone. (B) Post-suction skin demonstrates no damage nor erythema. (C) and (D): Benchmarking of suction against...
Published: 5/15/2026
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Inventor(s): Hao Lin, Jonathan Singer, David Shreiber, Jerry Shan, Jeffrey Zahn, Emran Lallow, Juliet Melnik, Nandita Jhumur
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Vaccine
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Customizable Collagen-Mimetic Hydrogels for Precision Modeling and Bioscaffold Engineering
Synthesis of cysteine flanked collagen-mimetic peptides (CMPs)
Invention Summary:
Hydrogels are essential tools which can mimic extracellular matrix environments; however, current systems lack precise molecular-level control over crosslinking density and porosity. Conventional approaches utilize non-specific, generic biopolymers with statistical...
Published: 2/20/2026
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Inventor(s): Sonal Gahlawat, David Shreiber
Keywords(s): Bioengineering scaffolds, Biomaterials, Peptides
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering
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Type-I Collagen Methacrylamide-Derivatized Hydrogels
Invention Summary:
Natural material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties....
Published: 4/27/2026
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Inventor(s): David Shreiber, Ian Gaudet
Keywords(s): Bioengineering scaffolds, Wound healing
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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A Platform Approach for Free Radical-Mediated Targeted Therapeutic Delivery
Invention Summary:
Various pathological states including tissue injuries, inflammation, degenerative diseases and cancer are frequently associated with elevated free radicals, such as reactive oxygen and nitrogen species. These locally-generated free radicals are extremely reactive and are known to damage cells and tissues to exacerbate the pathology....
Published: 2/20/2026
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Inventor(s): David Shreiber, Christopher Lowe, Emily DiMartini, Adam Gormley
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Physical Sciences & Engineering
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