ki-bum+lee - Available Technologies | Rutgers University Innovation Ventures

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Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
​ Schematic representation of MitoScript and its components Invention Summary: Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 10/25/2023   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s):  
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
Enhanced Intervertebral Disc Repair and Regeneration Using a Nano-Hybrid Gel
​ Nanomaterial (2D-Mn02)-embedded peptide hydrogel (NEPH) promotes cellular proliferation and tissue regeneration. Invention Summary: The limited capacity for regeneration, the presence of pro-inflammatory factors, and the complex extracellular matrix (ECM) microenvironment of degenerated intervertebral discs (IVD) remain significant issues...
Published: 1/16/2024   |   Inventor(s): Ki-Bum Lee, Brian Conley, Inbo Han
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering
Injectable Bioorthogonal Hydrogel for Intervertebral Disc Regeneration
​ IVD recovery imaging which demonstrates the efficacy and regeneration capability of the BIOGEL loaded with TGFB Invention Summary: Intervertebral disc degeneration (IVD) is the leading cause of back pain amongst humans and is a precursor to more severe conditions. To address this issue, a team led by Rutgers scientists have developed...
Published: 1/16/2024   |   Inventor(s): Ki-Bum Lee, Jeffrey Luo, Inbo Han
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering
Spatial Dopant Separation using Core-Shell Architecture For Upconversion Luminescent Enhancement in the Erbium-Doped System
Invention Summary: Upconversion nanoparticles (UCNPs) have gained increasing attention for various biomedical applications due to their high photostability, low autofluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emission intensities due to undesirable energy back-transfer. Further, the use of high-power density...
Published: 10/12/2022   |   Inventor(s): Ki-Bum Lee, Hudifah Rabie, Nicholas Pasquale
Keywords(s): Imaging, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Medical Imaging
High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues. Invention Summary: Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming. In nature,...
Published: 10/12/2022   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
Versatile CRISPR-Cas9 Gene Editing System
Successful gene editing in neurons differentiated from patient-derived neural stem cells. Left panel, gene editing using control guide RNA; Right panel, gene editing using MeCP2 guide RNA. Invention Summary: CRISPR-Cas-mediated genome editing makes effective gene therapy of human disease feasible. Although viral delivery of CRISPR-Cas...
Published: 10/12/2022   |   Inventor(s): Ki-Bum Lee, Hyeon-Yeol Cho, Myung-Sik Yoo
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Rare Disease, Technology Classifications > Therapeutics
Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid. B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord Invention Summary: 3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 8/9/2023   |   Inventor(s): Ki-Bum Lee, Christopher Rathnam, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
Dual-Enhanced Raman Scattering-Based Nanoarray Biosensors
A schematic showing graphene-gold hybrid nanoarray for nucleic acid detection and cellular biosensing Invention Summary: Raman spectroscopy is a nondestructive, label-free technique that uses laser light to discriminate cell and tissue types. While Surface enhanced Raman scattering (SERS) has demonstrated great potential to analyze a variety of bio/chemical...
Published: 4/21/2024   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
One-Step Exosome Isolation and Detection
81BD;line-height: 1;border-collapse: collapse; } Extract and concentrate exosomes immunomagnetically, analyze exosomal miRNA sensitively via metal-enhanced fluorescence effect. Invention Summary: Exosomes and their inner contents play critical roles in intercellular communication and signaling. The use of exosomes as next-generation biomarkers...
Published: 12/10/2023   |   Inventor(s): Ki-Bum Lee, Jin-Ho Lee
Keywords(s): Biosensor
Category(s): Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
NanoScript – Nanoparticle-based Synthetic Transcription Factor for Therapeutic Gene Modulation
Invention Summary: Since its introduction over two decades ago, the advancement of synthetic transcription factors has faced significant challenges, including poor membrane penetration, intracellular degradation, limited nuclear localization, low gene activation, and low synthesis efficiency. Rutgers scientists have developed a novel synthetic...
Published: 8/31/2022   |   Inventor(s): Ki-Bum Lee, Sahishnu Patel
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Research Tools, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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