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Search Results - anti-cancer

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DEVELOPMENT OF SPECIFIC CRK-LIKE ADAPTOR PROTEIN INHIBITORS FOR CANCER THERAPY
NC5 inhibits tumor growth and prolongs survival in vivo. NC5 treatment inhibits TNBC tumor growth and prolongs mice survival in xenograft and PDX mouse models. (A) Survival of mice bearing MDA-MB-231-Luc orthotopic xenograft tumors following treatment with vehicle (black line), Gleevec (blue line), or NC5 (red line). (B) Survival of mice bearing PDX...
Published: 1/5/2023   |   Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
Method for Generating Memory T-cells In Vitro and Their Use in Immunotherapy
Invention Summary: Dendritic cell-based immunotherapies have been tested for the treatment of cancer patients with limited success. The limited success is probably due to the ineffective activation of specific T-cells by injected dendritic cells. In vitro generation of memory T-cells that can respond to cancer cells could circumvent ineffective T-cell...
Published: 11/3/2022   |   Inventor(s): Shigeko Yamashiro (Matsumura), Fumio Matsumura, Aya Matsumura
Keywords(s): Anti-cancer, Immunoassay
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
SAHMI: Microbiome-based screening method for cancer and other diseases
​ ​ Screening methodology and principle data identifying differences in microbiome diversity from disease state in pancreatic cancer Invention Summary: The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 8/8/2022   |   Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
High Affinity/Specificity Bispecific Natural Killer Cell Engager for Cancer Immunotherapy
­​ Fig. 1: Schematic representation of the structure of a mAb (A) and a BiKE (B), and their functions. While mAbs engage NK cells with low affinity/specificity, BiKE binds to NK cells with high affinity/specificity resulting in enhanced anticancer efficacy and reduced side effects. Invention Summary: Monoclonal antibodies (mAb) facilitate...
Published: 11/10/2022   |   Inventor(s): Arash Hatefi, Shahryar Khoshtinat Nikkhoi
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
Combined Opioidergic and Beta-Adrenergic Drugs for Cancer and Immune Diseases
­​ Invention Summary: One of the major cancer therapy approaches that is being heavily investigated is immunotherapy. Immunotherapy involves modulating the cancer patient’s own immune system to identify tumors and cancer cells as foreign to their body. Currently, the major pathways being studied involve regulating the function...
Published: 11/2/2022   |   Inventor(s): Dipak Sarkar
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Cancer
Iodinated Salicylate-Polymers
​ ​ FIG. 2( a) is a cross-sectional view of an apparatus or article including a medical device and an iodinated polymer coating in accordance with some embodiments. FIG. 2( b) is a perspective view of the medical device, shown in FIG. 2( a), having a surface that is partially coated with the iodinated polymer coating in accordance...
Published: 8/31/2022   |   Inventor(s): Kathryn Uhrich, Ashley Carbone
Keywords(s): Anti-cancer, Drug Delivery, Imaging, Implants, Polymers & Composites, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Polymers/Composites/Materials
Biomarkers for Identifying Patients at High Risk of Progressing from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary: Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 9/16/2022   |   Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
Leukemia inhibitory factor- Protective role for radiation/chemo-induced gut syndrome and GVHD
Invention Summary: Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury This is also true for Graft-versus-host disease (GVHD) which remains a major complication after allogeneic hematopoietic stem cell transplantation, a widely-used therapy for hematologic malignancies...
Published: 10/4/2022   |   Inventor(s): Wenwei Hu, Zhaohui Feng, Jianming Wang, Huaying Wang
Keywords(s): Anti-cancer, Gastrointestinal disease, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
A Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals. Invention Summary: A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 10/4/2022   |   Inventor(s): Roger Howell, Behrooz Vaziri, Han Wu, Atam Dhawan
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics, or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals. Invention Summary: A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 8/29/2022   |   Inventor(s): Roger Howell, Jordan Pasternack, John Akudugu
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
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