letao+yang - Available Technologies | Rutgers University Innovation Ventures

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Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
​ Schematic representation of MitoScript and its components Invention Summary: Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 9/12/2024   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s):  
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues. Invention Summary: Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming. In nature,...
Published: 9/12/2024   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid. B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord Invention Summary: 3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 9/12/2024   |   Inventor(s): Ki-Bum Lee, Christopher Rathnam, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
Dual-Enhanced Raman Scattering-Based Nanoarray Biosensors
A schematic showing graphene-gold hybrid nanoarray for nucleic acid detection and cellular biosensing Invention Summary: Raman spectroscopy is a nondestructive, label-free technique that uses laser light to discriminate cell and tissue types. While Surface enhanced Raman scattering (SERS) has demonstrated great potential to analyze a variety of bio/chemical...
Published: 9/12/2024   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration
Invention Summary: The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have...
Published: 9/12/2024   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy, Technology Classifications > Therapeutics
Biodegradable Scaffold for Advanced Stem Cell Therapy
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet Invention Summary: While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation. Researchers at Rutgers University...
Published: 9/12/2024   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Biomaterials, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics