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“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control. Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large...
Published: 7/14/2021   |   Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
Personalized and Timed Release of Biomolecules
Invention Summary: Protein/peptide-based therapeutics are powerful medications, however their use is often hampered by very short half-lives and the necessity for intravenous or subcutaneous injections. Researchers from Rutgers University and Massachusetts General Hospital have developed a novel method to deliver protein/peptide-based therapeutics...
Published: 3/2/2020   |   Inventor(s): Biju Parekkadan, Alexandra Burr, Alfred Tamayo
Keywords(s): Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Cell Therapy, Technology Classifications > Gene Therapy
A Novel Approach for Expansion of NK and CAR-modified NK Cells
Fold expansion of NK cells from cord blood expanded with irradiated K562-mIL21 and RU-Feeder Cells Invention Summary: Chimeric antigen receptor T-cell immunotherapy (CAR-T cell therapy) requires engineering of T cells harvested from the patient. Natural killer (NK) cells are also cytotoxic immune cells, but work somewhat differently from T cell....
Published: 1/3/2020   |   Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Cell Lines
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer, Technology Classifications > Cell Therapy
Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration
Invention Summary: The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have...
Published: 8/19/2019   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy, Technology Classifications > Therapeutics
Cell Culture Scale-Up via 3D Bioactive Microcapsule
Capsules are designed to protect cells from shear, non-fouling, and customized for ease-of-use and recovery of cells. Invention Summary: Industrial cell culture scale-up is a critical unit operation in biopharmaceutical processes. Culturing adherent cells is particularly challenging, since they can’t simply be cultured in suspension but instead...
Published: 7/24/2018   |   Inventor(s): Biju Parekkadan, Ayesha Aijaz
Keywords(s):  
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy