gene+editing - Available Technologies | Rutgers University Innovation Ventures

Search Results - gene+editing

7 Results Sort By:
Controlled Muscle-Specific Gene Delivery
​ ​ Treatment with the AAV gene therapy with doxycycline (B) induced expression of the target gene. Invention Summary: Adeno-associated virus (AAV) vector-based gene therapy has the potential to treat a number of rare diseases. However, only two AAV-based gene therapies have been approved by the FDA, primarily due to toxicity and lack of specificity. Researchers...
Published: 8/25/2022   |   Inventor(s): Renping Zhou
Keywords(s): Gene editing
Category(s): Technology Classifications > Gene Therapy, Technology Classifications > Healthcare & Life Sciences
Novel gene drive based on eliciting piRNA biogenesis in insect pests
​ Transgenic Anopheles gambiae larvae expressing fluorescent marker gene Invention Summary: Malaria is one of the most impactful diseases in tropical and subtropical regions and is transmitted through human contact with infectious mosquitoes. Crop pests create a large economic and social impact through direct damage to plants and spread...
Published: 7/14/2022   |   Inventor(s): Cory Henderson, Christina Bergey
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Pest Control, Technology Classifications > Ag Biotech
Novel Maturation‐defective Attenuated Chlamydia Vaccine
­​ ​ Invention Summary: Millions of American men and women are infected with Chlamydia each year. Without proper treatment, a substantial proportion of chlamydia-infected women may develop infertility and other health problems. To date, no Chlamydia vaccine is available. Chlamydia is an obligate intracellular bacterium with a unique...
Published: 5/26/2022   |   Inventor(s): Huizhou Fan
Keywords(s): Gene editing
Category(s): Technology Classifications > Vaccine, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
Lightning-fast Genome Variant Detection
Invention Summary: Current human whole genome sequencing projects produce massive amounts of data, often creating significant computational challenges. Different approaches have been developed for each type of genome variant and method of detection, necessitating users to run multiple algorithms to find variants. Researchers at Rutgers University...
Published: 10/11/2021   |   Inventor(s): Andrey Grigoriev, Sean Smith
Keywords(s): Bioinformatics, Gene editing
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences
dCas9 Protein Allele Sequestration for Improved CRISPR Gene Editing
style="line-height:normal">​ Invention Summary: CRISPR technology is widely used in research to edit genes in animals and cell lines and is moving towards therapeutic use in the clinic. Inherent to almost all methods employed in gene editing is the lack of control in target gene usage. A method to direct cleavage of only a single target within...
Published: 3/22/2021   |   Inventor(s): Peter Romanienko, Ghassan Yehia
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Research Tools
Versatile CRISPR-Cas9 Gene Editing System
Successful gene editing in neurons differentiated from patient-derived neural stem cells. Left panel, gene editing using control guide RNA; Right panel, gene editing using MeCP2 guide RNA. Invention Summary: CRISPR-Cas-mediated genome editing makes effective gene therapy of human disease feasible. Although viral delivery of CRISPR-Cas...
Published: 3/16/2021   |   Inventor(s): Ki-Bum Lee, Hyeon-Yeol Cho, Myung-Sik Yoo
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Rare Disease, Technology Classifications > Therapeutics
Treatment for Neuropsychiatric Disorders by Intravitreal Injection of DREADD Followed by Eye Drops or Pills Containing DREADD agonist
Figure 1. DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like...
Published: 5/7/2018   |   Inventor(s): Gary Aston-Jones, Hannah Bowrey
Keywords(s): Gene editing, Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics