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New method for biosynthesis of hydroxylated polymethoxyflavones
­ ​ The potential benefits of hydroxylated polymethoxyflavones Invention Summary: Hydroxylated polymethoxyflavones (OH-PMFs), are a class of novel flavonoid compounds found in citrus plants with very low abundance. OH-PMFs could be produced through semi-chemical or semi-bio synthesis from their PMF counterparts, but the technique to...
Published: 8/11/2022   |   Inventor(s): Qingrong Huang, Chi-Tang Ho, Shiwei Su
Keywords(s): Food preservatives/additives, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Physical Sciences & Engineering
Novel ChABC formulation with machine learning-guided automation
​ ​ Invention Summary: Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 8/2/2022   |   Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
Wireless Power-up and Readout of Label-free Electronic Detection of Protein Biomarkers
The schematic of the WPT system. Invention Summary: Electronic biosensors are involved in various applications including medical diagnostics and healthcare monitoring. Additionally, wireless power transfer is suited for remote use of biosensors without direct electrical connection. However, wireless readout of a label-free electronic biosensor...
Published: 7/20/2022   |   Inventor(s): Mehdi Javanmard, Hassan Raji, Pengfei Xie, Seyed Mahmoodi
Keywords(s): Biosensor
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Sensors, Technology Classifications > Diagnostics
Continuous Process for API Formulation and Manufacturing
se; } ​ ​ A comparison of dissolution profiles for impregnated ibuprofen (IBU) tablets and direct compression IBU tablets Invention Summary: A major challenge in pharmaceutical product development is the formation of homogenous blends containing small amount of active pharmaceutical ingredients (APIs). Poor...
Published: 6/9/2022   |   Inventor(s): Fernando Muzzio, Benjamin Glasser, Thamer Omar
Keywords(s): Chemical and petrochemical industry, Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
Continuous Process for API Formulation and Manufacturing
​ ​ A comparison of dissolution profiles for impregnated ibuprofen (IBU) tablets and direct compression IBU tablets Invention Summary: A major challenge in pharmaceutical product development is the formation of homogenous blends containing small amount of active pharmaceutical ingredients (APIs). Poor mechanical...
Published: 6/9/2022   |   Inventor(s): Fernando Muzzio
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering
Continuous Melt-Coating for Improving API Solubility and Loading
​ ​ Invention Summary: Poor solubility is a major obstacle to bringing a drug candidate into the market. Existing methods including micronization, amorphization, spray drying and hot melt extrusion that aim to improve solubility are expensive, difficult to implement, and associated with problems such as instability, limitation in drug loading....
Published: 6/9/2022   |   Inventor(s): Fernando Muzzio, Zhanjie Liu, Gerardo Callegari, Douglas Hausner
Keywords(s): Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
Enhancing the Trustworthiness and Effectiveness of Internet Services
Invention Summary: For an internet service to attract clients, it must generate a degree of trust in the services it provides. Such trust can be the consequence of good and solid reputation of a service. But only a small percentage of internet services can garner such reputation. A service may try to gain the trust of potential clients by making suitable...
Published: 6/2/2022   |   Inventor(s): Naftaly Minsky
Keywords(s): Networks
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Telecommunications & Networking, Technology Classifications > Physical Sciences & Engineering
Electrostatic Actuator with Embedded Microfluidic Channels for Biological Applications
​ Invention Summary: Microsystem platforms for System-On-A-Chip devices often require the integration of multiple microfluidic functions, such as pumping and actuation components. Pneumatic actuation is commonly used due to the ease of fabrication with soft-lithography techniques. However, these methods do not provide complete actuation control...
Published: 5/25/2022   |   Inventor(s): Fernando Antonio Rebolledo Uscanga, Jeffrey Zahn
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
Sterically-Defined Biaryl L-Shaped N-Heterocyclic Carbene Complexes and Methods
​ ​ Invention Summary: Buchwald dialkylbiarylphosphines are the most widely used class of ligands in catalysis. The resulting cross-coupling reactions of this class of catalysts have a wide range of applications in both the industry and academia, especially in the fields of medical chemistry, drug discovery, biochemistry, geochemistry, natural...
Published: 5/11/2022   |   Inventor(s): Michal Szostak, Tongliang Zhou, Shiyi Yang
Keywords(s): Catalysts
Category(s): Technology Classifications > Catalysts, Technology Classifications > Physical Sciences & Engineering
Amino Decorated L-Shaped Heterobidentate NHC Ligands on Imidazo[1,5-a]pyridine Architecture and Methods
​ ​ Invention Summary: Dalphos ligands are among the most successful and widely used arlyphosphine ligands in organic catalysis. They are among the most popular ligands in the optimization and development of new processes using Au catalysis, where the stabilization of Au intermediates by five-membered chelates plays an essential role in catalysis...
Published: 5/11/2022   |   Inventor(s): Michal Szostak, Pengcheng Gao
Keywords(s): Catalysts
Category(s): Technology Classifications > Catalysts, Technology Classifications > Physical Sciences & Engineering
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