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Novel FISH probes for the prognosis of malignant transformation in Barrett’s epithelium
Left: Translocations as visualized by FISH assay during metaphase. Right: Fusion as visualized in human esophageal adenocarcinoma tissue sectionInvention Summary:Barrett’s epithelium (BE) is a premalignant tissue that can progress into esophageal adenocarcinoma (EA) following the metaplasia→low grade dysplasia→ high grade dysplasia→cancer sequence....
Published: 2/12/2025
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Inventor(s): Kiron Das, Manisha Bajpai, Hana Aviv
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Application of a PS-Targeting Molecule Combined with Memory T cell Antigen for Therapeutic, Diagnostic, and Adjuvant Use
PS binding molecules could restore inactive or memory T cell functions.
Invention Summary:
Phosphatidylserine (PS) exposure on the cell surface is often a signal for phagocytosis and can lead to an immunosuppressive effect. Therefore, its inhibition by PS-binding biomolecules can promote a more immuno-responsive microenvironment. However,...
Published: 1/21/2025
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Inventor(s): Alok Choudhary
Keywords(s): Antibacterial, Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Infectious Disease, Technology Classifications > Healthcare & Life Sciences
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Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction
Non-covalent direct inhibition of the Keap1-Nrf2 PPI resulting in upregulation of ARE-gene expression. Thus, increase ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions.
Invention Summary:
The Keap1-Nrf2-ARE system could protect...
Published: 1/14/2025
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Inventor(s): Longqin Hu, Ahmed Ali
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Identification of NFAT5 as a novel target for preventing KRAS targeted therapy resistance
Inhibiting NFAT5 attenuates pancreatitis-induced resistance to KRAS inhibition and extends mouse survival.
Invention Summary:
Resistance to KRAS targeted therapy in cancers involves epithelial-to-mesenchymal transition (EMT), which poses challenges for effective targeting. However, the mechanism underlying EMT associated KRAS resistance...
Published: 1/6/2025
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Inventor(s): Pingping Hou, Daiyong Deng
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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PRISM: Precise Identification of Species of the Microbiome
Invention Summary:
The human microbiome plays a critical role in health and disease, influencing conditions such as cardiovascular disease, cancer, and autoimmune disorders. However, analysis of microbial genetics data has struggled to overcome the effects of false positive and false negative data. Computational methods are further constrained...
Published: 12/17/2024
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Inventor(s): Bassel Ghaddar, Subhajyoti De
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
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MYC Program as a biomarker of response to treatment with Enzalutamide
Invention Summary:
Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to...
Published: 12/12/2024
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Bioinformatic Methods for Determining Resistance to Cancer Treatments
Invention Summary:
Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible.
Researchers at Rutgers University have...
Published: 11/12/2024
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Inventor(s): Antonina Mitrofanova, Sukanya Panja, Sarki Abdulkadir, Vishal Kothari, Edward Schaeffer
Keywords(s): Bioinformatics, Biomarkers, Digital Health, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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A novel inhibitory mimetic peptide
slows down tumor development
Inhibitory peptide increases caspase3 activity (A) by blocking GC1/Trx1 complex thereby limiting cell proliferation by inducing cell death (B).
Invention Summary:
Soluble guanylyl cyclase (GC1) and thioredoxin 1 (Trx1), when physically interacting and attaching to each other, they acquire the ability to induce changes in other target...
Published: 7/22/2024
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Inventor(s): Annie Beuve
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Off-the-Shelf CAR-Macrophages for Solid Tumors
Invention Summary:
Chimeric Antigen Receptor (CAR) therapy requires isolation of the respective immune cells from the patient’s blood, genetic manipulation, and infusion of the modified cells back into the patient’s body. This makes it personalized and effective but expensive. The CAR-T (modified T cells) therapy has shown...
Published: 1/11/2024
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Inventor(s): Pingping Hou
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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Methods of diagnosing B cell malignancies and detecting B cell malignancy relapse
Workflow schematic of the diagnostic platform for detecting B cell malignancies.
Invention Summary:
B cell malignancies comprise more than 50% of blood cancers and approximately 90% of all lymphomas. Existing technologies for the detection of B cell malignancies include modern imaging technologies, flow cytometry of B cell subpopulations, cytogenetic...
Published: 2/14/2025
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Inventor(s): Ping Xie, Jaeyong Jung, Roger Strair, Samantha Gokhale, Lauri Goodell, Amer Assal
Keywords(s): Cancer biomarkers
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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