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Expanding Human Primary Liver Tissues into Functional Organoids
­ ​ Invention Summary: Chronic liver diseases account for approximately two million deaths per year- one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Unfortunately, there are few treatment options for these conditions, and they commonly require organ transplants. The primary...
Published: 9/14/2022   |   Inventor(s): Hatem Sabaawy, Fredric Wondisford
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
SAHMI: Microbiome-based screening method for cancer and other diseases
​ ​ Screening methodology and principle data identifying differences in microbiome diversity from disease state in pancreatic cancer Invention Summary: The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 4/20/2022   |   Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
High Affinity/Specificity Bispecific Natural Killer Cell Engager for Cancer Immunotherapy
­​ Fig. 1: Schematic representation of the structure of a mAb (A) and a BiKE (B), and their functions. While mAbs engage NK cells with low affinity/specificity, BiKE binds to NK cells with high affinity/specificity resulting in enhanced anticancer efficacy and reduced side effects. Invention Summary: Monoclonal antibodies (mAb) facilitate...
Published: 4/20/2022   |   Inventor(s): Arash Hatefi, Shahryar Khoshtinat Nikkhoi
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
Combined Opioidergic and Beta-Adrenergic Drugs for Cancer and Immune Diseases
­​ Invention Summary: One of the major cancer therapy approaches that is being heavily investigated is immunotherapy. Immunotherapy involves modulating the cancer patient’s own immune system to identify tumors and cancer cells as foreign to their body. Currently, the major pathways being studied involve regulating the function...
Published: 4/19/2022   |   Inventor(s): Dipak Sarkar
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Cancer
Biomarkers for Identifying Patients at High Risk of Progressing from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary: Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 11/30/2021   |   Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
Leukemia inhibitory factor- Protective role for radiation/chemo-induced gut syndrome and GVHD
Invention Summary: Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury This is also true for Graft-versus-host disease (GVHD) which remains a major complication after allogeneic hematopoietic stem cell transplantation, a widely-used therapy for hematologic malignancies...
Published: 10/14/2021   |   Inventor(s): Wenwei Hu, Zhaohui Feng, Jianming Wang, Huaying Wang
Keywords(s): Anti-cancer, Gastrointestinal disease, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
JNK Inhibitor that Prevents Chemotherapy-induced Premature Ovarian Failure
JNK Inhibitor SP600125 prevented DOX-induced Primordial Follicle Loss Invention Summary: Premature ovarian failure (POF) is a disease characterized by the depletion of primordial follicles in women’s ovaries before the age of 40, and is a major side effect of chemotherapy in childhood-age, adolescent and young adult female cancer patients....
Published: 10/1/2021   |   Inventor(s): Shuo Xiao
Keywords(s):  
Category(s): Technology Classifications > Cancer
A Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals. Invention Summary: A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 9/17/2021   |   Inventor(s): Roger Howell, Behrooz Vaziri, Han Wu, Atam Dhawan
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics, or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals. Invention Summary: A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 9/17/2021   |   Inventor(s): Roger Howell, Jordan Pasternack, John Akudugu
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
New Vector Platform for Concurrent Tumor Imaging, Therapy, and Evaluation of Response to Therapy
Diagnosis of HER2+ cancer metastasis lesions in mouse using a genetically engineered targeted vector in conjunction with MRI. The MRI followed by voxel-by-voxel analysis of scans showed that the vector makes it possible to differentiate HER2+ from HER2- cancer lesions in mouse lungs Invention Summary: The human epidermal growth factor receptor-2...
Published: 6/7/2021   |   Inventor(s): Arash Hatefi
Keywords(s): Breast Cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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