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Bioinformatic Methods for Determining Resistance to Cancer Treatments
Invention Summary:
Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible.
Researchers at Rutgers University have...
Published: 5/18/2023
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Inventor(s): Antonina Mitrofanova, Sukanya Panja, Sarki Abdulkadir, Vishal Kothari, Edward Schaeffer
Keywords(s): Bioinformatics, Biomarkers, Digital Health
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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Methods of diagnosing B cell malignancies and detecting B cell malignancy relapse
Workflow schematic of the diagnostic platform for detecting B cell malignancies.
Invention Summary:
B cell malignancies comprise more than 50% of blood cancers and approximately 90% of all lymphomas. Existing technologies for the detection of B cell malignancies include modern imaging technologies, flow cytometry of B cell subpopulations, cytogenetic...
Published: 1/6/2023
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Inventor(s): Ping Xie, Jaeyong Jung, Roger Strair, Samantha Gokhale
Keywords(s): Cancer biomarkers
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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DEVELOPMENT OF SPECIFIC CRK-LIKE ADAPTOR PROTEIN INHIBITORS FOR CANCER THERAPY
NC5 inhibits tumor growth and prolongs survival in vivo. NC5 treatment inhibits TNBC tumor growth and prolongs mice survival in xenograft and PDX mouse models. (A) Survival of mice bearing MDA-MB-231-Luc orthotopic xenograft tumors following treatment with vehicle (black line), Gleevec (blue line), or NC5 (red line). (B) Survival of mice bearing PDX...
Published: 3/24/2023
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Inventor(s): Dongfang Liu, Xuening Wang
Keywords(s): Anti-cancer, Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Expanding Human Primary Liver Tissues into Functional Organoids
Invention Summary:
Chronic liver diseases account for approximately two million deaths per year- one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Unfortunately, there are few treatment options for these conditions, and they commonly require organ transplants. The primary...
Published: 9/14/2022
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Inventor(s): Hatem Sabaawy, Fredric Wondisford
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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SAHMI: Microbiome-based screening method for cancer and other diseases
Screening methodology and principle data identifying differences in
microbiome diversity from disease state in pancreatic cancer
Invention Summary:
The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 8/8/2022
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Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Combined Opioidergic and Beta-Adrenergic Drugs for
Cancer and Immune Diseases
Invention Summary:
One of the major cancer therapy approaches that is being heavily investigated is immunotherapy. Immunotherapy involves modulating the cancer patient’s own immune system to identify tumors and cancer cells as foreign to their body. Currently, the major pathways being studied involve regulating the function...
Published: 2/15/2023
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Inventor(s): Dipak Sarkar
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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Biomarkers for Identifying Patients at High Risk of Progressing
from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary:
Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 9/16/2022
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Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Leukemia inhibitory factor- Protective role for radiation/chemo-induced gut syndrome and GVHD
Invention Summary:
Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury This is also true for Graft-versus-host disease (GVHD) which remains a major complication after allogeneic hematopoietic stem cell transplantation, a widely-used therapy for hematologic malignancies...
Published: 10/4/2022
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Inventor(s): Wenwei Hu, Zhaohui Feng, Jianming Wang, Huaying Wang
Keywords(s): Anti-cancer, Gastrointestinal disease, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
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JNK Inhibitor that Prevents Chemotherapy-induced Premature Ovarian Failure
JNK Inhibitor SP600125 prevented DOX-induced Primordial Follicle Loss
Invention Summary:
Premature ovarian failure (POF) is a disease characterized by the depletion of primordial follicles in women’s ovaries before the age of 40, and is a major side effect of chemotherapy in childhood-age, adolescent and young adult female cancer patients....
Published: 2/15/2023
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Inventor(s): Shuo Xiao, Yingzheng Wang
Keywords(s):
Category(s): Technology Classifications > Cancer, Technology Classifications, Technology Classifications > Healthcare & Life Sciences
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A Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals.
Invention Summary:
A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 10/4/2022
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Inventor(s): Roger Howell, Behrooz Vaziri, Han Wu, Atam Dhawan
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
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