Search Results - longqin+hu

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New Drugs for the Prevention of Kidney Stones

In vivo efficacy study of an LH prodrug expressed as days CaOx crystals were detected in mouse urine/mouse/week Invention Summary: Hyperoxaluria is a condition characterized by excessive urinary excretion of oxalate. It can result from inherited genetic mutations, intestinal diseases, or a diet high in oxalate. This often leads to calcium...

Published: 8/15/2024 | Inventor(s): Longqin Hu, Yiling Wang

Keywords(s): Drug Discovery/Screening

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Novel Inhibitors of Keap1-Nrf2 Protein-Protein Interaction

Novel Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction Invention Summary: Nrf2 is a key transcription factor mediating anti-inflammatory and antioxidant responses in the body. Keap1 is a well-known repressor of Nrf2 that targets Nrf2 for its rapid proteasomal degradation. Dysfunctional Keap1-Nrf2 axis contributes to...

Published: 5/15/2024 | Inventor(s): Longqin Hu, Dhulfiqar Abed

Keywords(s): Small molecules

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics