Small Molecule Extracellular Inhibitors of TAM Receptors for Cancer Therapy
The TAM receptors (Tyro3, Axl, and Mertk) are a family of three homologous receptor tyrosine kinases (RTKs) that play important roles in tissue homeostasis, immune response, and the resolution of inflammation. Besides the intracellular catalytic kinase domain common to all kinases, the TAMs uniquely contain an extracellular domain...
Inventor(s): William Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Stanley Kimani, Thomas Comollo, Kamalendra Singh
Keywords(s): Anti-cancer, Brain Cancer, Breast Cancer, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics