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Method for Generating Memory T-cells In Vitro and Their Use in Immunotherapy
Invention Summary: Dendritic cell-based immunotherapies have been tested for the treatment of cancer patients with limited success. The limited success is probably due to the ineffective activation of specific T-cells by injected dendritic cells. In vitro generation of memory T-cells that can respond to cancer cells could circumvent ineffective T-cell...
Published: 11/3/2022   |   Inventor(s): Shigeko Yamashiro (Matsumura), Fumio Matsumura, Aya Matsumura
Keywords(s): Anti-cancer, Immunoassay
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
Enzyme Catalyzed Toehold Mediated Strand Displacement (TMSD)
​ ​ Invention Summary: Toehold mediated strand displacement (TMSD) is widely used in nanotechnology applications such as DNA nano-circuits and devices. The toeholds which are small single‐stranded DNA overhangs, are often utilized in kinetically controlled complex biochemical circuits. Existing toehold mediated strand displacement (TMSD)...
Published: 8/12/2022   |   Inventor(s): Smita Patel, Laura Johnson, Gayatri Patel, Anupam Singh
Keywords(s): Biosensor, Catalysts, Nanotechnology
Category(s): Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences
Electrostatic Actuator with Embedded Microfluidic Channels for Biological Applications
​ Invention Summary: Microsystem platforms for System-On-A-Chip devices often require the integration of multiple microfluidic functions, such as pumping and actuation components. Pneumatic actuation is commonly used due to the ease of fabrication with soft-lithography techniques. However, these methods do not provide complete actuation control...
Published: 5/25/2022   |   Inventor(s): Fernando Antonio Rebolledo Uscanga, Jeffrey Zahn
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
RNA-Aptamer-Mediated Base Editing System
​ ​ Invention Summary: The CRISPR/Cas9 system is a powerful tool for targeted genetic engineering in organisms ranging from animals to plants. Cas9 has intrinsic nuclease activity, which causes sequence specific DNA double-strand breaks (DSBs), leading to activation of cellular pathways such as homology dependent repair (HDR) for gene conversion...
Published: 5/10/2022   |   Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Research Tools, Technology Classifications > Gene Therapy
High Throughput Library Preparation of Long Genomic DNA Targets
​ ​ Overall workflow for preparing the LASSO library. Invention Summary: Advances in DNA sequencing have led to an exponential increase in the quantity of sequence data, whereas limited achievable maximum gene length (<200 bp) can produce highly biased libraries with constraints on sequence homology....
Published: 3/17/2022   |   Inventor(s): Biju Parekkadan, Lorenzo Tosi
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
Systems and Methods for Kinetic Measurement and Structure Determination of Macromolecules
Invention Summary: Microscopic images of cellular structure in biological samples can reveal important information regarding biological processes and cellular architecture. A correlative approach (CLEM), which uses both optical and electron microscopy, produces the most comprehensive results. For example, light microscopy information can be used...
Published: 3/2/2022   |   Inventor(s): Arkadiusz Kulczyk
Keywords(s): Machines & Instruments
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Research Tools, Technology Classifications > Medical Imaging
Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary: The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 12/1/2021   |   Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
PulseLab: An Integrated and Expandable Toolbox for Pulse Wave Velocity-base Blood Pressure Estimation
​​ Invention Summary: Cuff-less blood pressure (BP) estimation methods have been long pursued as substitutions for the conventional BP measurement methods to facilitate continuous and automatic monitoring of BP. The PWV (pulse wave velocity)-BP models, describing the relationship between the PWV and the BP, have been derived and used in recent...
Published: 9/27/2021   |   Inventor(s): Laleh Najafizadeh, Weinan Wang
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Research Tools, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences
Efficient and Non-Genotoxic Gene Transfer System for Stem Cells
Comparison of efficiency and toxicity of transfection reagents carrying different amounts of DNA for mesenchymal stem cells (MSCs). These cells are primary cells and considered hard-to-transfect. Panel A shows the transfection efficiency of “Rutgers Transfection System” in comparison to the five most widely used commercially available reagents;...
Published: 7/7/2021   |   Inventor(s): Arash Hatefi, Xuguang Chen, Alireza Nomani
Keywords(s): Stem Cells, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
dCas9 Protein Allele Sequestration for Improved CRISPR Gene Editing
style="line-height:normal">​ Invention Summary: CRISPR technology is widely used in research to edit genes in animals and cell lines and is moving towards therapeutic use in the clinic. Inherent to almost all methods employed in gene editing is the lack of control in target gene usage. A method to direct cleavage of only a single target within...
Published: 3/22/2021   |   Inventor(s): Peter Romanienko, Ghassan Yehia
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Research Tools
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