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The HμB (High-Efficiency μ-Fluidic Barrier)
Figure 1. The Hμb being used with a conventional microscope stage.
Invention Summary:
In the pharmaceutical and cosmetics industries, it is pertinent to screen for safety and dosage efficacy of developed drugs and compounds. These experiments can be costly and use equipment that can only be operated by skilled technicians and...
Published: 9/13/2023
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Inventor(s): Maribel Vazquez, Juan Pena-Carvajal
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
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Magneto-optical Kerr effect (MOKE) Spectrometer in Broad TeraHertz (THz) Frequency Range
Fig. 1: Top: Schematics of proposed sub-THz Martin-Puplett scanning interferometer for MOKE spectroscopy. Bottom: Prototype test bench in development.
Invention Summary:
Quantum magnetism effects are extensively sought for in contemporary materials research. Recent studies of magneto-optical polar Kerr effect (MOKE), in which rotation of polarization...
Published: 7/7/2023
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Inventor(s): Girsh Blumberg, Urmas Nagel, Toomas Room
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Physical Sciences & Engineering
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Optogalvanic Effect Detection System
Block Diagram of system
Invention Summary:
Current technologies for low specific activity radiocarbon analysis are currently limited in precision and accuracy by sample size requirements, background effects, long sample measurement times, and difficulty of use.
Researchers at Rutgers have developed an optogalvanic effect detection...
Published: 3/20/2023
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Inventor(s): Daniel Murnick, Mark Deguzman, Al Dutcher
Keywords(s): Drug Discovery/Screening, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Enzyme Catalyzed Toehold Mediated Strand Displacement (TMSD)
Invention Summary:
Toehold mediated strand displacement (TMSD) is widely used in nanotechnology applications such as DNA nano-circuits and devices. The toeholds which are small single‐stranded DNA overhangs, are often utilized in kinetically controlled complex biochemical circuits. Existing toehold mediated strand displacement (TMSD)...
Published: 1/24/2023
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Inventor(s): Smita Patel, Laura Johnson, Gayatri Patel, Anupam Singh
Keywords(s): Biosensor, Catalysts, Nanotechnology
Category(s): Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences
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Method for Generating Memory T-cells In Vitro and Their Use in Immunotherapy
Invention Summary:
Dendritic cell-based immunotherapies have been tested for the treatment of cancer patients with limited success. The limited success is probably due to the ineffective activation of specific T-cells by injected dendritic cells. In vitro generation of memory T-cells that can respond to cancer cells could circumvent ineffective T-cell...
Published: 11/3/2022
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Inventor(s): Shigeko Yamashiro (Matsumura), Fumio Matsumura, Aya Matsumura
Keywords(s): Anti-cancer, Immunoassay
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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Electrostatic Actuator with Embedded Microfluidic Channels for Biological Applications
Invention Summary:
Microsystem platforms for System-On-A-Chip devices often require the integration of multiple microfluidic functions, such as pumping and actuation components. Pneumatic actuation is commonly used due to the ease of fabrication with soft-lithography techniques. However, these methods do not provide complete actuation control...
Published: 11/8/2022
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Inventor(s): Fernando Antonio Rebolledo Uscanga, Jeffrey Zahn
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
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RNA-Aptamer-Mediated Base Editing System
Invention Summary:
The CRISPR/Cas9 system is a powerful tool for targeted genetic engineering in
organisms ranging from animals to plants. Cas9 has intrinsic nuclease activity, which causes sequence specific DNA double-strand breaks (DSBs), leading to
activation of cellular pathways such as homology dependent repair (HDR) for gene conversion...
Published: 12/2/2022
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Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Research Tools, Technology Classifications > Gene Therapy
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High Throughput Library Preparation of Long Genomic DNA Targets
Overall workflow for preparing the LASSO library.
Invention Summary:
Advances in DNA sequencing have led to an exponential increase in the quantity of sequence data, whereas limited achievable maximum gene length (<200 bp) can produce highly biased libraries with constraints on sequence homology....
Published: 7/26/2023
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Inventor(s): Biju Parekkadan, Lorenzo Tosi
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Systems and Methods for Kinetic Measurement and Structure Determination of Macromolecules
Invention Summary:
Microscopic images of cellular structure in biological samples can reveal important information regarding biological processes and cellular architecture. A correlative approach (CLEM), which uses both optical and electron microscopy, produces the most comprehensive results. For example, light microscopy information can be used...
Published: 4/11/2023
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Inventor(s): Arkadiusz Kulczyk
Keywords(s): Machines & Instruments
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Research Tools, Technology Classifications > Medical Imaging
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Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary:
The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 9/21/2023
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Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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