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Gsx1 GENE THERAPY TO TREAT SPINAL CORD INJURY
Gsx1 treatment promotes recovery of locomotion function in injured mice.
Invention Summary:
Spinal cord injury (SCI) can lead to permanent disruption of nervous system function. There is no effective treatment for promoting recovery of motor function after SCI currently available on the market. Previous research on SCI treatment focused on...
Published: 1/11/2023
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Inventor(s): Li Cai, Misaal Patel, Lisa Lyu
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy, Technology Classifications > CNS Disorder
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Therapeutic Human Monoclonal Antibody (HUMAB) with Extremely Potent and Broadly Neutralizing Activity for Omicron and Other CoV-2 Variants
Potent breadth and cross-reactivity of novel CoV2 neutralizing human monoclonal antibody that can neutralize the highly immune-evasive BQ.1/BQ.1.1 variants that are currently responsible for ≅ 50% of CoV2 infection in US.
Invention Summary:
The emergence of highly immune evasive SARS-CoV2 escape mutants require an immediate response...
Published: 1/27/2023
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Inventor(s): Alok Choudhary, Abraham Pinter
Keywords(s): Antibodies, Respiratory Disease
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Diagnostics
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RNA-Aptamer-Mediated Base Editing System for Agriculture
Invention Summary:
The CRISPR/Cas system is a powerful tool for precision genetic engineering in organisms including plants. However, the conventional CRISPR technology depends on DSBs which may lead to undesired genetic events such as off-target insertions, deletions, and chromosomal translocations. The Base Editing technology...
Published: 12/2/2022
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Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
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Method for Generating Memory T-cells In Vitro and Their Use in Immunotherapy
Invention Summary:
Dendritic cell-based immunotherapies have been tested for the treatment of cancer patients with limited success. The limited success is probably due to the ineffective activation of specific T-cells by injected dendritic cells. In vitro generation of memory T-cells that can respond to cancer cells could circumvent ineffective T-cell...
Published: 11/3/2022
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Inventor(s): Shigeko Yamashiro (Matsumura), Fumio Matsumura, Aya Matsumura
Keywords(s): Anti-cancer, Immunoassay
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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Expanding Human Primary Liver Tissues into Functional Organoids
Invention Summary:
Chronic liver diseases account for approximately two million deaths per year- one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Unfortunately, there are few treatment options for these conditions, and they commonly require organ transplants. The primary...
Published: 9/14/2022
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Inventor(s): Hatem Sabaawy, Fredric Wondisford
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel ChABC formulation with machine learning-guided automation
Invention Summary:
Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 10/12/2022
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Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
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RNA-Aptamer-Mediated Base Editing System
Invention Summary:
The CRISPR/Cas9 system is a powerful tool for targeted genetic engineering in
organisms ranging from animals to plants. Cas9 has intrinsic nuclease activity, which causes sequence specific DNA double-strand breaks (DSBs), leading to
activation of cellular pathways such as homology dependent repair (HDR) for gene conversion...
Published: 12/2/2022
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Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Research Tools, Technology Classifications > Gene Therapy
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Innovative Assessment of Cardiovascular Function for Individualized Treatment, Training and Diet Plans
Invention Summary:
Measures to assess cardiovascular health range from simple tests such as blood pressure, resting heart rate, or stress test to ones that are highly invasive such as pulmonary catheterization. In patients at risk for peripheral artery disease, such as diabetics, there are other measures including reactive hyperemia tests...
Published: 5/2/2022
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Inventor(s): Andrew Gow
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 8/22/2022
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
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Use of Retinoids in Congenital Erythropoietic Porphyria
Invention Summary:
Congenital erythropoietic porphyria (CEP) is an unaddressed orphan diseased caused by a rare genetic disorder leading to accumulation of uro/coproporphyrin-I (uro-I) in tissues due to inhibition of the enzyme uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe photosensitivity, and photo-mutilation....
Published: 1/9/2023
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Inventor(s): Bishr Omary, Jordan Shavit
Keywords(s): Small molecules
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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