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Method for Generating Memory T-cells In Vitro and Their Use in Immunotherapy
Invention Summary: Dendritic cell-based immunotherapies have been tested for the treatment of cancer patients with limited success. The limited success is probably due to the ineffective activation of specific T-cells by injected dendritic cells. In vitro generation of memory T-cells that can respond to cancer cells could circumvent ineffective T-cell...
Published: 11/3/2022   |   Inventor(s): Shigeko Yamashiro (Matsumura), Fumio Matsumura, Aya Matsumura
Keywords(s): Anti-cancer, Immunoassay
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
Expanding Human Primary Liver Tissues into Functional Organoids
­ ​ Invention Summary: Chronic liver diseases account for approximately two million deaths per year- one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Unfortunately, there are few treatment options for these conditions, and they commonly require organ transplants. The primary...
Published: 9/14/2022   |   Inventor(s): Hatem Sabaawy, Fredric Wondisford
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Novel ChABC formulation with machine learning-guided automation
​ ​ Invention Summary: Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 8/2/2022   |   Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
RNA-Aptamer-Mediated Base Editing System
​ ​ Invention Summary: The CRISPR/Cas9 system is a powerful tool for targeted genetic engineering in organisms ranging from animals to plants. Cas9 has intrinsic nuclease activity, which causes sequence specific DNA double-strand breaks (DSBs), leading to activation of cellular pathways such as homology dependent repair (HDR) for gene conversion...
Published: 5/10/2022   |   Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Research Tools, Technology Classifications > Gene Therapy
Innovative Assessment of Cardiovascular Function for Individualized Treatment, Training and Diet Plans
​ ​ Invention Summary: Measures to assess cardiovascular health range from simple tests such as blood pressure, resting heart rate, or stress test to ones that are highly invasive such as pulmonary catheterization. In patients at risk for peripheral artery disease, such as diabetics, there are other measures including reactive hyperemia tests...
Published: 5/2/2022   |   Inventor(s): Andrew Gow
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
​ S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control.​ Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 4/20/2022   |   Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
Use of Retinoids in Congenital Erythropoietic Porphyria
Invention Summary: Congenital erythropoietic porphyria (CEP) is an unaddressed orphan diseased caused by a rare genetic disorder leading to accumulation of uro/coproporphyrin-I (uro-I) in tissues due to inhibition of the enzyme uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe photosensitivity, and photo-mutilation....
Published: 4/20/2022   |   Inventor(s): Bishr Omary
Keywords(s): Small molecules
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
High Affinity/Specificity Bispecific Natural Killer Cell Engager for Cancer Immunotherapy
­​ Fig. 1: Schematic representation of the structure of a mAb (A) and a BiKE (B), and their functions. While mAbs engage NK cells with low affinity/specificity, BiKE binds to NK cells with high affinity/specificity resulting in enhanced anticancer efficacy and reduced side effects. Invention Summary: Monoclonal antibodies (mAb) facilitate...
Published: 4/20/2022   |   Inventor(s): Arash Hatefi, Shahryar Khoshtinat Nikkhoi
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
Biodegradable and Biocompatible Polymers for Controlled NSAID Delivery
­ ​ A. Drug delivery system hydrolysis – composed of 1 (Ibuprofen), 2 (naproxen) and 3 (tartatic acid) into polymer backbones. B. Hydrolytic degradation of the ibuprofen-based polyester. Invention Summary: Ibuprofen and naproxen are commonly used to treat pain and swelling associated with rheumatoid arthritis and osteoarthritis....
Published: 3/17/2022   |   Inventor(s): Kathryn Uhrich, Roselin Rosario-Melendez
Keywords(s): Biomaterials, Inflammation, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Iodinated Salicylate-Polymers
​ ​ FIG. 2( a) is a cross-sectional view of an apparatus or article including a medical device and an iodinated polymer coating in accordance with some embodiments. FIG. 2( b) is a perspective view of the medical device, shown in FIG. 2( a), having a surface that is partially coated with the iodinated polymer coating in accordance...
Published: 3/17/2022   |   Inventor(s): Kathryn Uhrich, Ashley Carbone
Keywords(s): Anti-cancer, Drug Delivery, Imaging, Implants, Polymers & Composites, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Polymers/Composites/Materials
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