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RED LIGHT THERAPY DEVICE FOR INTRAVENTRICULAR HEMORRHAGE IN NEWBORNS
Schematic prototype and general appearance of the external fontanelle intraventricular hemorrhage light (EFIL) device
Invention Summary:
Transcranial Photo Biomodulation (tPBM) uses light to treat brain-related diseases, such as intraventricular hemorrhage (IVH). In vivo studies on IVH-induced adult and neonatal mice show, increased clot resorption,...
Published: 9/25/2023
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Inventor(s): Garrett Gianneschi
Keywords(s): Machines & Instruments
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences
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Off-the-Shelf CAR-Macrophages for Solid Tumors
Invention Summary:
Chimeric Antigen Receptor (CAR) therapy requires isolation of the respective immune cells from the patient’s blood, genetic manipulation, and infusion of the modified cells back into the patient’s body. This makes it personalized and effective but expensive. The CAR-T (modified T cells) therapy has shown...
Published: 9/20/2023
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Inventor(s): Pingping Hou
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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Dynamic Light Spectrum Absorption Eyewear
A perspective view of some components of eyewear
Invention Summary:
Chromotherapy or Colorology is a known holistic or alternative treatment which has been used for healing and psychological well-being of an individual. Qualitative and quantitative data exists that demonstrates the impact of color on an individual’s psychological...
Published: 9/20/2023
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Inventor(s): Glenn Amatucci, Alexandra Amatucci
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Energy & Battery, Technology Classifications > Healthcare & Life Sciences
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The HμB (High-Efficiency μ-Fluidic Barrier)
Figure 1. The Hμb being used with a conventional microscope stage.
Invention Summary:
In the pharmaceutical and cosmetics industries, it is pertinent to screen for safety and dosage efficacy of developed drugs and compounds. These experiments can be costly and use equipment that can only be operated by skilled technicians and...
Published: 9/13/2023
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Inventor(s): Maribel Vazquez, Juan Pena-Carvajal
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
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Microparticles and Machine Learning Detect Surface Receptors in a Multifrequency Microfluidic Cytometer
Graphical overview depicts the detection of electrically-sensitive cell membrane receptors: (A) Microparticles with varied aluminum oxide-coatings (20nm and 10nm) are (B) coated with specific antibodies (anti-CD66b for 20 nm, anti-CD11b for 10nm) to (C) target inflammatory neutrophil receptors, resulting in cell-particle conjugates indicating...
Published: 9/1/2023
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Inventor(s): Umer Hassan, Mehdi Javanmard, Brandon Ashley
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering
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Gel-Tethered Molecular Beacons for Detection of Microbes
Invention Summary:
Pathogen detection and characterization is a critical first step in the course of care for individuals suffering from these infectious diseases, and the speed by which this pathogen detection occurs can make all the difference between life or death for many patients. Currently, the gold standard for microbe quantification is either...
Published: 8/24/2023
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Inventor(s): Salvatore Marras, Xiaoguang Dai, Matthew Libera
Keywords(s): Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
Schematic representation of MitoScript and its components
Invention Summary:
Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 7/17/2023
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s):
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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A treatment to promote skin wound healing
Treatment of wounds with TGM shows improved recovery compared to control group in a span of 10 days.
Invention Summary:
Helminths are potent modulators of immune function capable of stimulating an immune response that includes significant wound healing effector functions. Effective wound repair requires both the direct reconstruction...
Published: 9/17/2023
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Inventor(s): William Gause
Keywords(s): Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Plant-based system for generation of single-domain antibodies to combat viral infections
Plant-derived antibodies designed to target SARS- CoV-2 bind to SARS-CoV2 spike protein similar to bacteria derived antibodies based on ELISA.
Invention Summary:
The use of neutralizing antibodies is a strategy for treating viral infections, especially for individuals who are immunocompromised or have high-risk medical conditions. Mass production...
Published: 6/27/2023
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Inventor(s): Tamara Minko, Natalia Pogrebnyak, Andrew Shen, Obeid Malekshah
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Vaccine
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SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2.
Invention Summary:
Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 6/7/2023
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Inventor(s): Jun Wang, Edward Arnold, Francesc Ruiz Figueras, Prakash Jadhav, Bin Tan, Ahmadullah Ansari, Ashima Chopra
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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