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A Method of Aggregating Environmental DNA for
Surveillance of terrestrial eDNA is achieved by: (1) Sampling of spatially distributed eDNA (2) A strategy to aggregate species-specific samples (3) Concentration of target eDNA (4) Extraction of eDNA and testingInvention Summary: Earlyrecognition and rapid eradication of exotic species can prevent detrimental ecological or economic effects. However,...
Published: 1/12/2022   |   Inventor(s): Rafael Valentin, Julie Lockwood, Dina Fonseca
Keywords(s): Biosensor, Pest control
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Pest Control, Technology Classifications > Physical Sciences & Engineering
MicroRNA Based Therapeutics for Parkinson’s Disease
Protection of the mouse brain by microRNA-7 against the toxicity of a-synuclein (A) Tyrosine hydroxylase (TH) stained coronal section of mouse brain injected in the right striatum with AAV-miR-7 or non-targeting (NT) vector following by a-synuclein preformed fibrils (PFF) or PBS. (B) Substantia nigra sections. (C) Nigral dopamine neuron count. (D) Striatal...
Published: 12/22/2021   |   Inventor(s): Mary Maral Mouradian, Eunsung Junn
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
MicroRNA-7 Gene Therapy Promotes Functional Recovery Following Spinal Cord Injury
Following sever spinal cord compression, the AAV-miR-7 injected mice showed improved locomotor recovery, which is characterized by the Basso Mouse Scale (BMS). Invention Summary: Spinal cord injury (SCI) results in partial or complete loss of sensory or motor function. According to the National Spinal Cord Injury Statistical Center,...
Published: 12/22/2021   |   Inventor(s): Mary Maral Mouradian, Eunsung Junn, Myung-Sik Yoo
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
Immunotherapy for Inflammatory Bowel Disease (IBD)
­ ​​​​​H&E staining of colons from Zbtb20 WT and Zbtb20 cKO mice treated with DSS. Survival curves for WT and cKO mice following treatment with DSS in drinking water. Adoptive transfer of Zbtb20 expressing Tregs rescues mice from death and protects. Mice are also protected from excessive weight loss (not shown). Invention Summary:...
Published: 12/9/2021   |   Inventor(s): Derek Sant'Angelo, Lisa Denzin
Keywords(s): Autoimmune
Category(s): Technology Classifications > Healthcare & Life Sciences
Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV.Cationic Amphiphile Concentration (μM)Invention Summary:Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion, premature...
Published: 12/1/2021   |   Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Biodegradable and Versatile Copolymers to Promote Wound Healing
Invention Summary:Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise for promoting topical and surgical wound healing, as SA is known to reduce local pain and inflammation as well as potentially prevent fibrous adhesion formation by reducing scar tissue. The release is stable over a...
Published: 12/1/2021   |   Inventor(s): Kathryn Uhrich, Sabrina Snyder
Keywords(s): Biomaterials, Drug Delivery, Neurological disorder & neuropathic pain, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary:The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 12/1/2021   |   Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
Biomarkers for Identifying Patients at High Risk of Progressing from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary: Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 11/30/2021   |   Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
Improved Nerve Conduits for Treatment of Peripheral Nerve Injuries
Scanning electron microscope image of conduits Invention Summary: Nerve conduits are used for treatment of peripheral nerve injuries. However, the current conduits are associated with poor healing resulting from swelling and reduction of luminal volume, suture pull-out, collapse, kinking, compression, and lack of mechanical strength to withstand...
Published: 11/11/2021   |   Inventor(s): Joachim Kohn
Keywords(s): Biomaterials, Neurological disorder & neuropathic pain, Polymers & Composites, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials
High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues. Invention Summary: Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming....
Published: 11/10/2021   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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