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Tirzepatide and other GLP1RA as a novel treatment for patients with congenital generalized lipodystrophy
The image represents the mechanism of action of Tirzepatide. Image courtesy: Rabbani et al., 2024
Invention Summary:
Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder, affecting approximately 1 in 10 million...
Published: 12/5/2024
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Inventor(s): Christoph Buettner, Svetlana Ten
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Three‐Dimensional, Load‐Sharing, Pre‐Vascularized
Scaffold for Bone Regeneration
Bi-weekly x-rays (A) showed progressive bone regeneration up to 10 weeks. The reconstructed CT images (B & C) show bone growing into and within the scaffold while the scaffolds maintained their mechanical strength.
Invention Summary:
Over 600,000 bone grafting procedures are performed in the US annually. While bone autografting is the gold...
Published: 11/25/2024
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Inventor(s): Joseph Freeman, Shreya Madhavarapu, Adhithi Lakshmikanthan
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Sertraline: Anti-Mycotic and Anti-Obesity Applications
Allosteric binding of sertraline with PAP results in a drastic reduction of yeast cells
Invention Summary:
Triacylglycerols are the main form of fat in the human body. Two key intermediates in triacylglycerol synthesis include phosphatidic acid and diacylglycerol....
Published: 11/20/2024
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Inventor(s): George Carman, Geordan Stukey
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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IDENTIFYING TREATMENT RESPONSE SIGNATURES
Invention Summary:
Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible.
Researchers at Rutgers University have...
Published: 11/12/2024
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Inventor(s): Antonina Mitrofanova, Sukanya Panja
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level
NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription.
Invention Summary:
As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating...
Published: 11/25/2024
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Inventor(s): Ki-Bum Lee, Sy-Tsong Chueng, Hyeon-Yeol Cho, Young Sup Yoon
Keywords(s): Nanoparticles
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning.
Invention Summary:
Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024
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Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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GDA Inhibitors for the Treatment of Spinal Cord-Induced Neuropathic Pain
Invention Summary:
Spinal cord injury (SCI) and its associated chronic pain can significantly diminish quality of life. While therapies like spinal cord stimulation and neuromodulation offer potential pain relief, current pharmacological options fall short, often proving ineffective, short-lived, and laden with side effects, including addiction....
Published: 11/6/2024
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Inventor(s): Bonnie Firestein-Miller, Stella Elkabes
Keywords(s): Neurological disorder & neuropathic pain, Spinal Cord
Category(s): Technology Classifications > Therapeutics, Technology Classifications > CNS Disorder, Technology Classifications > Healthcare & Life Sciences
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MYC Program as a biomarker of response to treatment with Enzalutamide
Invention Summary:
Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to...
Published: 10/11/2024
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel topical formulation of Cyclosporine
Patient outcome: Left- 79-year-old patient after 3.5 months. Right- 50-year-old patient after 4 weeks of treatment with the novel formulation. Ref: JAAD Case Rep. 2023 Aug 20;40
Invention Summary:
Pyoderma Gangrenosum (PG) is a rare, acute inflammatory skin disorder characterized by the rapid development of large, painful ulcers. PG frequently...
Published: 9/26/2024
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Inventor(s): Amy Pappert, Cindy Wassef, Radhika Shah
Keywords(s): Dermatology
Category(s): Technology Classifications > Healthcare & Life Sciences
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Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling
CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux
Invention Summary:
Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of...
Published: 10/18/2024
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Inventor(s): Skylar Chuang, Ki-Bum Lee
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology
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