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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
­ Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19 Invention Summary: Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical...
Published: 4/4/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences
Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19 Invention Summary: Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for...
Published: 4/25/2024   |   Inventor(s): Jeisac Guzmán Rivera, Maria Gennaro, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
Decentralized, Privacy-preserving Navigation Recommendation System
se; } ​ The recommendation system provides a proactive and personalized route for a user’s movement indoors or outdoors. Invention Summary: Contact tracing has been shown to be an effective disease control measure and a key strategy for preventing further spread of the COVID-19 pandemic. However, smartphone contact tracing tools have...
Published: 5/8/2024   |   Inventor(s): Dario Pompili, Saman Aliari Zonouz, Vidyasagar Sadhu
Keywords(s): Wireless
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > COVID-19, Technology Classifications > Software & Algorithms, Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Healthcare & Life Sciences
Two-Way Knowledge Distillation for Federated Learning
​ The workflow of the Fed2KD framework. Red arrows indicate the knowledge distillation direction. Invention Summary: Current contact tracing reporting platforms for infectious diseases are limited by their reactive nature, centralized approach, use of GPS, and privacy risk due to exchange of user data. Existing federated learning (FL) frameworks...
Published: 4/21/2024   |   Inventor(s): Dario Pompili, Chuanneng Sun
Keywords(s):  
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > COVID-19, Technology Classifications > Software & Algorithms
Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome
​ Fig 1. The potential added value of testing for novel biomarkers including FCGBP, MRC1, and LBP in children with MIS-C include the quick and accurate diagnosis, treatment, and prognosis.​ Invention Summary: The multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for timely, accurate disease...
Published: 4/21/2024   |   Inventor(s): Maria Gennaro, Jeisac Guzmán Rivera, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
Plant-based system for generation of single-domain antibodies to combat viral infections
Plant-derived antibodies designed to target SARS- CoV-2 bind to SARS-CoV2 spike protein similar to bacteria derived antibodies based on ELISA. Invention Summary: The use of neutralizing antibodies is a strategy for treating viral infections, especially for individuals who are immunocompromised or have high-risk medical conditions. Mass production...
Published: 4/21/2024   |   Inventor(s): Tamara Minko, Natalia Pogrebnyak, Andrew Shen, Obeid Malekshah
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Vaccine
SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 4/25/2024   |   Inventor(s): Jun Wang, Edward Arnold, Francesc Ruiz Figueras, Prakash Jadhav, Bin Tan, Ahmadullah Ansari, Ashima Chopra
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
Serological/ELISA-Based Test For COVID-19
Invention Summary: The unprecedented outbreak and spread of SARS-CoV-2 has led to rapid development of the COVID-19 pandemic. Since its beginning in 2020, the virus has rapidly evolved due to its spread, causing the generation of novel variants like Omicron more recently. Thus, there is still an unmet need for more specific, reliable, and high throughput...
Published: 4/21/2024   |   Inventor(s): Maria Gennaro, Abraham Pinter
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19
Therapeutic Human Monoclonal Antibody (HUMAB) with Extremely Potent and Broadly Neutralizing Activity for Omicron and Other CoV-2 Variants
­​ Potent breadth and cross-reactivity of novel CoV2 neutralizing human monoclonal antibody that can neutralize the highly immune-evasive BQ.1/BQ.1.1 variants that are currently responsible for ≅ 50% of CoV2 infection in US. Invention Summary: The emergence of highly immune evasive SARS-CoV2 escape mutants require an immediate response...
Published: 4/21/2024   |   Inventor(s): Alok Choudhary, Abraham Pinter
Keywords(s): Antibodies, Respiratory Disease
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Diagnostics
“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
​ S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control.​ Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 5/8/2024   |   Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
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