High Affinity/Specificity Bispecific Natural Killer Cell Engager for Cancer Immunotherapy
Fig. 1: Schematic representation of the structure of a mAb (A) and a BiKE (B), and their functions. While mAbs engage NK cells with low affinity/specificity, BiKE binds to NK cells with high affinity/specificity resulting in enhanced anticancer efficacy and reduced side effects.
Monoclonal antibodies (mAb) facilitate...
Inventor(s): Arash Hatefi, Shahryar Khoshtinat Nikkhoi
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
Efficient and Non-Genotoxic Gene Transfer System for Stem Cells
Comparison of efficiency and toxicity of transfection reagents carrying different amounts of DNA for mesenchymal stem cells (MSCs). These cells are primary cells and considered hard-to-transfect. Panel A shows the transfection efficiency of “Rutgers Transfection System” in comparison to the five most widely used commercially available reagents;...
Inventor(s): Arash Hatefi, Xuguang Chen, Alireza Nomani
Keywords(s): Stem Cells, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
New Vector Platform for Concurrent Tumor Imaging, Therapy, and Evaluation of Response to Therapy
Diagnosis of HER2+ cancer metastasis lesions in mouse using a genetically engineered targeted vector in conjunction with MRI. The MRI followed by voxel-by-voxel analysis of scans showed that the vector makes it possible to differentiate HER2+ from HER2- cancer lesions in mouse lungs
The human epidermal growth factor receptor-2...
Inventor(s): Arash Hatefi
Keywords(s): Breast Cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer