Wireless Readout & Label-Free Detection of Protein Biomarkers

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The prototype has been built and tested using PBS spiked with HMGB1 protein. Voltage response by adding (A) NC to the well, and (B) protein sample to the well


Invention Summary:

The high demand for point-of-care (POC) biosensors is evident from their worldwide market projection of approximately $37 billion by 2026. The conventional use of enzyme linked immunoabsorbent assay (ELISA) for protein quantification is cost-and-time inefficient, highlighting the need for improved biosensors.

Rutgers researcher Dr. Mehdi Javanmard and his team have invented a nanowell array sensor system capable of performing electrochemical impedance spectroscopy-based biomarker sensing in the blood. Firstly, the use of electric field immobilizes the probe antibodies in the nanowell, followed by change of impedance during the binding of biomarkers to the immobilized antibodies. These label-free assays can detect cortisol and other biomarkers such as TNF-α with a dynamic sensitive range of 10-500 ng/l. Further advancement by the team includes resonance inductive coupling based wireless transmission capabilities, which enables implantation of the biosensor for continuous label-free detection of protein biomarkers in situ.

Market Applications:

  • POC in vitro diagnostic device for biomarker detection in the blood.
  • Continuous monitoring of intradermal biomarkers. 
  • Serology testing of antibodies.

Advantages:

  • Label-free detection using changes in impedance as the readout.
  • Works under high salt condition (e.g. in serum). 
  • Comparable performance to ELISA.
  • Wireless sensing of protein biomarkers.

Publications:

Intellectual Property & Development Status: Provisional application filed. Patent pending. Available for licensing and/or research collaboration. For any business development and other collaborative partnerships, contact:  marketingbd@research.rutgers.edu

Patent Information:
ID: MP-2022-059P
Category:

Inventors:
Licensing Manager:
Eusebio Pires
TechAdvance Manager
Rutgers, The State University of New Jersey
ep620@research.rutgers.edu
Business Development:
Eusebio Pires
Senior Manager, Technology Marketing & Business Development
Rutgers, The State University of New Jersey
ep620@research.rutgers.edu
Keywords: