Latest technologies from Rutgers the State University of New Jersey

Method for performing federated learning in non-convex problems

christopher.perkins@rutgers.edu — Tue, 14 Apr 2026 13:32:35 GMT

FeCA roadmap. 1st column: The centralized dataset distributed to clients. 2nd column: The k-means clustering results on different clients under non-IID data sample scenario, where black triangles and squares represent centroids. 3rd column: Eliminating one-fit-many centroids in Algorithm 2, indicated by hollow squares and triangles. 4th column: Centroids sent to the server. 5th column: Aggregation of received centroids on the server where red crosses represent recovered centroids. Invention Summary: FeCA, a one-shot federated clustering method, provides data privacy and enhanced p...

Modular Scanning Probe Microscopy (SPM) Head and Compact UHV Probe Transfer System

christopher.perkins@rutgers.edu — Fri, 10 Apr 2026 07:39:21 GMT

Connection of STM head to transfer mechanism in RT chamber Invention Summary: Traditional scanning probe microscopy (SPM) systems face a range of significant technical and operational challenges that hinder performance and flexibility. Rigid, hard-wired connections restrict head configurations, while probe transfers between chambers risk compromising vacuum integrity. Large instrument footprints and cumbersome navigation systems make operation in confined ultra-high vacuum (UHV) and high magnetic field environments particularly difficult. Cryogen-free STM setups are further hamper...

Low profile and compact transfer mechanism for remote controlled assembly of probes in ultra‐high vacuum and low temperature environments

christopher.perkins@rutgers.edu — Fri, 27 Mar 2026 11:20:54 GMT

STM head top plate and deposition and recovery tools. (a) STM head top transfer plate for attaching to the tools. (b) Deposition tool arms/hooks engaged with STM head transfer plate handles. (c) Deposition tool from a front and side view. (d) Recovery tool from a front and side view. Invention Summary: Scanning probe microscopy (SPM), a key invention in nanoscience, has now been extended to a wide spectrum of basic and applied fields. Its application to basic science led to a paradigm shift in understanding and perception of matter at its nanoscopic and even atomic levels. SPM use...

High-Efficiency Electrospray Deposition for Sub-Plume-Scale Surfaces

christopher.perkins@rutgers.edu — Fri, 27 Mar 2026 09:58:19 GMT

Schematic of the electrospray setup. (a) Schematic and (b) photograph of an electrospray deposition experiment. White dashed lines are provided as a guide to the eye of the plume. (c) Schematic of the improved spray system and process, highlighting different enhancements (E#). In stage 1, a negative polarity spray (E1) is sprayed directly at a large extractor ground (E2) coated in insulator (E3). In stage 2, a grounded target with an insulating mask (E4) is placed on the extractor ground (E2). It is then sprayed by the spray solution at positive polarity which is stabilized by a foc...

SARS-CoV-2 Papain-Like Protease (PLpro) Inhibitors

christopher.perkins@rutgers.edu — Fri, 27 Mar 2026 09:03:16 GMT

Invention Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a global health risk despite the availability of vaccines and two oral antivirals, molnupiravir and Paxlovid. Limitations including modest efficacy, drug–drug interactions, and the emergence of resistance, particularly to nirmatrelvir, highlight the urgent need for additional oral antivirals with novel mechanisms of action. The papain-like protease (PLpro) is an essential viral enzyme required for polyprotein processing and viral replication, and also suppresses host innate immun...

Antiviral Compositions for Enterovirus D68 and an FP-Based Method for Validating Candidate Compounds

christopher.perkins@rutgers.edu — Fri, 27 Mar 2026 08:51:51 GMT

Invention Portfolio Summary: Enterovirus D68 (EV-D68) is an RNA virus in the Picornaviridae family, is a re-emerging pediatric pathogen associated with recurrent outbreaks, can cause severe respiratory disease, and has also been linked to acute flaccid myelitis (AFM), whose incidence has risen steadily over the past decade. There are no approved antivirals or vaccines, representing a major unmet medical need. Reported inhibitors, including those targeting the viral 2C protein, lack sufficient potency, selectivity, and pharmacokinetic profiles for clinical development. Rutgers re...

REALM: Smarter, Faster, and More Reliable Document Re-Ranking

christopher.perkins@rutgers.edu — Fri, 27 Mar 2026 06:14:05 GMT

Workflow of recursive relevance modeling framework for LLM-based document re-ranking Invention Summary: Most Large Language Model LLM-based re-rankers produce single-point relevance scores without modeling uncertainty, even though LLM outputs are inherently stochastic. Treating these predictions as deterministic leads to unstable rankings, sensitivity to prompt phrasing, and disordered top-k results—especially for borderline documents. Rutgers researchers have developed REALM: Recursive Bayesian Uncertainty-Aware L...

Non-Invasive Closed-Loop Diaphragmatic Pacer for SUDEP Prevention

christopher.perkins@rutgers.edu — Fri, 27 Mar 2026 05:58:02 GMT

Invention Summary: Epileptic seizures can cause central respiratory arrest, a phenomenon called Sudden Unexpected Death in Epilepsy (SUDEP) which needs immediate respiratory support within 3 minutes to avoid death. The absence of reliable biomarkers further limits preventive measures to avoid SUDEP. Here, a wearable diaphragmatic pacer that non-invasively detects and prevents sudden unexpected death in epilepsy by stimulating breathing during seizures. Rutgers researchers have developed an innovative technology that provides a non-invasive solution to sudden unexpected death in ...

Effortless Biometric User Authentication for Extended Reality (XR) Headsets Using Vital-Sign Harmonics

christopher.perkins@rutgers.edu — Tue, 10 Mar 2026 13:17:06 GMT

Technology harnesses harmonics of vital sign vibrations to realize effortless (does not require any explicit user actions) and inbuilt (uses motion sensors available on all XR headsets) XR user authentication Invention Summary: As extended reality (XR) technologies advanced and became more integrated into everyday digital environments, new challenges emerged in securing user authentication. Traditional security mechanisms—such as passwords, PIN codes, and conventional biometric systems—proved increasingly incompatible with immersive interfaces. In response, t...

AN INTRA-OCULAR METHOD TO TREAT NEUROPSYCHIATRIC DISORDERS

christopher.perkins@rutgers.edu — Wed, 04 Mar 2026 11:22:07 GMT

Figure A indicates in rats the latency as a measure of time to escape from a maze. Figure B indicates AD rats with PRAM therapeutic showed less time to escape the maze, demonstrating improved memory and spatial recall Invention Summary: Alzheimer’s disease (AD) affects over 55 million people worldwide and is projected to triple by 2050. Current FDA approved treatments such as cholinesterase inhibitors and amyloid targeting therapies provide modest symptomatic benefits without meaningfully altering disease progression or addressing the full spect...

Rare-earth Doped Nanocomposite Materials for Photonics Applications

christopher.perkins@rutgers.edu — Mon, 23 Feb 2026 11:12:58 GMT

Invention Summary: An esteemed Rutgers University Professor of Materials Science has developed an optically transparent composite material comprised of highly Rareearth- doped solid solution inorganic nanoparticles. These nanocomposite particles can be dispersed in a matrix of polymers, glass, liquid, or crystalline material. The nanoparticles are constructed of low phonon energy metal halides such as CaF2 or LaCL3, or oxyhalides, doped with Rare-earth active ions up to 60 mol percent, a particle loading level unseen in prior technologies. The dispersed nanoparticles in a matrix range be...

Enhancers for gene delivery to specific motor neuron subtypes

christopher.perkins@rutgers.edu — Fri, 20 Feb 2026 13:17:56 GMT

Enhancers demonstrating motor neuron subtype specificity Invention Summary: Specific types of motor neurons become dysfunctional and degenerate in motor neurons diseases like amyotrophic lateral sclerosis and Charcot Marie tooth syndrome. To reduce the risk of toxicity from ubiquitous or non-specific expression of gene therapies, there is a need for development of vectors that allow restricted viral expression of gene therapies in specific motor neuron subtypes Rutgers inventors identified novel DNA enhancers that can activate gene expression specifically in gamma and alpha mot...

Electrotherapy for dental implants

christopher.perkins@rutgers.edu — Fri, 20 Feb 2026 10:29:52 GMT

In Situ electrochemical repassivation therapy of titanium dental implants can restore corrosion resistance and enhance cellular biocompatibility. Invention Summary: Peri-implantitis affects up to 25% of dental implant patients and is a leading cause of implant failure, representing a global market burden exceeding $1B annually. Current treatments focus on decontamination but fail to address the underlying material failure of titanium implants: progressive corrosion driven by inflammation. The present gold standard antimicrobial treatments fail to treat >50% of cases highlightin...

Balloon Catheters

christopher.perkins@rutgers.edu — Fri, 20 Feb 2026 07:39:17 GMT

Vacuum-Tooth Brush Attributes: On-off switch, Vaccum power (hi-low), Easy-Empty (or disposable) fluid & debris collector cup, Ergonomic design, Battery-operated and Affordable. Invention Summary: There is a need for a powered toothbrush that has a built-in pump and waste container that automatically removes the liquids from the oral cavity while brushing the teeth. The removal of these potentially harmful and infectious materials aids in the prevention of pneumonia caused by oral bacteria (via Streptococcus mutans) and other respiratory and tra...

Method for Enhancing Immunoregulatory Effect of Stem Cells

christopher.perkins@rutgers.edu — Fri, 20 Feb 2026 06:14:56 GMT

IL-17A promotes MSC-Mediated immunosupressive effect. Changes in cell proliferation as shown in microscopy Invention Summary: Autoimmune diseases occur when the immune system attacks the body’s tissue components. Mesenchymal stem/stromal cells (MSCs) have been used as treatment to many autoimmune disorders such as type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. MSCs can be derived from various tissues and are multipotent stem cells that can differentiate into adipocytes, chondrocytes, and osteoblasts and are responsible for repairing and regenera...

Regulating urea in infant nutrition to support early-life microbiome development and health

christopher.perkins@rutgers.edu — Thu, 12 Feb 2026 07:34:41 GMT

Synchronizing infant nutrition with early-life biology. Rutgers researchers propose replacing static infant nutrition with formulations inspired by human breast milk. Regulated urea delivery aligned with infant developmental needs and microbiome sustenance enables next-generation nutrition for infants. Invention Summary: Current infant nutritional products, including formulas, typically provide fixed urea levels that do not reflect the temporally regulated fluctuations observed in human breast milk across early life. Such static formulations are not designed to account for age- or...

Analysis of Immune Repertoire with Fluorogenic Probes

christopher.perkins@rutgers.edu — Mon, 09 Feb 2026 08:09:31 GMT

Rapid analysis of T cells for the diagnosis of diseases in which the T cell repertoire is altered. Cells are distributed in aqueous droplets and their T cell receptor mRNAs are amplified in presence of “sloppy” molecular beacons. The melt profiles of molecular beacons in thousands of droplets reveals the T cell repertoire of the individual. Invention Summary: In our immune system, B cells produce antibodies, and T cells express T-cell receptors. To recognize a diverse array of antigens that an individual will encounter in their life, immune cells...

Gradient Porosity Electrodes for Li-Ion Batteries

christopher.perkins@rutgers.edu — Fri, 06 Feb 2026 11:28:28 GMT

Schematic representing porosity of each layer in a laminated LCO electrode (beige curvy lines represent the electrode’s porosity). Invention Summary: There is a pressing need to increase the specific energy of Li-ion batteries to increase range of electric vehicles and decrease cost of the battery. In theory, increasing the thickness of electrodes can result in a large increase in the percentage of active materials leading to significant enhancements in energy density and reductions in cost...

A Platform Technology for Accelerated Activation of Fluorescent Probes and Prodrugs

christopher.perkins@rutgers.edu — Fri, 23 Jan 2026 11:46:59 GMT

Invention Summary: Existing bioimaging and prodrug technologies rely on conventional self-immolative linkers that often suffer from slow or incomplete payload release, resulting in suboptimal imaging contrast or therapeutic index. While inefficient probe activation limits imaging resolution, inadequate drug release poses significant risks: aggressive tumors may continue to proliferate, adapt, develop drug resistance, or actively efflux the prodrug. In addition, probes and prodrugs must cross the plasma membrane of target cells to enable selective intracellular activation. Consequen...

Fortified Oral Rehydration Beverage

christopher.perkins@rutgers.edu — Thu, 15 Jan 2026 09:16:35 GMT

Diarrheal Duration in children who received fORT or ORT. A. Duration from start of treatment to first solid stool. Diarrhea duration was reduced by 30% (39 hours) in the fORT group compared to ORT, p < 0.05. B. Duration from start of treatment to last diarrheal stool. Diarrheal duration was reduced by 30% (35 hours) in the fORT group compared to ORT, p = 0.07. Invention Summary: According to the World Health Organization (WHO), nearly 500,000 children under the age of 5 die every year from diarrhea. The most common causes of diarrhea in the U.S. are viral in origin,...

Digital Vivarium – RFID Census Database and Scanning Application

christopher.perkins@rutgers.edu — Thu, 11 Dec 2025 11:58:25 GMT

RFID scanner with application on screen Invention Summary: Traditional research animal census methods rely on manual counts or generic inventory tools that are error-prone, inefficient, and not designed for cage-level tracking. Existing RFID systems from other industries are often too complex or poorly suited for animal facility workflows. Rutgers researchers have developed the Digital Vivarium – RFID Census Database and Scanning Application, a streamlined, standalone solution that automatically captures and transmits cage-card RFID data through an integ...

Diagnostic Assays and Methods for Detecting Pathogens

christopher.perkins@rutgers.edu — Tue, 09 Dec 2025 06:22:53 GMT

A novel sample processing method for the co-extraction of DNA/RNA from Mycobacterium tuberculosis (TB) and SARS-COV-2, complementing a novel near-patient CRISPR test for tuberculosis detection (CRISPR SHINE TB). Invention Summary: Tuberculosis and COVID-19 are infectious diseases with high mortality rates caused by Mycobacterium tuberculosis (TB) and SARS-CoV-2. Co-infection is increasing in prevalence, but methods for single-sample co-detection are limited by efficacy and ease of use. As the areas with particularly high rates of co-infection worldwide are often ...

Evidence‐Based Practice for the Clinical Nutrition Practitioner

christopher.perkins@rutgers.edu — Mon, 08 Dec 2025 10:19:40 GMT

Clinical dietician practice challenges Invention Summary: Registered dietitian nutritionists (RDNs) have a role to play in improving health, preventing disease and managing acute and chronic conditions. Medical nutrition therapy is integral in managing different diseases such as diabetes, obesity, metabolic disorders, and cardiovascular diseases. The need of an educational practice module for RDNs to develop a targeted nutritional plans for individuals with different needs is highly essential. Rutgers educators and researchers developed an evidence-based educational modu...

Customizable Collagen-Mimetic Hydrogels for Precision Modeling and Bioscaffold Engineering

christopher.perkins@rutgers.edu — Tue, 02 Dec 2025 06:36:17 GMT

Synthesis of cysteine flanked collagen-mimetic peptides (CMPs) Invention Summary: Hydrogels are essential tools which can mimic extracellular matrix environments; however, current systems lack precise molecular-level control over crosslinking density and porosity. Conventional approaches utilize non-specific, generic biopolymers with statistical or random crosslinking of polymer chains. These approaches offer limited control and poor reproducibility resulting in significant variation between batches. Chemical crosslinking agents offer greater precision in controlling crosslinking ...

Aerodynamic and vibration damping skin for cylindrical structures

christopher.perkins@rutgers.edu — Fri, 14 Nov 2025 09:55:49 GMT

Unit cell of locally-resonant lattice tuned to damp noise source. Invention Summary: During rocket launches and stage separations, intense vibrations and shock waves can damage sensitive payload electronics. Traditional isolation systems are often heavy and increase fuel consumption, making lightweight vibration-damping solutions essential. Rutgers innovators have developed a novel lightweight skin technology that integrates resonating lattice designs into spacecraft structures. These structures capture and redistribute shock energy, extending the duration over which the ...

Method to Achieve Total Acoustic Transmission between Water and Air

christopher.perkins@rutgers.edu — Fri, 31 Oct 2025 11:11:54 GMT

A plane wave is incident from the water side of the asymmetric panel. The plates are separated by ribs set a distance 𝑑 apart with the intermediate space assumed to be air. Invention Summary: Effective sound transmission between water and air is challenging due to the vastly different acoustic impedances. Current methods are limited as they rely on fluid layers or membranes to match the misaligned impedances. Rutgers researchers have developed a novel method for the seamless transmission between water and air. Two thin elastic plates, supported by periodically spaced rib...

Scalable Magneto-Optical Trap and Gravimeter

christopher.perkins@rutgers.edu — Fri, 31 Oct 2025 07:33:42 GMT

(a) Side-view schematic of dual-MOT. (b) Mounted mirrors. (c) MOT mirror. (d) Incident laser beam. (e) Passing through laser beam after the 1st mirror. (f) Passing-through laser beam after the 2nd mirror. Invention Summary: Cold-atom-sensors such as atomic gravimeters have been used in geological surveys and navigation. The complexities involved in their design often limit the application scope of such sensors and the ability to support compact designs. For instance, the simultaneous measurement of the vertical absolute gravity value and gravity gradient using atomic gravimeters i...

Scalable Magneto-Optical Trap and Gravimeter

christopher.perkins@rutgers.edu — Fri, 31 Oct 2025 07:31:00 GMT

Plasma-Electrochemical System for Green Ammonia Production

christopher.perkins@rutgers.edu — Mon, 27 Oct 2025 11:01:25 GMT

Invention Summary: Ammonia is one of the most widely produced industrial chemicals, primarily used for fertilizer production. Ammonia has also emerged as a potential hydrogen carrier for green power storage. The dominant industrial process for ammonia production is the Haber-Bosch process, which operates under high temperature and high pressure conditions. The Haber-Bosch process relies on H2 produced from fossil fuels and accounts for over 1% of global CO2 emissions. Current approaches to reduce CO2 emissions in ammonia production utilize electrochemical methods. However, these me...

Atomic Scale Topological Magneto-resistance Sensor

christopher.perkins@rutgers.edu — Fri, 24 Oct 2025 10:58:43 GMT

Experimental setup for electrical transport measurement on the pyrochlore heterostructure, and STM image near the interface of EIO/DTO. Invention Summary: In advanced electronics and quantum technologies, there is a growing demand for materials that offer highly tunable, low-power, and robust quantum states for applications such as magnetic sensing, spintronics, and quantum computing. Rutgers researchers have developed a novel synthesis technique that combines solid-phase epitaxy (SPE) with pulsed laser deposition (PLD). This hybrid method enables the creation of atomically s...

Novel diagnostics measures clock gene expression for early detection of fetal alcohol spectrum disorder

christopher.perkins@rutgers.edu — Fri, 17 Oct 2025 08:55:46 GMT

Novel salivary diagnostic test to measure circadian clock gene expression in FASD children using saliva samples. Invention Summary: Alcohol drinking during pregnancy leads to fetal alcohol spectrum disorder (FASD) accounting for about 2-5% of children in North America. Early diagnosis of FASD is imperative to prevent brain damage in FASD patients. There is no specific diagnostic test available so far. Rutgers researchers notably identified the core-clock genes expression in a rhythmic pattern in human saliva. The expression pattern is si...

Nanoscale 3D Thermal Metrology via Scanning Electron Resistance Thermometry (SE-TherM)

christopher.perkins@rutgers.edu — Mon, 13 Oct 2025 06:11:40 GMT

(A) SEM image and (B) Temperature map of the device under test Invention Summary: It can be difficult to measure thermal properties at the nanoscale on operating microelectronics in a nondestructive, non-contact and real-time manner. The lack of such nanoscale thermal metrology tools affects quality control in modern microelectronics and impedes rational electro-thermal design of semiconductor devices. Rutgers researchers have developed an innovative technique that leverages modified commercial Scanning Electron Microscopes (SEM) to provide subsurface temperature mapping ...

Biomaterial-mediated Extracellular Vesicle Delivery CNS Regeneration

christopher.perkins@rutgers.edu — Fri, 03 Oct 2025 10:43:45 GMT

Reduction in cortical lesion volume post-TBI (a) and post-treatment (b); remyelination as shown by luxol fast blue-staining post-TBI (c) and post-treatment (d); and enhanced expression of occludin post treatment (f) as compared to post-TBI (e). Invention Summary: More than 3 billion people worldwide are affected by central nervous system injuries and diseases, including traumatic brain injuries, neurodegeneration, and glioma. As many as 30% of these patients experience persistent neurological deficits following mild CNS injury, with rates as high as 65% in moderate-to-severe cases...

Prolonged Persistance of Lacticaseibacillus rhamnosus in the Digestive Tract

christopher.perkins@rutgers.edu — Thu, 25 Sep 2025 06:42:31 GMT

Recovered CFUs from daily fecal matter after repetitive autologous murine gastrointestinal track gavages. (A) Log10 of the CFU counts from fecal matter obtained after gavage of wild type L. rhamnosus (n=2). (B) Log10 of the CFU counts from fecal matter obtained after gavage of Evolution 1, which used colonies selected from gavage 1 (n=2). (C) Log10 of the CFU counts from fecal matter obtained after the gavage of Evolution 2 (n=2). Invention Summary: Lacticaseibacillus is a well‐known genus of probiotic bacteria with Lacticaseibacillus rhamnosus GG being used in clinical appl...

The MaxVac powered toothbrush: Suction Toothbrush and Related Methods

christopher.perkins@rutgers.edu — Tue, 23 Sep 2025 09:12:09 GMT

MaxVac- Powered Toothbrush with Evacuation Technology

christopher.perkins@rutgers.edu — Tue, 23 Sep 2025 09:12:00 GMT

Vacuum-Tooth Brush Attributes: On-off switch, Easy-Empty (or disposable) fluid & debris collector cup, Ergonomic design, Battery-operated and Affordable. Invention Summary: A novel powered toothbrush that couples a vacuum suction and waste container to an existing toothbrush that automatically removes the liquids from the oral cavity while brushing the teeth. It can be used anywhere and any time since water is self-contained. It removes potentially harmful and infectious materials that can be swallowed caused by oral bacteria. Current evacuation...

Gold Nanocluster-Based PROTAC Targeting pTau

christopher.perkins@rutgers.edu — Fri, 12 Sep 2025 06:25:39 GMT

Gold nanocluster binds both pTau and E3 ligase, initiating the ubiquitin-proteasome pathway and degrading pTau, as seen via immunostaining (Blue – Hoechst, red – TUJ1, green – pTau) Invention Summary: Hyperphosphorylated tau protein, a key clinical marker for various neurodegenerative diseases, leads to abnormal aggregation of tau protein. Phosphorylated tau is a hallmark of Alzheimer’s Disease, and is also indicated in various other neurodegenerative diseases such as Progressive Supranuclear Palsy, Pick’s Disease, various types of dementia, Chronic T...

Chemogenetic Treatment for Neurodegenerative and Neuropsychiatric Disorders

christopher.perkins@rutgers.edu — Wed, 10 Sep 2025 11:22:25 GMT

DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like behavior as measured by the forced swim test (FST). Abbreviations: chronic dark rearing (DD); chronic dark rearing with a control virus expressed in retinal cells (DD-GFP); DREADD receptors-mediated activation of retinal cells during chronic ...

Low Overhead MIMO‐OTFS Channel Estimation

christopher.perkins@rutgers.edu — Fri, 05 Sep 2025 12:33:32 GMT

Overview of method to reduce pilot overhead Invention Summary: Orthogonal time frequency space (OTFS) modulation provides reliable communication in high mobility environments and is a promising candidate for 6G, but existing approaches require large amounts of pilot overhead when transmitting. This wastes bandwidth as well as limiting scalability in multi-input multi-output (MIMO) devices since the guard regions must not overlap between antennas. Rutgers researchers have created a novel approach for MIMO OTFS systems that significantly reduces pilot overhead b...

Virtual Array for Dual Function MIMO Radar Communication Systems using OTFS Waveforms

christopher.perkins@rutgers.edu — Fri, 05 Sep 2025 12:31:11 GMT

Angle estimation performance of the OTFS system on 3 targets with all DD bins used as shared. Black lines represent ground truth Invention Summary: Multi-input multi-output (MIMO) technology is widely used for its ability to communicate with multiple devices simultaneously. A major advantage of MIMO radars is their capacity to form virtual arrays. However, existing Dual-Function MIMO Radar-Communication (DFRC) systems employing orthogonal time frequency space (OTFS) waveforms—considered a leading candidate for 6G—cannot generate MIMO virtual arrays without severe...

Extracellular Vesicles (EVs) from Placenta and Umbilical Cord (UC) Normalize Preeclampsia (PE) Stem Cells

christopher.perkins@rutgers.edu — Tue, 02 Sep 2025 07:29:35 GMT

Z. Wang, R. Yang, J. Zhang, et al., “Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance,” Mediators of Inflammation 2021 (2021): 5558048 Invention Summary: PE is a serious pregnancy complication affecting 5–8% of pregnancies worldwide and is a leading cause of maternal and fetal morbidity and mortality. Despite its prevalence and severity, effective treatments remain limited. Rutgers researchers have developed a novel therapeutic approach. They utilized EVs isolated from healthy placenta-derived mesenchymal stem cells (P-MSCs...

Nutrition Screening Algorithm for Cleft Repair

christopher.perkins@rutgers.edu — Thu, 28 Aug 2025 11:46:49 GMT

Invention Summary: Cleft lip and palate are common craniofacial birth defects affecting approximately one in 700 live births. Early intervention via surgical repair can improve appearance, speech, hearing, and psychosocial development. Models for fast identification and surgical intervention for affected infants and children, including models from not-for-profit and charity organizations have been introduced, leading to increased access to surgical repair across the globe. However, there is a need for preoperative nutrition assessment to ensure identified pediatric patients will ha...

In situ gel vehicle for ophthalmic drug delivery

christopher.perkins@rutgers.edu — Thu, 28 Aug 2025 08:39:37 GMT

Polymer compositions were screened with amplitude oscillation and show synergistic effects with simulated tear fluid Invention Summary: Effective ophthalmic drug delivery remains a significant challenge due to the eye’s natural defense mechanisms, including blinking, tear turnover, and nasolacrimal drainage, which rapidly clear topically applied medications. While in situ gelling systems have been explored to address this issue, many rely on external triggers such as temperature or pH changes that may fail to form robust gels under physiological conditions. Therefore, ...

Enhancing Privacy in Radar-Based Vital Sign Monitoring via Non-Linear FMCW Waveforms

christopher.perkins@rutgers.edu — Thu, 21 Aug 2025 08:18:26 GMT

Privacy-preserving radar vital sign monitoring thanks to a novel non-linear FMCW waveform: Authorized users recover vital signs accurately, while eavesdroppers receive unintelligible signals Invention Summary: Vital sign monitoring offers a contactless, low-cost and continuous solution for the monitoring of vital signs in patients. However, current solutions suffer from privacy issues that allow passive listeners to decipher these signals, thereby revealing sensitive vital sign information to eavesdroppers. Rutgers researchers have created a novel non-...

Restoration of circadian rhythms impairs formation of cancer stem cells and the growth of tumorspheres

christopher.perkins@rutgers.edu — Thu, 21 Aug 2025 08:09:44 GMT

Circadian restoration prevents tumor growth and poor prognosis Invention Summary: Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, worsened by the presence of cancer stem cells (CSCs). These CSCs increase tumor recurrence and are responsible for tumor initiation and propagation. While conventional chemotherapy eliminates most cancer cells within a tumor, it can also inadvertently promote the survival and proliferative capacity of CSCs, which are inherently more resistant to current treatments. Rutgers researchers have found a link between the lo...

Efficient Deep-Blue LEDs Based on Hybrid Copper Iodide Emissive Layer

christopher.perkins@rutgers.edu — Tue, 19 Aug 2025 06:39:45 GMT

Components of a blue LED incorporating hybrid Cul emissive layer Invention Summary: Blue light emitting diodes (LEDs) are essential to energy-efficient lighting technologies, especially for the creation of white light. However, deep blue emitting cadmium-based quantum dots and lead-based perovskites pose toxicity and environmental concerns while organic and perovskite-based blue LEDs also suffer from poor structural and spectral stability. Rutgers researchers have developed high-efficiency, stable, and eco-friendly deep-blue LEDs using solution-processable copper–iodide ...

Dentin Booster

christopher.perkins@rutgers.edu — Fri, 08 Aug 2025 12:02:29 GMT

Invention Summary: Dentin is a crucial part of our teeth, fortifying the enamel and providing protection from bacteria. Protecting the dentin layer itself from damage, such as that caused by acid and bacteria, is vital to dental hygiene. Without proper protection, tooth decay rates increase, and dentin can be slow to repair itself. Dentin Booster™ is a groundbreaking product that strengthens and protects dentin, reducing acid and bacterial vulnerability (Fig. 1). Developed by Rutgers researcher, Dr. Saghiri and his team, the product uses ascorbic acid 2-phosphate (AA...

Fluorescence Polarization Probe for identifying inhibitors of Enterovirus D68 2C

christopher.perkins@rutgers.edu — Fri, 08 Aug 2025 11:27:44 GMT

Design of the 2C fluorescence polarization probe Jun14157 and assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where both infections and incidence of AFM have been consistently increasing for the past decade. Various inhibitors targeting EV-D68’s protein 2C have been reported with antiviral activity, which were generated using a truncated, synthetic ...

“Y”-shaped symmetric Enterovirus D68 2C inhibitors are antiviral drug candidates

christopher.perkins@rutgers.edu — Fri, 08 Aug 2025 11:24:12 GMT

Graphical abstract describing design of “Y”-shaped symmetric 2C inhibitors. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where both infections and incidence of AFM have been consistently increasing for the past decade. Recent efforts in EV disease research have identified compounds with limited efficacy in the inhibition of EV-D68. However, additi...

New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates

christopher.perkins@rutgers.edu — Fri, 08 Aug 2025 11:20:22 GMT

Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link). Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness have focused on developing oral antiviral medications that target highly conserved viral components, including polymerases and proteases essential for replication. For example, nirmatrelvir, an ...

ReadyCoach: Innovations Focused on Inspiring Educators and Empowering Students

christopher.perkins@rutgers.edu — Mon, 04 Aug 2025 08:40:06 GMT

ReadyCoach provides tools to enhance school personnel collaboration and growth, flexibility to meet local education needs, and innovations to empower students as successful learners. ReadyCoach algorithms automate the completion of essential educational tasks that facilitate positive outcomes for children. Invention Summary: Educators face an increasingly complex landscape where they must make data-driven decisions that address diverse academic and behavioral needs across entire classrooms and individual students. Yet, the process of interpreting assessment data, forming intervent...

Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates

christopher.perkins@rutgers.edu — Thu, 31 Jul 2025 13:43:23 GMT

Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where both infections and incidence of AFM have been consistently increasing for the past decade. Recent efforts in EV disease research have identified ...

Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates

christopher.perkins@rutgers.edu — Thu, 31 Jul 2025 13:36:20 GMT

Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness have focused on developing oral antiviral medications that target highly conserved viral components, including polymerases and proteases essential for replication. For example, nirmatrelvir, an inhi...

Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates

christopher.perkins@rutgers.edu — Thu, 31 Jul 2025 09:24:15 GMT

A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness have focused on developing oral antiviral medications that target highly conserved viral components, including polymerases and proteases essential for replication. For example, nirmatrelvir, an inhibitor of the SARS-CoV-2 main protease (Mpro) an...

Specific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia

christopher.perkins@rutgers.edu — Thu, 31 Jul 2025 08:51:20 GMT

Preliminary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine, methadone for opioid addiction, and naloxone for reversing opioid overdoses. However, there are no pharmaceutical approaches to preventing opioid tolerance and addiction that are available for clinical use. Mechanisms underlying mu opioid act...

Boosting Stem Cell Editing with CRISPR Nanoparticles

christopher.perkins@rutgers.edu — Wed, 23 Jul 2025 06:24:41 GMT

Invention Summary: Gene editing in hematopoietic stem cells (HSCs) holds immense promise for curing genetic blood disorders such as sickle cell anemia and β-thalassemia. However, a major hurdle lies in the safe, efficient, and targeted delivery of CRISPR/Cas9 systems into these delicate stem cells. There is a critical need for innovative delivery platforms that can precisely guide genome editing tools into HSCs, enhancing treatment outcomes while minimizing unintended consequences. Rutgers inventors have developed a groundbreaking nucleic acid nanoparticle...

CD8 T Cell Senescence Gene Signatures that Predict Response to Chimeric Antigen Receptor T cell Therapy in Diffuse Large B Cell Lymphoma (ff)

christopher.perkins@rutgers.edu — Tue, 22 Jul 2025 08:53:10 GMT

Invention Summary: CAR T-cell therapy has emerged as a promising treatment for patients with refractory B-cell malignancy. However, the response to CAR T-cell therapy can potentially be restricted due to age-related decline in immune function, known as immunosenescence. It is marked with the increase in senescence of CD8+ T cells. Predicting the efficacy of CAR T-cell therapy in older patients presents a significant challenge. To overcome this, there is a need to develop biomarkers capable of efficiently identifying the epigenetic mechanisms that drive CD8+ T-cell senes...

Methods and Reagents to Modulate Pathogen Immunity and Abiotic Stress Tolerance for Resilient Agriculture

christopher.perkins@rutgers.edu — Thu, 10 Jul 2025 09:28:52 GMT

Invention Summary: Modulating plants’ immunity and resilience to microbial pathogens, salt stress and droughts is key to improving crop production. An increasing body of research has shown that plant type II metacaspases, specifically AtMC9 and its orthologs in crops, regulate plants’ defenses to fungal and bacterial pathogens in a complex fashion through its pro-cell death function. Recently, Rutgers researchers also discovered that AtMC9 is a key enzyme for the production of the phytocytokine peptide, Pep3, which can increase plants’ salt and drought resil...

Large Language Model Agent Operating Systems

christopher.perkins@rutgers.edu — Thu, 03 Jul 2025 08:59:09 GMT

Performance enhancement for execution time with AIOS compared to Linux above, with AIOS architecture shown below Invention Summary: The integration and deployment of large language model (LLM)-based intelligent agents has been fraught with issues of sub-optimal scheduling and resource allocation of agent requests, difficulties in maintaining context during interactions between agents and the LLM, and the complexities inherent in integrating heterogeneous agents with different capabilities and specializations. The rapid increase of agent quantity and complexity further exacer...

Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer

christopher.perkins@rutgers.edu — Tue, 24 Jun 2025 11:28:23 GMT

Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models. Invention Summary: Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all breast cancers, poses significant therapeutic challenges due to its poor response to conventional treatments and highly invasive nature. The primary treatment option, surgery, poses several challenges. Notably, it is difficult to achieve comple...

Systems and Methods for Detecting Acute Changes in Blood Pressure and Creating Alarm, from Photoplethysmogram

christopher.perkins@rutgers.edu — Tue, 24 Jun 2025 11:24:29 GMT

Invention Summary: Recently, the data-driven capabilities of deep learning have been leveraged in blood pressure (BP) monitoring systems that utilize photoplethysmogram (PPG) signals. These advancements aim to enhance estimation accuracy, clinical applicability, and ultimately, patient outcomes. However, challenges persist—particularly regarding the generalizability and reliability of these models. Rutgers researchers introduce a novel system and method for continuous monitoring of significant changes (elevations or drops) in blood pressure using a self-contras...

ScoreHMR: 3D Pose Estimation using Diffusion Guided Models

christopher.perkins@rutgers.edu — Tue, 24 Jun 2025 11:20:13 GMT

Example results from the new model that uses an iterative refinement approach to achieve better image-model alignment to solve inverse problems for 3D human pose and shape reconstruction. Invention Summary: Recovering a 3D human pose and shape from 2D images is a challenging problem to solve computationally due to the complex nature of the articulated 3D joint locations in a human body. Due to its widespread applications in a great variety of areas, such as human motion analysis, human–computer interaction (VR video games), robotics, 3D human pose estimation has recently att...

Active vibration cancellation and control for scanning probe microscopy

christopher.perkins@rutgers.edu — Tue, 10 Jun 2025 08:12:22 GMT

Demonstration of filtering techniques used for both ground and acoustic noise Invention Summary: Scanning Probe Microscopes (SPMs) are often bulky due to the need for passive noise isolation. Active noise cancellation techniques can alleviate some of the distortion, but still struggle with acoustic noise. Rutgers researchers have created a suite of techniques to actively reduce extraneous vibrations during a scanning probe microscope (SPM) measurement, and/or filter the distortions caused by such probe vibrations in the SPM images obtained by post-processing. This...

Biodegradable Polymers for Gene Delivery

christopher.perkins@rutgers.edu — Thu, 05 Jun 2025 16:45:51 GMT

Invention Summary: In gene therapy, a key challenge is delivering therapeutic genes to target cells, which requires gene delivery vectors. While viral vectors are effective, they pose risks such as immune responses and toxicity. Non-viral vectors, particularly cationic polymers, are preferred for their safety, cost-effectiveness, and high loading capacity, but their high molecular weight, positive charge, and non-degradable nature cause cytotoxicity, limiting their clinical use. Researchers at Rutgers and collaborators from Boston College have developed biodegradable catio...

Novel Antibiotic Inhibiting Elongation Factor Complex in Gram-Positive Bacteria

christopher.perkins@rutgers.edu — Thu, 05 Jun 2025 08:52:03 GMT

Invention Summary: Antibiotic resistance remains a global health challenge with millions of related deaths each year. Gram-positive bacterial infections, like those caused by Staphylococcus aureus, are likely to acquire and develop resistance to clinically available antibiotics. Therefore, it is crucial to identify and develop novel antibiotics with unique mechanisms of action that are effective against these pathogens. Using a novel approach, Rutgers researchers, in collaboration with NIH researchers, have identified a compound (MGC-10) that targets gram-positive bacteria. The...

Synthesis of Non-steroidal Anti-Inflammatory Compounds to Promote Wound Healing

christopher.perkins@rutgers.edu — Fri, 30 May 2025 08:36:32 GMT

Graph shows the average skin punch biopsy weight of mice treated topically with nitrogen mustard (NM) to induce skin inflammation. Mice additionally treated with polyamine-imidazole conjugates showed a marked decrease in skin inflammation. Invention Summary: Non-steroidal Anti-Inflammatory drugs (NSAIDs) are widely available for over-the-counter use to reduce pain, inflammation and fever. However, traditional NSAIDs are often limited by short duration of action and lack of wound healing benefits. Developing a new class of NSAIDs that is more efficient, longer-lasting, and capable...

Glycosylated RNA in Exosome Extracellular Vesicles

christopher.perkins@rutgers.edu — Wed, 28 May 2025 11:33:45 GMT

Overview of experimental approach used to demonstrate exosome-mediated intercellular transfer of glycoRNAs Invention Summary: Exosomes play a significant role in diverse cellular functions and responses. These structures are believed to furnish cells with a signaling mechanism facilitated by the cargo enclosed within the exosome. This cargo encompasses a range of constituents such as DNA, RNA, lipids, metabolites, and cellular proteins. Rutgers inventors have identified that the RNA components within exosomes are modified in a process involving glycosylation—a novel form ...

TMAAC: A Communication-aware, Localized Transformer-based Multi-Agent Actor-Critic Framework

christopher.perkins@rutgers.edu — Mon, 05 May 2025 11:22:48 GMT

Invention Summary: Wildfires release pollutants comprising a mixture of gases and fine particulate matter (PM2.5) which are hazardous to human health. Researchers at Rutgers University have designed a novel two-phase, environmentally friendly, low-cost air purification device that could run off a backup battery for emergencies. Market Applications: • Air purification in wildfire smoke environments Advantages: • Low-cost Publications: • Low-cost Intellectual Property & Development Status:&nb...

Methods and Systems for Autonomous Agent Control

christopher.perkins@rutgers.edu — Mon, 05 May 2025 11:22:05 GMT

Invention Summary: The challenges posed by high-risk and hazardous environments include knowledge gaps and unknown territories, rendering the deployment of human personnel both dangerous and undesirable. Unmanned Aerial Vehicles (UAVs) have increasingly become the preferred solution in these scenarios and to support Search-and-Rescue (SAR) missions. However, a key challenge for multiple UAVs is maintaining stable communication, despite disconnections, to ensure efficient coordination and control. Rutgers researchers have developed two novel coordination frameworks––H...

Miniaturized In-Field Simultaneous Water Vapor and Aperture Measurement of Dynamic Stomatal Conductance

christopher.perkins@rutgers.edu — Mon, 05 May 2025 11:20:15 GMT

Invention Summary: Stomata, the micro-size pores on the plant leaves, open and close to respond to both external environmental changes and internal growth factors, thereby, are crucial to plants photosynthesis and transpiration processes. While stomata conductance has long been measured, how stomata dynamically respond to multitude environmental changes across a field have not yet been well characterized. Rutgers researchers have developed a cutting-edge sensing device designed for large-scale distributive deployment in a field to measure dynamic behaviors of stomata...

In-field simultaneous measurement of stomata morphology and water release dynamics with environmental temperature and carbon dioxide monitor

christopher.perkins@rutgers.edu — Mon, 05 May 2025 11:19:37 GMT

Invention Summary: Based on the surrounding environment, stomata alter their shape (by opening or closing) to optimize photosynthesis. While stomata conductance has long been developed, a comprehensive understanding of the structural dynamics of the stomata has yet to be fully understood. Rutgers researchers have developed a cutting-edge sensor designed to study the dynamic behavior of stomata on plant leaves, focusing on their real-time responses to environmental conditions such as light, temperature, and CO2 levels. It features a unique chamber with humidity sensors and ...

Competency Med Assessment Pro

christopher.perkins@rutgers.edu — Thu, 01 May 2025 10:23:38 GMT

Invention Summary: Competency Medical Assessment Pro (MAP) is a real‐time online assessment system developed as an innovative solution designed to streamline the feedback process to medical students, focusing on the 13 Entrustable Professional Activities (EPAs) essential for medical school graduation, as outlined by the AAMC (American Association of Medical Colleges). Rutgers researchers have developed this system that enables faculty to efficiently assess and provide formative feedback to students, promoting active learning and self‐improvement. The system enables faculty...

Buccal swab-based biomarkers for schizophrenia

christopher.perkins@rutgers.edu — Wed, 30 Apr 2025 06:23:11 GMT

mRNA normalized fold expression from transcript of interest Invention Summary: Schizophrenia (SCZ) is a debilitating and chronic brain disorder characterized by symptoms, such as hallucinations, delusions, and disorganized thoughts. Current diagnostic criteria rely solely on behavioral observations and do not account for molecular and clinical neuroscience-based data. Likewise, treatment for SCZ is also based on behavioral symptom management rather than targeting underlying biological mechanisms. This frequently results in poor outcomes and low treatment compliance. In the interes...

Novel RF radiation sensing materials and devices

christopher.perkins@rutgers.edu — Thu, 10 Apr 2025 13:36:35 GMT

The change in resistance with the application of RF radiation is shown at different temperatures for thin films of NdNiO3 (at 25°C), VOx (at 60°C), and VO2 (at 75°C), respectively. The upper panels show the time of RF on and off whereas the lower panels show the corresponding change in resistance with RF radiation. The resistance increases with RF radiation for NdNiO3 and decreases for VO2 and VOx thin films. Invention Summary: Radio Frequency (RF) sensing is a revolutionary technology that spans across various fields such as wireless communication and medical imaging....

Resistance-Based RF Sensing Using Quantum Materials

christopher.perkins@rutgers.edu — Thu, 10 Apr 2025 13:35:42 GMT

Machine-Learning-based Joint Doppler Estimation and Compensation in Underwater Acoustic Communications

christopher.perkins@rutgers.edu — Thu, 10 Apr 2025 12:41:10 GMT

A.) Summary figure of ML-driven technologies to improve underwater acoustic communication for a variety of applications. These technologies enhance image and video transmission while adapting for underwater conditions that may interfere with signal transmission. B.) Schematic for integration of JSCC, ASVTuw, and Doppler effect compensation technologies in underwater image and video reconstruction Invention Summary: Image and video transmission are key elements for underwater exploration. Underwater acoustic communication (UAC) is an established method where transmitted sound waves...

ASVTUW: ADAPTIVE SCALABLE VIDEO TRANSMISSION IN UNDERWATER ACOUSTIC MULTICAST NETWORKS

christopher.perkins@rutgers.edu — Thu, 10 Apr 2025 12:40:17 GMT

Machine Learning-Driven Solutions for Enhanced Underwater Communication

christopher.perkins@rutgers.edu — Thu, 10 Apr 2025 12:38:50 GMT

Epstein Barr Virus -specific T cells and their therapeutic use in lung cancer

christopher.perkins@rutgers.edu — Wed, 09 Apr 2025 11:59:58 GMT

Invention Summary: Scientists from the Rutgers University and Stanford University have discovered T cell receptor molecules targeting a novel antigen upregulated in cancer. This discovery has potential value for cancer-targeting therapies, particularly CAR T therapies. Currently, a limited number of CAR T therapies indicated for a narrow range of cancer types are in the clinic, so expanding the repertoire of antigens and cancers that CAR T cells can successfully target is critical for broader utilization of this powerful technology. Researchers profiled the specificities of tumo...

Small molecules that target RNA structures within the CoV genome

christopher.perkins@rutgers.edu — Wed, 09 Apr 2025 11:50:03 GMT

Chemical structure of the three lead molecules derived from the focused library screen against OC43-infected Vero E6 cell screening (Zafferani et al 2021) Invention Summary: The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication and to serve as leads for antiviral therapeutic development. Inventors from Rutgers, Case Western University, and Duke University have invented small molecules intended to serve as lead ...

Anti-sense Oligonucleotide Targets Insulin Receptor Isoform A

christopher.perkins@rutgers.edu — Tue, 08 Apr 2025 07:45:38 GMT

IR-A ASO targets the exon 10-12 junction in of IR-A mRNA. Invention Summary: Breast cancer is one of the most common cancers among women, and while effective treatment options exist, there remains a critical need to enhance their efficacy and reduce their off-target effects to minimize toxicity. Expression of Insulin receptor-A (IR-A), one of two isoforms of the insulin receptor, is correlated with worsened breast cancer prognosis and resistance to therapy. Previous attempts to knock-down transcripts encoding IR-A resulted in nonselective knockdown of both IR...

Scarlet Sunrise Bi-Color Grape Tomato

christopher.perkins@rutgers.edu — Wed, 02 Apr 2025 12:09:29 GMT

The fruit color of ‘Scarlet Sunrise’ is qualitatively different than any other known grape tomato cultivar. The striking interaction of pink and yellow hues in the fruit epidermis imparts a unique quality that cannot be quantified. Invention Summary: Scarlet Sunrise bi-color grape tomato is a new and unique variety of grape tomato, which was created through traditional plant breeding. The variety has attractive grape-pear shaped bi-color (red and yellow) fruit which are firm, crack-resistant, flavorful, with good shelf life and e...

Tricyclic Inhibitors of Ribosome‐Inhibiting Proteins

christopher.perkins@rutgers.edu — Thu, 27 Mar 2025 08:55:06 GMT

An image that shows p-stalk binding blockage would lead to the prevention of damage caused by Shiga or Ricin toxins Invention Summary: Shiga Toxin-producing E. coli (STEC) are very common bacteria that can cause infections that lead to approximately 100,000 illnesses, 3,000 hospitalizations, and about 90 deaths annually in the United States. Shiga toxins can cause hemorrhagic colitis and hemolytic uremic syndrome (HUS), which is the most common cause of renal failure in infants and young children in the United States. No effective therapy exists for ricin or Shiga toxin intox...

Lab in the Box: Remote Digitized Clinical Trial and Patient Assessment

christopher.perkins@rutgers.edu — Thu, 13 Mar 2025 05:58:57 GMT

Invention Summary: Behavioral and physical assessments are conducted routinely for the diagnosis and proper treatment of individuals. Current assessment methods require patients and subjects to be physically present at laboratories and clinics. This requirement prevents certain sectors of the population from being properly evaluated or joining clinical trials due to the traveling required and physical constraints. There are no known existing approaches for remote and affordable behavioral analysis protocols. Rutgers researchers have developed an affordable method t...

CHIR99021 Loaded Polymeric Scaffolds for the Treatment of Muscle Injuries

christopher.perkins@rutgers.edu — Thu, 06 Mar 2025 12:36:49 GMT

CHIR99021 administration reduces adipocyte differentiation (as seen by lipid droplet formation) in adipogenic cultures of stem cells. (A) Oil Red O staining for lipids 14 days after adipogenic induction. (B) Quantification of Oil Red O staining after 14 and 21 days.) Invention Summary: The most common injury among athletes are muscle injuries, an injury to the myotendinous junction (MTJ) is especially troublesome. Severe injuries of this kind require surgical intervention that pose a greater risk of reinjury due to fatty infiltration of the muscle, which prevents healthy tissue ...

Multi‐modal composite modeling: modeling & material discovery for complex material and tissue synthesis

christopher.perkins@rutgers.edu — Fri, 28 Feb 2025 09:58:12 GMT

Invention Summary: In 2021, there were over 200,000 traumatic brain injury (TBI) related hospitalizations and over 69,000 TBI-related deaths. Many more neurological diseases and injuries depend on research using brain tissue. Mechanical characterization of brain tissues (and other soft non-linear composites) and their computational modeling for understanding brain tissues’ responses to illness and injury is of great interest. However, acquiring brain tissue for repeatable experimental characterization is difficult due to their tacky and ultrasoft nature. Rutgers researche...

Additive Manufacturing Using Laser Direct Write with Self-Limiting Electrospray Deposition

christopher.perkins@rutgers.edu — Tue, 25 Feb 2025 06:03:01 GMT

A laser consolidates the self-limiting electrosprayed green body allowing for targeting by the spray to create a new layer. Invention Summary: Laser direct write is a high precision, maskless laser fabrication technique with wide use in microelectronics, flexible circuits, semiconductor manufacturing, etc. However, material selection is limited, printing multiple materials is extremely difficult, and limited throughput restricts the thickness of materials. Rutgers researchers have developed a method combining their previously developed electrospray techniques with...

BLTP3A (also known as UHRF1BP1) silenced CAR-T cells demonstrate elevated efficacy against High-grade serous carcinoma (HGSC)

christopher.perkins@rutgers.edu — Fri, 21 Feb 2025 11:10:23 GMT

Impairing BLTP3A elevates T cells activity via enhanced recycling of TCR and CAR machinery through the endosomal system. Invention Summary: Despite recent advances in cancer immunotherapy, objective responses remain rare. This is partly due to an incomplete understanding of the complex immunosuppressive mechanisms operating within the tumor microenvironment (TME). Rutgers researchers have discovered that an uncharacterized molecule expressed in T cells, BLTP3A suppresses protective T cell activities in the TME—and impairs the efficacy of TCR-T and CAR-T cel...

Intervertebral Disc Repair Using a 3D Porous Hybrid Protein Nanoscaffold

christopher.perkins@rutgers.edu — Fri, 21 Feb 2025 07:06:06 GMT

Histological analysis of rat intervertebral disc tissue prior to (left) and post injury (center) compared to 6 weeks post treatment (right). Invention Summary: Degeneration of fibrocartilaginous tissues, such as intervertebral discs (IVD), knee menisci, and other tendon-bone junctions, can lead to debilitating pain. IVD degeneration is the leading cause of back pain and is a precursor to more severe conditions such as hernia, bone spurs, and arthritis. Current treatments include NSAIDs, physical therapy, and surgery. However, current therapies for combating the inflammation that ...

Cell-Based Biosensor for Monitoring Neuronal Stem Cell Differentiation

christopher.perkins@rutgers.edu — Fri, 21 Feb 2025 07:00:27 GMT

Movement of fluorescent cargo (EGFP, green) from the cytoplasm to the nucleus (Hoechst, blue) as early as 10 minutes after stimulation with hippocalcin Invention Summary: Monitoring neuronal differentiation in stem cells is vital to advance regenerative stem cell therapies and our understanding of various neurodegenerative diseases. Traditional techniques (RT-qPCR, Western Blotting, immunofluorescence staining, flow cytometry) are time consuming, involve invasive or destructive measurements, offer limited resolution for monitoring individual cells and are prone to artifacts introd...

Novel FISH probes for the prognosis of malignant transformation in Barrett’s epithelium

christopher.perkins@rutgers.edu — Wed, 12 Feb 2025 09:54:54 GMT

Left: Translocations as visualized by FISH assay during metaphase. Right: Fusion as visualized in human esophageal adenocarcinoma tissue section Invention Summary: Barrett’s epithelium (BE) is a premalignant tissue that can progress into esophageal adenocarcinoma (EA) following the metaplasia→low grade dysplasia→ high grade dysplasia→cancer sequence. Although patients with BE have a 120-fold higher risk of developing EA, only 30% of the patients with high grade dysplasia actually develop cancer. The current standard of care is to identify the BE tissue during e...

Use Of Generative AI and Impedance Cytometry for Ionic Microscopy and Cell Imaging

christopher.perkins@rutgers.edu — Thu, 06 Feb 2025 07:39:01 GMT

Invention Summary: Traditional cell identification methods, often relying on complex microscopy or fluorescence-activated cell sorting (FACS), are time-consuming, and require expensive and bulky instruments. This highlights the need for more precise, rapid, and affordable diagnostic tools. Rutgers researchers have developed a novel system combining impedance flow cytometry with generative AI that automatically classifies biological cells. This system measures impedance variations as cells pass through an electric field and uses a trained neural network to generate virt...

Treatments for tuberculosis and non-tuberculous mycobacterial infections: dual-targeted rifamycin-AAP conjugates (RifaAAPs)

christopher.perkins@rutgers.edu — Fri, 31 Jan 2025 08:09:46 GMT

Invention Summary: RifaAAPs are novel dual-targeted, low-resistance-emergence, orally-available compounds for treatment of tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections--including drug-resistant, multi-drug-resistant (MDR), and extensively-drug-resistant (XDR) strains. Researchers indicate that RifaAAPs comprise the core pharmacophore of rifampin (Rif; a first-line anti-TB drug that binds to the mycobacterial RNA polymerase active center and sterically blocks RNA synthesis) covalently linked to an N-aroyl-N-aryl-phenylalaninamide (AAP; a pro...

ANTIBACTERIAL AGENTS: DUAL-TARGETED RNA POLYMERASE INHIBITORS (BENZOXAZINO-RIFAAAPS

christopher.perkins@rutgers.edu — Fri, 31 Jan 2025 08:08:07 GMT

ANTIBACTERIAL AGENTS: CO-SOLVENT-FREE, SURFACTANT-FREE FORMULATIONS OF PYRONINS

christopher.perkins@rutgers.edu — Fri, 31 Jan 2025 07:40:15 GMT

Invention Summary: APYs are novel, orally available compounds for treatment of infections caused by Gram-positive bacterial pathogens, fastidious Gram-negative bacterial pathogens, and some non-fastidious Gram-negative bacterial pathogens--including drug-resistant and multi-drug-resistant (MDR) strains. Our researchers have indicated that APYs exhibit potent in vitro antibacterial activity against all Gram-positive and all fastidious Gram-negative bacterial pathogens relevant to lower-respiratory-tract infections and skin-and-soft-tissue infections, including Staphylococ...

ANTIBACTERIAL AGENTS: O-ALKYL-DEUTERATED PYRONINS (PYS) AND ARYL PYRONINS (APYS)

christopher.perkins@rutgers.edu — Fri, 31 Jan 2025 07:37:42 GMT

Treatments for drug-susceptible and drug-resistant bacterial infections: arylmyxopyronins (APYs)

christopher.perkins@rutgers.edu — Fri, 31 Jan 2025 07:33:17 GMT

Microglia Cell Therapy for the Treatment of Neurodegenerative Diseases

christopher.perkins@rutgers.edu — Fri, 31 Jan 2025 05:58:50 GMT

Human Microglia Invention Summary: Alzheimer’s Disease (AD) accounts for over 60% of dementia cases in people over 65. Individuals with Down Syndrome (DS) are at higher risk for AD and myeloid leukemia due to somatic mutations in hematopoietic cells. Interestingly, some DS individuals with AD neuropathology do not experience cognitive decline. Recent studies suggest that somatic mutations may protect against cognitive decline, though the specific mutations driving this effect remain unknown. Understanding why some DS individuals are resilient is crucial for uncovering these ...

Photolabile Sulfinate Protecting Groups for SuFEx synthesis of sulfonyl fluorides, sulfonamides, and sulfones with applications in drug discovery and manufacture

christopher.perkins@rutgers.edu — Thu, 30 Jan 2025 07:14:11 GMT

Photo-labile SPGs protect sulfur-containing compounds in cross-coupling, acidic, and basic conditions. SPGs will convert to sulfonyl fluoride upon light exposure (See preprint below). Invention Summary: Sulfur-derived functional groups such as sulfonyl fluorides, sulfonamides, and sulfones have a significant role in the synthesis of complex molecules, including pharmaceutical drugs. However, synthesis of these drugs is challenging as the integrity of sulfur-derived functional groups is compromised under most drug synthesis conditions. Sulfinate Protecting Groups (SPGs) are used to m...

Novel N-Heterocyclic Carbene Ligands for Transition-Metal Catalysis

christopher.perkins@rutgers.edu — Tue, 28 Jan 2025 06:14:24 GMT

Invention Summary: N-heterocyclic carbenes (NHCs) are tremendously valuable ligands in homogeneous catalysis. Some of the most popular ligands are NHCs that have demonstrated success in a number of organometallic transformations of great interest both in academia and industry. However, synthesizing NHCs poses challenges due to their air and moisture sensitivity, necessitating rigorous conditions and specialized equipment. Rutgers researchers have developed a family of NHCs that offer a wide range of steric hindrance, electronic tunability by introducing novel ...

Enterovirus D68 capsid inhibitors as antivirals

christopher.perkins@rutgers.edu — Mon, 27 Jan 2025 06:36:31 GMT

Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals or vaccines against EV-D68 as available treatments for patients infected with this virus. Rutgers researchers have developed a series of EV-D68 capsid-specific inhibitors that target the viral capsid protein VP1. Upon binding to VP1, this nove...

Progressive Supranuclear Palsy Rating Scale (PSPRS)

christopher.perkins@rutgers.edu — Fri, 24 Jan 2025 06:58:47 GMT

Changes in Scores of PSP patients Over Time Invention Summary: Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disease that involves the gradual deterioration of the brain that leads to loss of balance, difficulty walking, vision problems and cognitive impairment. The Progressive Supranuclear Palso Rating Scale (PSPRS) developed by Rutgers researcher, Dr. Lawrence Golbe, MD, measures the severity of impairment in patients with PSP. The rating system provides a quantitative measure of disability across 28 items in 6 primary domains of clinical impa...

Wireless Readout & Label-Free Detection of Protein Biomarkers

christopher.perkins@rutgers.edu — Wed, 22 Jan 2025 11:10:22 GMT

The prototype has been built and tested using PBS spiked with HMGB1 protein. Voltage response by adding (A) NC to the well, and (B) protein sample to the well Invention Summary: The high demand for point-of-care (POC) biosensors is evident from their worldwide market projection of approximately $37 billion by 2026. The conventional use of enzyme linked immunoabsorbent assay (ELISA) for protein quantification is cost-and-time inefficient, highlighting the need for improved biosensors. Rutgers researcher Dr. Mehdi Javanmard and his team have invented a nanowell array sensor ...

Application of a PS-Targeting Molecule Combined with Memory T cell Antigen for Therapeutic, Diagnostic, and Adjuvant Use

christopher.perkins@rutgers.edu — Tue, 21 Jan 2025 12:10:52 GMT

PS binding molecules could restore inactive or memory T cell functions. Invention Summary: Phosphatidylserine (PS) exposure on the cell surface is often a signal for phagocytosis and can lead to an immunosuppressive effect. Therefore, its inhibition by PS-binding biomolecules can promote a more immuno-responsive microenvironment. However, there is no prior evidence showing that PS-binding molecules are capable of restoring the effector function of antigen non-responsive or exhausted memory T cells. Rutgers researchers discovered that PS-binding molecules could incre...

Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction

christopher.perkins@rutgers.edu — Tue, 14 Jan 2025 08:14:04 GMT

Non-covalent direct inhibition of the Keap1-Nrf2 PPI resulting in upregulation of ARE-gene expression. Thus, increase ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions. Invention Summary: The Keap1-Nrf2-ARE system could protect cells against oxidative stress involving in many diseases. Targeting Keap1-Nrf2 protein-proteins interaction (PPI) is a promising therapeutic strategy for oxidative stress-related diseases. Many of the known Keap1-Nrf2 PPI inhibitors ...

Immobilizing enzymes by crosslinking biomolecular condensates

christopher.perkins@rutgers.edu — Thu, 09 Jan 2025 09:41:21 GMT

Proposed method for immobilizing enzymes by engineering enzyme-RGG fusion proteins, inducing phase separation into biomolecular condensates, and cross-linking condensates. Invention Summary: Enzyme immobilization techniques for industrial use often impede the effectiveness of the biocatalyst. A promising alternative method involves utilizing liquid-liquid phase separation (LLPS) of proteins. By appending intrinsically disordered regions to folded proteins, LLPS can be facilitated. When proteins are sequestered in biomolecular condensates, they can be positioned closely enough for ...

Modified Simmons Catheter

christopher.perkins@rutgers.edu — Wed, 08 Jan 2025 11:52:52 GMT

Neurointerventions with improved success Invention Summary: The global neurovascular catheter market size was valued at USD 2.88 billion in 2020 and is expected to expand at a compound annual growth rate of 6.7% from 2021 to 2028. Neurointerventionalists, interventional radiologists, cardiologists, and vascular surgeons often can have difficulties using the commonly used Simmons catheter or any other double curve or a diagnostic angiography catheter for endovascular interventions for neurological/ peripheral vascular or cardiac disorders. This catheter te...

Privacy Friendly Federated Missing Data Processing for Improved ML and Downstream Analysis

christopher.perkins@rutgers.edu — Tue, 07 Jan 2025 07:25:19 GMT

Cafe not only outperforms local and standard federated models but also surpasses centralized models that have full access to all the data, which is both surprising and groundbreaking. Invention Summary: Decentralized machine learning (ML) models, such as Federated Learning (FL), often face limitations due to incomplete data in distributed datasets. This issue is further complicated by the heterogeneity of missing data, where the distribution of missing data varies across datasets. These discrepancies, caused by privacy concerns or systematic errors, undermine data preproce...

Identification of NFAT5 as a novel target for preventing KRAS targeted therapy resistance

christopher.perkins@rutgers.edu — Mon, 06 Jan 2025 07:35:15 GMT

Inhibiting NFAT5 attenuates pancreatitis-induced resistance to KRAS inhibition and extends mouse survival. Invention Summary: Resistance to KRAS targeted therapy in cancers involves epithelial-to-mesenchymal transition (EMT), which poses challenges for effective targeting. However, the mechanism underlying EMT associated KRAS resistance and potential target treatments for KRAS inhibitor resistance cancers are still urgent to be known. Rutgers researchers delineated the molecular and cellular mechanisms and found the druggable target for this process, thereby...

Discriminating anti DDoS (DAD) Attacks

christopher.perkins@rutgers.edu — Tue, 17 Dec 2024 08:10:29 GMT

High level Architecture for Distributed anti Denial (DAD) of Service solution Invention Summary: With the increasing reliance on digital services, Distributed Denial of Service (DDoS) attacks have become one of the most challenging cybersecurity threats. These attacks aim to disrupt access to online resources by overwhelming servers with malicious traffic, often causing service outages and significant financial losses. Traditional DDoS defenses rely on limiting traffic volume, but these can impact legitimate users, leading to suboptimal user experiences and reputational risks. ...

Accelerated Image Reconstruction (MRI)

christopher.perkins@rutgers.edu — Tue, 17 Dec 2024 08:07:45 GMT

Comparison of the adaptive unrolled method's effectiveness against two other contemporary deep unrolling techniques (M1 and M2). M1 produces a blurry reconstruction, M2 results in a clear but structurally inaccurate output. In contrast, the adaptive unrolling method achieves reconstruction that closely matches the Ground Truth in both sharpness and structural accuracy. Invention Summary: Magnetic Resonance Imaging (MRI) is a widely used imaging modality for clinical diagnostics and the planning of surgical interventions. Accelerated MRI seeks to mitigate the inherent limitatio...

PRISM: Precise Identification of Species of the Microbiome

christopher.perkins@rutgers.edu — Tue, 17 Dec 2024 07:52:33 GMT

Invention Summary: The human microbiome plays a critical role in health and disease, influencing conditions such as cardiovascular disease, cancer, and autoimmune disorders. However, analysis of microbial genetics data has struggled to overcome the effects of false positive and false negative data. Computational methods are further constrained by inadequate benchmarking and the complexity of large datasets. To address these issues, improved experimental protocols and more robust analytical frameworks are needed to reliably identify tissue-resident microbial signals in human genomic...

Digital tool measures movement patterns during social interaction to support autism diagnosis

christopher.perkins@rutgers.edu — Fri, 13 Dec 2024 07:48:48 GMT

Overview of the digital ADOS process, where sensors yield biometric data that are analyzed by signal processing tools in a machine learning approach to differentiate between patient type and group. Invention Summary: The Autism Diagnosis Observation Schedule (ADOS) is the gold standard for autism diagnosis. However, a significant number of people remain undiagnosed due to the limited number of clinicians who administer the assessment and the considerable amount of time it takes to complete. Furthermore, despite the thoroughness of the ADOS, its diagnostic accuracy for female patie...

MYC Program as a biomarker of response to treatment with Enzalutamide

christopher.perkins@rutgers.edu — Thu, 12 Dec 2024 11:55:29 GMT

Invention Summary: Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to more lethal forms of prostate cancer and eventual death. Researchers at Rutgers University and Northwestern University have identified NME as an upstream regulatory partner of MYC in CRPC and have demonstrated that NME2-MYC increased act...

Leveraging On‐board UAV Motion Estimation for Lightweight Macroscopic Crowd Identification

christopher.perkins@rutgers.edu — Thu, 12 Dec 2024 07:35:34 GMT

Crowd motion detected by our invention (top) versus competing algorithm (bottom) Invention Summary: Crowds can often be difficult to monitor in real time due to limitations of current algorithms and processing power. Drones provide a bird’s eye view of crowds but lack the on-board processing power to provide real-time feedback. Rutgers researchers have created a novel, fast, and lightweight approach that makes conscious use of the onboard resources available in an Unmanned Aerial Vehicle (UAV) for the detection and identification of dominant crowd motion patterns in real...

Tirzepatide and other GLP1RA as a novel treatment for patients with congenital generalized lipodystrophy

christopher.perkins@rutgers.edu — Thu, 05 Dec 2024 12:16:39 GMT

The image represents the mechanism of action of Tirzepatide. Image courtesy: Rabbani et al., 2024 Invention Summary: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder, affecting approximately 1 in 10 ...

Real-Time Battery Health and Charge Diagnosis via Thermal Conductivity/Diffusivity Analysis

christopher.perkins@rutgers.edu — Mon, 02 Dec 2024 08:52:45 GMT

A flexible thin-film sensor is installed on a LIB cell for the thermal conductivity/diffusivity measurement. The sensor has patterns that can deposit heat and measure local temperature simultaneously. Invention Summary: The reliable measurement of a battery’s state of health (SOH) and state of charge (SOC) is critical in battery management systems for monitoring battery packs in electric vehicles, mobile phones, and many other devices. Open Circuit Voltage (OCV) is a general method to measure the SOC, but it is still challenging to apply to some cell chemistries that have a ...

Sterically-Hindered and Strongly Sigma-Donating Triazole NHC Ligands Technology

christopher.perkins@rutgers.edu — Mon, 02 Dec 2024 06:57:03 GMT

General structure of classical NHCs and the present invention Invention Summary: NHC ligands (NHC = N-heterocyclic carbene) are the most popular ligands in transition-metal-catalysis, organocatalysis, organic synthesis and materials science, among other applications. Rutgers researchers have developed a novel sterically-hindered and strongly sigma-donating NHC ligands on 1H-1,2,3-triazol-5-ylidene architecture. The ligands belong to a class of abnormal N-heterocyclic carbenes, where the metal is bound to the C4 or C5 position of the heterocyclic ring rather than in the typic...

Three‐Dimensional, Load‐Sharing, Pre‐Vascularized Scaffold for Bone Regeneration

christopher.perkins@rutgers.edu — Mon, 25 Nov 2024 12:09:20 GMT

Bi-weekly x-rays (A) showed progressive bone regeneration up to 10 weeks. The reconstructed CT images (B & C) show bone growing into and within the scaffold while the scaffolds maintained their mechanical strength. Invention Summary: Over 600,000 bone grafting procedures are performed in the US annually. While bone autografting is the gold standard, it requires additional graft harvesting surgery and the supply of autologous bone is limited. Alternatively, allografting increases the supply of bone grafts but poses risks for disease transmission and immune rejection. Current sy...

IDENTIFYING TREATMENT RESPONSE SIGNATURES

christopher.perkins@rutgers.edu — Tue, 12 Nov 2024 06:28:09 GMT

Invention Summary: Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible. Researchers at Rutgers University have identified several bioinformatic methods for the identification of biomarkers of resistance to specific treatments for specific types of cancer. These algorithms are: TR-2-Path – a de novo mechanism-centric regulatory network that encodes ...

NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level

christopher.perkins@rutgers.edu — Tue, 12 Nov 2024 06:12:35 GMT

NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription. Invention Summary: As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating symptoms. Synthetic transcription factors have shown promise in the treatment of mitochondrial disorders. However, they have faced significant challenges to their efficacy as a treatment...

miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation

christopher.perkins@rutgers.edu — Tue, 12 Nov 2024 05:58:32 GMT

Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including cardiovascular disease, cancer, etc. Recently, a series of glucagon-like peptide-1 agonists, such as semaglutide (Ozempic®) or tirzepatide (Mounjaro®), have shown great results for weight loss. However, these drugs are delivered systemica...

Ecofriendly and Highly Efficient Phosphors for Light-Emitting Diodes

christopher.perkins@rutgers.edu — Thu, 07 Nov 2024 07:04:15 GMT

Copper iodide based highly luminescent phosphor can produce internal quantum yield of up to 98% when excited with 365 nm light Invention Summary: The global market for light-emitting diodes (LEDs) is projected to account for up to 80% of light sources by 2030. However, the commercial phosphor used during their fabrication is made from rare-earth elements (REEs); hence contributing to mining-related environmental hazards. Rutgers researchers have developed highly efficient REE-free phosphors that can off...

Rare-Earth-Element Free Yellow Phosphors for White Light-Emitting Diodes

christopher.perkins@rutgers.edu — Thu, 07 Nov 2024 06:51:57 GMT

Yellow phosphor emits white light when excited with the 460 nm blue lighting. The blue LED (left half; top) when coated with dispersed yellow phosphor (right half; top) emits white light. Invention Summary: Despite their low energy consumption and higher efficiency, white light-emitting diodes made of blue chip coupled with yellow phosphor has disadvantages of high correlated color temperature, relatively low color rendering index and the use of rare-earth elements (REE). Rutgers researchers have developed a new REE-free yellow phosphor made of metal organic frameworks (MOF...

Hybrid Lighting Phosphors with High Quantum Efficiency, and Enhanced Thermal and Photostability

christopher.perkins@rutgers.edu — Thu, 07 Nov 2024 06:36:24 GMT

This rare-earth element-free invention can be used in LEDs to generate the entire visible spectrum Invention Summary: The use of rare earth elements in the phosphor coating of light-emitting diodes (LEDs) and compact fluorescent lamps (CFLs) raises environmental concerns; hence it requires alternative solutions ...

GDA Inhibitors for the Treatment of Spinal Cord-Induced Neuropathic Pain

christopher.perkins@rutgers.edu — Wed, 06 Nov 2024 06:33:59 GMT

Invention Summary: Spinal cord injury (SCI) and its associated chronic pain can significantly diminish quality of life. While therapies like spinal cord stimulation and neuromodulation offer potential pain relief, current pharmacological options fall short, often proving ineffective, short-lived, and laden with side effects, including addiction. To improve long-term outcomes and address these limitations, the development of novel therapeutics specifically targeting post-SCI pain is imperative. Rutgers researchers have identified a compound (B9), which inhibits cypin, a GDA t...

A Three-Buckyball Platform to Synthesize Structurally Defined Water-Soluble Metallofullerene Derivatives

christopher.perkins@rutgers.edu — Tue, 05 Nov 2024 06:57:12 GMT

Invention Summary: Fullerenes, an allotrope of carbon, are polyhedral closed cages. Fullerenes are able to host additional atoms within their inner spheres. Fullerenes hosting electropositive metals (e.g. Sc, Gd, La), known as endohedral metallofullerenes (EMFs), are especially interesting as the encapsulated metals provide additional properties such as high proton relaxivity for use as MRI contrast agents or interesting reactivity. Rutgers researchers are developing a suite of chemical transformations to functionalize fullerenes (and EMFs) and in...

Tailor-made MOF for the separation of alkane isomers

christopher.perkins@rutgers.edu — Thu, 31 Oct 2024 08:18:56 GMT

Schematic example of highly selective propane/propylene separation process through the adsorbent bed of the metal-organic framework Invention Summary: The separation of alkane isomers, especially propane and propylene, represents a critical yet challenging process in the petrochemical industry to produce high-quality gasoline. Current distillation technology is energy intensive, so an alternative is necessary. Adsorptive separation by porous solids offers lower energy costs and higher efficiency. Rutgers researchers have developed a series of metal organic frameworks (MOFs) for...

A Solution for Community-Based Parking: Vehicle Information Systems

christopher.perkins@rutgers.edu — Fri, 11 Oct 2024 09:34:18 GMT

Ultrasonic sensor on car detects parked cars and vacant spaces. Invention Summary: Searching for available on-street parking is a persistent urban challenge, leading to increased congestion, wasted time, and higher emissions. Creating a spot-accurate map of parking availability challenges GPS l...

Novel cermet composite for nuclear waste immobilization

christopher.perkins@rutgers.edu — Wed, 09 Oct 2024 12:15:43 GMT

1.5-inch diameter cermet synthesized using hot uniaxial sintering Invention Summary: Nuclear power generates ~10% of electricity globally and ~20% in developed economies. High-level waste, expected to be produced at the back end of advanced reactor fuel cycles, includes metals, oxides, halide salts, and carbon/graphite (TRISO fuel particles). Immobilization of high-level waste to a single waste stream presents a considerable challenge. The current state-of-the-art nuclear w...

Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling

christopher.perkins@rutgers.edu — Thu, 19 Sep 2024 11:31:38 GMT

CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux Invention Summary: Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of death worldwide. Two of the main contributors to atherosclerosis include (1) impaired clearance of apoptotic cells (efferocytosis) and (2) formation of cholesterol crystals which enrich lesion foam cells. Rutgers researchers ...

Activity-Based Aptamers as Next-Generation Bioimaging Tools and Diagnostics

christopher.perkins@rutgers.edu — Mon, 16 Sep 2024 06:51:05 GMT

Invention Summary: As more and diverse biomarkers are identified for critical pathophysiological processes, there is a growing need to develop easily applied, reliable, and adaptable diagnostic tools. Rutgers researchers have developed a smart molecular toolbox that fulfill these criteria. This toolbox, termed the activity-based aptamer (ABA) system, enables a single nucleic acid scaffold to detect unique and structurally diverse disease-associated biomarkers, ranging from organic and inorganic small molecules to enzymes. Furthermore, surfaces that are grafted with these ABA sy...

SuperSelective PCR Primers

christopher.perkins@rutgers.edu — Sat, 14 Sep 2024 06:22:00 GMT

Structure of a SuperSelective primer for the detection and quantitation of rare mutant sequences in the presence of 1,000,000 wild-type sequences; and a demonstration that the number of amplification cycles required to generate a signal above background is inversely linearly proportional to the logarithm of the number of mutant molecules in the original sample. Invention Summary: “SuperSelective” primers enable the detection and quantitation of somatic mutations whose presence relates to cancer diagnosis, prognosis, and therapy in real-time PCR assays that can analyze ...

Sensor‐based Real‐time Tracking‐game for Ankle Proprioception

christopher.perkins@rutgers.edu — Tue, 10 Sep 2024 08:10:26 GMT

Gyroscope setup used for the tracking game along with an example cursor path and participant cursor. Invention Summary: One out of every four older adults fall every year in the US, leading to potentially devastating consequences. In addition to muscle strength assessment and training, which is the primary research focus, proprioceptive assessment and improvement is critical since it can be the major or primary contributing factor to postural balance and poor balance recovery from tripping. Current approaches for assessing proprioceptive performance are not reliable or sensit...

Ion‐exchangeable transparent and opaque glass‐ceramics

christopher.perkins@rutgers.edu — Fri, 23 Aug 2024 10:16:04 GMT

Photos of heat-treated glass-ceramics Invention Summary: Recently, the display glass industry is transitioning from using glass to glass‐ceramic due to its higher mechanical strength. Similarly, instead if aluminum, glass-ceramic is becoming the preferred material for back covers of smartphones and other devices to enable effective wireless charging. Rutgers researchers have created a glass-ceramic material, based on the nepheline and spinel system. Nepheline provides a strong glass‐forming ability, and it can be chemically strengthened. The presence of the spinel phase increas...

Flame Synthesis of Carbon-Based Films on Liquid Surfaces

christopher.perkins@rutgers.edu — Thu, 15 Aug 2024 11:39:25 GMT

Schematic of an ethylene-air premix flame impinging on the liquid surface of a distilled water bath, producing carbon-based films on the liquid surface Invention Summary: The production of thin, carbon-based films on liquid surfaces often leaves behind MgO impurities, requires additional purification steps, and is reliant on the use of substrates, including dry ice and Mg particles. Rutgers researchers have created a novel production method for carbon-based thin films via combustion, without substrates. The characteristics of the resulting films can be customized by modifying ...

New Drugs for the Prevention of Kidney Stones

christopher.perkins@rutgers.edu — Thu, 15 Aug 2024 07:18:51 GMT

In vivo efficacy study of an LH prodrug expressed as days CaOx crystals were detected in mouse urine/mouse/week Invention Summary: Hyperoxaluria is a condition characterized by excessive urinary excretion of oxalate. It can result from inherited genetic mutations, intestinal diseases, or a diet high in oxalate. This often leads to calcium oxalate kidney stones. While surgery is necessary for severe cases and some rare primary hyperoxaluria from specific genetic mutations can be addressed with the recently available siRNAs, general management of most cases involves drinking a large...

Novel non-canonical subgenomic mRNAs from SARS-CoV-2

christopher.perkins@rutgers.edu — Tue, 13 Aug 2024 11:06:24 GMT

Schematics of SARS-CoV-2 genome and subgenomic mRNAs. Production of sgmRNAs can introduce unusual deletions and junctions in COVID variants. Invention Summary: Although COVID-19 emergency is “officially over”, the potential threat of novel variants, which may lead to severe disease, has not disappeared. Despite the huge numbers of publications on SARS-CoV-2 in the past 4 years, the research community has only scratched the surface of many aspects of virus biology. For example, analysis of patient samples shows that novel open reading frames and genes appear in variants...

Tao: Microarchitecture Simulation with Machine Learning

christopher.perkins@rutgers.edu — Fri, 09 Aug 2024 13:42:21 GMT

Simulation accuracy comparison with the state-of-the-art. Invention Summary: Microarchitecture designers rely on simulators to validate, optimize, and manufacture hardware that meets specific design requirements. Out of the current simulators, executive-driven simulators are often slow and require a high level of expertise, trace-driven simulators have low accuracy, and deep-learning-based stimulators fail to meet performance metrics such as causing branch mispredictions or cache misses. Rutgers researchers have redesigned and optimized a deep-learning microarchitecture...

Novel GalNAc-siRNA Conjugates as a Treatment for High Blood Triglycerides and Fatty Liver Disease

christopher.perkins@rutgers.edu — Thu, 08 Aug 2024 06:30:42 GMT

H&E staining of mice liver sections showing protection against high blood triglyceride and MASLD induced by a high-fat diet in knockout mice. Invention Summary: Diabetes and obesity are the major contributors to the pathological accumulation of triglyceride (TAG) in the blood and liver, resulting in metabolic syndrome, myocardial infarction, stroke, vascular occlusive diseases, and metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD has surpassed alcoholic liver disease as the most common chronic liver disease worldwide and can progress to hepatitis, ...

Scan Ease: Temporary Bone-Supported Intraoral Scan Alignment Tool

christopher.perkins@rutgers.edu — Wed, 07 Aug 2024 13:24:22 GMT

Invention Summary: This innovation addresses a critical gap in digital dentistry techniques for aligning pre-extraction records to post-extraction records, especially in cases of implant placements with or without teeth extractions using intra-oral scanners. Rutgers researchers have developed a fiducial marker that can be inserted into the bone without any surgical incision through the mucosa, aiding in aligning preoperative intraoral scans to postoperative intraoral scans as well as intraoral scans to Cone Beam Computed Tomography for cases involving partially dentate...

FaceGroup: Continual Face Authentication

christopher.perkins@rutgers.edu — Tue, 06 Aug 2024 07:14:05 GMT

Paradigm for FaceGroup system: enrollment, group authentication & individual authentication. Invention Summary: ‘Authentication’ rather than just ‘trust’ is now a changing paradigm for many users and service providers and thus the concept of Zero Trust (ZT) emerged. This for sure, provides enhanced security level for network architectures. Although there are many authentication methods for physical access control, the methods suitable for continual authentication should be able to be conducted remotely, preferably cloud-based. Rutgers researchers hav...

Risk Stratification Integrating mHealth and Artificial Intelligence

christopher.perkins@rutgers.edu — Mon, 29 Jul 2024 09:44:51 GMT

Portable Ultrasound Equipment improves patient access at the point of care Invention Summary: Cardiovascular disease is the leading cause of death in the United States, resulting in more than 600,000 deaths. Over 28 million Americans are diagnosed with heart disease and contribute more than $30 billion in healthcare-related expenses. Many patients who experience a heart attack do not undergo cardiac imaging and have a higher risk of adverse events, including another cardiovascular incident. Though the emergence of point-of-care ultrasound (POCUS) enables wider access to imaging, r...

Synthetic Echocardiogram from ECG

christopher.perkins@rutgers.edu — Mon, 29 Jul 2024 09:40:33 GMT

Steps used to develop a machine learning model to extract heart features from electrocardiography results Invention Summary: Echocardiography (echo) uses high-frequency sound waves to create images of the heart and show its size, shape, and function. It is a valuable tool for detecting blood clots, tumors, structural defects, muscle performance, and heart size, among others, for men, women, and children. Moreover, there are no side effects, and it is a painless procedure. Due to the COVID-19 pandemic, new advances in telemedicine for cardiology, specifically, tele-echocardiography...

Dynamic Flow Phantom for Cardiac Intervention Pre-Planning and Testing

christopher.perkins@rutgers.edu — Mon, 29 Jul 2024 09:36:03 GMT

A 3D Patient-Specific Anatomical Heart Model Invention Summary: Heart disease is the leading cause of death for both men and women in the United States. During the past 50 years, the landscape for heart disease has been changed by pharmacological advancements and device innovation. Routine preoperative imaging is necessary for optimal planning of surgical interventions and procedures. 3D printing is a widely used technique that builds lifelike replicas of the human heart to address the planning stages of operations and overcome limitations with procedures. Rutgers researchers ...

Surgical Artificial Intelligence Ureteral Injury Prevention System for Robotic and Laparoscopic Surgery

christopher.perkins@rutgers.edu — Wed, 24 Jul 2024 06:46:11 GMT

Image legend: The software will offer surgeons a real‐time monitoring system for the position of the ureters Invention Summary: Overall incidence of significant ureteral injury in gynecologic and colorectal surgeries is 1.7% and 1.9%, respectively. The risk of injury is higher in cases with a complex history of prior surgery, radiation, inflammatory conditions or mass obscuring anatomic planes. Rutgers researchers have developed an AI‐based technology to assist in preventing iatrogenic ureter injury. The new system will continuously monitor the location of the surgical instrum...

Bioinformatic Methods for Determining Resistance to Cancer Treatments

christopher.perkins@rutgers.edu — Mon, 15 Jul 2024 12:13:31 GMT

Detecting Driver Phone Usage Exploiting Inertial Sensors

christopher.perkins@rutgers.edu — Fri, 28 Jun 2024 04:11:58 GMT

Scheme showing how the technology determines the cell phone location. Invention Summary: According to the Insurance Institute for Highway Safety (IIHS), “The National Safety Council reports that cell phone use while driving leads to 1.6 million crashes each year. With nearly 660,000 injuries occur each year from accidents caused by texting while driving”. Rutgers researchers have developed a technology that utilizes sensors in mobile devices to determine whether the phone is located on the driver's or passenger’s side of the vehicle. This is accomplished b...

R/ECON™ I-O: An Economic Impact Model

christopher.perkins@rutgers.edu — Wed, 05 Jun 2024 11:53:45 GMT

Invention Summary: The R/ECONTM Input-Output Model (I-O) shows how sectors of an economy interact. For a given industry, the model shows the “production recipe” for the goods and services the industry sells and the shares of its revenues that are consumed by other industries in the economy. The R/ECONTM I-O model’s generates estimates of interregional trade by sector that are based on those conceived by the Regional Science Research Institute. Those estimates are recognized by the academic community as the most reliable estimates available. R/ECONTM can customize model...

Cardiac Ultrasonic Fingerprinting: An Approach for High-throughput Myocardial Feature Phenotyping

christopher.perkins@rutgers.edu — Fri, 10 May 2024 12:12:32 GMT

Cardiac Ultrasound Fingerprinting is an approach for high throughput extraction of myocardial features Invention Summary: Tissue characterization of myocardial pathology has been an area of intense research and development due to the rising incidence of cardiovascular conditions and the growing geriatric population globally. Although Cardiac Magnetic Resonance (CMR) is largely used to associate myocardial imaging features with pathological assessments, its cost limits its usage. Rutgers researchers have developed a myocardial image analysis technique called myocardial ultraso...

Standardized Individual Pain Assessment Tool

christopher.perkins@rutgers.edu — Fri, 10 May 2024 09:21:44 GMT

A pipeline for utilizing facial, motor, and cardiac signals to measure an individual’s pain threshold Invention Summary: Self‐reporting of a person’s subjective level of pain is highly variable. This is due to individual differences in the way human beings experience pain. At present, no objective physiological scale of pain exists that also reflects the person's level of pain tolerance. This creates several challenges such as appropriately managing pain in patients with chronic conditions or communication disorders, and the ability to accurately measure the impa...

CAR-NK based combinatorial treatment for drug-resistant tumors

christopher.perkins@rutgers.edu — Wed, 08 May 2024 14:41:34 GMT

Incucyte Killing Assay Images with AnnexinV cell death signal in MKI-Resistant HCC (Top panel). Chromium-51 release assays comparing GRP78 CAR-NK Killing to Naïve NK killing of various MKI-resistant tumor cell lines (bottom panels). Values shown are Means ± SEM. Significant p values indicated in red. Invention Summary: CAR-NK therapies have minimal toxicities compared to CAR-T therapy. Heat shock proteins (HSP), such as Glucose Regulated Protein 78 (GRP78), are valuable targets to treat cancers. GRP78 is a protein-folding chaperone that resides in the endoplasmic reti...

IntelliGenes: AI/ML pipeline for biomarker discovery and patient diagnosis

christopher.perkins@rutgers.edu — Thu, 25 Apr 2024 12:32:42 GMT

A pipeline combining classical statistics and machine learning algorithms is used to identify disease-associated biomarkers and predict disease risk Invention Summary: Gene Expression Analysis and Genome‐wide association studies provide an unprecedented understanding of the genetic basis of human disease by uncovering millions of loci associated with various complex disease phenotypes. However, these are unable to completely map biomarkers and predict disease with high accuracy. The key limitation is our lack of technology to analyze the complete genome or transcriptome of patien...

Electroosmotic Acoustic Transducer

christopher.perkins@rutgers.edu — Tue, 23 Apr 2024 11:40:29 GMT

Electro-mechanical transduction is achieved when the ionic fluid is acoustically or electrically excited within the device’s capillaries Invention Summary: Sound generating devices have varying applications in fluidic and soft tissue environments; including speakers for private and recreational swimming pools, medical diagnostic (ultrasound) devices, and deep-sea signaling applications. Typically, sound generating devices create pressure waves by mechanical deflection of electromagnetic or piezoelectric elements at discrete or limited resonant frequency bands. The def...

Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection

christopher.perkins@rutgers.edu — Thu, 04 Apr 2024 10:23:27 GMT

Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19 Invention Summary: Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for timely, accurate disease diagnosis and prognosis. Rutgers researchers have used proteomics to expand a previous list of biomarkers for MIS-C and SARS‐CoV‐2 infection. Proteomics analysis of 17 MIS-C patients and 20 severe COVID-...

Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection

christopher.perkins@rutgers.edu — Mon, 11 Mar 2024 20:38:43 GMT

XO-Dontia: Invisible tooth markings for increasing tooth-accuracy in dental procedures

christopher.perkins@rutgers.edu — Mon, 11 Mar 2024 12:58:00 GMT

(Left) Teeth marked with XO-Dontia under normal light exposure. (Right) The same, marked teeth when exposed to black, UV light. Invention Summary: Dentists use tooth numbering systems in order to mark, on referral forms and patient records, the exact teeth that must be removed via dental extractions. However, tooth numbering systems differ between dental specialties, and similarities between primary “baby” teeth and adult teeth, often cause human error in these procedures – resulting in the incorrect tooth being extracted and an unnecessary physical and financial ...

A novel inhibitory mimetic peptide slows down tumor development

christopher.perkins@rutgers.edu — Thu, 07 Mar 2024 07:33:03 GMT

Inhibitory peptide increases caspase3 activity (A) by blocking GC1/Trx1 complex thereby limiting cell proliferation by inducing cell death (B). Invention Summary: Soluble guanylyl cyclase (GC1) and thioredoxin 1 (Trx1), when physically interacting and attaching to each other, they acquire the ability to induce changes in other target proteins such as caspase‐3, modifying their properties. The complex GC1/Trx1 modifies caspase‐3 and makes it inactive with an outcome where cell death is inhibited, and proliferation of tumor cells proceeds. Rutgers researchers have develope...

Proximity Doping for Silicon Structures

christopher.perkins@rutgers.edu — Tue, 27 Feb 2024 11:09:56 GMT

Long-term passivation stability of Phosphorus-doped polysilicon samples Invention Summary: In semiconductor industries, Spin-on-dopants (SOD) are being used as an alternative to conventional solution for forming doped poly-Si junctions and homogeneously diffused junctions. However, SOD also has its own limitation; Organic residues remained on the surface are hard to be removed and increases the process costs notably due to the need to include additional removal steps. Rutgers researchers have developed a new process to create high purity doped poly-Si junctions and ...

Rutgers PerioCalc App

christopher.perkins@rutgers.edu — Fri, 23 Feb 2024 08:42:14 GMT

PerioCalc is a cutting-edge Periodontal Calculator app designed to educate users on the latest classification of Periodontal Diseases and Conditions. Invention Summary: Over 40% of American adults suffer from gum disease. Researchers at Rutgers University have developed this app which provides an intuitive interface for healthcare providers to learn how to implement in practice to properly and timely diagnose periodontal patients. The PerioCalc is an educational periodontal classification calculator that helps dental students and dentists understand what data to consider and h...

Blood–Brain Barrier-Penetrant Anti-Inflammatory Neuroprotective Nanoparticles for Alzheimer’s Disease

christopher.perkins@rutgers.edu — Wed, 21 Feb 2024 06:18:45 GMT

Invention Summary: Alzheimer's disease (AD) is characterized by progressive neurodegeneration and a high mortality rate in the elderly. Current therapeutic strategies fall short in halting the underlying cognitive decline and nerve cell damage. The primary features of AD are the accumulation of extracellular amyloid plaques, uncontrolled activation of microglial cells, and neuroinflammation. Researchers at Rutgers University are developing a novel nanoparticle platform based on amphiphilic macromolecules to address the multifactorial pathology of Alzheimer’s disease. ...

Decentralized, Privacy-preserving Navigation Recommendation System

christopher.perkins@rutgers.edu — Thu, 08 Feb 2024 06:58:14 GMT

The recommendation system provides a proactive and personalized route for a user’s movement indoors or outdoors. Invention Summary: Contact tracing has been shown to be an effective disease control measure and a key strategy for preventing further spread of the COVID-19 pandemic. However, smartphone contact tracing tools have seen limited uptake, likely due to user privacy concerns and their reactive rather than proactive nature. Rutgers researchers have developed a navigation system that proactively provides recommendations to users on the best routes or location...

Spotted-wing drosophila repellants from anthracnose-infected fruit

christopher.perkins@rutgers.edu — Mon, 29 Jan 2024 10:28:44 GMT

Figure 1. Ethyl butanoate and ethyl (E)-but-2-enoate show equal or greater repulsion of D. suzukii adults to blueberries compared to 3 known repellents vs. control. Non-responders are D. suzukii adults that did not make a choice between any group of blueberries. Adapted from Fig 5. Rering CC. et al. (2023). Invention Summary: Spotted-wing drosophila (Drosophila suzukii) is a highly destructive pest of thin-skinned fruits, such as berries and cherries, causing global economic losses in agriculture. Current solutions to control these pests include chemical insecticides, biological ...

Communication-efficient Federated Learning NG-RAN Design with Fronthaul Awareness

christopher.perkins@rutgers.edu — Mon, 29 Jan 2024 10:18:37 GMT

Fig. 1: Structure of federated learning-based NG-RAN algorithm. Invention Summary: Mobile network operators are faced with meeting demands beyond 5G networks, such as opening/virtualizing radio access network (RAN) layers, maintaining privacy, and achieving ultra-low latencies, high data rates, and low operational expenses for data transmission. Next generation RAN (NG-RAN) is a current solution to achieve flexibility and efficiency using the next generation fronthaul interface (NGFI) standard. However, the issue remains that fronthaul traffic must be reduced and privacy must be ...

Two-Way Knowledge Distillation for Federated Learning

christopher.perkins@rutgers.edu — Mon, 29 Jan 2024 10:11:47 GMT

The workflow of the Fed2KD framework. Red arrows indicate the knowledge distillation direction. Invention Summary: Current contact tracing reporting platforms for infectious diseases are limited by their reactive nature, centralized approach, use of GPS, and privacy risk due to exchange of user data. Existing federated learning (FL) frameworks that can be used for alternative disease-tracking are limited to homogenous models and ignore user preferences and varying device properties. Rutgers researchers have developed a novel, 2-way knowledge distillation-based FL framework (&ld...

A Method for Secure and Privacy-Preserving Feature Encoding to Enable Federated Data Augmentation and Input Validation

christopher.perkins@rutgers.edu — Sun, 21 Jan 2024 20:15:49 GMT

2-step overview of the method Invention Summary: Predictive analytics are essential for optimizing industrial processes, but distributed sensitive data lacks generalizability, suffers from bias, and can't be gathered centrally. Although federated learning and privacy-preserving methods solve data mining problems, they face scalability and utility issues. Rutgers researchers developed an (International award-winning) efficient, scalable, and secure method for validating distributed sensitive data and federated learning. It uses a novel encoding scheme based on symmetric key ...

Upcycling Polypropylene into Carbon-based Nanomaterials

christopher.perkins@rutgers.edu — Tue, 05 Dec 2023 18:13:43 GMT

Fig. 1. Scheme on invention: from polypropylene pellets to carbon-based nanomaterials with graphitic structure. Left: PP raw materials. Right: X-ray photoelectron spectroscopy of PP, graphite, and CDs from different reaction temperature. Inset: 6.5 μm * 5.25 μm image of carbon dots under dark-field scattering mode with microscopy. Invention Summary: Polypropylene (PP) plastic waste is one of the most common types of plastic waste that is both thermally and chemically extremely stable – rendering them difficult to upcycle. Current methods of recycling PP u...

Rutgers High Carvacrol Producing Oregano Lines ‘Pierre’ and ‘Eli’

christopher.perkins@rutgers.edu — Tue, 05 Dec 2023 15:25:30 GMT

Rutgers Oregano lines: Pierre and Eli Invention Summary: Rutgers oregano selection and crop improvement program has developed two new oregano (Origaum vulgare) varieties, named as ‘Pierre’ and ‘Eli’, following extensive multi-year evaluation under different environments. These two plant varieties were propagated vegetatively and showed good field performance in the Mid-Atlantic region. They demonstrate upright growth, making it suitable for mechanical harvest. Rutgers researchers have developed ‘Pierre’ and ‘Eli’ lines which were...

Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome

christopher.perkins@rutgers.edu — Thu, 16 Nov 2023 13:28:30 GMT

Fig 1. The potential added value of testing for novel biomarkers including FCGBP, MRC1, and LBP in children with MIS-C include the quick and accurate diagnosis, treatment, and prognosis. Invention Summary: The multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for timely, accurate disease diagnosis and prognosis. Rutgers researchers used proteomics to discover biomarkers in the plasma of children with MIS-C. These include Fc gamma binding protein (FCGBP), Mannose receptor C-1 (MRC1), and LPS-binding protein (LBP). The...

Polyelectrolyte Complexes (PEC) for Promoting Wound Healing and Hair Growth

christopher.perkins@rutgers.edu — Sat, 11 Nov 2023 20:03:58 GMT

The pictures show the progression of wound closure and hair growth around the skin wound. Both PEC film groups show improved wound closure and signs of hair growth as early as day 21. The hair growth is primarily localized to the skin area that was under the PEC film during treatment. Invention Summary: Common complications of diabetes include chronic, non-healing wounds of the skin (about 25% of diabetic patients), hair shaft thinning, and diffuse hair loss. Underlying causes include prolonged inflammation that impairs progression thro...

Ultra-high-resolution micro-thermometer using Tunneling-Diffusion Edge Sensor (TDES)

christopher.perkins@rutgers.edu — Fri, 03 Nov 2023 12:50:44 GMT

High-resolution room-temperature thermometers described in the literature as a function of their resolution and footprint area. Highlighted area shows microscale and nanokelvin resolution. The projected resolution and footprint of the proposed Tunneling-Diffusion Edge Sensor (TDES) are marked in blue. Invention Summary: Ultrahigh-resolution thermometry is critical for future advances in bio-calorimetry, bolometry for sensing and imaging in infrared and terahertz (THz) range, as well as thermal metrology for electronic, optoelectronic and quantum devices. Rutgers researchers have si...

Nutraceuticals for Preventing Leaky Gut

christopher.perkins@rutgers.edu — Tue, 24 Oct 2023 14:21:06 GMT

Image Legend: Control intestinal organoids and organoids conditioned to have a leak, or more permeable barrier, were treated with nutraceuticals which clearly prevented increased permeability in the “leaky” organoids. Similar findings were observed in cell culture and in vivo Invention Summary: More than 22 million Americans suffer from chronic autoimmune and inflammatory diseases that are linked to a “leaky” gut, i.e., easily permeable for inappropriate entry by bacteria and toxins into the blood. Certain beneficial bacteria living in a healthy human gut ...

Biologic inhibitors to reduce adverse effects of traditional opioids without compromising analgesia

christopher.perkins@rutgers.edu — Mon, 16 Oct 2023 21:24:42 GMT

Invention Summary: Mu opioids, including morphine, fentanyl, and oxycodone, remain the mainstream drugs for moderate-to-severe pain management in the clinic despite their side-effects, such as tolerance, reward, addiction, and respiratory depression. However, misusing these mu opioids can magnify their side-effects and promote the development of opioid use disorder, a main cause of the worldwide opioid epidemic and opioid overdose deaths, which have been climbing steeply in the United States in recent years. There is a dire need for developing novel therapeutic strategies and me...

Novel Sargassum-Based Polymer Composite Filaments for 3D Printing

christopher.perkins@rutgers.edu — Fri, 29 Sep 2023 11:22:48 GMT

Examples of prints made with Sargassum-loaded filament Invention Summary: As a direct effect of ocean warming and nutrient enrichment, tons of brown macroalgae known as sargassum, have b...

RED LIGHT THERAPY DEVICE FOR INTRAVENTRICULAR HEMORRHAGE IN NEWBORNS

christopher.perkins@rutgers.edu — Mon, 25 Sep 2023 13:21:47 GMT

Schematic prototype and general appearance of the external fontanelle intraventricular hemorrhage light (EFIL) device Invention Summary: Transcranial Photo Biomodulation (tPBM) uses light to treat brain-related diseases, such as intraventricular hemorrhage (IVH). In vivo studies on IVH-induced adult and neonatal mice show, increased clot resorption, reduced intracranial pressure and improved functional outcomes after red-light therapy. tPBM devices have been previously used in traumatic brain injury (TBI) and stroke treatments in adults, and tPBM has been demonstrated to be safe ...

ESMM Biosensor for Personalized Phagocytosis Quantification in Infections

christopher.perkins@rutgers.edu — Wed, 20 Sep 2023 16:36:32 GMT

A) Biosensor cross-sectional schematic demonstrating phagocyte with microparticles through sensing region B) Corresponding bipolar pulse generated with each passage of the cell C) Top view of biosensor where magnetic is placed on side to generate field and to modulate the cell speed Invention Summary: Point-of-care biomedical technologies are crucial for early infection diagnosis, risk stratification, and effective treatment response evaluation. However, developing these sensors involves overcoming technological challenges and integrating multiple fields, while current cli...

Off-the-Shelf CAR-Macrophages for Solid Tumors

christopher.perkins@rutgers.edu — Wed, 20 Sep 2023 15:07:02 GMT

Invention Summary: Chimeric Antigen Receptor (CAR) therapy requires isolation of the respective immune cells from the patient’s blood, genetic manipulation, and infusion of the modified cells back into the patient’s body. This makes it personalized and effective but expensive. The CAR-T (modified T cells) therapy has shown promise in hematological cancers, but are less so in solid tumors. CAR-macrophages have received interest recently for their “tumor-homing” and “immune-modulating” abilities which may improve their CAR cell efficacy in...

Dynamic Light Spectrum Absorption Eyewear

christopher.perkins@rutgers.edu — Wed, 20 Sep 2023 13:07:52 GMT

A perspective view of some components of eyewear Invention Summary: Chromotherapy or Colorology is a known holistic or alternative treatment which has been used for healing and psychological well-being of an individual. Qualitative and quantitative data exists that demonstrates the impact of color on an individual’s psychological state in order to induce a wide range of responses, ranging from relaxation through to performance-oriented states. It is apparent that there is a need for new therapeutic treatments in place of, or in conjunction with, pharmac...

In situ formation of 2D nanoparticles within elastomers for electromechanical sensing and flexible pressure pad

christopher.perkins@rutgers.edu — Thu, 14 Sep 2023 09:31:39 GMT

Adding graphite and elastomer to batch mixer for in situ exfoliation Invention Summary: It has been known that a material’s electrical, mechanical, and chemical properties can be enhanced with the addition of graphene nanoparticles. Typically, the nanoparticles are created separately from the bulk material and are injected into the polymer and allowed to cure. Rutgers researchers have developed a novel method to exfoliate the nanoparticles while inside the polymer matrix. This single step procedure is accomplished by adding the bulk graphite to the polymer ...

The HμB (High-Efficiency μ-Fluidic Barrier)

christopher.perkins@rutgers.edu — Wed, 13 Sep 2023 17:31:44 GMT

Figure 1. The Hμb being used with a conventional microscope stage. Invention Summary: In the pharmaceutical and cosmetics industries, it is pertinent to screen for safety and dosage efficacy of developed drugs and compounds. These experiments can be costly and use equipment that can only be operated by skilled technicians and experts. Rutgers researchers have developed a novel microfluidic device able to examine the integrity of cell barriers, such as vascular barriers along different parts of the brain, spinal cord, gut barrier, pulmonary barrier, and the blood re...

Complexes of N-heterocyclic carbenes for hydro-functionalization reactions

christopher.perkins@rutgers.edu — Sun, 10 Sep 2023 19:48:04 GMT

Structures of Cu-NHC Complexes. Note that the same structures are available for Ag-NHC and Au-NHC Invention Summary: Unsymmetrical N-heterocyclic carbenes (NHCs) hold pivotal significance in modern catalysis and material science due to their versatile and tunable properties. Their unique electronic and steric attributes enable tailored interactions with metal catalysts, enhancing catalytic activity and selectivity. However, synthesizing NHCs poses challenges due to their air and moisture sensitivity, necessitating rigorous conditions and specialized equipment. Rutgers resea...

On-line Analytical Workflow for Automated Monitoring of mAb Glycosylation during Biomanufacturing

christopher.perkins@rutgers.edu — Thu, 31 Aug 2023 13:42:44 GMT

Schematic of N-GLYcanyzer PAT Workflow for Integrated Upstream Analysis of Monoclonal Antibody Titer and N-linked Glycosylation Invention Summary: Continuous process for biologic manufacturing in biopharmaceutical industry relies on prompt feedback of process parameters for decision making as they may quickly influence the critical quality attributes (CQA’s) of the biologic that may alter drug efficacy and safety. N-linked Glycosylation is an important CQA known to influence the efficiency and safety of biologics and is known to change throughput of the upstream biopro...

Microparticles and Machine Learning Detect Surface Receptors in a Multifrequency Microfluidic Cytometer

christopher.perkins@rutgers.edu — Thu, 31 Aug 2023 10:21:23 GMT

Graphical overview depicts the detection of electrically-sensitive cell membrane receptors: (A) Microparticles with varied aluminum oxide coatings (20nm and 10nm) are (B) coated with specific antibodies (anti-CD66b for 20 nm, anti-CD11b for 10nm) to (C) target inflammatory neutrophil receptors, resulting in cell-particle conjugates indicating receptor presence. (D) Individual object measurements occur in flowing conditions using microfluidic impedance cytometry, applying multiple frequencies to (E) distinguish the coating-thickness-dependent frequency responses of aluminum oxide-coa...

Gel-Tethered Molecular Beacons for Detection of Microbes

christopher.perkins@rutgers.edu — Thu, 24 Aug 2023 08:56:08 GMT

Invention Summary: Pathogen detection and characterization is a critical first step in the course of care for individuals suffering from these infectious diseases, and the speed by which this pathogen detection occurs can make all the difference between life or death for many patients. Currently, the gold standard for microbe quantification is either DNA amplification by PCR or in-vitro culturing of microbial colonies. Despite PCR’s speed, its characterization ability is limited and cultures are still needed to fully inform the course of care. Such cultures often take days ...

Flexible Electronics and Sensors from Ion-Containing Polysaccharides

christopher.perkins@rutgers.edu — Tue, 15 Aug 2023 06:59:13 GMT

Top - The initial shape-fixing ratio of the cellulose polymer. Bottom- The shape-recovery ratio of the cellulose polymer after one week at room temperature. Invention Summary: Sustainable materials have become attractive to reduce carbon footprint. Cellulose is a biobased material that is renewable and economical. Recent discoveries in films constructed from cellulose-based materials have demonstrated shape‐memory behavior and electro-spinning leading to applications in reusable sensors, flexible batteries, electroactive fibrous mats and/...

Lipid-Based Probes for Biological Redox Detection

christopher.perkins@rutgers.edu — Fri, 04 Aug 2023 09:09:09 GMT

Utility of a selected lipid-based redox probe (DPPC-TC-ONOO–). Detection of peroxynitrite (ONOO–) and nitrative stress in diverse lipid environments: biomimetic and biological membranes, lipid-rich organelles and tissues. Invention Summary: The local concentration of redox agents (reactive nitrogen and oxygen species) is tightly regulated in cells to maintain homeostasis and prevent cell damage. Lipid membranes and lipid-rich organelles and tissues can be chemically damaged by reactive redox agents. Uncontrolled redox agent concentration and reactivity has been linked to...

Nanoparticles for Direct Regulation of Mitochondrial Gene Expression

christopher.perkins@rutgers.edu — Mon, 17 Jul 2023 06:54:50 GMT

Schematic representation of MitoScript and its components Invention Summary: Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as a promising tool for developing novel therapeutic interventions for mt-associated diseases, their potential for direct, effective, and target-specific modulation of mitochondrial gene expression remains largely untapped. Rutgers scientis...

Spreadsheet for Load Rating of Gusset Plate

christopher.perkins@rutgers.edu — Mon, 10 Jul 2023 06:25:53 GMT

Gusset plate Invention Summary: Gusset Plates are essential components of steel bridges and used to connect beams and columns. Concerns about the safety and reliability of gusset plates have been brought up to the bridge community after the collapse of the I-35W Bridge in Minneapolis in 2007. An essential aspect to ensure public safety as well as property, load rating analysis of existing gusset plates, needs to be appropriately established. A team led by Hani Nassif, along with Peng Lou and Chan Yang at Rutgers Infrastructure Monitoring Evaluation Group (RIME) developed a s...

A treatment to promote skin wound healing

christopher.perkins@rutgers.edu — Fri, 07 Jul 2023 07:40:11 GMT

Treatment of wounds with TGM shows improved recovery compared to control group in a span of 10 days. Invention Summary: Helminths are potent modulators of immune function capable of stimulating an immune response that includes significant wound healing effector functions. Effective wound repair requires both the direct reconstruction of the injured tissue and suppression of pro-inflammatory responses. In addition, “scar tissue” formation during wound healing must be prevented. Scientists from Rutgers University and ...

Magneto-optical Kerr effect (MOKE) Spectrometer in Broad TeraHertz (THz) Frequency Range

christopher.perkins@rutgers.edu — Fri, 07 Jul 2023 07:27:21 GMT

Fig. 1: Top: Schematics of proposed sub-THz Martin-Puplett scanning interferometer for MOKE spectroscopy. Bottom: Prototype test bench in development. Invention Summary: Quantum magnetism effects are extensively sought for in contemporary materials research. Recent studies of magneto-optical polar Kerr effect (MOKE), in which rotation of polarization is detected with high precision for beam reflected from surface of a quantum material, have emerged as key experimental probe to identify time-reversal-symmetry-breaking. Gaining the insights to the underlying mechanisms leading to the nove...

Count Basie Collection

christopher.perkins@rutgers.edu — Thu, 06 Jul 2023 07:45:02 GMT

William J. "Count" Basie. William J. “Count” Basie is a legendary jazz icon, one of the most popular and recognized figures in American music. He was a jazz pianist, composer, and bandleader who strengthened the relationship between jazz and the blues and created swing as one of jazz's prominent forms. Count Basie's music bridged racial divides and brought people together during an era of legal segregation in America. In June of 2018, the Institute of Jazz Studies (IJS) at Rutgers University-Newark acquired the archives of Count Basie. The...

Finite-Element-based Methodology for Training Neural Network Surrogate Models

christopher.perkins@rutgers.edu — Tue, 27 Jun 2023 09:55:47 GMT

Comparison of FE-PINN predictions with FEM solutions. Red-boxed cases were used for training, all other cases are predictions. Example mesh with boundary conditions marked is shown in lower right. Invention Summary: The finite element method (FEM) has emerged as a powerful technique for modeling physical problems in various disciplines. Such models can be very accurate and fully interpretable, but usually have relatively larger computational cost for large systems. Rutgers researchers have developed a FE-PINN (finite element-physics-informed neural network) technology, which ena...

Plant-based system for generation of single-domain antibodies to combat viral infections

christopher.perkins@rutgers.edu — Tue, 27 Jun 2023 09:08:34 GMT

Plant-derived antibodies designed to target SARS- CoV-2 bind to SARS-CoV2 spike protein similar to bacteria derived antibodies based on ELISA. Invention Summary: The use of neutralizing antibodies is a strategy for treating viral infections, especially for individuals who are immunocompromised or have high-risk medical conditions. Mass production of these antibodies would be necessary to become a viable option to meet demands for viral treatment, but relies primarily on mammalian cell culture systems, which are very expensive and time-consuming. Rutgers researchers have developed ...

SARS-COV-2 papain-like protease inhibitors as antivirals

christopher.perkins@rutgers.edu — Wed, 07 Jun 2023 20:37:26 GMT

Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed. The papain-like protease (PLpro) of SARS‐CoV‐2 is a validated antiviral drug target inhibiting viral replication and there are no FDA approved inhibitors in this class. Rutgers researchers have designed a battery of PLpro inhibitors w...

Efficient Optical Method for Measuring the Length Distribution of Nanotubes, Nanowires and other 1D Nanoparticles

christopher.perkins@rutgers.edu — Thu, 01 Jun 2023 11:23:45 GMT

The effect of the magnitude of electric field on nanoparticle alignment Invention Summary: One-dimensional nanomaterials, such as carbon nanotubes (CNTs) or metal nanowires have unique properties such as high electrical and high thermal conductivities which are influenced by the length of the particles. In order to tune the process to obtain a desired length it is important to have efficient analytical methods that reveal length values. Traditional techniques to measure particle length distributions are scanning electron microscopy (SEM), atomic force microscopy (AFM), size exclus...

Improving Object Detection and Instance Segmentation of Eukaryotic Cells Using Semantic Aware Data Augmentation

christopher.perkins@rutgers.edu — Wed, 17 May 2023 12:52:17 GMT

Invention Summary: Machine Learning and Artificial Intelligence (AI)-Driven analysis have provided great advancements in microscopic imaging in the Biomedical field. The efficacy of many of these systems relies on the availability of many well-defined and empirically annotated images to serve as training data to teach such advanced neural networks how to properly identify and analyze target pictures. Manual generation of such images is time labor prohibitive, and many attempts have been made to artificially generate images realistic enough to train such models. However, many...

TGFβ-treatment of organoid cultures primes for regenerative therapy of damaged epithelia

christopher.perkins@rutgers.edu — Tue, 16 May 2023 07:05:53 GMT

A) GI epithelial organoids treated with TGFβ (right panel) acquire a spherical morphology and regenerative identity compared to vehicle-treated organoids (left panel). B-D) Organoids treated with TGFβ engraft more efficiently into the colon of mice exhibiting ulcerative colitis-like disease based on fluorescent micrographs (B), size per colonized area (C) and average size of colonized area per mouse (D). Invention Summary: The gastrointestinal (GI) tract consists of epithelial cells that are essential for tissue function but susceptible to damage and the functional cell of s...

Bact-Builder

christopher.perkins@rutgers.edu — Mon, 08 May 2023 06:41:08 GMT

Invention Summary: Mycobacterium tuberculosis infects a quarter of the world's population and was the second leading infectious disease killer after SARS-CoV-2 in 2020. The H37Rv strain of M. tuberculosis is widely used in laboratory experiments, but current genome assembly tools are unreliable and lack consistency. Rutgers researchers have integrated an algorithm called Bact-Builder to address this gap. The novel pipeline uses consensus building to generate highly accurate gap-closed bacterial genomes from raw sequencing data. This novel pipeline has been tested to provide ...

Elastomeric Polyurethane Sealer

christopher.perkins@rutgers.edu — Thu, 04 May 2023 10:42:09 GMT

New root canal sealer can more thoroughly fill gaps during root canal treatment compared to commercial sealants. Invention Summary: Root canal sealers are essential for filling gaps during treatment, but shrink upon setting, leaving undesirable gaps that promote infections. Rutgers University researchers have developed Elastomeric Polyurethane Sealer (EPS), an expandable biomaterial tailored for root canal treatment. EPS surpasses previous sealants by seamlessly filling the root canal space without impacting the tooth structure, preventing gaps and enhancing infection preve...

Wireless power transfer via partially magnetized pavement

christopher.perkins@rutgers.edu — Tue, 02 May 2023 20:38:13 GMT

Design concept of partially magnetized pavement layer Invention Summary: Lack of access to charging infrastructure and longer charging time have limited electric vehicle (EV) adoption. One promising solution is to utilize inductively coupled power transfer (ICPT)-based wireless charging modules embedded in the pavement for dynamic charging. However, power transfer efficiency can be greatly affected by the distance between the transmitter and receiver coil and frequency mismatch due to pavement construction. Rutgers researchers have designed a partially magnetized pavement to im...

Multiple-DOF energy harvester from vibrations

christopher.perkins@rutgers.edu — Tue, 02 May 2023 20:34:13 GMT

Cantilevers with 1, 2 and 3 degrees of freedom Invention Summary: Piezoelectric energy harvesters mounted on bridges, pavements and other transportation infrastructure can potentially replace batteries for powering autonomous sensors by converting ambient kinetic energy into electric energy. Due to complications and uncertainties of vibration modes encountered in the field, single-beam cantilever-based energy piezoelectric energy harvesters may not be able to resonate at the vibration frequency on bridges. Researchers at Rutgers have designed vibration-based energy harvesters ...

PSP Rating Scale: Instructional Video

christopher.perkins@rutgers.edu — Tue, 02 May 2023 12:00:11 GMT

Changes in scoring of PSP patients over time in three groups, categorized based on the onset age of the disease in patients. Invention Summary: Progressive supranuclear palsy (PSP) is a brain disorder that affects a person’s ability to move due to a gradual increase in brain cell damage over time. Symptoms of PSP increase in types and severity. Because of the wide range of symptoms that can manifest, it can be difficult to break down the stage of PSP of a patient and to determine the effectiveness of treatments. Rutgers University Professor Lawrence I. Golbe. M.D. is...

Method to Detect Suspicious In-Baggage Object Using Commodity WiFi

christopher.perkins@rutgers.edu — Tue, 02 May 2023 08:14:36 GMT

An illustration of the system developed to use WiFi signal to detect objects of different materials. Invention Summary: To help keep consumers safe, airports and many facilities deploy different kinds of screening equipment to scan baggage and other items. Traditional in-baggage suspicious object detection involves either manual examination (e.g., setting up checkpoint at every entrance) or dedicated equipment (e.g., surveillance camera, X-ray machine, ultra-wide-band scanner) and incurs high cost and deployment overhead, making them hard to scale. Rutgers researchers have de...

New Antimalarials Based on the TBN Scaffold

christopher.perkins@rutgers.edu — Wed, 05 Apr 2023 15:46:57 GMT

Invention Summary: Malaria infects over 200 million people and results in nearly half a million deaths as well as up to $12 billion USD in lost economic activity. Although the prevalence of malaria has decreased steadily over the last two decades, progress has stagnated in recent years due to the emergence of drug-resistant malarial strains. These adapted infections are the focus of current anti-malarial research efforts. Rutgers researchers have identified a new class of Naphthyridine Carboxamide based anti-malarial small-molecule inhibitors that are as potent as current...

Enhanced Intervertebral Disc Repair and Regeneration Using a Nano-Hybrid Gel

christopher.perkins@rutgers.edu — Fri, 24 Mar 2023 09:50:09 GMT

Nanomaterial (2D-Mn02)-embedded peptide hydrogel (NEPH) promotes cellular proliferation and tissue regeneration. Invention Summary: The limited capacity for regeneration, the presence of pro-inflammatory factors, and the complex extracellular matrix (ECM) microenvironment of degenerated intervertebral discs (IVD) remain significant issues that must be addressed despite significant research to find effective treatments. To overcome the issues outlined above, a team led by Rutgers, created an injectable peptide hydrogel utilizing nanomaterials that hierarchically self-assemble t...

Injectable Bioorthogonal Hydrogel for Intervertebral Disc Regeneration

christopher.perkins@rutgers.edu — Fri, 24 Mar 2023 09:43:07 GMT

IVD recovery imaging which demonstrates the efficacy and regeneration capability of the BIOGEL loaded with TGFB Invention Summary: Intervertebral disc degeneration (IVD) is the leading cause of back pain amongst humans and is a precursor to more severe conditions. To address this issue, a team led by Rutgers scientists have developed a novel injectable hydroGEl technology to address IVD. In brief, the hydroGEL is composed of succinylated gelatin-tetrazine and succinylated gelatin-norbornene and loaded with a TGFb growth factor. After the succinylated gelatin soluti...

Benchtop Laser-Based Radiocarbon Analysis System

christopher.perkins@rutgers.edu — Mon, 20 Mar 2023 11:41:35 GMT

Block Diagram of Laboratory Radiocarbon analyzer Invention Summary: Drug metabolism studies require highly sensitive radiocarbon (C14) detection. Accelerator mass spectrometry (AMS) is a gold standard method for drug metabolism and related studies, but the high cost, low speed, complexity and large footprint of AMS instruments prohibits on-site testing. While liquid scintillation counters have a more compact footprint, they do not provide the necessary sensitivity for many drug studies. Researchers at Rutgers have developed a low-cost, benchtop, laser-based system for quantification o...

Phebox Ligands and Methods of Making Same

christopher.perkins@rutgers.edu — Mon, 20 Mar 2023 10:52:21 GMT

The Phebox ligand Invention Summary: Phebox ligands are organic complexes useful for a number of catalytic transformations of other organic molecules, including transformations of alkanes generally requiring harsh conditions. Since catalytic transformations using this class of ligands intrinsically involve the activation of C-H bonds, the degradation of the phebox ligand via reactions of the C-H bonds of the aryl position (benzylic or aryl C-H bonds) is potentially problematic. Rutgers researchers have developed the bis-CF3-Phebox ligand and its non-obvious preparati...

SYNTHETIC DATA GENERATION WHILE PRESERVING OBSERVABLE AND MISSING DATA DISTRIBUTIONS

christopher.perkins@rutgers.edu — Sat, 11 Mar 2023 10:15:20 GMT

Model illustrating synthetic data generation Invention Summary: Developers and analysts often require large, accurately labeled datasets when training AI models, though it can be unrealistically time-consuming and expensive, and in many cases impossible due to privacy and confidentiality, to obtain real-world datasets. Algorithms are developed to generate synthetic data, which instead of the real-world data, are used for modeling and training purposes. However, generating synthetic data that accurately represents original data and preserves missing data has been a ch...

Highly Aromatic Catnip Rich in E,Z-Nepetalactone

christopher.perkins@rutgers.edu — Fri, 10 Mar 2023 11:28:12 GMT

A bar graph showing the dose-response landing inhibition curve for the mosquito species Aedes aegypti for the noted repellent treatments at 0.01%, 0.1%, and 1%. The treatments included DEET & N. cataria ‘CR3” crude essential oil. Invention Summary: Catnip is a short-lived perennial herb that contains a volatile oil dominated by nepetalactones. This oil is well known to provide euphoric effects on cats. Nepetalactones are also highly effective at repelling insects and thus can protect against insect-borne diseases. With climate change, warmer weather is fost...

Tracking Facial Features Using Cluster of Point Distribution Models

christopher.perkins@rutgers.edu — Tue, 28 Feb 2023 08:46:59 GMT

Invention Summary: There is a need to address automobile driver alertness and driver fatigue aiding towards safe driving solutions. There is also a demand for higher levels of security to combat any threats to safety of our homes or our nation. Rutgers researchers have developed a technology for real-time tracking of facial feature shapes, and expressions on a non-linear manifold applied to pose prediction, expression recognition, and eye tracking. The technology proposes a novel framework for tracking faces across large head rotations at near real-time processing rates. It also pro...

Electrospray Approach for the Targeted Nourishment of Plants

christopher.perkins@rutgers.edu — Thu, 23 Feb 2023 08:24:21 GMT

Schematic representation of holder for growth media of the plant with and without nylon liner Invention Summary: Advancement of technologies to supply water and nutrients for plants where resources are limited and expensive is a significant challenge that needs to be addressed. While electrostatic spray is an ideal solution and has been used to apply pesticides to plants for decades, the issue is that it has too high an electric current to directly water plants. The invention describes a process of providing plant nutrients and water through electrospray deposition addressing ...

MONITORING VITAL SIGNS OF MULTIPLE PERSONS VIA SINGLE PHASED-MIMO RADAR

christopher.perkins@rutgers.edu — Thu, 09 Feb 2023 10:44:35 GMT

BR and HR estimation by applying frequency analysis on the phase of mmWave signals Invention Summary: Existing real-time cardiovascular disease monitoring methods are mostly based on wearable solutions, such as finger pulse meters, smart watches, electro-cardiograms (ECGs). These methods are intrusive, costly, require direct contact with the patient and can only obtain one single vital sign information at a time. To overcome these problems, devices were developed to use radio frequency (RF) signals for contact-less vital sign monitoring. However, these devices operate at fixed fr...

Non-contact Vital Sign and Motion Detection Sensor

christopher.perkins@rutgers.edu — Thu, 09 Feb 2023 10:39:39 GMT

Proposed SRO integrated MTM LWA for multi-target vital sign detection Invention Summary: It is essential to keep track of one’s respiration rate (RR) and heart rate (HR) for a healthier life. Existing real-time cardiovascular disease monitoring methods are mostly based on wearable solutions, such as finger pulse meters, smart watches, electrocardiograms, However, these wearables require a direct contact with the patient and can only obtain one single vital sign information at a time, besides, it may cause discomfort, skin damage, and hygiene issues. Cert...

Optogalvanic Effect Detection System

christopher.perkins@rutgers.edu — Mon, 06 Feb 2023 11:32:50 GMT

Block Diagram of system Invention Summary: Current technologies for low specific activity radiocarbon analysis are currently limited in precision and accuracy by sample size requirements, background effects, long sample measurement times, and difficulty of use. Researchers at Rutgers have developed an optogalvanic effect detection system for determining the radiocarbon content of carbon dioxide in an electrical discharge. This system uses fixed frequency lasers, proprietary electronic circuitry and analysis algorithms. The system is highly efficient, requiring samples of on...

Serological/ELISA-Based Test For COVID-19

christopher.perkins@rutgers.edu — Thu, 02 Feb 2023 05:44:57 GMT

Invention Summary: The unprecedented outbreak and spread of SARS-CoV-2 has led to rapid development of the COVID-19 pandemic. Since its beginning in 2020, the virus has rapidly evolved due to its spread, causing the generation of novel variants like Omicron more recently. Thus, there is still an unmet need for more specific, reliable, and high throughput assays to fight against this highly infectious pathogen. Rutgers researchers have developed a serological/ELISA-based test for SARS-CoV-2 with higher sensitivity and high throughput capacity. The team generated a novel fusion antige...

Anchorage System for Prestressing Non-metallic Tendons

christopher.perkins@rutgers.edu — Thu, 02 Feb 2023 05:15:01 GMT

Invention Summary: The anchorage system has been the biggest challenge for each structural system that involves the use of fiber-reinforced polymer (FRP) tendons. There are many successful designs and systems that been proposed by other teams to anchor and tension these tendons. However, current alternatives are either expensive or hard to fabricate. Researchers at Rutgers University have developed a novel anchorage system that bonds non-metallic tendons to the sleeve system and secures the force of the tensioned non-metallic tendons using a slotted plate system. The purpose...

SPINEL AND NICKEL PHOSPHIDE CATALYSTS FOR WATER SPLITTING

christopher.perkins@rutgers.edu — Tue, 31 Jan 2023 15:47:38 GMT

Amount of Ni in the electrolyte during chronopotentiometric (CP) analysis in both acid and alkali. For comparison Ni2P in acid is also shown Invention Summary: Hydrogen is a versatile energy carrier and a valuable bulk chemical used for storing intermittent renewable energy and it also serves as a major chemical feedstock. Hydrogen can be produced from a variety of resources, electrochemical water splitting being one of them. This technique requires the use of electrolyzers containing Platinum (Pt) or Nickle (Ni) electrodes. Pt electrodes provide high efficiency; however, they are...

Autonomic Cloud Federation

christopher.perkins@rutgers.edu — Tue, 24 Jan 2023 08:26:48 GMT

Invention Summary: The integration of cloud service types/vendors is non-trivial and has many requirements for business applications. Although there is a proliferation of cloud offerings, it has been widely noted that “no single provider successfully addresses all segments of the market.” Rutgers researchers have developed Autonomic Cloud Federation technology to address this gap. It is a framework designed for enabling dynamically federated multi-clouds on demand. It is a hybrid infrastructure integrating public and private clouds, data centers, and enterprise gr...

Enzyme Catalyzed Toehold Mediated Strand Displacement (TMSD)

christopher.perkins@rutgers.edu — Tue, 24 Jan 2023 06:38:35 GMT

Invention Summary: Toehold mediated strand displacement (TMSD) is widely used in nanotechnology applications such as DNA nano-circuits and devices. The toeholds which are small single‐stranded DNA overhangs, are often utilized in kinetically controlled complex biochemical circuits. Existing toehold mediated strand displacement (TMSD) reactions rely on spontaneous annealing and strand exchange reaction These reactions are typically slow and thereby limiting many applications. There is a need for a catalyst to speed up these reactions but till date there a...

Multipurpose UV sensitive monomer capable of conjugating complex macromolecules

christopher.perkins@rutgers.edu — Mon, 23 Jan 2023 07:44:55 GMT

Polymer-Alkyne Conjugates using UV sensitive monomer with linker Invention Summary: Biorthogonal “click” chemistry allows for the controlled introduction of multiple bioactive groups in a single molecule. Strain-promoted alkyne-azide cycloaddition (SPAAC) is an attractive click reaction in bioconjugate chemistry since it does not require the presence of toxic catalysts...

Gsx1 GENE THERAPY TO TREAT SPINAL CORD INJURY

christopher.perkins@rutgers.edu — Wed, 11 Jan 2023 15:36:40 GMT

Gsx1 treatment promotes recovery of locomotion function in injured mice. Invention Summary: Spinal cord injury (SCI) can lead to permanent disruption of nervous system function. There is no effective treatment for promoting recovery of motor function after SCI currently available on the market. Previous research on SCI treatment focused on cell transplantation, glial scar repression, or promoting axon regrowth. Although these efforts have laid important groundwork in the field, their translation into clinical practice has been limited due to the lack of significa...

Rapid Diagnostics of Tick-borne Diseases

christopher.perkins@rutgers.edu — Fri, 06 Jan 2023 13:27:40 GMT

Invention Summary: Tick-borne diseases are a major health problem in the United States. Among them, Lyme disease due to the Borrelia spp., Anaplasmosis due to Anaplasma spp., and Babesiosis caused by Babesia spp., account for a large number of cases occurring throughout the country. Although treatment is readily available to combat these pathogens, a delay in initiating treatment can have deadly consequences. In many cases, treatment is started with clinical suspicion alone due to the rapid onset and progression of disease symptoms. This aggressive approach toward treatment ste...

Methods of diagnosing B cell malignancies and detecting B cell malignancy relapse

christopher.perkins@rutgers.edu — Fri, 06 Jan 2023 09:11:09 GMT

Workflow schematic of the diagnostic platform for detecting B cell malignancies. Invention Summary: B cell malignancies comprise more than 50% of blood cancers and approximately 90% of all lymphomas. Existing technologies for the detection of B cell malignancies include modern imaging technologies, flow cytometry of B cell subpopulations, cytogenetic techniques, immunohistochemical staining, and Ig gene clonality analyses by PCR or sequencing. The sensitivity of all these existing methods is dependent on adequate sizes of tumors or adequate numbers of malignant B cells prese...

DEVELOPMENT OF SPECIFIC CRK-LIKE ADAPTOR PROTEIN INHIBITORS FOR CANCER THERAPY

christopher.perkins@rutgers.edu — Wed, 04 Jan 2023 15:40:26 GMT

NC5 inhibits tumor growth and prolongs survival in vivo. NC5 treatment inhibits TNBC tumor growth and prolongs mice survival in xenograft and PDX mouse models. (A) Survival of mice bearing MDA-MB-231-Luc orthotopic xenograft tumors following treatment with vehicle (black line), Gleevec (blue line), or NC5 (red line). (B) Survival of mice bearing PDX TM00089 tumors following treatment with vehicle (black line) and NC5 (red line). Invention Summary: The Crk family of adaptor proteins are important as key players in tumorigenesis and immune responses. Phosphorylation of Crk prot...

ADENO-ASSOCIATED VIRUS (AAV) DIRECTED ANTIOXIDATIVE GENE THERAPY FOR THE PREVENTION AND TREATMENT OF NOISE-INDUCED HEARING LOSS

christopher.perkins@rutgers.edu — Wed, 04 Jan 2023 14:43:38 GMT

SOD1 gene therapy (blue) shows a persistent neuroprotective effect compared to the severe hearing loss observed in the control animals (purple) Invention Summary: Hearing loss is the third most common chronic health problem in the United States, with noise-induced hearing loss effecting nearly 1 out of every 4 adults (over 60M). Inner ear hearing damage is prevalent from recreational and occupational noise exposures, like music concerts, construction sites, factory settings, and military jobs. Such acoustic traumas are the cause of noise-induced hearing loss (NIHL) as it le...

Repurposing Anthelmintics: Effects of Rafoxanide and Copper-Functionalized SBA-15 Carriers Against Methicillin-Resistant Staphylococcus aureus

christopher.perkins@rutgers.edu — Thu, 22 Dec 2022 12:45:23 GMT

Invention Summary: Due to the rise in bacterial resistance to conventional antibiotics, materials that can administer antimicrobial drugs in a regulated manner more effectively are critically needed. While new antibiotic classes are created and widely used, existing, affordable compounds can be repurposed to treat bacterial infections. Rutgers researchers have developed and characterized nanoparticles that contain a combination of anthelmintics and copper ions and have tested their bactericidal properties against wild-type S. aureus. They have found that th...

Techniques for Measuring Atypical Neurodevelopment in Neonates Based on Auditory Brainstem Response (ABR) Tests

christopher.perkins@rutgers.edu — Mon, 19 Dec 2022 07:56:31 GMT

Comparison of ABR signatures from neonates who showed typical (blue) or delayed and narrow, atypical (red) later diagnosed with autism spectrum disorder (ASD). Invention Summary: Neurodevelopmental disorders such as cerebral palsy and autism are primarily diagnosed through identification of key behaviors and symptoms. To do this, features of the disorders must be first noted by parents or guardians during daily lives and then brought into attention of the pediatrician. However, because of the latency in motor skill development, it is difficult to diagnose these conditions early ...

Dynamic Neurodevelopmental-Growth Chart of Central and Peripheral Nervous Systems

christopher.perkins@rutgers.edu — Mon, 19 Dec 2022 07:56:24 GMT

Method for data acquisition and assessments of neuromotor control development using brief video recordings. Invention Summary: Diagnosis of neurodevelopmental disorders relies on clinical tests that depend on observation of a set of behavioral benchmarks that are then mapped to a scale. These scales are not standardized for anatomical differences and nonlinear rates of growth in early life. They rely on subjective observation of patients and consequently, are prone to miss other key patterns and signs that are difficult to identify with the naked eye. There is a large need for m...

Therapeutic Human Monoclonal Antibody (HUMAB) with Extremely Potent and Broadly Neutralizing Activity for Omicron and Other CoV-2 Variants

christopher.perkins@rutgers.edu — Mon, 19 Dec 2022 06:45:43 GMT

Potent breadth and cross-reactivity of novel CoV2 neutralizing human monoclonal antibody that can neutralize the highly immune-evasive BQ.1/BQ.1.1 variants that are currently responsible for ≅ 50% of CoV2 infection in US. Invention Summary: The emergence of highly immune evasive SARS-CoV2 escape mutants require an immediate response from the scientific community to control breakthrough infections in COVID-19 vaccinated individuals and to limit the pathogenicity associated with infection in immunocompromised and elderly people. While the emergency authorization for monoclona...

Bismuth Oxyfluoride based Nanocomposite as Electrode Material

christopher.perkins@rutgers.edu — Fri, 09 Dec 2022 10:58:52 GMT

First 3 cycles of the BiO0.5F2/C nanocomposite and galvanostatic curve. Invention Summary: Batteries have become essential compact and high-energy-density power sources for several applications, including electric vehicles, smartphones, manufacturing, grid storage, and many others. As such, the demand for batteries and accompanying technologies is growing exponentially, creating a significant need for a drastic improvement of the energy density of the cells. Rutgers researchers have developed a novel electrode material comprising nanocrystalline bismuth oxyfluoride compou...

FLUORIDE TECH PORTFOLIO

christopher.perkins@rutgers.edu — Thu, 08 Dec 2022 06:30:07 GMT

JINISHA

RNA-Aptamer-Mediated Base Editing System for Agriculture

christopher.perkins@rutgers.edu — Wed, 30 Nov 2022 12:52:06 GMT

Invention Summary: The CRISPR/Cas system is a powerful tool for precision genetic engineering in organisms including plants. However, the conventional CRISPR technology depends on DSBs which may lead to undesired genetic events such as off-target insertions, deletions, and chromosomal translocations. The Base Editing technology overcomes the requirement of DNA DSBs for gene editing. Rutgers researchers have developed one of the two base editing platform technologies that allow sequence directed base editing in DNA or RNA. The system utilizes an RNA aptamer designe...

‘Hunterdon’ Hazelnut Resistant to Eastern Filbert Blight

christopher.perkins@rutgers.edu — Tue, 29 Nov 2022 11:42:31 GMT

Invention Summary: Rutgers University initiated hazelnut research and breeding program in 1996 to address the fatal tree disease eastern filbert blight (EFB) caused by the naturally occurring fungus, Anisogramma anomala. Rutgers researchers made large seed collections across Eastern Europe, the Caucuses, and Central Asia to cross and breed the collected trees for eastern US trials. The program spans over 25 years as of 2022, and Rutgers now has 25,000 trees on 20 acres in various stages of evaluation. The result of a cross of ‘Sacajawea’ x Oregon State Unive...

‘Somerset’ Hazelnut Resistant to Eastern Filbert Blight

christopher.perkins@rutgers.edu — Tue, 29 Nov 2022 11:39:44 GMT

Invention Summary: Rutgers University initiated hazelnut research and breeding program in 1996 to address the fatal tree disease eastern filbert blight (EFB) caused by the naturally occurring fungus, Anisogramma anomala. Rutgers made large seed collections across Eastern Europe, the Caucuses, and Central Asia to cross and breed the collected trees for eastern US trials. The program spans over 25 years as of 2022, and Rutgers now has 25,000 trees on 20 acres in various stages of evaluation. The result of a cross of Oregon State University selection OSU 665.123 x &l...

‘Raritan’ Hazelnut Resistant to Eastern Filbert Blight

christopher.perkins@rutgers.edu — Tue, 29 Nov 2022 11:35:43 GMT

Invention Summary: Rutgers University initiated hazelnut research and breeding program in 1996 to address the fatal tree disease eastern filbert blight (EFB) caused by the naturally occurring fungus, Anisogramma anomala. Rutgers researchers made large seed collections across Eastern Europe, the Caucuses, and Central Asia to cross and breed the collected trees for eastern US trials. The program spans over 20 years as of 2019, and Rutgers now has 25,000 trees on 20 acres in various stages of evaluation. The result of a cross of Oregon State University selectio...

‘Monmouth’ Hazelnut Resistant to Eastern Filbert Blight

christopher.perkins@rutgers.edu — Tue, 29 Nov 2022 11:32:18 GMT

‘OSU 541.147’ ‘The Beast’ Hazelnut Resistant to Eastern Filbert Blight

christopher.perkins@rutgers.edu — Tue, 29 Nov 2022 11:25:14 GMT

Invention Summary: Rutgers University initiated hazelnut research and breeding program in 1996 to address the fatal tree disease eastern filbert blight (EFB) caused by the naturally occurring fungus, Anisogramma anomala. Rutgers researchers through partnering with members of the Hybrid Hazelnut Consortium (Oregon State University, Rutgers University, Arbor Day Foundation, University of Nebraska Lincoln/Nebraska Forest Service), has jointly developed ‘OSU 541.147’, which is a cross of NY 616 (C. americana ‘Rush’ x C. avellana &lsquo...

Mobile Health Diagnostic for Schizophrenia

christopher.perkins@rutgers.edu — Thu, 03 Nov 2022 09:48:36 GMT

Invention Summary: Schizophrenia is a psychiatric disorder characterized by hallucinations, disorganized thought, delusions, and a decline in both mental and physical functioning. The disorder affects about 1% of the population. Early detection and treatment significantly improves patient response to treatment; and can prevent progression to full relapse by prompting adequate clinical intervention. In addition, currently schizophrenia diagnosis requires a diagnostic battery such as the SCID-II personality assessment which can take up to an hour and must be admi...

Method for Generating Memory T-cells In Vitro and Their Use in Immunotherapy

christopher.perkins@rutgers.edu — Thu, 03 Nov 2022 09:48:08 GMT

Invention Summary: Dendritic cell-based immunotherapies have been tested for the treatment of cancer patients with limited success. The limited success is probably due to the ineffective activation of specific T-cells by injected dendritic cells. In vitro generation of memory T-cells that can respond to cancer cells could circumvent ineffective T-cell activation, thereby greatly enhancing the efficiency of cancer immunotherapy. Rutgers researchers have developed a method to generate polyclonal, antigen-specific memory T-cells in vitro. The T-cell generation in vitro ...

Submerged-Plasma Process for the High Rate Production of Graphene Nanoflakes

christopher.perkins@rutgers.edu — Thu, 03 Nov 2022 09:47:22 GMT

Invention Summary: Carbon nanomaterials, such as nanotubes and graphene, have received a lot of attention because of their excellent and one-of-a-kind electrical, physical, and morphological properties. One of graphene's most notable properties is its high carrier mobility at room temperature. As a result, nanographene is appealing as a channel material for the next generation of ultrafast electronics or nanofiller for thermal management in multifunctional composites. Generally, these materials are often synthesized using expensive and time-consuming processes like chemica...

Bismuth Fluoride based Nanocomposite as Electrode Material

christopher.perkins@rutgers.edu — Sun, 23 Oct 2022 17:33:48 GMT

Specific discharge capacities versus cycle numbers for the BiF3/C nanocomposite high-energy milled for 30 min, 1 h, 2 h and 4 h. Invention Summary: Batteries have become essential compact and high-energy-density power sources for several applications, including electric vehicles, smartphones, manufacturing, grid storage, and many others. As such, the demand for batteries and accompanying technologies is growing exponentially, creating a significant need for a drastic improvement of the energy density of the cells Rutgers researchers have developed a novel electrode material c...

Copper Fluoride based Nanocomposite as Electrode Material

christopher.perkins@rutgers.edu — Sun, 23 Oct 2022 17:12:51 GMT

Voltage as a function of specific capacity for a CuF2 nano- composite with varying amounts of MoO3 and a CuF2 nanocomposite with a carbon conductive matrix Invention Summary: Batteries have become essential compact and high-energy-density power sources for several applications, including electric vehicles, smartphones, manufacturing, grid storage, and many others. As such, the demand for batteries and accompanying technologies is growing exponentially, creating a significant need for a drastic improvement of the energy density of the cells Rutgers researchers have develop...

Metal Fluoride and Phosphate Nanocomposite as Electrode Material

christopher.perkins@rutgers.edu — Sun, 23 Oct 2022 17:04:16 GMT

Voltage and Capacity profiles of nanocomposite material containing various weight percent of lithium dihydrogen phosphate exhibiting that specific capacity is exemplary for all the compositions with many compositions achieving >400 mAh/g based on the weight of the entire composite Invention Summary: Batteries have become essential compact and high-energy-density power sources for several applications, including electric vehicles, smartphones, manufacturing, grid storage, and many others. As such, the demand for batteries and accompanying technologies is growing expon...

Iron Oxyfluoride Electrodes for Electrochemical Energy Storage

christopher.perkins@rutgers.edu — Sun, 23 Oct 2022 16:56:01 GMT

Comparison between two FeOxF2-x and macro-FeF2 based nanocomposites exhibits improved electrochemical performance in the former materials with higher energy density and better capacity retention upon cycling Invention Summary: Batteries have become essential compact and high-energy-density power sources for several applications, including electric vehicles, smartphones, manufacturing, grid storage, and many others. As such, the demand for batteries and accompanying technologies is growing exponentially, creating a significant need for a drastic improvement...

Image Processing for Light Mobile Ultrasound Devices

christopher.perkins@rutgers.edu — Thu, 06 Oct 2022 08:45:18 GMT

Invention Summary: Ultrasound and other medical imaging devices generate images by scanning biological structures and/or tissues of patients. These images aid in the diagnosis of serious illnesses such as cancer. Issues such poor quality and clarity of scanned images or conditions associated with the patient during scans or skill of the technician can lead to incorrect or misdiagnosis. Rutgers researchers have developed a novel method to enable mobile devices to accurately display medical images and identify objects of interest in these images. These methods uses a neural ...

“Alex Takes Care of a Lake”: A Children’s book about Aquatic Invasive Species

christopher.perkins@rutgers.edu — Thu, 08 Sep 2022 07:02:44 GMT

Invention Summary: "Alex Takes Care of a Lake" is a creative work designed, written and illustrated by Joanne Diglio, a local children’s author, illustrator and teacher, and Pat Rector, a county Environmental and Resource Management Agent. Synopsis One day a curious boy named Alex is kayaking on a lake when he comes across a water chestnut, an aquatic invasive species. After learning about the harm aquatic invasive species cause nature, he decides to help take care of the environment. Details This creative work is one that educates children...

Collision-Free Dynamic Window Approach for Moving Obstacles

christopher.perkins@rutgers.edu — Mon, 29 Aug 2022 07:14:50 GMT

Image depicts admissible velocity identification of the agent through sampling-based mobility characterization of the moving obstacle Invention Summary: Within Dynamic window approach (DWA) systems, the agent lacks a mechanism that actively avoids collision when all its projected velocities are deemed inadmissible. While this passive approach ensures that the chosen velocities are collision-free, it may result in the agent coming to a complete stop if no admissible velocities are available, causing rear-end collisions. . Rutgers researchers have developed an algorith...

Controlled Muscle-Specific Gene Delivery

christopher.perkins@rutgers.edu — Thu, 25 Aug 2022 09:46:42 GMT

Treatment with the AAV gene therapy with doxycycline (B) induced expression of the target gene. Invention Summary: Adeno-associated virus (AAV) vector-based gene therapy has the potential to treat a number of rare diseases. However, only two AAV-based gene therapies have been approved by the FDA, primarily due to toxicity and lack of specificity. Researchers at Rutgers have developed a novel method for designing AAV gene therapy with the ability to regulate gene expression in diseased tissues. It uses a muscle enhancer, muscle creatine kinase (MCK), and a specific promoter tha...

Moving on from Supportive Housing (MOSH) Training

christopher.perkins@rutgers.edu — Tue, 16 Aug 2022 07:36:53 GMT

Invention Summary: The transition from supportive housing and other forms of homeless services to mainstream housing without embedded support services is a critical transition period for persons with histories of homelessness, criminal justice involvement, mental illness, substance abuse, and other prior barriers to housing stability. Under a grant from the NJ Department of Community affairs, Dr. Tiderington (PI), Dr. Zippay (co-PI), and several collaborators developed a curriculum that provides supervisors and frontline case managers with the skills needed to assist formerly h...

IMPROVING BIOTRANSFORMATION OF NOBILETIN BY NANODISPERSION

christopher.perkins@rutgers.edu — Thu, 11 Aug 2022 14:19:46 GMT

The potential benefits of hydroxylated polymethoxyflavones Invention Summary: Hydroxylated polymethoxyflavones (OH-PMFs), are a class of novel flavonoid compounds found in citrus plants with very low abundance. OH-PMFs could be produced through semi-chemical or semi-bio synthesis from their PMF counterparts, but the technique to generate OH-PMFs with OH substitution at 6 or 7 position is very limited. There is a need for more sustainable method to produce OH-PMFs, especially 6- or 7- OH-PMFs, at a higher yield. Rutgers researchers have developed...

New method for biosynthesis of hydroxylated polymethoxyflavones

christopher.perkins@rutgers.edu — Thu, 11 Aug 2022 13:03:00 GMT

Method and Apparatus to Accelerate Convolutional Neural Networks

christopher.perkins@rutgers.edu — Mon, 08 Aug 2022 12:05:18 GMT

The overall architecture of the accelerator with the Im2Col unit and a systolic array based GEMM unit Invention Summary: Neural network is widely used in numerous domains such as video processing, speech recognition, and natural language processing. It includes the training phase which is performed in the cloud or on a larger cluster of machines and an inference phase which is usually performed on the edge devices, which typically have limited memory and compute resource with strict requirements on energy usage. Rutgers researchers have developed a novel hardware...

Nitrous Oxide Sedation for the Dental Team (Video and DVD)

christopher.perkins@rutgers.edu — Tue, 02 Aug 2022 06:54:54 GMT

Invention Summary: Nitrous Oxide Sedation for the Dental Team DVD is an instructional video for dental practitioners such as dental hygienists, assistants, dentists and students. The DVD teaches and shows how to monitor Nitrous Oxide Sedation (NOS). Video Content: Dr. Vaishali Singhal created the NOS DVD in response to a lack of supplemental educational material about NOS monitoring. The 21-minute video demonstrates the parts and use of a nitrous oxide machine and provides information about different NOS machines. A step-by-step NOS scenario with narration provides a demonstratio...

Novel ChABC formulation with machine learning-guided automation

christopher.perkins@rutgers.edu — Tue, 02 Aug 2022 06:30:54 GMT

Invention Summary: Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For treating SCI-related scarring, scientists have identified Chondroitinase ABC (ChABC), an enzyme that breaks down the extracellular network and allows for regeneration of neuronal axons. However, a major limitation to t...

Safe Autonomous Emergency Maneuvering Feature for Self-Driving Cars

christopher.perkins@rutgers.edu — Thu, 28 Jul 2022 06:54:53 GMT

Autonomous scaled vehicle platform Invention Summary: Extreme driving maneuvers performed by professional car drivers can potentially be used as active safety features for passenger vehicles under emergency situations. Control design of these extreme driving strategies is challenging since these extreme driving operations usually occur at the maximum limit of the vehicle’s maneuverability. Rutgers researchers have developed a model-based reinforcement learning (RL) method which uses Constrained Markov Decision Processing (CMDP) to find a risk-free control policy for au...

PKC412 restores functionality of the keratin cytoskeleton in the skin disorder epidermolysis bullosa simplex

christopher.perkins@rutgers.edu — Thu, 21 Jul 2022 08:37:53 GMT

Invention Summary: Epidermolysis bullosa simplex (EBS) is a highly penetrant genetic condition that causes fragility of skin keratinocytes resulting in fluid-filled skin blisters that erode upon scratching or minor pressure on the skin. There is no good cure for EBS, and treatment typically involves preventive and/or supportive care to protect skin from painful blistering. Researchers from Leipzig and Rutgers Universities have shown that keratinocytes from patients with EBS are protected from injury by the multi-kinase inhibitor PKC412. Treatment with PKC412 improves epithe...

Wireless Power-up and Readout of Label-free Electronic Detection of Protein Biomarkers

christopher.perkins@rutgers.edu — Wed, 20 Jul 2022 08:02:27 GMT

The schematic of the WPT system. Invention Summary: Electronic biosensors are involved in various applications including medical diagnostics and healthcare monitoring. Additionally, wireless power transfer is suited for remote use of biosensors without direct electrical connection. However, wireless readout of a label-free electronic biosensor for the detection of protein biomarkers remains challenging. Rutgers researchers have developed a wireless power transfer (WPT) nanowell impedance sensor to detect protein biomarkers in situ. The biosensor setup consists of two inductively...

Novel gene drive based on eliciting piRNA biogenesis in insect pests

christopher.perkins@rutgers.edu — Thu, 14 Jul 2022 07:24:42 GMT

Transgenic Anopheles gambiae larvae expressing fluorescent marker gene Invention Summary: Malaria is one of the most impactful diseases in tropical and subtropical regions and is transmitted through human contact with infectious mosquitoes. Crop pests create a large economic and social impact through direct damage to plants and spread of pathogens. Some estimates suggest a single pest, corn rootworm, causes $1 billion in damage annually in the U.S. alone. Methods to combat insect pests have primarily relied on pesticide applications whi...

A user-centered approach to the development of a diet education tool for older adults with tooth loss

christopher.perkins@rutgers.edu — Wed, 29 Jun 2022 12:34:44 GMT

Invention Summary: For older adults with missing teeth, it can be difficult to eat healthy. They may have trouble chewing harder-to eat foods or may feel uncomfortable or embarrassed eating with friends and family because of their missing teeth. Under a grant from the Academy of Nutrition and Dietetics Foundation, Dr. Rena Zelig utilized a user centered approach to develop an evidence-based diet education brochure, which provides dietary guidance for older adults with tooth loss. This brochure was developed based on the findings from qualitative research (patient interviews), sta...

Correcting Flawed Photograph Effects in Captured Medical Images

christopher.perkins@rutgers.edu — Wed, 15 Jun 2022 09:57:04 GMT

Background: Ultrasound and other medical imaging devices scan biological structures or tissues of a patient to aid in the diagnosis of serious illnesses such as cancer. Clarity and poor quality of scanned images due to conditions associated with the patient at time of image capture, or the skill of the technician capturing the scanned image can lead to incorrect or misdiagnosis of diseases. Invention Description: Dr. Rick Mammone and Dr. Christine Podilchuk, researchers at Rutgers University, have developed new, quick, cost-effective, and accurate solution for the enhancem...

Correcting Image Distortion in Captured Medical Images

christopher.perkins@rutgers.edu — Wed, 15 Jun 2022 09:45:40 GMT

Background: There are many instances where quick and easy interpretation of a medical images, such as an x-ray, CT scan, MRI or ultrasound is useful. In these instances, the digital transfer of medical images between systems, providers, or users is difficult and time consuming due to the lack of interoperability of software protocols between imaging and diagnostic systems. Invention Description: Dr. Rick Mammone and Dr. Christine Podilchuk, researchers at Rutgers University have developed new, quick, cost-effective, and accurate solution for transmitting and interpret...

Heat Map Medical Image Diagnostic

christopher.perkins@rutgers.edu — Wed, 15 Jun 2022 09:13:27 GMT

Background: Ultrasound and other medical imaging devices scan biological structures or tissues of a patient to aid in the diagnosis of serious illnesses such as cancer. Often, clarity and quality of scanned images are suspect due to conditions associated with the patient or the skill of the technician capturing the scanned image and can lead to incorrect or misdiagnosis. Methods to assist in understanding regions of interest in the medical image are helpful in clarifying the elements of images relevant to a diagnosis. Invention Description: Dr. Rick Mammone and Dr. Christine Podi...

Correcting Image Artifacts in Medical Images

christopher.perkins@rutgers.edu — Wed, 15 Jun 2022 09:05:04 GMT

Background: Ultrasound and other medical imaging technologies remove noise from scanned images by combining the scanned images in an averaging process that reduces and/or eliminates noise inherent in an imaging session. An artifact of the averaging process is blurring effects introduced to the resulting image which diminish the chances of a correct diagnosis because it makes it impossible to identify distinguishable edges that would be associated with an object of interest within the medical image and necessary for diagnosis. Invention Description: Dr. Rick Mammone and Dr. ...

Suspicious Object Detection in Medical Images

christopher.perkins@rutgers.edu — Wed, 15 Jun 2022 08:40:32 GMT

Background: Ultrasound and other medical imaging devices generate images by scanning biological structures and/or tissues of patients. These images aid in the diagnosis of serious illnesses such as cancer. Issues such poor quality and clarity of scanned images or conditions associated with the patient during scans or skill of the technician can lead to incorrect or misdiagnosis. Invention Description: Dr. Rick Mammone and Dr. Christine Podilchuk, researchers at Rutgers University, have developed a novel method to assist in the identification of objects of interest in medic...

Continuous Process for API Formulation and Manufacturing

christopher.perkins@rutgers.edu — Thu, 09 Jun 2022 06:45:46 GMT

A comparison of dissolution profiles for impregnated ibuprofen (IBU) tablets and direct compression IBU tablets Invention Summary: A major challenge in pharmaceutical product development is the formation of homogenous blends containing small amount of active pharmaceutical ingredients (APIs). Poor mechanical properties of APIs further exacerbate the problem. A Rutgers research team led by Prof. Muzzio has developed and tested a new pharmaceutical product development process by combining continuous manufacturing with API impregnation. I...

Continuous Process for API Formulation and Manufacturing

christopher.perkins@rutgers.edu — Thu, 09 Jun 2022 06:43:55 GMT

Continuous Melt-Coating for Improving API Solubility and Loading

christopher.perkins@rutgers.edu — Thu, 09 Jun 2022 06:40:17 GMT

Invention Summary: Poor solubility is a major obstacle to bringing a drug candidate into the market. Existing methods including micronization, amorphization, spray drying and hot melt extrusion that aim to improve solubility are expensive, difficult to implement, and associated with problems such as instability, limitation in drug loading. A Rutgers research team led by Prof. Muzzio has developed a novel melt-coating method to enhance the solubility of poorly soluble active pharmaceutical ingredients (APIs). Using continuous heating and shearing, a small amount of low meltin...

Enhancing the Trustworthiness and Effectiveness of Internet Services

christopher.perkins@rutgers.edu — Thu, 02 Jun 2022 15:09:07 GMT

Invention Summary: For an internet service to attract clients, it must generate a degree of trust in the services it provides. Such trust can be the consequence of good and solid reputation of a service. But only a small percentage of internet services can garner such reputation. A service may try to gain the trust of potential clients by making suitable promises, writing them on its website. But there is no good reason for potential clients to trust such promises of most services. This situation makes it very hard for the vast majority of services to compete with the few reputabl...

Novel Maturation‐defective Attenuated Chlamydia Vaccine

christopher.perkins@rutgers.edu — Thu, 26 May 2022 11:30:50 GMT

Invention Summary: Millions of American men and women are infected with Chlamydia each year. Without proper treatment, a substantial proportion of chlamydia-infected women may develop infertility and other health problems. To date, no Chlamydia vaccine is available. Chlamydia is an obligate intracellular bacterium with a unique developmental cycle consisting of two cell types: the infectious but non-proliferative elementary body (EB) and the proliferative but noninfectious reticulate body (RB). Successful chlamydial infection requires all th...

Electrostatic Actuator with Embedded Microfluidic Channels for Biological Applications

christopher.perkins@rutgers.edu — Wed, 25 May 2022 07:48:28 GMT

Invention Summary: Microsystem platforms for System-On-A-Chip devices often require the integration of multiple microfluidic functions, such as pumping and actuation components. Pneumatic actuation is commonly used due to the ease of fabrication with soft-lithography techniques. However, these methods do not provide complete actuation control for precise reproducibility and require off-chip pneumatic connections, resulting in loss of integration capabilities. Rutgers researchers have developed a novel MEMS-micromachined Parylene-based electroactive membrane(s) (µPEMs) w...

Use of purified Epichloë festucae antifungal protein for dollar spot control on turfgrass

christopher.perkins@rutgers.edu — Wed, 11 May 2022 12:34:58 GMT

Invention Summary: The dollar spot disease is a major challenge for turfgrass fields, especially golf courses. The commonly used solution to control this disease is fungicides, which can be hazardous and limited in effectiveness; thus, the need for an alternative solution is imminent. Rutgers researchers in the department of plant biology have identified a novel endophyte antifungal protein that can limit the spread of the dollar spread disease. Importantly, the team has also established efficient and advanced protocols for constructing and purifying the E. festucae an...

Sterically-Defined Biaryl L-Shaped N-Heterocyclic Carbene Complexes and Methods

christopher.perkins@rutgers.edu — Wed, 11 May 2022 12:31:59 GMT

Invention Summary: Buchwald dialkylbiarylphosphines are the most widely used class of ligands in catalysis. The resulting cross-coupling reactions of this class of catalysts have a wide range of applications in both the industry and academia, especially in the fields of medical chemistry, drug discovery, biochemistry, geochemistry, natural product synthesis, small molecule synthesis, and polymer synthesis. Rutgers Scientists have invented a sterically defined L-shaped NHC ligands analogous to Buchwald dialkylbiarylphosphines. This novel sterically defined L-shaped biar...

Amino Decorated L-Shaped Heterobidentate NHC Ligands on Imidazo[1,5-a]pyridine Architecture and Methods

christopher.perkins@rutgers.edu — Wed, 11 May 2022 12:26:23 GMT

Invention Summary: Dalphos ligands are among the most successful and widely used arlyphosphine ligands in organic catalysis. They are among the most popular ligands in the optimization and development of new processes using Au catalysis, where the stabilization of Au intermediates by five-membered chelates plays an essential role in catalysis that is not available by other families of ligands. Rutgers’s scientists have invented amino-decorated heterobidentate L-shaped NHC ligands that are analogous to DalPhos aryl phosphine ligands. This class of ligands is focused on p...

RNA-Aptamer-Mediated Base Editing System

christopher.perkins@rutgers.edu — Tue, 10 May 2022 08:48:03 GMT

Invention Summary: The CRISPR/Cas9 system is a powerful tool for targeted genetic engineering in organisms ranging from animals to plants. Cas9 has intrinsic nuclease activity, which causes sequence specific DNA double-strand breaks (DSBs), leading to activation of cellular pathways such as homology dependent repair (HDR) for gene conversion and nonhomologous end joining (NHEJ) for gene inactivation. However, the dependence on DSBs may lead to undesired genetic events such as off-target insertions, deletions, and chromosomal translocations. ...

A Deep Learning Approach for Channel Prediction in Mobile Relay

christopher.perkins@rutgers.edu — Mon, 09 May 2022 07:52:21 GMT

Invention Summary: Optimal positioning of mobile relays is critical to relay motion control in mobile relay beamforming networks. It requires Channel State Information (CSI) of the potential positions to predict the channel state, which is hard to obtain in a spatiotemporally variable channel. Rutgers researchers have developed novel deep learning method of guiding relay motion to maximize the cumulative Signal‐to‐Interference+Noise Ratio (SINR) at the destination, where they approached with a model-free deep Q learning method. They proposed two modified Multilayer Perceptron...

Simultaneous Sensing and Communication by Multiple‐Input Multiple‐Output (MIMO) Dual‐Function Radar Communication (DFRC) System

christopher.perkins@rutgers.edu — Mon, 09 May 2022 07:01:00 GMT

Invention Summary: In orthogonal frequency division multiplexing (OFDM) system, the subcarriers are generally assigned to antennas where the transmissions of the antennas are orthogonal. To increase the efficiency of the communication bandwidth, the carriers should be assigned to antennas in a shared way which would result in coupling of the target parameters (range, angle, speed). Decoupling of these parameters is a challenging problem. Rutgers researchers have developed a novel scheme of decoupling the radar parameters that enables high bandwidth utilization in OFDM ra...

Paper-Based Nano-Biosensor for Cytokine Detection

christopher.perkins@rutgers.edu — Fri, 06 May 2022 11:49:11 GMT

Invention Summary: Cytokines are a class of regulatory proteins that are important physiological and pathological markers commonly used for the prognosis and diagnosis of diseases such as cancer, Alzheimer’s and rheumatoid arthritis, as well as for monitoring responses to injuries. Researchers at Rutgers University have developed a novel method for fabricating paper-based nano-biosensors for the detection of cytokines using a conductive ink composed of graphene nanoflakes (GNF) and a conductive polymer...

Innovative Assessment of Cardiovascular Function for Individualized Treatment, Training and Diet Plans

christopher.perkins@rutgers.edu — Mon, 02 May 2022 15:50:27 GMT

Invention Summary: Measures to assess cardiovascular health range from simple tests such as blood pressure, resting heart rate, or stress test to ones that are highly invasive such as pulmonary catheterization. In patients at risk for peripheral artery disease, such as diabetics, there are other measures including reactive hyperemia tests and pulse wave velocity. While adequate for assessing overt cardiac or peripheral artery disease, these measures do not provide a complete view of the patients’ cardiovascular health. A more complete view can be provided by lo...

“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment

christopher.perkins@rutgers.edu — Wed, 20 Apr 2022 09:26:49 GMT

S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control. Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited treatment options. New emerging COVID-19 variants, incomplete vaccine efficacy and vaccine hesitancy, and immunocompromised people unable to receive the vaccine – all indicate a large unmet need for an effective COVID-19 treatment despi...

Use of Retinoids in Congenital Erythropoietic Porphyria

christopher.perkins@rutgers.edu — Wed, 20 Apr 2022 09:11:57 GMT

Invention Summary: Congenital erythropoietic porphyria (CEP) is an unaddressed orphan disease caused by a rare genetic disorder leading to accumulation of uro/coproporphyrin-I (uro-I) in tissues due to inhibition of the enzyme uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe photosensitivity, and photo-mutilation. Currently there is no specific treatment for CEP, except bone marrow transplantation. Researchers at Rutgers University have shown that fluorescent porphyrins cause protein aggregation that interferes with protein function, an...

SAHMI: Microbiome-based screening method for cancer and other diseases

christopher.perkins@rutgers.edu — Wed, 20 Apr 2022 09:08:47 GMT

Screening methodology and principle data identifying differences in microbiome diversity from disease state in pancreatic cancer Invention Summary: The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer deaths, and remains difficult to study with its large fibrotic tumor volume that hinders sampling and cellular mechanistic studies by existing bulk profiling methods. With increasing interest in using the microbiome for treatment of disease, cur...

Combined Opioidergic and Beta-Adrenergic Drugs for Cancer and Immune Diseases

christopher.perkins@rutgers.edu — Tue, 19 Apr 2022 08:27:01 GMT

Figure 1. (Left) Combined, synergistic treatment with naltrexone (NTX), propranolol (PRO), and Anti-PD1 antibody shows decrease in tumor size, by volume. (Right) Combined treatment of NTX, DPDPE, and PRO similarly decreases tumor size compared to controls. Invention Summary: One of the major cancer therapy approaches that is being heavily investigated is immunotherapy. Immunotherapy involves modulating the cancer patient’s own immune system to identify tumors and cancer cells as foreign to their body. Currently, the major pathways being studied involve re...

Multiplexed 3D printing

christopher.perkins@rutgers.edu — Wed, 13 Apr 2022 07:12:51 GMT

Invention Summary: Motivation: Extrusion-based 3D printing of polymer- or polymer-composite parts can realize new applications in metamaterials, batteries, energy, and robotics. Limitations of existing printing methods: Current extrusion-based 3D printing methods increase throughput by increasing line width and thus cannot resolve complex features (Fig. A). Overprinting and machining prevent creation of complex geometries, like 3D metamaterials, due to limited geometric access while machining (Fig. B). Multiplexed printing with conventional toolpaths is confined to repeating geometri...

Hard and crack-resistant glass

christopher.perkins@rutgers.edu — Thu, 07 Apr 2022 11:37:01 GMT

Invention Summary: Brittleness of glass has been perceived as its gravest handicap in the glass technology space. While the glass industry has always strived to design a "hard" and "crack-resistant" glass, it has been generally accepted by glass scientists that it is hard to achieve both these properties in the oxide glasses. Recent literature in the glass space revealed that a hard and crack resistance glass can be obtain using a Al2O3 – SiO2 binary system. However, to synthesize such composition of glass requires high melting temperatures (>1800...

Collision Avoidance Algorithm for Autonomous Vehicles and Robots

christopher.perkins@rutgers.edu — Tue, 05 Apr 2022 14:32:39 GMT

Invention Summary: Autonomous navigation in a dynamic environment is a challenging task, especially when the motion of the elements populating the environment are unknown in advance and must be updated dynamically. An autonomous vehicle or robot must be able to follow a clear path towards its destination by anticipating the imminent behavior of moving obstacles and computing a safe driving path. Researchers at Rutgers have invented a safe, and reliable collision avoidance system for robots and autonomous vehicles, which can sense and avoid obst...

Post-Print Physical Vetting of 3D Prints with Minimal Embedded Nano-Material Assessor

christopher.perkins@rutgers.edu — Mon, 04 Apr 2022 06:47:13 GMT

Overview of the Model System Invention Summary: 3D printing has become highly desirable in industrial manufacturing and biomedical applications. Outsourcing the manufacturing to a 3D printing facility leaves the user without access to the printers and a lack of physical verification to determine whether small defects, invisible to the naked eye, have been inserted. Like other automated systems, there is a need for safety parameters and end-user verification. Researchers at Rutgers University and collaborators developed methods for physical verification of 3D printed structures. Real-tim...

Highly Soluble and Eco-friendly Luminescent Hybrid Material for Lighting Phosphors

christopher.perkins@rutgers.edu — Thu, 24 Mar 2022 09:20:19 GMT

CuX-based AIO-type hybrid luminescent materials incorporating ionic and coordinate bonds Invention Summary: Copper Halide (CuX) based inorganic-organic hybrid luminescent materials (HLMs) are low-cost, non-toxic, highly stable, and offer strong luminescence with internal quantum yield of up to 98% @ 365 nm excitation. Yet, their major limitation is the poor solution processability. Rutgers researche...

Economical Carbon Fiber-Reinforced Co-Continuous Immiscible Polymer Blends

christopher.perkins@rutgers.edu — Thu, 24 Mar 2022 09:12:02 GMT

Invention Summary: Immiscible polymer blends (IMPBs) offer versatility in tailoring properties via synergistic combinations of blend components to optimize orthogonal properties more economically than chemical synthesis of a new polymer. Researchers at Rutgers University have developed a novel processing method to produce high performance carbon fiber-reinforced co-continuous immiscible polymer blends. The blends were formulated from high-performance thermoplastic polymer, polysulfone (PSU), and a semi-crystalline polymer, polyetheretherketone (PEEK), and further reinforce...

Amphiphilic macromolecules with novel hydrophobic segments

christopher.perkins@rutgers.edu — Thu, 17 Mar 2022 14:13:45 GMT

Invention Summary: Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads to leads to formation of foam cells and secretion of inflammatory mediators. Hence, new agents and methods for treating atherosclerosis are needed. Researchers at Rutgers University have designed a novel amphiphilic macromolecules’ (AMs...

Amphiphilic Polymer Stabilized Nanoparticles with Enhanced Biological Stability and Activity

christopher.perkins@rutgers.edu — Thu, 17 Mar 2022 14:09:49 GMT

Experimental oxLDL macrophage cellular uptake results after 24-hr incubation with AM micelle or NP configurations under serum free conditions (white bars), 5% FBS (gray bars) and 20% FBS (black bars). Invention Summary: According to Centers for Disease Control and Prevention nearly 25% of deaths in the US is due to cardiovascular disease (CVD). Atherosclerosis is a condition involving the accumulation of lipid-rich plaques and chronic inflammation of the vascular wall. Plaque deposits initiate when low-density lipoproteins accumulate in the artery wall and subsequently unde...

High Throughput Library Preparation of Long Genomic DNA Targets

christopher.perkins@rutgers.edu — Thu, 17 Mar 2022 07:14:10 GMT

Overall workflow for preparing the LASSO library. Invention Summary: Advances in DNA sequencing have led to an exponential increase in the quantity of sequence data, whereas limited achievable maximum gene length (<200 bp) can produce highly biased libraries with constraints on sequence homology. Long-adapter single-strand oligonucleotide (LASSO) probes libraries were thus developed to allow highly multiplexed amplification of thousands of kilobase-sized DNA targets in the same reaction volume available for downstream ...

Energy-Efficient Tensor Decomposition-Based Deep Neural Network Compression with High Accuracy

christopher.perkins@rutgers.edu — Thu, 17 Mar 2022 05:20:38 GMT

Figure: Procedure of the Compression Framework using ADMM for a TT-format DNN Model. Invention Summary: Deep Neural Networks (DNNs) are widely used in different computer vision tasks. Large-size DNN models cause high storage and computational demands and many DNN model compression methods, such as tensor decomposition are used to reduce it. However, compression of Convolutional Neural Network (CNN) using Tensor Train (TT) based decomposition causes significant loss of accuracy. Researchers at Rutgers University developed a method of TT-based model compression...

Time Varying Metamaterial-Enabled Directional Modulation Schemes for Physical Layer Security in Wireless Communication Links

christopher.perkins@rutgers.edu — Wed, 16 Mar 2022 12:38:15 GMT

Simulated bit-error-rate (BER) for the decoding performance of a receiver corresponding to a proposed transmission scheme. Invention Summary: With continuing advancements in wireless communication systems and emerging applications of Internet-of-Things (IoT) devices, there is an urgent need to develop physical-layer (PHY) focused secure communication schemes to avoid high computational and battery burdens from cryptographic strategies. Researchers at Rutgers University proposed novel transmission architectures to ...

A New Design Paradigm for Inbody Wireless Charging

christopher.perkins@rutgers.edu — Thu, 03 Mar 2022 11:22:47 GMT

Invention Summary: Each year, millions of patients improve their quality of life through medical implants. However, the implants require batteries which need to be replaced on a regular basis through surgery, introducing extra complications, cost and risk. Rutgers researchers have developed a system comprised of software-hardware for far-field wireless power transfer to charge a medical implant residing in deep tissue of a humans. The novel technology is able to continuously charge the medical implant by using near-optimal beamforming power and is able to charge even when the ...

Methods for Blood Pressure Estimation from Short Duration of Photoplethysmogram (PPG) Signals via Transfer Learning

christopher.perkins@rutgers.edu — Fri, 25 Feb 2022 14:34:49 GMT

Invention Summary: Hypertension or high blood pressure affects a large percentage of the global adult population. Frequent self-monitoring of blood pressure (BP) is important for long-term adherence and compliance to clinical advice. However, given the intrinsic inconvenience of conventional cuff- or tonometry-based blood pressure monitors, less than 30% of patients with a BP monitoring device at home measure their BP more than twice a day. There is hence a need for a more convenient, cuff-less alternative, which enables automatic and distraction-free BP monitoring. ...

A Small Peptide Capable of Sustained Hydrogen Evolution

christopher.perkins@rutgers.edu — Tue, 22 Feb 2022 10:46:13 GMT

Invention Summary: Hydrogen is a clean fuel that can produce electricity when combined with oxygen in a fuel cell, with water being the only by-product. Manufacturing of hydrogen through coal gasification, biomass gasification or natural gas, however, is energy-intensive and has carbon by-products. Alternatively, green hydrogen production employs electrolysis of water, which can be produced using renewable energy such as wind and solar. Rutgers scientists have designed a 13 L-amino acid peptide that can catalytically generate hydrogen under anaerobic conditions wh...

Spatial Dopant Separation using Core-Shell Architecture For Upconversion Luminescent Enhancement in the Erbium-Doped System

christopher.perkins@rutgers.edu — Mon, 21 Feb 2022 13:00:41 GMT

Invention Summary: Upconversion nanoparticles (UCNPs) have gained increasing attention for various biomedical applications due to their high photostability, low autofluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emission intensities due to undesirable energy back-transfer. Further, the use of high-power density excitations at 980 nm may cause serious overheating and thus cellular damages under continuous irradiation. Researchers at Rutgers University have developed a single-crystal core–shell–shell “sandwich” structured...

Microbiome-Leveraged Organic Herbicide

christopher.perkins@rutgers.edu — Fri, 18 Feb 2022 12:56:13 GMT

Invention Summary: At present, all herbicides are deleterious to human health. There is an unmet need to develop herbicides that are not harmful to people. Ethylene is a microbe-produced hormone that stimulates plant cell growth. However, in excess, ethylene causes stress in plants due to overproduction of superoxide, a highly potent form of reactive oxygen species (ROS). Thus, the excess ethylene causes plant cells to produce superoxide, resulting in increased oxidative stress in plants that leads to plant death. Rutgers researchers have developed a natural herbicide composition...

Cellularized Nerve Regeneration Graft to Remediate Peripheral Nerve Injury

christopher.perkins@rutgers.edu — Fri, 18 Feb 2022 12:49:20 GMT

Invention Summary: Peripheral Nerve Injuries (PNI) arising from physical trauma, cancers, or other nervous system pathologies are associated with higher costs and socioeconomic impact globally. Currently available technologies to remediate nerve injury are often unsuccessful in restoring nerve functions to its original capacity and cost of managing PNIs is on the rise. The autograft used in nerve graft surgery has 50% success rate with only 25-50% of pre-injury function is regained. Cadaveric allograft or even the artificial biopolymer conduit used lacks cells and trophic factors an...

Detection of Botnet Malware using AI-based Keystroke Dynamics

christopher.perkins@rutgers.edu — Tue, 04 Jan 2022 14:24:15 GMT

Remote authentication framework (TUBA) Summary: Key loggers are a form of malware (bots) that eavesdrop on users to steal keystroke sequences that can then be used to hack individual’s identity. This form of malware enables the capture of user ids, passwords, credit card numbers, bank accounts and pins – causing personal, governmental, military and enterprises harm. Determining whether a computer is infected or not can be very challenging. Malicious bots are stealthy and difficult to detect using conventional anti-virus Software. Some bots even...

MicroRNA Based Therapeutics for Parkinson’s Disease

christopher.perkins@rutgers.edu — Wed, 22 Dec 2021 13:55:21 GMT

Protection of the mouse brain by microRNA-7 against the toxicity of a-synuclein (A) Tyrosine hydroxylase (TH) stained coronal section of mouse brain injected in the right striatum with AAV-miR-7 or non-targeting (NT) vector following by a-synuclein preformed fibrils (PFF) or PBS. (B) Substantia nigra sections. (C) Nigral dopamine neuron count. (D) Striatal TH density. (E) Performance on the rotarod. Invention Summary: Parkinson’s disease (PD) is a common neurogenerative disorder that affects approximately 1% of the population over the age of 60. The characteristic...

MicroRNA-7 Gene Therapy Promotes Functional Recovery Following Spinal Cord Injury

christopher.perkins@rutgers.edu — Wed, 22 Dec 2021 13:46:50 GMT

Following sever spinal cord compression, the AAV-miR-7 injected mice showed improved locomotor recovery, which is characterized by the Basso Mouse Scale (BMS). Invention Summary: Spinal cord injury (SCI) results in partial or complete loss of sensory or motor function. According to the National Spinal Cord Injury Statistical Center, more than 290,000 people are suffering from SCI in the U.S., with 17,810 new SCI cases occurring each year. Depending on the severity and level of the injury along the spine, SCI can be life-threatening. The recovery process o...

Immunotherapy for Inflammatory Bowel Disease (IBD)

christopher.perkins@rutgers.edu — Thu, 09 Dec 2021 05:59:32 GMT

H&E staining of colons from Zbtb20 WT and Zbtb20 cKO mice treated with DSS. Survival curves for WT and cKO mice following treatment with DSS in drinking water. Adoptive transfer of Zbtb20 expressing Tregs rescues mice from death and protects. Mice are also protected from excessive weight loss (not shown). Invention Summary: Inflammatory bowel diseases (IBD) are chronic idiopathic disorders causing inflammation of the gastrointestinal (GI) tract with a high prevalence rate. Specific and effective treatments for these diseases are limited. There is a clear ne...

Novel System for High-Yield Production of Proteins and Protein Domains

christopher.perkins@rutgers.edu — Wed, 01 Dec 2021 06:51:26 GMT

Invention Summary: The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed proteins and the inability of common expression vectors such as E.coli to translate “rare codons” from other organisms. Rutgers scientists have recently devised a novel expression system to produce mRNA transcripts without the d...

Biomarkers for Identifying Patients at High Risk of Progressing from Barrett’s Esophagus to Esophageal Adenocarcinoma

christopher.perkins@rutgers.edu — Tue, 30 Nov 2021 06:22:10 GMT

Invention Summary: Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance are periodical follow-up endoscopy, which suffers from low cost-effectiveness and inconsistent patient compliance since the incidence of EAC is low. Thus, there is an urgent need to identify biomarkers associated with a high risk...

Controllable Quantum Point Junction on the Surface of an Antiferromagnetic Topological Insulator

christopher.perkins@rutgers.edu — Thu, 11 Nov 2021 06:21:43 GMT

Depiction of a magnetic domain wall (a) and a step edge (b) on the surface of an antiferromagnetic (alternating black arrows) topological insulator creating quantum wires that can intersect (c) to form a stable quantum point junction (QPJ). Invention Summary: Surface and edge-state engineering of topological materials offers great promise for future electronic devices, in particular, the topologically-protected chiral (one-way) or helical (two-way) edge states provide dissipationless “quantum wires" with potential applications in sensor, low-power electronics, and quant...

Improved Nerve Conduits for Treatment of Peripheral Nerve Injuries

christopher.perkins@rutgers.edu — Thu, 11 Nov 2021 05:55:47 GMT

Scanning electron microscope image of conduits Invention Summary: Nerve conduits are used for treatment of peripheral nerve injuries. However, the current conduits are associated with poor healing resulting from swelling and reduction of luminal volume, suture pull-out, collapse, kinking, compression, and lack of mechanical strength to withstand the traction of moving joints. Rutgers scientists have developed an improved biocompatible nerve conduit for nerve re-generation, where a porous fiber tube is coated with a bioresorbable hydrogel. The fibers are formed from a resorbable,...

High-throughput Nanoarray Screening Platform for Multi-Cellular Applications

christopher.perkins@rutgers.edu — Wed, 10 Nov 2021 05:11:23 GMT

Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues. Invention Summary: Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming. In nature, ECM is structurally complex, spanning a wide range of sizes and hierarchical topographies. However, biomaterials (e.g., hydrogels and nanofibers) used as a synthetic ECM for cellular reprogramming are often designed at a reduced comp...

An Algorithm for Identification of Treatment-response Biomarkers to Chemotherapies

christopher.perkins@rutgers.edu — Thu, 28 Oct 2021 10:20:23 GMT

Invention Summary: In the last decade, several computational methods have been successfully applied to understand cancer initiation and progression through integration of genomic and epigenomic data. However, despite recent advances in discovering a wide array of novel chemotherapy agents, identification of patients with poor and favorable response prior to treatment administration remains a major challenge in clinical oncology and cancer management. Researchers at Rutgers university have developed a novel generalizable genome-wide computational framework that identifies biomarkers vi...

Rutgers’ Rosebell Red Habanero

christopher.perkins@rutgers.edu — Wed, 27 Oct 2021 05:37:18 GMT

Invention Summary: Rutgers "Rosebell Red" pepper is a unique habanero developed from a field cross between African and Mexican habanero peppers. It has been evaluated at Rutgers research centers in Southern and Central New Jersey between 2010 and 2019. The "Rosebell Red" was selectively developed based on its unique qualities and consistency over years of breeding, and is ready for release into the market. The "Rosebell Red" is distinct in large fruit size, wall firmness and attractive rosebell-like fruit shape. It has a notable bright glossy red co...

Leukemia inhibitory factor- Protective role for radiation/chemo-induced gut syndrome and GVHD

christopher.perkins@rutgers.edu — Thu, 14 Oct 2021 08:01:25 GMT

Invention Summary: Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury This is also true for Graft-versus-host disease (GVHD) which remains a major complication after allogeneic hematopoietic stem cell transplantation, a widely-used therapy for hematologic malignancies and blood disorders. Rutgers researchers discovered that leukemia inhibitory factor (LIF), a naturally occurring cytokine, present in the intestinal stem cells and is critical in maintaining intestinal epithelial cell prol...

Lightning-fast Genome Variant Detection

christopher.perkins@rutgers.edu — Mon, 11 Oct 2021 09:16:08 GMT

Invention Summary: Current human whole genome sequencing projects produce massive amounts of data, often creating significant computational challenges. Different approaches have been developed for each type of genome variant and method of detection, necessitating users to run multiple algorithms to find variants. Researchers at Rutgers University have developed the Genome Rearrangement Omni-Mapper (GROM), a novel comprehensive method of variant detection, combining mismatch, split-read, read pair, and read depth WGS evidence. GROM boasts lightning-spee...

PEG Nanocarriers, Nanogels and Synthesis Methods

christopher.perkins@rutgers.edu — Thu, 07 Oct 2021 11:53:03 GMT

Invention Summary: A novel platform of PEG-only nanocarriers and nanogels has been developed by Rutgers scientists. The nanocarriers can be used from 100Da-100- kDa and are capable of forming stable nanogels and nanogel aggregates in a variety of sizes from 20-30nm up to >1000nm. The carriers and gels have improved solubility over existing technologies and provide for enhanced loading of drug agents. Several methods have been developed to create and tailor a wide variety of polymers and copolymers utilizing an assortment of cross-linkers and functional groups to alter surface char...

High-resolution Accelerating Mobile Deep Vision with Content-aware Parallel Offloading

christopher.perkins@rutgers.edu — Tue, 05 Oct 2021 11:09:53 GMT

Invention Summary: As mobile devices continuously generate streams of images and videos, a new class of mobile deep vision applications is rapidly emerging, which usually involve the use of deep neural networks on the multimedia data in real-time. To support such applications, the ability to offload the computation, especially the inference processing, to edge clouds has proved effective. Existing solutions often assume a dedicated and powerful server exists, to which the entire inference can be offloaded. In reality, it may not be possible to find such a server and therefore a need to ma...

JNK Inhibitor that Prevents Chemotherapy-induced Premature Ovarian Failure

christopher.perkins@rutgers.edu — Fri, 01 Oct 2021 13:21:50 GMT

JNK Inhibitor SP600125 prevented DOX-induced Primordial Follicle Loss Invention Summary: Premature ovarian failure (POF) is a disease characterized by the depletion of primordial follicles in women’s ovaries before the age of 40, and is a major side effect of chemotherapy in childhood-age, adolescent and young adult female cancer patients. POF can cause early menopause, infertility, as well as multiple ovarian endocrine disorders. There is a need for treating, ameliorating, and/or preventing follicle loss and/or POF in the young female cancer patients. Ru...

Method of Calibration Using Master Calibration Function

christopher.perkins@rutgers.edu — Mon, 27 Sep 2021 13:12:54 GMT

Mass errors generated by regular calibration equations and by the master calibration equation. Invention Summary: As instrumental parameters and a sample introduction may fluctuate or drift slightly, it is necessary to perform a calibration of the instrument before measuring. The widely used method is through establishing a calibration function using a single set of constants obtained by curve-fitting. However, obtaining the data for the constants is subject to random errors and the calibration equation can have deviations, resulting in errors in subsequently ca...

PulseLab: An Integrated and Expandable Toolbox for Pulse Wave Velocity-base Blood Pressure Estimation

christopher.perkins@rutgers.edu — Mon, 27 Sep 2021 12:23:44 GMT

Invention Summary: Cuff-less blood pressure (BP) estimation methods have been long pursued as substitutions for the conventional BP measurement methods to facilitate continuous and automatic monitoring of BP. The PWV (pulse wave velocity)-BP models, describing the relationship between the PWV and the BP, have been derived and used in recent BP-estimation studies. However, currently, there exist no toolboxes and graphical user interfaces (GUIs) that enable pre-processing, visualization and analysis of signals for the problem of BP estimation. Rutgers researchers have developed Pulse...

A Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics or Other Agents

christopher.perkins@rutgers.edu — Fri, 17 Sep 2021 11:06:04 GMT

Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals. Invention Summary: A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic agents by diseased cells varies dramatically even under ideal conditions. Accordingly, treatment with a single pharmaceutical is not likely to target all cells adequately to achieve the desired therapeutic outcome. To increase treatment e...

Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics, or Other Agents

christopher.perkins@rutgers.edu — Fri, 17 Sep 2021 11:03:05 GMT

Thermo-Activated Lubricant Additives for Improving Engine Efficiency and Fuel Economy

christopher.perkins@rutgers.edu — Mon, 16 Aug 2021 13:08:54 GMT

Controlled Release Friction Reduction over Time Invention Summary: Friction modifiers (FMs) have been extensively studied as lubricant additives that could improve lubricity of base oil friction profiles to enhance fuel economy by the petrochemical and automobile industries. There are two classes of FMs, the ash FM (organo-molybdenum molecules) and ashless FM (sulfur-free organic molecules). The ashless modifiers such as fatty acid esters have the added advantage of being more environmentally friendly. However, current fatty acid molecules degrade too quickly and result in reduced ...

Novel Process for Early Diagnosis and Treatment of Diabetic

christopher.perkins@rutgers.edu — Tue, 10 Aug 2021 14:22:46 GMT

Invention Summary: Sixty to seventy percent of diabetes patients suffer from the nerve disorder diabetic peripheral neuropathy (DPN), which causes pain, tingling, numbness in extremities and can lead to devastating (complications such as falls, amputations, muscle weakness, unsteady gait and foot ulcers. Current diagnostic methods for neuropathy are silent during the early stages of the disease and detect demyelination at a relatively advanced stage. Early detection allows for better disease management through optimal intervention and lifestyle changes; and has the potential to ...

Arkham Patients’ Psychology AP Study Resource

christopher.perkins@rutgers.edu — Fri, 30 Jul 2021 10:57:02 GMT

Invention Summary: Psychiatrists at Rutgers University have created a unique educational resource for use in promoting and teaching Psychology at a high school level. In particular, the “Arkham Patients’ (Ark) Psychology” curriculum provides a unique program that promotes participation in Advanced Placement (“AP”) Psychology courses by providing a fun and engaging means to draw students into the material while maintaining a high educational standard...

Communication Perception Estimate Scale (CoPES)

christopher.perkins@rutgers.edu — Fri, 30 Jul 2021 10:42:45 GMT

Invention Summary: Communication and language disorders occur in over 5% of the general population and estimates show them to be more prevalent in youth with psychiatric disorders that require psychiatric services. Early detection in young patients can improve treatment for the communication disorders (CDs) and the additional associated diagnoses. Description Comprehensive assessment of CDs is expensive, time-consuming, and is impractical in most clinical settings, particularly inpatient and most ...

Port-of-Entry Simulation System (POESS)

christopher.perkins@rutgers.edu — Fri, 30 Jul 2021 10:26:01 GMT

Invention Summary: Fast and sustained secure flows of people and freight through a Port-of-Entry (POE) are essential to the U.S. economy. Excessive delays not only inconvenience passengers, but also disrupt supply chains downstream the POE, often causing severe economic damage. In addition, they elevate carbon footprint resulting in environmental and public health impacts. US Custom and Borders Protection (CBP)—a component of the Department of Homeland Security (DHS)—has been responsible for facilitating vehicular an...

Polynomiography

christopher.perkins@rutgers.edu — Fri, 30 Jul 2021 09:36:00 GMT

The ideas for Polynomiography grew out of Dr. Bahman Kalantari’s research into polynomial root-finding, an ancient and historic subject that continues to find new applications with each generation of mathematicians and scientists. The term “polynomiography”, coined by Dr. Kalantari, is a combination of the word “polynomial” and the suffix “graphy.” A "polynomiograph" is an individual rendered image. Invention Summary: Polynomiography is a fusion of math and art, which as software gives rise to a new f...

2-D Hand Hygiene Game for Healthcare Professionals

christopher.perkins@rutgers.edu — Fri, 30 Jul 2021 07:23:54 GMT

Invention Summary: Studies have shown that healthcare workers wash their hands half the time they should. The CDC points out the importance of washing hands, not only often, but also properly with the right techniques helps insure a safe environment for patient care. With the rise of hospital acquired infections, following proper hand hygiene techniques can significantly reduce the diseases transmitted from person to person. Descript...

MigraineMedPick

christopher.perkins@rutgers.edu — Wed, 28 Jul 2021 11:26:59 GMT

Invention Summary: Migraine and tension-type headache (TTH) are among the most common medical complaints and causes of disability, chronically afflicting up to 5% of the population. There are a wide variety of abortive and preventive medications for migraine treatment. These medications contain a variety of contra-indications depending on a patient’s medical profile – current medical problems, blood pressure, heart rate, etc. Some of these contra-indications have significant and potentially dangerous health implications. For patients with multiple medical...

Novel Light-Field Messaging Captured in a Camera

christopher.perkins@rutgers.edu — Wed, 28 Jul 2021 11:10:42 GMT

Invention Summary: Light Field Messaging (LFM) is a process of embedding, transmitting, and receiving hidden information in video that is displayed on a screen and captured by a handheld camera. The goal of the system is to minimize perceived visual artifacts of the message embedding, while simultaneously maximizing the accuracy of message recovery on the camera side. LFM requires photographic steganography for embedding messages that can be displayed on a screen and captured by a camera. Unlike digital steganography, the embedding requirements are significantly more challenging due to the c...

Rutgers’ Jumbo-Habanero (Capsicum Chinense)

christopher.perkins@rutgers.edu — Tue, 27 Jul 2021 07:53:46 GMT

Invention Summary: Rutgers' Jumbo-Habanero (Jumbo-Hab) is an open-pollinated pepper variety that was developed from a field cross between African and Mexican habanero peppers. The plant is bushy with mostly bifurcative branching, 30-32” tall and 40-50” wide, and very attractive at maturity with red ripe pendulous fruit. It is an annual in NJ, but maybe perennial in tropical climate. Plant starts to flower 7-8 weeks after transplanting, and first fruit ripens about 12 weeks after transplanting. Average fruit number is 63/plant, and average fruit weight is 23 g. Ripe fruit ...

Rutgers' UFO-Habanero (Capsicum Chinense)

christopher.perkins@rutgers.edu — Tue, 27 Jul 2021 07:48:27 GMT

Invention Summary: Rutgers' UFO-Habanero (UFO-Hab) is an open-pollinated pepper variety that was developed from a field cross between African and Mexican habanero peppers. The plant is bushy with bifurcative branching, 30-36” tall and 38-49” wide, and very attractive at maturity with red ripe pendulous fruit. It is an annual in NJ, but maybe perennial in tropical climate. Plant starts to flower 7-8 weeks after transplanting, and first fruit ripens about 12 weeks after transplanting. Average fruit number is 90/plant, and average fruit weight is 17.5 g. Ripe fruit durabilit...

Patient-Centered Model for Protein-Energy Wasting

christopher.perkins@rutgers.edu — Tue, 27 Jul 2021 07:23:57 GMT

Invention Summary: Protein-energy wasting (PEW) is a term proposed by the International Society of Renal Nutrition and Metabolism (ISRNM), referring to the multiple nutritional and catabolic alterations that occur in patients suffering with chronic kidney disease (CKD). To increase awareness, identify research needs, and provide the basis for future work ISRNM has recommended the nomenclature of PEW and formulated a model that theorizes etiological factors which may negatively impact nutritional status and contribute to morbidity and mortality. The ISRNM PEW model is based...

Rutgers Hazelnut Varieties Resistant to Eastern Filbert Blight

christopher.perkins@rutgers.edu — Mon, 19 Jul 2021 13:02:38 GMT

Invention Summary: Rutgers University initiated a hazelnut research and breeding program in 1996 to address the fatal tree disease eastern filbert blight (EFB) caused by the naturally occurring fungus, Anisogramma anomala. Rutgers made large seed collections across Eastern Europe, the Caucuses, and Central Asia to cross and breed the collected trees for eastern US trials. The program spans over 20 years as of 2019, and Rutgers now has 25,000 trees on 20 acres in various stages of evaluation. About 2% of trees were discovered to have some resistance. Utilizing these, advanced...

“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment

christopher.perkins@rutgers.edu — Wed, 14 Jul 2021 13:24:04 GMT

CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control. Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large unmet need remains for an effective COVID-19 treatment despite vaccine deployment. Immunocompromised people unable to receive the vaccine, COVID-19 variant strains, incomplete vaccine efficacy and vaccine hesitancy indicates a continuation of C...

Sigma-1 Receptor Antagonists – Non-Addictive Pain Management

christopher.perkins@rutgers.edu — Fri, 09 Jul 2021 07:35:00 GMT

Invention Summary: The sigma 1 receptor (S1R), a molecular chaperone protein located in the endoplasmic reticulum and plasma membranes, plays important roles in various pathological disorders including pain. The potential commercial applications of novel S1R antagonists are twofold: 1) as stand-alone therapy for the treatment of chronic neuropathic pain; 2) as combination therapy with opioids for the treatment of moderate-to-severe pain but with significantly fewer and less serious adverse effects. Rutgers researchers have developed a new class of compounds, with the lead molecules name...

Efficient and Non-Genotoxic Gene Transfer System for Stem Cells

christopher.perkins@rutgers.edu — Wed, 07 Jul 2021 09:26:50 GMT

Comparison of efficiency and toxicity of transfection reagents carrying different amounts of DNA for mesenchymal stem cells (MSCs). These cells are primary cells and considered hard-to-transfect. Panel A shows the transfection efficiency of “Rutgers Transfection System” in comparison to the five most widely used commercially available reagents; Panel B shows the viability of cells after transfection with “Rutgers Transfection System” in comparison to the same five commercially available ones. The most efficient vectors and their corresponding toxicities are highlight...

Film Forming Foam (FFF) for Burn Wounds/Burnflex

christopher.perkins@rutgers.edu — Tue, 22 Jun 2021 08:37:33 GMT

Invention Summary: Many available dressings on the market use latex, PVC, or polyurethane as barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may be coated in silver sulfadiazine, a commonly used antibiotic for large burn wounds. These coatings are of limited access to lower incomes because of their cost. There exists a need for a novel dressing that provides economic and efficacious wound healing. R...

Static and Dynamic MRI Reconstruction and Segmentation

christopher.perkins@rutgers.edu — Fri, 18 Jun 2021 07:50:39 GMT

Channel-wise Attention Network Model (MICCAN) Motion Guided Dynamic Reconstruction (MODRN) Joint Reconstruction and Segmentation Invention Summary: Magnetic resonance imaging (MRI) technology is a widely used imaging technology but has several drawbacks including: the amount of time necessary for a scan, the requirement for a breath hold when imaging the heart and post-processing that does not support reconstruction and segmentation as a single automated task, without a need for manual intervention. To better reconstruct ...

New Vector Platform for Concurrent Tumor Imaging, Therapy, and Evaluation of Response to Therapy

christopher.perkins@rutgers.edu — Mon, 07 Jun 2021 15:14:31 GMT

Diagnosis of HER2+ cancer metastasis lesions in mouse using a genetically engineered targeted vector in conjunction with MRI. The MRI followed by voxel-by-voxel analysis of scans showed that the vector makes it possible to differentiate HER2+ from HER2- cancer lesions in mouse lungs Invention Summary: The human epidermal growth factor receptor-2 (HER2) is overexpressed in different cancers and has been used as an important biomarker for aggressive tumors with metastatic potential. Currently in clinic, cancer diagnosis includes whole body imaging using computed tomography (CT)...

Pyrrole-based Inhibitors of PfPKG for the Treatment of Malaria

christopher.perkins@rutgers.edu — Fri, 04 Jun 2021 08:03:48 GMT

Invention Summary: The emergence and spread of artemisinin-resistant plasmodium falciparum in Southeast Asia is a compelling reminder to develop new drugs for malaria prophylaxis and treatment. Drugs that target pre-erythrocytic stages are an essential component of the anti-malarial effort because a decrease in liver infection by sporozoites significantly reduces severity and incidence of malaria. Existing anti-malarial that target pre-erythrocytic stages, such as primaquine, tafenoquine and atovaquone, have significant side-effects or are expensive. Therefore, there is an acu...

RUTGERS ASPHALT ANALYSIS TOOL PACK

christopher.perkins@rutgers.edu — Wed, 02 Jun 2021 11:45:29 GMT

Innvention Summary: Modern asphalt pavement performance testing has quickly evolved into simple physical testing procedures with intensive and complex analyses of collected data. To facilitate larger adoption of the testing protocols and associated data analysis by both the private industry and DOTs, engineers in the Rutgers Center for Advanced Infrastructure and Transportation (CAIT) have created the Rutgers Asphalt Analysis Took Pack (RAAT-Pack). The software can provide analysis for several asphalt performance testing specifications by uploading a...

A METHOD FOR SYNTHESIZING MEDICAL DATA LEARNT FROM DISTRIBUTED GAN

christopher.perkins@rutgers.edu — Tue, 25 May 2021 09:43:41 GMT

Learning without sharing medical images Segmentation using synthetic images Invention Summary: Large volumes of data are necessary to train machine learning (ML) algorithms (especially for medical image analysis.) HIPAA and other privacy regulations make it difficult to obtain sufficiently large volumes of disease related images (e.g., from different medical institutions) necessary for training machine learning models used in artificial intelligence (AI) based medical applications or medical analysis purpose. Rutgers researchers have developed a data privac...

Novel Inhibitors of Keap1-Nrf2 Protein-Protein Interaction

christopher.perkins@rutgers.edu — Mon, 10 May 2021 16:57:59 GMT

Novel Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction Invention Summary: Nrf2 is a key transcription factor mediating anti-inflammatory and antioxidant responses in the body. Keap1 is a well-known repressor of Nrf2 that targets Nrf2 for its rapid proteasomal degradation. Dysfunctional Keap1-Nrf2 axis contributes to oxidative stress and inflammation underlying multiple disease conditions, including cancer, chronic obstructive pulmonary diseases (COPD), Alzheimer’s and Parkinson’s diseases, chronic kidney diseases (CKD) and diabetes. Therefore, ...

Predicting Therapeutic Resistance to Tamoxifen in Cancer Treatment

christopher.perkins@rutgers.edu — Mon, 10 May 2021 06:15:51 GMT

Invention Summary: Currently, patients with ER+ breast cancer are administered tamoxifen without considering their potential response to this therapy. Thousands of women take the tamoxifen only to discover that their tumors do not respond or that they develop resistance over time. The ability to screen patients ahead of the therapy administration can improve disease course, management an outcome as patients at risk of resistance can be offered alternative regimens. Rutgers Researchers have identified molecular pathways and their read-out genes as marker...

Optimal Relay Beamforming with Predictive Relay Selection for mmWave Communications in Urban Environments

christopher.perkins@rutgers.edu — Fri, 07 May 2021 18:28:48 GMT

Invention Summary: Millimeter wave (mmWave) communications supports high data rates with extremely high frequency, showing the promising potential in the future wireless communications including 5G networks. However, their sensitivity to blockage and severe signal attenuation present challenges in their deployment in urban settings. Current solutions to this dilemma are resource demanding and introduce network latency Rutgers scientists have introduced a novel relay beamforming approach for mmWave communications in an urban scenario. The system model consists of s...

A New Method to Enhance Lung Cancer Treatment

christopher.perkins@rutgers.edu — Fri, 16 Apr 2021 10:55:43 GMT

Invention Summary: Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer. Small molecule Tyrosine Kinase (TK) Inhibitors acting on the Epidermal Growth Factor Receptors (EGFRs) are standard therapies for patients with NSCLC harboring EGFR-TK inhibitor-sensitizing mutations. However, fewer than 10 % of patients with NSCLC benefit from this therapy. Moreover, this therapy can cause severe systemic toxicities and is ineffective in preventing non-canonical EGFR signaling. Rutgers researchers have developed a novel multi-tier biotechnology treatment a...

Single Atom Catalyst on Holey Graphene Nanoplatelets

christopher.perkins@rutgers.edu — Mon, 05 Apr 2021 12:58:28 GMT

Invention Summary: The drive to replace precious platinum group metal (PGM)-based oxygen reduction reaction (ORR) catalysts has boosted the research and development of PGM free single-atom catalyst. However, numerous challenges remain in large scale practical application, efficiency, and long-term durability. Rutgers Researchers have developed a time and energy efficient microwave assisted approach for the direct fabrication of electrochemical single-atom catalysts (E-SAC) without the requirement of post-treatment. The as-prepared Cu-E-SAC, where Cu-active centers we...

Moldable Porous Nanocomposite Resins

christopher.perkins@rutgers.edu — Wed, 31 Mar 2021 11:06:57 GMT

Nanoporous monoliths fabricated at various length scales (a) microscale pillar; (b) mm-scale cone; (c) inch-scale hand cast. Invention Summary: A key issue with a majority of the current technologies for creating porous monoliths is that they require high temperature treatments or incur significant materials shrinkage. For many applications, shape is critical and low-temperature substrates or environments are necessary. Researchers at Rutgers University have developed a new method to synthesize porous resin-particle nanocomposite monoliths. This invention diffe...

Small Molecule Inhibitors of MIF for Inflammatory Diseases

christopher.perkins@rutgers.edu — Wed, 31 Mar 2021 08:34:27 GMT

Small molecules targeting to the inflammatory cytokine MIF could be a treatment for various diseases Invention Summary: A wide range of diseases can be addressed by targeting inflammatory cytokines. Although there are monoclonal antibody drugs that target, e. g., Tumor Necrosis Factor (TNF), no orally administrable small molecule inhibitor of inflammatory cytokines is presently available to meet medical and market needs. Rutgers scientists have identified new isoidide derivatives as inhibitors of Macrophage Migration Inhibitory Factor (MIF). The molecules suppress T...

dCas9 Protein Allele Sequestration for Improved CRISPR Gene Editing

christopher.perkins@rutgers.edu — Mon, 22 Mar 2021 19:59:28 GMT

Invention Summary: CRISPR technology is widely used in research to edit genes in animals and cell lines and is moving towards therapeutic use in the clinic. Inherent to almost all methods employed in gene editing is the lack of control in target gene usage. A method to direct cleavage of only a single target within a cell would be beneficial to research and therapeutic gene editing for the following reasons: 25-30% of gene targets are essential for embryo development, most of which are also necessary for cell growth strong cellular DNA damage response can alter cellular...

Versatile CRISPR-Cas9 Gene Editing System

christopher.perkins@rutgers.edu — Tue, 16 Mar 2021 06:59:42 GMT

Successful gene editing in neurons differentiated from patient-derived neural stem cells. Left panel, gene editing using control guide RNA; Right panel, gene editing using MeCP2 guide RNA. Invention Summary: CRISPR-Cas-mediated genome editing makes effective gene therapy of human disease feasible. Although viral delivery of CRISPR-Cas agent is quite efficient, the safety concern limited its clinic applications. On the other hand, the current available non-viral delivery methods can’t reach the goal for effective genome-editi...

Finger-input Touch Authentication using Physical Vibration (VibWrite)

christopher.perkins@rutgers.edu — Mon, 15 Feb 2021 10:48:34 GMT

Invention Summary: Researchers at Rutgers University have created an innovative authentication system named VibWrite. The system places an inexpensive vibration motor and receiver on a solid surface, such as wood, metal, plastic, glass (e.g., a door panel, a desk or an appliance). The motor sends vibrations to the receiver. When a user touches the surface with a finger, the vibration waves change and create a unique signature per user and per finger. This invention turns any rigid surface into a touchscreen for user authentication. The invention supports use of a user’s physiologi...

Online Instruction in Psychology Laboratory Classes: Cognition, Sensation & Perception Labs

christopher.perkins@rutgers.edu — Tue, 09 Feb 2021 07:01:04 GMT

Dr. Eileen Kowler is a Distinguished Professor in the Psychology Department in the Rutgers School of Arts and Sciences. She received her Ph.D. in Psychology from the University of Maryland in 1978, and joined the Psychology faculty at Rutgers in 1980 after postdoctoral work at New York University. She is also a member of the graduate faculty of Biomedical Engineering and is on the Executive Committee of the Rutgers Center for Cognitive Science. She edited the reference work Eye Movements and Their Role in Visual and Cognitive Processes (published by Elsevier), and serv...

DIFFNET

christopher.perkins@rutgers.edu — Tue, 09 Feb 2021 06:23:21 GMT

Dr. Pengfei Zhang is a practicing physician in the Rutgers Health Robert Wood Johnson Hospital Department of Neurology. He is Board-certified for Neurology, specializing in headaches and migraines. He is a graduate of Georgetown University School of Medicine, and completed his residency at Mount Sinai Hospital in New York. Invention Summary: Migraine and tension-type headache (TTH) are among the most common medical complaints and causes of disability, chronically afflicting up to 5% of the population. Coming up with a set of potential diagnoses for a clinic...

New Cell Therapy Device for Isolating Cells and Exosomes

christopher.perkins@rutgers.edu — Tue, 02 Feb 2021 11:01:13 GMT

GMP-grade closed-system clinical cell therapy device for isolation and delivery of cells and exosomes. Invention Summary: Regenerative medicine research has become an important field of study due to the ability of regenerating cells to restore a wide variety of cell types. Regenerating cells can be isolated from multiple sources and can be used in a variety of applications such as cell therapy, in vitro disease modeling, genome editing, immunotherapy, and drug screening. The identification and isolation of regenerating cells and their derived exosomes are challenging, due to their...

New Cell Therapy Strategy for Treatment of Spinal Cord Injuries

christopher.perkins@rutgers.edu — Tue, 02 Feb 2021 10:57:02 GMT

Cell therapy strategy for spinal cord injuries and regenerative diseases. Invention Summary: Spinal cord injuries (SCI) are damages to the spinal cord neural tissues that cause sensory loss and motor paralysis. SCI patients have no options for curative therapy. Thus, a mild contusion to the spinal cord results in massive neuronal and glial cell loss, demyelination, cavitation and glial scarring, resulting in detrimental functional effects, including loss of sensory perception, distal motor paralysis and severe functional impairment. There is a need for an effective therapy that en...

Internal Vibration Isolation for A Cryogen-free Cryostat to Operate Scanning Tunneling Microscopes

christopher.perkins@rutgers.edu — Tue, 26 Jan 2021 12:30:53 GMT

Invention Summary: Cryogen-free cryostats have attracted attention due to their significant reduction in cost and labor to cool systems to cryogenic temperatures. With cryogen-free cryostats helium does not need to be refilled, which allows experiments to run indefinitely without interruption. This also means that the costly drawing from the worlds scarce helium supply is avoided. However, a major disadvantage with cryogen-free cryostats is that their pulse tubes generate strong mechanical vibration (noise) which interferes with the quality of vibration sensitive measurements, such as s...

Compact, Transferable and Modular Scanning Probe Microscope Head

christopher.perkins@rutgers.edu — Tue, 26 Jan 2021 12:15:37 GMT

Scanning probe microscope head Invention Summary: Scanning probe microscopy (SPM) offers access to material characteristics at the nanometer scale. However, integrating SPMs into research environments poses challenges: incompatibility with cryogenic temperature and high magnetic fields, noisy laboratory environment, and integration issues with other instruments. Typically, these require costly solutions. The Rutgers modular, pluggable SPM head solves many of these issues and is transferable between mK to room temperatures, from ambient to ultra-high vacuum, in a high-v...

Negative Capacitance Oxide TFT on Glass

christopher.perkins@rutgers.edu — Tue, 26 Jan 2021 11:18:47 GMT

(a) Transfer characteristics of reference TFT and NC-TFT with inset showing gate leakage. (b) Extracted SS values of reference TFT and NC-TFT. Invention Summary: Scaling down operating voltage and reducing power consumption remain a significant challenge in the evolution of integrated circuits (IC). Negative capacitance field effect transistor (NC-FET) is designed to reduce operation voltage and power consumption by reducing the subthreshold swing (SS) value through the use of ferroelectric materials. However, improvements have been limited due to high temperature fabrication pr...

Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers

christopher.perkins@rutgers.edu — Tue, 26 Jan 2021 06:59:00 GMT

A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone. Invention Summary: More than half of all cancers harbor a mutation in the p53 gene which plays an essential role as a tumor suppressor. Restoring wild type p53 function has been shown to have potent anti-cancer activity and also improves th...

Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers

christopher.perkins@rutgers.edu — Tue, 26 Jan 2021 06:57:59 GMT

Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers

christopher.perkins@rutgers.edu — Tue, 26 Jan 2021 06:45:48 GMT

Deposition of Microscale Coatings by Self-Limiting Electrospray

christopher.perkins@rutgers.edu — Mon, 11 Jan 2021 10:04:52 GMT

a. Overview of thickness-limited electrospray deposition (ESD). Electrostatically-driven spray creates a charged film which redirects charged incident droplets. b. and c. SEM images of spray results, illustrating the wide range of morphologies and particle size which can be obtained with this method(b: nanowires, c: hollow spheres). Invention Summary: Researchers at Rutgers University have developed a scalable, cost-effective method for depositing microscale coatings of a wide variety of materials and composites compatible with complex additive manufactured or micromachined structures. ...

Human Normal and Cancer Organoid Culture with Defined Components for Six Different Tissue Types

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 16:00:52 GMT

Invention Summary: An organoid is a small three-dimensional (3-D) cellular tissue structure that highly resembles the in-vivo organ from which it is originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from six different cancer types and normal tissues derived from patients suffering from glioblastoma, prostate, breast, kidney, lung, and bladder cancers. Using this new human organoid culture methodology, stem cell-derived organoids are generated from human primary tissues at 80-90% efficiency within 4 weeks. The ...

Method for Sintering Ultrahigh Melting Temperature Covalent Non-oxide Ceramics

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:43:48 GMT

Parallel plate capacitor configuration used to apply an electric field and to achieve low-temperature sintering of a non-oxide ceramic (B4C) Invention Summary: Bulk and composite structural ceramics can be fabricated by sintering, forming particulate matter into a desired shape and then subjecting the formed body to high temperatures (2/3 of the melting temperature) and high pressures (250 MPa). These fabrication conditions are costly and lead to decomposition of non-oxide ceramics. Researchers at Rutgers have devised a method of sintering ultrahigh melting temperature covalent...

Waveguide Array for High Density Integration with Low Crosstalk

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:43:08 GMT

Top: Average transmission of each waveguide output port (indicated by color) Invention Summary: The success of silicon photonic devices depends on high integration density. However, at the sub-wavelength scale, waveguides suffer from high crosstalk. The present technology reduces crosstalk at the sub-micron scale by using a superlattice of waveguides. Within each supercell, there is a sub-array of waveguides with different propagation constants. Differences in propagation constants may be due to differences in width, length, or materials. A creative “interlacing-recombina...

NOCQuest: Method to Determine Number of Contributors in a DNA Mixture

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:42:55 GMT

Invention Summary: DNA collected at a crime scene can be used as evidence against and as a clue in the determination of the perpetrator(s) of the crime. Use of this biological evidence, however, can be complicated if DNA from multiple individuals is present. The reliability of the DNA sample can come into question as to whether a match is the result of a match of the individuals DNA or if the aggregate of the samples matches the suspects DNA. Rutgers scientists have developed a method for estimating the number of contributors to a DNA sample. This technology uses the ...

DUAL-MODE LOW-PHASE-NOISE OSCILLATOR

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:40:44 GMT

Invention Summary: Oscillation is a common phenomenon to virtually all areas of science. Many products in the marketplace use oscillators as a means of keeping time such as the quartz crystal used in modern watches. These oscillators, while commonly used, exhibit a variety of instabilities resulting from aging, noise, and frequency changes caused by factors such as: temperature, acceleration, ionizing radiation, power supply voltage, shock, and vibration. These instabilities impart noise to the circuit resulting in numerous adverse effects on system performance. Researchers at Rut...

Biocompatible and Biodegradable Films for Effective Prevention of Postoperative Adhesions

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:40:35 GMT

Shear modulus of polyelectrolyte complex (PEC) films (red) compared to soft tissue and competing materials (blue). Invention Summary: Adhesions often form after surgery, causing chronic abdominal or pelvic pain. Currently available adhesion prevention products form only a physical barrier against adhesions and have undesirable properties, such as brittleness and the inability to function in the presence of blood. Rutgers scientists have developed novel biodegradable and non-toxic polyelectrolyte complex (PEC) films with anti-adhesive and anti-inflammatory properties. These PEC-based fi...

Inorganic, Mineral-based Polymers with Ionic Crosslinks

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:39:03 GMT

Inorganic ionomers show characteristic behavior of polymers, including fiber formation (left) and flow (center). However, they have high thermal stability: like silicate glass (top right), inorganic ionomers (bottom right) they do not burn or produce fumes when exposed to flame. Invention Summary: Traditional, carbon-based, organic polymers have many applications, but they rely on petroleum, a limited resource. Additionally, carbon-based polymers have low thermal stability and often release harmful chemicals when they break down. Researchers at Rutgers have developed polymers with inorg...

New Indentation Method Using Scanning Probe Microscope

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:38:32 GMT

Invention Summary: Accurate indentation measurement is fundamental to atomic force microscope (AFM)-based material property characterization as the force applied and the indentation generated are the two most important physical variables that must be measured in the characterization process. Large measurement errors occur when the measurement frequency range becomes large (i.e., broadband), or the indentation is measured in liquid on soft materials. Such large measurement errors are generated due to the inability of the conventional method to account for the convolution of the AFM instrum...

Multifunctional Rare Earth-Based Biophotonic Composites

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:37:25 GMT

Image showing use of bio-encapsulated Rare Earth (RE) doped nanoparticles targeting melanoma cells. Invention Summary: Researchers at Rutgers University have developed new rare earth (RE)-based light-emitting, multifunctional composites for use in various biomedical applications, such as non-invasive imaging, image–guided interventions, drug tracking and delivery, and photodynamic therapy applications. They found that the properties of the composites, in particular their aqueous stability, solubility, biocompatibility, and functionality, can be tailored for such applications by coa...

RAILWAY PLATFORM GAP BRIDGING UNIT

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:37:17 GMT

Invention Summary: In a recent report sponsored by the New Jersey Department of Transportation, it was found that car/platform gap injuries accounted for 25% of all injuries on NJ TRANSIT Rail lines, including death. Similar findings have been reported by other agencies, including the Long Island Rail Road and the Metropolitan Transit Agency of New York. These results prompted the Federal Railroad Safety Advisory Committee to address the seriousness of the car/platform gap issue. Researchers at Rutgers University have developed an apparatus that dynamically fills the gap between the doo...

Scalable Multiple Inverse-Diffusion Flame Synthesis of Graphene, Syngas and Liquid Fuel & Fabrication of Diamond-Reinforced Composites

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:36:27 GMT

A) A schematic multiple inverse-diffusion flames burner. B) Raman spectrum of the few-layer graphene (FLG) on Ni. C) HRTEM image of the FLG. The bottom right insert shows the electron diffraction pattern of the graphene sheet. The top left insert shows resolution magnified image of the graphitic lattice. Invention Summary: Carbon-based nanostructures and films define a new class of engineered materials that display remarkable physical, photonic and electronic properties. Production methods for making carbon-based nanostructures include ultrahigh vacuum annealing of SiC, and chemical vap...

Type-I Collagen Methacrylamide-Derivatized Hydrogels

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:36:03 GMT

Invention Summary: Natural material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties. Rutgers scientist Dr. David Shreiber invented a process for creating type I collagen and methacrylamide (CMA)-based hydrogel, which retains the properties of collagen such as self-assembly, biodegradability, and natural bioactivity. ...

FLUID FLOW ANALYSIS FOR CARDIOVASCULAR DIAGNOSTICS

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:35:54 GMT

Invention Summary: Following a heart attack or the development of some cardiovascular diseases, the movement of the heart walls during the cardiac cycle may change, which affects the motion of blood through the heart. Currently, valvular blood flow can be monitored using imaging techniques such as Doppler ultrasound or time-series MRI, however, the spatial resolutions of such techniques are poor. In addition, it is not possible to observe the detailed interaction of the blood flow and the endocardial surface of the heart. Therefore, the formation of cardiac thrombus remains difficult to p...

Nanotechnology-based Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:35:37 GMT

Two-in-one: Combined nanocarrier based targeted chemo and gene therapy 1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (after treatment). Invention Summary: Rutgers scientists have developed an ovarian tumor-targeted therapeutic delivery system that utilizes a nanocarrier delivery vehicle such as liposome ...

Spinel Catalysts for Water Oxidation/Water Splitting

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:35:00 GMT

Spinel compounds like LiCo2O4 catalyzes water oxidation at lower over-potental than industry standards (Ir, Ru, Pt, Pd) . The crystal structure determines the electro-catalytic performance, with other structures (layered, cubic) or compositions (AB2O4) more useful at different current densities Invention Summary: Development of water oxidation/ oxygen reduction catalysts to replace costly and inefficient platinum group metals in commercial electrolyzers and fuel cells has been an unmet need preventing global development of hydrogen technologies. One limitation to electrolyzer o...

Formulation and Manufacture of Pharmaceuticals by Impregnation onto Porous Carriers

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:34:40 GMT

Figure 1. SEM Pictures of pure Neusilin® and impregnated with Fenofibrate at 30% loading. Invention Summary: Rutgers scientists have developed a novel platform of pharmaceutical product development by utilizing fluid bed impregnation (FBI) of API solutions onto porous carriers. Impregnation of solutions into porous carriers allows extremely uniform distribution of small amounts of material, which can be used for drug dosage regulation. Currently, the method can be adjusted for drug content as low as 0.1% and as high as 10%, thus spanning the entire range of interest for poorly solubl...

Doxycycline Loaded Poly(Ethylene Glycol) Hydrogels for Healing Vesicant-Induced Ocular Wounds

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 15:34:29 GMT

Invention Summary: Rutgers scientists have invented a method of loading poly (ethylene glycol) hydrogels with doxycycline to treat vesicant-induced (i.e. sulfur mustard gas) ocular wounds. The effectiveness of doxycycline, an FDA approved drug in humans, was previously limited in ocular treatment due to tear washing on the eye’s surface. The new hydrogel system has increased viscosity which provides for prolonged corneal contact time and reduced drug loss from the corneal surface. The non-toxic, transparent hydrogels are easy to administer and would minimize patient discomfort. ...

Novel Complexes Of N-Heterocyclic Carbenes For Transition-Metal Catalysis

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 12:58:49 GMT

Invention Summary: Palladium-catalyzed cross-coupling reactions are tremendously valuable in the synthesis of small molecules and are among the most important methods for the construction of diverse chemicals. In numerous Pd-catalyzed reactions, NHCs (NHC = N-heterocyclic carbenes) are advantageous as ancillary ligands due to their strong -donation and steric tuning around the metal center. Rutgers scientists have characterized and analyzed reactivity of novel Pd(II)-NHC precatalysts, that are highly active in the Suzuki-Miyaura cross-coupling of amides by N–C(O) activation, Suzu...

Novel Bioherbicides that Suppress Weeds and Promote Plant Growth

christopher.perkins@rutgers.edu — Fri, 13 Nov 2020 12:55:15 GMT

Stunted growth of invasive Japanese knotweed when inoculated (Right panel) with Micrococcus luteus. Left panel: untreated Japanese knotweed; Right panel: bioherbicide treated Japanese knotweed Invention Summary: Rutgers University scientists have identified novel compositions of endophytic yeast and bacteria that reduce aggressive growth of invasive species and promote growth of host plants. These endophytes suppress the development of seedlings of weeds such as dandelion (Taraxacum officionale), curly dock (Rumex crispus), clover (Trifolium repens), Japanese knotweed (Fallopia japoni...

Modified Kisspeptin Receptor Agonist as Novel Treatment of MASLD

christopher.perkins@rutgers.edu — Thu, 22 Oct 2020 10:48:09 GMT

Invention Summary: Metabolically Dysfunctional-Associated Steatotic Liver Disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a highly prevalent chronic liver disease, affecting 38% of all adults and up to 14% of children, globally. It is anticipated that by 2040, the MASLD prevalence rate will increase to 55%, worldwide. In the U.S, nearly 86.3 million adults currently have MASLD. MASLD initiates with steatosis (lipid accumulation in the liver), which can then progress to steatohepatitis, fibrosis, cirrhosis and eventual liver failure. MASLD is now ...

Fine-Tune Cellulose Crystals in Biocomposites

christopher.perkins@rutgers.edu — Wed, 07 Oct 2020 06:45:45 GMT

Morphology change from crystalline (I. Pure Cellulose) to amorphous (III. coagulated in water) or semi-crystalline (IV. coagulated in H2O2) Invention Summary: Natural materials such as cellulose or silk can be used in a multitude of applications such as electrolyte batteries, filters, drug delivery systems and scaffolds for tissue engineering. Transforming natural resources from their native state to a more usable form is non-trivial and is technically challenging. Rutgers Researchers and collaborators have developed a facile method to modulate the crystallinity and crystal size of ...

Novel Ligands for Transition-Metal Catalysis

christopher.perkins@rutgers.edu — Tue, 08 Sep 2020 09:21:46 GMT

Invention Summary: N-heterocyclic carbenes (NHCs) are tremendously valuable ligands in homogeneous catalysis. IPr (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) represents the most important NHC. Rutgers scientists have developed novel, sterically bulky, easily accessible NHC ligand IPr# (referred to as “hash” series) that can be utilized as ancillary ligands in a broad range of catalytic reactions. These catalysts can activate unconventional and strong bonds with broad generality, providing ligands with extreme steric hindrance around the transition metal which is...

Flexible Multifunctional Elastomers Sensors Enhanced with in situ Formation of 2D Nanoparticles from Layered Materials

christopher.perkins@rutgers.edu — Tue, 08 Sep 2020 06:39:47 GMT

(a) elastomer enhanced with 2D nanoparticles is highly flexible; (b) elastomer sensor attached to arm to track the movement of fingers; (c) change in current value through the sensor due to finger motions Invention Summary: Conductive elastomeric polymer and rubber-based composites enhanced with graphene and other 2D nanoparticle fillers are capable of withstanding large strain in multiple directions, therefore they have shown tremendous promise as flexible sensors. However, conventional methods to produce 2D nanoparticles are expensive and mixing 2D nanoparticles with elastomers and r...

Boron Nitride Nanotube Membranes for Giant Power Generation

christopher.perkins@rutgers.edu — Fri, 04 Sep 2020 10:51:05 GMT

Fabrication method for vertically aligned BNNT membranes. Invention Summary: Rutgers scientists and collaborators have developed an innovative method to fabricate vertically aligned boron-nitride nanotube (BNNT) membranes with high nanopore density. BNNTs were aligned and concentrated in a liquid pre-polymer with an external field, and then locked in place by in-situ polymerization. The resulting membrane showed high ion selectivity even at high molarities and ultrafast cation transport. Under an osmotic concentration difference, the BNNT membranes generated electrical power at pow...

Novel Array Insert for One-Step 3D Cultures and Histological Processing

christopher.perkins@rutgers.edu — Thu, 03 Sep 2020 10:44:43 GMT

Schematic diagram of the technology. Organoid cultures can be grown in a basket array the size of a 96-well plate. The array can be shrunk down to fit into a histology cassette without need to transfer the culture. Invention Summary: Organoids are multicellular 3D structures that faithfully mimic their in vivo organ counterparts and are valuable tools for studying aspects of an organ in an in vitro setting. However, despite their use in research for over a decade, it is still challenging to process 3D cell cultures efficiently and accurately for histological assays. Histological analysis...

Synthetic Promoter-Based Azide Biosensor & Protein Induction System

christopher.perkins@rutgers.edu — Wed, 19 Aug 2020 07:44:51 GMT

(A) Escherichia coli BW25113-Wt cells with pCyn-v2-GFP plasmid were induced with varying azide concentrations and GFP fluorescence of cell lysate was measured over 24 hours. (B) E. coli BL21 contaning control pEC-GFP plasmid was induced with IPTG (isopropyl β-d-1-thiogalactopyranoside). (C). BW25113-Wt cells with pCyn-v2-GFP plasmid was incubated with 1-Glc-N3 vs. 2-Glc-N3 and induced GFP fluorescence of cell lysates due to azide release is shown here. Invention Summary: Azides are used as functional groups in fine chemicals and pharmaceuticals synthesis, and recently azide-function...

Novel Gene Therapy to Treat L-DOPA-Induced Dyskinesia

christopher.perkins@rutgers.edu — Tue, 18 Aug 2020 13:56:02 GMT

Viral vector injections of rAAV-∆FosB shRNA significantly reduced abnormal involuntary movements (AIMs) compared to control vector in a rat model of Parkinson’s disease. Invention Summary: Parkinson's disease (PD) is a progressive, debilitating, and currently incurable neurodegenerative disease. Long-term dopamine replacement therapy in PD leads to the development of abnormal involuntary movements known as L-DOPA–induced dyskinesia (LID). Alleviating this dyskinesia can lead to significant improvements in quality of life for patients with PD. The transcription factor ∆F...

Solidification Material for Soil Remediation

christopher.perkins@rutgers.edu — Thu, 13 Aug 2020 13:44:36 GMT

Fig 1. Depicts a comparison of triaxial CU strength for the mixture with Rutgers composition and Portland Cement Invention Summary: Management of dredged sediment can be problematic due to the presence of contamination limiting the likely pathways for disposal. The current method to manage these sediments involves stabilization and reuse of dredged material as capping or filling material for landfills and industrial sites. Contaminated dredged sediment is stabilized through the introduction of a binder. Portland cement is the primary binder used because of the interactions wit...

CerebroSense: A Brain Pulsatility Measurement Device

christopher.perkins@rutgers.edu — Wed, 12 Aug 2020 12:27:39 GMT

Invention Summary: During craniotomy, surgeons often determine the level of brain swelling based on finger tactile sensation in order to implement compensation measurements. However, under or over compensation can lead to severe complications such as cerebral ischemia. Researchers at Rutgers University and Stevens Institute of Technology have developed a portable device, CerebroSense, that utilizes a non-invasive sensing technology to provide a non-contact, quantitative, and real-time assessment of brain volume variations (pulsatility) during open brain surgery. CerebroSense has an ul...

Single-Step Multipurpose Surface Functionalization

christopher.perkins@rutgers.edu — Mon, 20 Jul 2020 08:54:10 GMT

Invention Summary: Surface functionalization offers a wide array of material properties, including wettability, chemical stability, biocompatibility, catalytic activity, sensing, antifouling, anti-microbial, and cell-affinity. Despite the great interest in controlling these properties, a surface functionalization technology that is simple, robust, and also generalizable has yet to be established. Rutgers researchers have developed an easy-to-apply, highly versatile drop coating technology for surface functionalization. Proof-of-concept testing has been performed by grafting bioactive ...

A Quick Estimation of Human Arterial Stiffness Using HRV

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:58:00 GMT

Invention Summary: Cardiovascular diseases (CVDs) are the leading cause of deaths worldwide. Arterial elasticity is an important indicator of existing cardiovascular risks of developing CVDs. Reduced arterial elasticity or increased arterial stiffness is known to be associated with hypertension, myocardial infarction and stroke. Being able to measure changes in arterial elasticity is crucial to the early detection of CVDs and successful treatments of these diseases subsequently. Arterial elasticity can be estimated from pulse transit time (PTT) or pulse wave velocity (PWV) measured by u...

Nanoelectronic Barcoding of Microparticles for Multiplexed Molecular Analysis

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:56:30 GMT

Invention Summary: Capability of detecting multiple protein and nucleic acid biomarkers is crucial to disease diagnosis and precision medicine. Barcoding of microparticles is one of the most common approaches for enabling multiplexed molecular assays. Although optical and plasmonic methods for barcoding particles have been developed, instrumentations involved are often bulky and expansive, preventing portability. Dr. Javanmard at Rutgers University has developed a novel system for portable, multiplexing biosensing applications. The multiplexing capability is achieved through the use of...

Low-Cost, Flexible, Paper-Based Plasma Sanitizer

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:56:23 GMT

Low-Cost, Flexible, Paper-Based Plasma Sanitizer Invention Summary: Healthcare-associated infections (HAIs) are a major challenge facing disease control organizations and healthcare providers worldwide. In 2011, there were 721,800 cases of HAIs reported in the US, with 75,000 patients ultimately dying from the infections. Because a leading cause of HAIs is improper sterilization and disinfection of medical tools and facilities, improved sterilization protocols could drastically reduce the number of HAIs. In order to address this need for improved medical sterilization in hospitals and p...

Gigantus1, A Newly Identified Gene Target for Improved Plant Growth and Yield in Agricultural Applications

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:53:55 GMT

Gts1- knockout plants (Gts-1) displayed faster germination and increased growth compared to wild-type (WT) plants. Invention Summary: Rutgers scientists discovered a new gene Gigantus1 (Gts1) in Arabidopsis thaliana, which significantly influences seed germination, growth and biomass accumulation in plants. The protein product GIGANTUS1 (GTS1) belongs to the WD40 protein superfamily, whose members are key regulators of plant development. Under the same growth conditions, Gts1 -knockout plants germinated faster and had significantly increased growth compared to WT plants (Fig. A...

In Vitro Model of Liver Steatosis for Screening of Drug Compounds

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:40:27 GMT

The decrease in liver steatosis in hepatocytes cultured in steatosis reducing medium. Invention Summary: Donor livers are frequently rejected due to high intracellular fat content, called steatosis, which increases the risk of primary graft non-function in transplant patients. Because liver transplantation remains the only effective treatment for end-stage liver disease, the inability to use steatotic livers significantly contributes to the worldwide donor liver shortage. Though several compounds have been identified for their potential to de-fatten steatotic livers, there is a need for...

Nutritional Supplement and Feed Compositions to Reduce the Incidence of Osteochondrosis Dissecans Lesions in Genetically Predisposed Foals

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:39:09 GMT

The dietary supplement formulation was developed based on an analysis of serum NMR data from yearling Standardbred horses with (green dots) and without (blue dots) OCD that showed the clear difference in metabolic profiles between genetically predisposed and unaffected horses. Invention Summary: Rutgers scientists and collaborators at Princeton University have developed a new dietary supplement specifically formulated to reduce the incidence of Osteochondrosis Dissecans (OCD) in genetically predisposed young horses. The dietary supplement was developed based on the results of nuclear mag...

Risk Terrain Modeling Diagnostics Software (RTMDx)

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:38:33 GMT

Invention Summary: Researchers at Rutgers who originally developed Risk Terrain Modeling, a methodology for diagnosing spatial crime vulnerabilities, have launched the Risk Terrain Modeling Diagnostics (RTMDx) Utility software. RTMDx helps to identify and communicate environmental factors associated with specific events. Reports produced can be used to anticipate places where illegal behavior and new crime incidents will emerge and/or cluster. Resources can then be developed for place-based interventions, strategically and tactically allocating resources, and prioritizing efforts t...

Anti-Diabetic Agents from Leaves of Combretum micranthum (Kinkeliba)

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:35:53 GMT

At 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group. Invention Summary: Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties. Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its na...

Uses of Kombo Butter Extract and Derived Compounds as Novel Neuroprotective Agents

christopher.perkins@rutgers.edu — Mon, 13 Jul 2020 12:34:40 GMT

Invention Summary: Rutgers scientists have developed novel methods to treat a variety of neurological disorders including ischemic stroke. The methods center on the use of novel neuroprotectants isolated from Kombo butter, an African nutmeg. The scientists additionally developed methods to produce and purify the Kombo butter, its extracts and derivatives. These compounds may find utility in the treatment of CNS. Market Applications: CNS Stroke Parkinson’s Alzheimer’s Neuroprotection Kombo butter Advantages: Complementary and alternative medicine. Intellectual Prop...

The Planck-Shannon Classifier Algorithm

christopher.perkins@rutgers.edu — Tue, 30 Jun 2020 11:30:40 GMT

There are many natural and human phenomena in the physical, biomedical, and social sciences that generate long-tailed asymmetric histograms (LTAH) that fit the Planckian Distribution Equation (PDE). It has been postulated that the Planckian process (defined as the physicochemical, socioeconomic, or cosmological processes that generate LTAH’s fitting PDE) involves a selection mechanism that can identify as special a subset of events out of all possible randomly organized events [1]. Figure 1. Some examples of long-tailed asymmetric histograms (LTAH's) that ...

ValiDNA: Forensic DNA Software

christopher.perkins@rutgers.edu — Tue, 30 Jun 2020 10:41:18 GMT

Invention Summary: DNA collected from a crime scene or environment can be used to determine the likely sources that explain the data. DNA signal is complex as it contains representations of partial genomes from any number of unknown contributors, which is ultimately affected by the processing decisions made by the laboratory. As such, advanced computational systems that help laboratories choose optimal laboratory conditions and provide useful information on the number and type of contributors to the evidence are needed. Rutgers researchers have developed a computational analysis...

Dementia Screening Tool for Home Health Care

christopher.perkins@rutgers.edu — Tue, 30 Jun 2020 09:06:47 GMT

Invention Summary Dementia is a common and growing public health problem in the United States and internationally. Researchers at Rutgers University have created a software integration to identify patients with significant cognitive impairment and probable dementia through the meaningful use of the standardized assessment data that is collected on all adult home health care patients using the U.S. Centers for Medicare & Medicaid Services (CMS) Outcome and Assessment Information Set (OASIS). Responses to routine OASIS questions are entered into a mathematical model to generate a dement...

Intellicount

christopher.perkins@rutgers.edu — Tue, 30 Jun 2020 08:25:26 GMT

Invention Summary: Aberrant synapse formation is implicated in a wide range of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and others. As a result, considerable effort has been invested in developing techniques and tools to understand the molecular mechanisms by which synapses form and function. Analysis of synaptic puncta by imaging synaptic proteins using immunofluorescent (IF) labeling is an established and commonly used technique. Existing approaches and materials used with IF to perform this analysis are time-consuming, prone to human err...

Novel Biofertilizer for Improving Plant Growth and Tolerance to Stress

christopher.perkins@rutgers.edu — Mon, 29 Jun 2020 07:17:38 GMT

Improved tomato root biomass after 21 days of salinity test Invention Summary: Rutgers University scientists have identified two new bacterial strains that can express 1-aminocyclopropane-1-carboxylate (ACC) deaminase, and a plant growth hormone. Its efficacy has been tested to benefit maize, tomato, and creeping bentgrass, a type of turfgrass. In particular, application of this biofertilizer can increase plant growth in terms of shoot biomass and root growth under low fertility, and enhance tolerance to heat stress, drought, and salinity stress. Bacteria present in fertilizer can dec...

Novel Sweet Basil Resistant to Downy Mildew

christopher.perkins@rutgers.edu — Mon, 29 Jun 2020 07:09:51 GMT

Reduced downy mildew symptoms and pathogen load two weeks after Peronospora belbahrii fungus exposure. Left panel: Gene-edited sweet basil; Right panel: Non-gene- edited sweet basil Invention Summary: Rutgers University scientists have developed a gene-edited sweet basil (Ocimum basilicum) line that is resistant to downy mildew by using CRISPR-editing technology. Specifically, CRISPR-gene editing was used to edit the sweet basil plants to reduce expression of homoserine kinase (HSK) and 2-oxoglutarate-Fe(II) oxygenase (2OGO). The novel basil has been tested for resistance against the ...

Conductive Polymer Nanocomposites Enhanced with in situ Formation of 2D Nanoparticles for Structural Sensors and Smart Materials

christopher.perkins@rutgers.edu — Mon, 22 Jun 2020 12:44:00 GMT

(a) Sensor used for structural monitoring. (b) Sensor performance during 30 N cyclic loading. (c) Temperature sensor monitored by thermal imaging camera. Invention Summary: Conductive thermoplastic polymer matrix nanocomposites enhanced with conductive 2D nanoparticles have applications for structural sensors and smart materials. However, mixing pre-formed 2D nanoparticles with polymers can lead to agglomeration and poor dispersion of the nanoparticles in the polymer matrix, hindering the commercialization of the nanocomposites. Researchers from Rutgers University have developed ...

Edge Assisted Real-time Object Detection

christopher.perkins@rutgers.edu — Thu, 18 Jun 2020 12:07:18 GMT

Image Credits: Zapp2Photo / Shutterstock Invention Summary: Most existing Augmented Reality (AR) and Mixed Reality (MR) systems understand the 3D geometry of surroundings but lack the ability to detect and classify complex objects in the real world- considered essential for these types of applications. Such capabilities can be enabled with deep Convolutional Neural Networks (CNN), but are limited by size due to difficulties in executing large neural networks on mobile devices. Offloading object detection to the edge or cloud is also, a challenge due...

Innovative Use of Mobile Devices for Medical Image Capture and Diagnostics

christopher.perkins@rutgers.edu — Tue, 16 Jun 2020 11:22:34 GMT

Invention Summary: There are many instances where quick and easy interpretation of a medical images, such as an x-ray, CT Scan, MRI or ultrasound is needed; for example, in a fast-paced trauma unit, or during a regional disaster or mass casualty incident. In these instances, the digital transfer of medical images, as wells as diagnosis, is difficult and time consuming due to the lack of interoperability of software protocols between imaging and diagnostic systems. Researchers at Rutgers University have developed a new, quick, cost-effective and accurate solution for tr...

Novel Ricin Inhibitors

christopher.perkins@rutgers.edu — Wed, 10 Jun 2020 14:06:45 GMT

(A) Model showing the interaction of Ricin toxin A (RTA) with the P stalk to access the sarcin/ricin loop (SRL) of the eukaryotic ribosome. 26S rRNA and 60S subunit are shown in light gray and dark gray, respectively. (B) The 50% inhibitory concentration (IC50) of fragments against RTA. Invention Summary: Ricin toxin is lethal to human at small doses, yet no FDA-approved vaccine or therapeutic exists to protect against ricin poisoning. Ricin inhibits protein synthesis by binding to ribosomes through the ricin toxin A subunit (RTA). To date, developing RTA active site inhibitors as rici...

Fluorescent Probe for Bacterial Cell Imaging and Screening of New Antibacterial Drugs

christopher.perkins@rutgers.edu — Mon, 11 May 2020 10:57:37 GMT

Visualization of the impact of FtsZ-targeting drug treatment in both Gram-positive and Gram-negative bacterial strains using BOFP. Bacteria were labeled with BOFP for 5 minutes just prior to visualization. Differential interference contrast (DIC) shows unstained bacteria and fluorescence shows BOFP-labeled bacteria. Invention Summary: At least 2.8 million people are infected, and more than 35,000 people die every year as a result of drug-resistant bacterial infections in the United States. There is an urgent need to develop new antibiotics against known and novel targets. FtsZ, an essent...

Nutrition Focused Physical Examination & Assessment (NFPE&A)

christopher.perkins@rutgers.edu — Thu, 07 May 2020 06:50:49 GMT

Summary: Nutrition focused physical examination and assessment (NFPE&A) refers to a head to toe physical examination by a Dietitian to determine signs and symptoms of malnutrition and nutrient deficiencies and factors impacting food and fluid intake and dysphagia risk, including inspection and palpation of the head, neck, mouth, muscle and fat stores and skin and cranial nerve examination. Integration of NFPE&A training and education can increase NFPE conduct by students in supervised practice and professional clinical practice as registered dietitian nutritionist...

High-Throughput Screening of Glycosynthases

christopher.perkins@rutgers.edu — Mon, 20 Apr 2020 07:21:30 GMT

Invention Summary: The ability to synthesize specific glycosidic linkages provides a way to produce designer glycans. Glycosytransferases that synthesize oligosaccharides are expressed poorly, have narrow substrate specificity and use expensive nucleotide sugars, limiting their utility in scaling-up glycan synthesis. Glycosynthases (GSs) offer an alternative biosynthetic approach to producing glycans in a facile manner. However, to date, only a limited number of GSs have been created from wild-type GHs using an inefficient empirical strategy. Rutgers researchers have implemented a dir...

Metallization of Plastics via Sacrificial Nanotransfer

christopher.perkins@rutgers.edu — Mon, 30 Mar 2020 06:18:26 GMT

Metalized plastic sample after demolding, plating up and polishing. Invention Summary: Durable metallization of plastics has been a challenge in the manufacturing of lightweight conductive surface composites. Researchers at Rutgers University have developed a scalable technique to metallize plastics via Sacrificial Nanotrasfer (SNT). The SNT process includes depositing a strike layer on a substrate, forming a nanomaterial layer with a nanotextured surface on the strike layer, embedding a polymeric material within the nanotextured surface and separating the strike layer from the substrat...

Coating with Self-Limiting Electrospray Deposition

christopher.perkins@rutgers.edu — Mon, 02 Mar 2020 07:21:52 GMT

Invention Summary: Researchers at Rutgers University have developed a scalable technique for depositing microscale coatings of a wide variety of materials and composites onto complex 3D additive or micromachined structures. The new coating process, based on self-limiting electrospray deposition (SLED), once deposited on the surface of a target material, generates a charged film that repels incident spray and redirects it to uncoated portions of the target material. It enables to conformally coat complex 3D structures without changing the location of the spray needle or orientation ...

Personalized and Timed Release of Biomolecules

christopher.perkins@rutgers.edu — Mon, 02 Mar 2020 07:05:01 GMT

Invention Summary: Protein/peptide-based therapeutics are powerful medications, however their use is often hampered by very short half-lives and the necessity for intravenous or subcutaneous injections. Researchers from Rutgers University and Massachusetts General Hospital have developed a novel method to deliver protein/peptide-based therapeutics via viral-mediated gene delivery or transplantation of genetically engineered cells. The expression of transduced genes and thus secretion/delivery of corresponding protein/peptide therapeutics can be achieved through various ways: 1)...

One-Step Exosome Isolation and Detection

christopher.perkins@rutgers.edu — Mon, 02 Mar 2020 07:01:08 GMT

Extract and concentrate exosomes immunomagnetically, analyze exosomal miRNA sensitively via metal-enhanced fluorescence effect. Invention Summary: Exosomes and their inner contents play critical roles in intercellular communication and signaling. The use of exosomes as next-generation biomarkers for stem cell differentiation monitoring and disease diagnosis has gained extensive interest in the biomedical research community. Current methods for exosome isolation are limited by large sample volumes and the requirement of specialized methodology (ultracentrifugation, chromatograph...

A Novel Vaccine Candidate Against Fungal Infection

christopher.perkins@rutgers.edu — Tue, 18 Feb 2020 10:25:34 GMT

Vaccination with a heat-killed mutant strain combined with an adjuvant enhances protection against fungal infections in a murine model, significantly improving survival protection against WT H99 challenge. Above are a series of graphs that show vaccine efficacy using the combination vaccine in intranasal inhalation, subcutaneous injection, and intramuscular injection models. Invention Summary: Invasive fungal infections kill over 1.5 million people annually with limited treatment options. Cryptococcus neoformans, for example, is a human fungal pathogen that often cau...

4D Printing of Microneedle Array for Enhanced Tissue Adhesion

christopher.perkins@rutgers.edu — Mon, 17 Feb 2020 11:42:36 GMT

Invention Summary: Microneedles are gaining attention because of the minimally invasive, pain-free, and easy-to-use nature. However, a major challenge for controlled long-term drug delivery or biosensing using microneedles is the low tissue adhesion. Rutgers researchers and collaborators have developed a method to fabricate microneedle array by a digital light processing 3D printing technique. Backward-facing curved barbs are created by desolvation-induced deformation utilizing cross-linking density gradient in a photocurable polymer. Barbs thickness and bending curvature are ...

Near infrared photocatalyst based on TiO2-coated gold nanoparticles

christopher.perkins@rutgers.edu — Thu, 13 Feb 2020 09:02:33 GMT

Invention Summary: Nanoparticles such as gold nanospheres, nanorods and nanostars are a promising additive to titanium dioxide (TiO2) to increase photocatalytic efficiency. Conventional TiO2-nanoparticles are promising materials to drive photocatalytic reactions using light. However, they can only use UV wavelengths to promote reaction. There is a need for materials with enhanced photocatalytic capacity under visible or infrared light in addition to UV. Rutgers researchers have developed a solution method to synthesize crystalline TiO2-coated gold nanostars at low-temperature,...

CAR-T and CAR-NK Immunotherapy for Hepatocellular Carcinoma

christopher.perkins@rutgers.edu — Wed, 12 Feb 2020 11:17:43 GMT

CAR-NK cells control progression of HCC in PDX model Invention Summary: Chimeric antigen receptor (CAR)-modified T cell therapy has become a promising immune-therapeutic strategy for the treatment of various blood cancers. Hepatocellular carcinoma (HCC) is the most common type of cancer that starts in the liver. HCC is the third most common cause of cancer-related death worldwide. It causes 662,000 deaths worldwide per year. Currently, there is no effective CAR-based immunotherapy to treat HCC. This invention disclosed a new chimeric antigen receptor targeting a surface marker of hep...

Improved Space Object Orbit Predictions

christopher.perkins@rutgers.edu — Thu, 06 Feb 2020 07:01:27 GMT

Invention Summary: Efficient, high precision orbit prediction is increasingly crucial for improved Space Situational Awareness (SSA), especially as the number of man-made objects in earth orbits continues to grow rapidly. Current orbit predictions that are solely grounded on physics-based models are not effective and robust enough to achieve the required accuracy. Scientists at Rutgers have designed a new strategy that fuses the newly developed machine learning (ML) approach with the classical orbit prediction using Extended Kalman Filters (EKF). This strategy defines the pseudo-phys...

NanoScript – Nanoparticle-based Synthetic Transcription Factor for Therapeutic Gene Modulation

christopher.perkins@rutgers.edu — Wed, 22 Jan 2020 07:15:48 GMT

Invention Summary: Since its introduction over two decades ago, the advancement of synthetic transcription factors has faced significant challenges, including poor membrane penetration, intracellular degradation, limited nuclear localization, low gene activation, and low synthesis efficiency. Rutgers scientists have developed a novel synthetic transcription factor (STF) platform capable of efficiently regulating the central dogma of molecular biology in a safe, non-viral, and transient manner. These STFs are composed of biocompatible nanoparticle core with modular transcription fac...

JSF-3285, A Novel KasA Inhibitor for Tuberculosis

christopher.perkins@rutgers.edu — Tue, 21 Jan 2020 09:04:34 GMT

Figure 1. Summary profile of JSF-3285: A) In vitro profile. B) X-ray crystal structure and binding constant for complex with KasA. C) In vivo profile in mouse chronic infection model. Invention Summary: New antibacterial drugs that treat multidrug resistant mycobacterium tuberculosis (MDR TB) represent an area of high medical need. The current tuberculosis treatment regimens involve multidrug combinations over an extended period and have associated side effects and toxicities. New TB drugs that reduce side effects and the total length of treatment may result in better patient ou...

DNA Logic-gated Proximity Assembly Circuit for Biochemical Sensing

christopher.perkins@rutgers.edu — Tue, 07 Jan 2020 11:20:17 GMT

Schematic summary of the dNANOSIS assay Invention Summary: Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid, and low-cost medical diagnosis that can be used by non-specialists at home, in the field or in an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and rapid treatment of the patients. POC testing requires unique features, including: (1) simplified operation (e.g. one-pot assay) by non-specialists at diverse locations, (2) easy-to-read signals, (3) a reliable and rapid assay and (4) low cos...

Low Profile Transfer Mechanism for Controlled Environments

christopher.perkins@rutgers.edu — Mon, 06 Jan 2020 11:26:30 GMT

Invention Summary: Various scientific and manufacturing processes are performed in special controlled environments (e.g., ultra-high vacuum, high radiation, air-stable, etc.) that require special chambers that maintain the desired environment. A device such as a superconducting magnet or cryostat is housed within the chamber that requires objects to be transferred during various operations. Current transfer mechanisms are large and rigid to accommodate the forces required to move objects to and from the device, and are typically very tall, requiring specialized laboratory space with very ...

Nanoparticle Delivery System for the Treatment of Non-Small Cell Lung Cancer and Targeted Cancer Therapy

christopher.perkins@rutgers.edu — Mon, 06 Jan 2020 10:29:17 GMT

Invention Summary: Rutgers scientists have invented a novel treatment strategy that relates to an intravenously (“IV”) administered lung targeted nanoparticle (NP)/ gel microparticle (GMP) delivery system for the treatment of non-small cell lung cancer (NSCLC). The delivery system delivers the chemotherapeutic agent camptothecin (CPT) along with a chemopotentiator. The chemopotentiator potentiates the effect of chemotherapeutic agents through stimulation of oxidative phosphorylation. Our chemopotentiation strategy confers two main advantages: (1) it induces an additive or syne...

A New Method to Treat Asthma and Allergic Reaction

christopher.perkins@rutgers.edu — Fri, 03 Jan 2020 08:22:46 GMT

PBS PeptideIntranasal peptide treatment inhibits ILC2-dependent mucus productionInvention Summary:Although most patients with asthma...

A Novel Approach for Expansion of NK and CAR-modified NK Cells

christopher.perkins@rutgers.edu — Fri, 03 Jan 2020 08:06:59 GMT

Fold expansion of NK cells from cord blood expanded with irradiated K562-mIL21 and RU-Feeder Cells Invention Summary: Chimeric antigen receptor T-cell immunotherapy (CAR-T cell therapy) requires engineering of T cells harvested from the patient. Natural killer (NK) cells are also cytotoxic immune cells, but work somewhat differently from T cell. Engineered NK cells (CAR-NK) can also be used to kill cancer cells. Compared with T-cell, NK based immunotherapy has less toxic side effects. However, it is hard to generate large quantities of expanded NK cells ex vivo since primary NK can only ...

Small Molecule Extracellular Inhibitors of TAM Receptors for Cancer Therapy

christopher.perkins@rutgers.edu — Fri, 13 Dec 2019 11:27:50 GMT

Invention Summary: The TAM receptors (Tyro3, Axl, and Mertk) are a family of three homologous receptor tyrosine kinases (RTKs) that play important roles in tissue homeostasis, immune response, and the resolution of inflammation. Besides the intracellular catalytic kinase domain common to all kinases, the TAMs uniquely contain an extracellular domain that distinguishes them among all known kinases. TAMs are overexpressed in many human cancers, thereby promoting tumor proliferation, migration, survival, and immune escape. TAM dysregulation tracks with more aggressive cancers, poorer predic...

Image Processing Neural Network Systems and Methods with Scene Understanding

christopher.perkins@rutgers.edu — Thu, 12 Dec 2019 10:46:59 GMT

Using ScenarioNet to find high-level similarities and differences between two images Purpose: The ability for computational agents to reason about the high-level content of real-world scene images is important for many applications. For example, for many applications (e.g. robotics, human-machine teaming, surveillance, and autonomous vehicles), an agent must reason about the high-level content of real-world scene images in order to make rational, grounded decisions that can be trusted by humans. It is often also necessary to have models that can be interpreted by humans in order ...

Dewetting-Based Spatial Light Modulator for High-Power Lasers

christopher.perkins@rutgers.edu — Thu, 12 Dec 2019 10:38:08 GMT

Invention Summary: Current spatial light modulator (SLM) technology relies on either digital mirror arrays or liquid crystal reflective and transmittive cells. However, due to the upper bounds on the maximum light intensity of those systems, the applications of SLMs in fields where high intensity is required are limited. Researchers at Rutgers University have developed dewetting-based SLMs which can cover all major laser wavelengths at similar pixel resolution and can work with high power laser source. The SLM in this invention comprises a mirror-like thin film and a layer of...

Scalable Fabrication of Pristine Holey Graphene Nanoplatelet

christopher.perkins@rutgers.edu — Thu, 05 Dec 2019 06:50:00 GMT

Invention Summary: Rutgers Researchers have developed a novel and scalable approach to fabricate pristine holey graphene nanoplatelets nearly free of defects and metal residues via dry microwave irritation. The hole edges can be controlled to be rich in zigzag geometry, which is the preferred structure for catalytic and electronic applications. The researchers have tested the potentials of this invention in catalytic applications in both electrochemical and chemical reactions. Molecular oxygen can be reduced directly to water with a 4e pathway in acidic solutions, which is critical for...

Scalable, Secure, and Broad-Spectrum Mechanism for Enforcement of Protocols

christopher.perkins@rutgers.edu — Tue, 19 Nov 2019 14:05:46 GMT

Agents Interacting based on Protocols Invention Summary: There is a growing realization in the commercial world that trust among members of a multi-agent systems operating electronically over the Internet is needed. Trust can be accomplished by enforcing (governing) electronically, a contract, policy, or another type of protocol to govern transactions among members. Rutgers researcher, Dr. Naftaly Minsky, has developed a novel control mechanism (“COP”) that governs interactions among members of multi-agent distributed systems — which can include software p...

Combination of two compounds present in Coffee Synergize to Protect against Parkinson’s & other Neurodegenerative Disorders

christopher.perkins@rutgers.edu — Mon, 23 Sep 2019 07:26:14 GMT

Synergistic neuroprotection by two compounds found in coffee (EHT/Caffeine) slow down brain degeneration in models of Parkinson’s Disease and Dementia with Lewy Bodies Invention Summary: Parkinson's disease (PD) is the second most common neurodegenerative disorder, and Dementia with Lewy bodies (DLB) is the second most common type of dementia after Alzheimer’s disease. Both these disorders are progressive, debilitating, and currently incurable. The protein alpha-Synuclein (α-Syn) aggregates as fibrils in Lewy-bodies and Lewy-neurites in the brain in both conditions...

Novel Computational Tool for Understanding Protein Interactions and Generating Energy Maps

christopher.perkins@rutgers.edu — Fri, 23 Aug 2019 12:55:03 GMT

Generation of the interior and exterior residues, which are predominantly hot and cold, respectively (red/salmon = high, white = middle, cyan/blue = low μ-factors), in a catalytic site of an enzyme using the novel computational model. Invention Summary: Most computational models rely on large numbers of weak interactions to describe protein energetics. One challenge of folding a protein through computer modeling and simulations using quantum mechanics lies in finding the global minimum of the protein conformational energy landscape which corresponds to a region close to the global e...

Computer-Aided Diagnosis of Cancer by Magnetic Resonance Spectroscopy

christopher.perkins@rutgers.edu — Fri, 23 Aug 2019 12:40:48 GMT

Comparison of MRS analysis using three different dataset reduction schemes. The white box corresponds to the potential cancer space defined from whole-mount histological sections. Colors correspond to the classification of tissue: Red = cancerous, blue = benign, green = indeterminate. Left: z-score; Middle: Principal component analysis (PCA); Right: Nonlinear dimensionality reduction (NLDR). Invention Summary: Combining structural information from Magnetic Resonance Imaging (MRI) with metabolic information from Resonance Spectroscopy (MRS) can greatly improve detection of cancer. Howev...

Automated Detection and Classification of Tumors from Digitized Histological Tissue Specimens

christopher.perkins@rutgers.edu — Fri, 23 Aug 2019 12:35:45 GMT

Flowchart illustration of the working of the algorithm Invention Summary: Computer-aided diagnosis (CAD) systems can automatically sort digitized medical images which can otherwise be a time-consuming process. Researchers at Rutgers have developed a CAD method to automatically distinguish between tumor and benign regions in digitized prostate histology. The image analysis is performed in a multi-resolution framework, which is similar to the method in which a pathologist would conduct diagnosis. The structure of interest is first segmented into smaller images to quickly scan and class...

Methods for Robust, Accurate and Real-time Localization of Needles in 2D and 3D Ultrasound

christopher.perkins@rutgers.edu — Fri, 23 Aug 2019 12:26:29 GMT

Invention Summary: Ultrasound imaging is commonly used to guide the placement of needles for tissue biopsies, catheter insertions, drainages, and anesthesia. However, visual artifacts make it difficult to locate the needle in cases of steep insertion angles (40-80 degrees) and depths (9 cm). Hence, there is a need for a method for real-time needle detection. Researchers at Rutgers University developed a novel method for automatically localizing a needle and other surgical tools using 2D/3D ultrasound in real-time. By applying deep learning-based convolution neural net...

High-throughput gene expression screening in activated T-cells using FISH-Flow

christopher.perkins@rutgers.edu — Fri, 23 Aug 2019 11:23:41 GMT

Induction of gene expression and subsequent detection by FISH-Flow. c-fos expression is induced in activated cells, which are readily identified by FISH-Flow. GFP: negative control, GAPDH: positive control. Invention Summary: Many immune responses to pathological conditions involve the activation of T-cells by specific antigens. The interactions between the antigens and the T-cell receptors (TCRs) lead to intracellular signaling cascades, which trigger changes in gene expression. These changes are typically assessed by protein presence, either at the cell surface or secreted, fo...

High-fidelity amplified FISH (amp-FISH) for sensitive and specific in situ detection of RNA

christopher.perkins@rutgers.edu — Fri, 23 Aug 2019 11:15:50 GMT

amp-FISH probes can distinguish single-nucleotide variations within single mRNA molecules and produces amplified signals in situ for both mutant and wild-type variants, each in a distinct color. Invention Summary: Fluorescence in situ hybridization (FISH) is used in clinical and research applications to detect and visualize specific nucleic acid targets within cells or tissues. Detection of rare or small nucleic acids species and distinction between targets that differ only by a single base, however, is challenging. Rutgers scientists have developed masked hairpin binary probes tha...

Panel & Software to Predict Therapeutic Resistance in Cancer Treatment

christopher.perkins@rutgers.edu — Fri, 23 Aug 2019 10:58:00 GMT

Invention Summary: According to the American Cancer Society, prostate cancer is the second most common malignancy in men and the second-highest cancer-related cause of death in American men. Androgen deprivation therapy (ADT), which reduces or prevents male hormones (androgens) from interacting with cancer cells, has been shown to be beneficial in treating prostate cancer in about half of all cases. However, for the remaining cases, ADT counterintuitively results in a more aggressive cancer. Therefore, knowing how a patient will respond to ADT before the start of therapy can ens...

Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration

christopher.perkins@rutgers.edu — Mon, 19 Aug 2019 06:55:47 GMT

Invention Summary: The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have been recently explored with the use of membrane modifications, spheroid-based 3D bio-printing and thermo-responsive polymers. However, cell assemblies...

Methods for Robust, Accurate and Real-time Localization of Needles in 2D and 3D Ultrasound

christopher.perkins@rutgers.edu — Mon, 17 Jun 2019 06:30:57 GMT

Computational Ultrasound for Improved Liver and Kidney Diagnosis

christopher.perkins@rutgers.edu — Fri, 14 Jun 2019 10:55:44 GMT

Invention Summary: Transabdominal ultrasound is the one of the most widely used imaging modality for initial imaging of patients diagnosed with liver diseases such as Hepatitis C virus and non-alcoholic fatty liver disease. However, current imaging processes cannot differentiate simple steatosis, nonalcoholic steatohepatitis, and hepatic fibrosis. Researchers at Rutgers University developed a novel method for the extraction of local phase image features from liver and kidney ultrasound data for the enhancement of medical image data. The invention enables a high level of visual clarity...

New Targeted Gene Therapy for Treatment of Duchenne Muscular Dystrophy

christopher.perkins@rutgers.edu — Thu, 13 Jun 2019 07:01:54 GMT

Invention Summary: Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. It is a genetic disorder and patients suffering from DMD experience gradual muscle weakness in early childhood and are non-ambulant by 12 years of age. The progressive nature of this disease leads to restrictive pulmonary function, diaphragm dysfunction and cardiomyopathy. At present there is no cure for DMD. Patients can only rely on therapies that can ease symptoms. There is a constant need to identify new therapeutic targets based on disease mechanism to complement th...

Rutgers Scarlet™ Strawberry

christopher.perkins@rutgers.edu — Wed, 12 Jun 2019 07:42:25 GMT

Invention Summary: Rutgers Scarlet Strawberry was bred to grow well in NJ’s wide range of soils and to withstand the dramatic swings in NJ’s climate. It was produced for consumers interested in the best tasting strawberries when picked and eaten fresh from the farm. Rutgers Scarlet is sweet, balanced with just the right amount of acidity. There is no need to add sugar, an important trait in an era when grocery store strawberries often lack real taste. The Rutgers Scarlet is also a beauty. It keeps its strawberry red color throughout, with no white middle. After over a ...

Signal Transmission Enabling Secret Communications

christopher.perkins@rutgers.edu — Mon, 22 Apr 2019 12:55:04 GMT

Invention Summary: Most modern secure communications systems today use cryptography to make a message unintelligible to an eavesdropper. This process comes with a cost: it lowers the maximum data rate, and can be computationally expensive. In addition, it requires complex encryption key sharing and management systems. Researchers at Rutgers University have developed a physical layer approach to secure communications. By using distributed beam forming and active feedback, the system aligns the transmitters’ phases at the target, precisely focusing energy at that poin...

Damage Resistant Glass-Ceramic

christopher.perkins@rutgers.edu — Mon, 22 Apr 2019 12:42:10 GMT

This material has better hardness and crack resistance than any commercially available glass Invention Summary: Rutgers University researchers have developed an Al2O3 rich damage resistant glasses and glass-ceramics, which exhibit Vickers hardness of >7 GPa and do not crack at loads as high as 2000 gf (19.6 N). The resistance to fracture is one of the most critical properties to define the applicability of oxide glasses in modern industries and infrastructure. In oxide glasses, surface flaws can lead to catastrophic failure, as tensile stress concentrated at the tips of the flaws. ...

Ultrasound-guided Alignment and Insertion of Percutaneous Cannulating Instruments

christopher.perkins@rutgers.edu — Fri, 05 Apr 2019 12:41:14 GMT

(Left) Device prototype. (Right) Short-axis ultrasound image of segmented vessel for insertion. Invention Summary: Gaining access to blood vessels is a critical first step in a plethora of diagnostic and therapeutic procedures (see market applications). The timely delivery of these interventions can affect morbidity and mortality, yet in difficult conditions, access can be highly challenging. Difficulties are exacerbated in patients with small, tortuous, or collapsed vessels, which are common in pediatric, elderly, chronically-ill, traumatic, and hypovolemic patients. Poorly introduced ...

New Technique to Grow Low Defect Single Crystalline Thin Films

christopher.perkins@rutgers.edu — Mon, 01 Apr 2019 07:52:26 GMT

Invention Summary: Rutgers Researchers have developed a method to grow a large scale of high quality single crystalline In2Se3 thin film using a temporal seed of Bi2Se3. This technology can be used in fabricating high quality In2Se3-incorporated devices, such as low-defect-density Bi2Se3, an archetypical 3D topological insulator. Interfacial and bulk defects have remained the major obstacles for further progress in the field of topological insulators (TI) since their discovery. To realize the functional TI devices for application in quantum computer and spintronics, a defect-suppress...

An Injectable and Long-Acting Local Anesthetics

christopher.perkins@rutgers.edu — Mon, 01 Apr 2019 07:43:27 GMT

Invention Summary: Local anesthetics prevent or relieve pain by interrupting nerve conduction. Even the long-acting local anesthetic agents (e.g., bupivacaine, levobupivacaine, ropivacaine) can only provide analgesia for 4-18 hours. Because of the short duration, local anesthetics often have to be given by repeated injection or continuous infusion. The inventors havedeveloped an injectable PLGA-coated ropivacaine, which has a dose-dependent, reversible, and long-lasting analgesic effect on post-operative pain and neuropathic pain. The maximal duration of this composition's analgesi...

Prodrugs and ADC Derivatives of Non-Camptothecin TOP1-Targeting Cancer Chemotherapeutics

christopher.perkins@rutgers.edu — Wed, 13 Mar 2019 13:14:39 GMT

Schematic Structure of an Antibody-Drug Conjugate (ADC) (en.wikipedia.org) Invention Summary: Topoisomerase 1 (Top1) is an essential enzyme in mammalian cells and is a validated target for the treatment of human cancers. Topotecan and irinotecan (camptothecin analogues) are two FDA approved Top1-targeted drugs. Despite being powerful anticancer drugs, camptothecin derivatives exhibit clinical limitations due to the instability of their α-hydroxylactone six-membered E-ring structure. Genz-644282 is a novel non-camptothecin topoisomerase I inhibitor developed by Rutgers scientists. G...

Engineered GH for Improved Glycan Polymer Synthesis

christopher.perkins@rutgers.edu — Wed, 06 Mar 2019 08:37:00 GMT

Invention Summary: Oligosaccharides and polysaccharides (or glycans) are complex macromolecules in living systems that serve critical structural and functional roles. In vitro synthesis of these complex biomolecules is very challenging. Glycosytransferases are naturally available enzymes that catalyze the synthesis of glycans, but have poor expression yield, narrow substrate specificity, and use expensive nucleotide sugars. Rutgers scientists have engineered a multifunctional family 5 glycosyl hydrolase (GH-5 called CelE) from Clostridium thermocellum into a transglycosidase to synthes...

Multilayer Stackable Tissue Culture Platform for 3D Co-Culture

christopher.perkins@rutgers.edu — Wed, 06 Mar 2019 08:30:11 GMT

Invention Summary: In a native tissue inside an animal, different types of cells co-exist and communicate with one another through the surrounding microenvironment using chemical and mechanical signaling. The lack of technology to recreate such a microenvironment in in vitro models results in either under or over prediction of results using conventional two-dimensional (2D) in vitro cell culture systems. Researchers at Rutgers have developed a simple device for 3D co-culture. Unlike conventional tissue culture inserts for co-culturing cell types in two or three separate compartments, t...

Explainable Decisions of Algorithms Using Examples

christopher.perkins@rutgers.edu — Tue, 26 Feb 2019 10:30:32 GMT

Artificial Intelligence algorithms (AI) and Machine Learning (ML) are used across a widening array of application domains. To trust the decisions made by these algorithms it is important for people to understand how they arrive at them. Invention Summary: Researchers at Rutgers University have created a novel solution that uses Bayesian Teaching for explaining the decisions made by AI algorithms. Bayesian Teaching is a model-agnostic system that samples data subsets to explain model inferences to a domain (but not necessarily technical) expert. This solution allows a user to ask ...

Iridium Catalyst for Dehydrogenative Dimerization of Ethylene to Yield 1,3-Butadiene

christopher.perkins@rutgers.edu — Thu, 21 Feb 2019 18:57:43 GMT

Schematic diagram of the catalytic dehydrogenative dimerization of ethylene to butadiene Invention Summary: 1,3-Butadiene is a chemical building block, most notably known for the production of synthetic elastomers and polymers. Traditionally, 1,3-butadiene is produced as a byproduct of naphtha cracking for ethylene production. Due to new sources, ethylene production has shifted away from naphtha cracking towards cracking ethane-rich shale gas. This has a left an unmet demand for 1,3-butadiene. Researchers at Rutgers University developed a new method of producing 1,3-butadiene using a p...

UAV-based Delivery of Solid Insecticide

christopher.perkins@rutgers.edu — Fri, 25 Jan 2019 11:35:14 GMT

Invention Summary: Mosquito borne diseases constitute more than half a billion illnesses and over a million deaths yearly. Wide-scale mosquito pesticide and larvicide dispersion (e.g., aerial dispersion) is no longer a viable option due to 1) posing public health concerns, and 2) urban area expansion into mosquito habitats, making mosquito control untenable. Hence, targeted delivery of mosquito control payloads to inaccessible areas should be used to avoid environmental contamination and adverse human effects. Rutgers researchers have developed a new mechanism for the targeted delivery...

Novel Nanomaterial for Prolonged and Sustained Antibacterial Efficacy

christopher.perkins@rutgers.edu — Fri, 18 Jan 2019 11:00:53 GMT

a) BAC release profile at pH 4.0, 5.0, 6.5, and 7.4. b) The percentage of S. aureus survival upon exposure to BAC loaded nanoparticles after 0, 3, and 6 hours. Invention Summary: Quaternary ammonium cationic (QAC) surfactants are one of the preferred choices for antibacterial applications. The compounds are water and oil soluble, and they cover a broad spectrum of antimicrobial efficacy including gram-positive and gram-negative contaminations. In applications such as bandages and surgical dressings, extended release of active compounds would be beneficial and desirable. Researchers at ...

Value-based Information Flow Tracking for Mobile, Wearable, and IOT Sensor Devices

christopher.perkins@rutgers.edu — Fri, 18 Jan 2019 07:02:50 GMT

Invention Summary: Mobile devices have a variety of sensors that enable a wide range of useful applications from step tracking to point of care medical services. In addition, sensors are now in automobiles, IoT and other devices. As the use of devices with sensors increase, it becomes important that information from theses sensors does not leak to outside parties. Researchers at Rutgers university and UCLA have designed a novel Information Flow Tracking (IFT) technique and software, called METRON, that implements a value-based tracking solution to detect potential data leaks from apps ...

A Novel, Tailor-Made MOF for Exceptionally Efficient Separation of Propane and Propylene

christopher.perkins@rutgers.edu — Thu, 06 Dec 2018 09:21:51 GMT

Invention Summary: Separating mixtures of propane and propylene is often challenging and energy intensive. In industrial settings this separation is typically performed by cryogenic distillation, requiring low temperature and/or pressure. Metal-organic frameworks (MOFs) are emerging as promising low-energy alternatives to energy-intensive distillations, as their performance is often comparable to industrial benchmarks with a reduced energetic cost. Researchers at Rutgers University have developed a novel MOF for efficient separation of propylene and propane by size-selective exclusion....

FileWall: Controlling Access to Network File Systems

christopher.perkins@rutgers.edu — Wed, 28 Nov 2018 13:22:11 GMT

Summary: Filewall describes a system architecture for extending and enhancing file system functionality in a network, without modifying the underlying file system clients and servers. FileWall is meant to interpose on a network path between file system clients and servers. It operates by using file systems extensions that transform messages as they flow between clients and servers. Advantages: FileWall provides a powerful method for controlling access to a file system using customized extensions into existing file systems. It enables tailoring existing files syste...

Flexible High Voltage Thin Film Transistor for Self-powered Wearable Electronics

christopher.perkins@rutgers.edu — Wed, 28 Nov 2018 13:03:36 GMT

f-HVTFT mounted on a platform for bending test Invention Summary: Wearable systems have been emerging for broad applications. One of the major technical challenges for the technology is its power management. The self-powered wearable electronics which aim to provide users continuous, non-interrupted, and hassle-free experiences are highly desired. However, current self-powered technology faces 3 challenges: (1) unstable due to the environment variations; (2) requirement of an external bulky power management component, and (3) built on the rigid substrate. To address these issues, a res...

Boundless Analytics

christopher.perkins@rutgers.edu — Mon, 26 Nov 2018 12:31:41 GMT

Invention Summary: Data scientists take an enormous mass of messy data points (unstructured and structured) and use math, statistics, and programming to clean, massage, and organize them. Then they apply analytic expertise (e.g. industry knowledge, contextual understanding, skepticism of existing assumptions) to uncover hidden solutions to business challenges. This process of uncovering hidden patterns visualized as plots take a tremendous amount of programming, which is often quite repetitive and tedious. As a result. companies need to hire highly paid, in short supply, data s...

Novel metal-organic frameworks for efficient separation of alkane isomers

christopher.perkins@rutgers.edu — Fri, 19 Oct 2018 06:52:19 GMT

Schematic representation of two-stage MOFs absorbent bed for the separation of alkane mixtures to pure form of each isomer (straight line, mono-branched and di-branched) Invention Summary: The separation of alkane isomers represents a critical yet challenging process in the petrochemical industry to produce high-quality gasoline. As an alternative technology to energy intensive distillations, adsorptive separation by porous solids offers lower energy cost and higher efficiency. Researchers at Rutgers University have developed a series of novel metal-organic frameworks (MOFs) for the ef...

A Molecular Trap for Capturing Radioactive Organic Iodides from Nuclear Waste

christopher.perkins@rutgers.edu — Wed, 19 Sep 2018 08:40:46 GMT

Molecular trap is 340% more efficient than current processes Invention Summary: Rutgers University researchers have developed a metal-organic framework (MOF) molecular trap to remove radioactive organic iodides (ROI) from nuclear waste streams. Nuclear power provides ~11% of the world’s electricity currently. How to safely dispose nuclear waste is still a big challenge we are facing. 129I and 131I and other iodine isotopes generated from the fission reaction of uranium and plutonium in nuclear reactors are a suspected cause of thyroid cancer. 129I has a half-life of 15.7 milli...

Novel Monodisperse PEGtide Dendrons as Nanocarrier for Drug Delivery

christopher.perkins@rutgers.edu — Tue, 24 Jul 2018 12:02:21 GMT

Representative Structure of PEGtide Invention Summary: Dentrimers and dendrons have generated tremendous interest as nanocarriers for various drug delivery applications. Rutgers scientists have developed a series of novel monodisperse PEGtide dendrons with versatility to accommodate various drug delivery demands. PEGtide dendrons containing alternating discrete poly (ethylene glycol) (dPEG) and amino acid/peptide moieties defines a new family of dendrons with significantly improved safety, biocompatibility and purity compared to its peers. A tunable interior void size that can reache...

Resolvable Spray-On Hydrogel as Wound Dressing and Drug Delivery Agent

christopher.perkins@rutgers.edu — Tue, 24 Jul 2018 11:45:22 GMT

Invention Summary: Hydrogel-based wound dressing is an accepted clinical practice for the promotion of wound healing and/or drug delivery. However, current hydrogel-based technologies have disadvantages including difficulty in removal, prone to gelling during packaging or storage, and requiring temperature manipulation before administration. Rutgers scientists have developed a novel and easy to use hydrogel wound dressing that gels in-situ immediately upon the mixture of two solution systems. This hydrogel can be administered by a spray and has a unique feature of reversibility, which ...

Rapid and Efficient Production of High Lysine and High Methionine Quality Protein Maize

christopher.perkins@rutgers.edu — Thu, 05 Jul 2018 08:57:15 GMT

Lysine and methionine content of novel Quality Protein Maize lines, the opaque high lysine line W64A o2, and non-transgenic AxB. Observe that PE5, α-γ- kernels have the highest lysine and methionine levels, but are opaque. PE5, γ- has high lysine and methionine levels and a vitreous kernel, making it the best candidate for QPM animal feed. Invention Summary: Rapid production of novel Quality Protein Maize (QPM) lines with improved protein quality and vitreous kernels, suitable for animal feed without synthetic methionine supplementation. Conversion of elite lines to...

Nanowell Array Sensor Chip for Biosensing in Blood Samples

christopher.perkins@rutgers.edu — Wed, 20 Jun 2018 07:38:53 GMT

Entire multiwell plate chip and a schematic view of the 2-μm nanowell array sensor. The sensor is comprised of an array of 25 nanowells etched on the overlapping electrode surface. Invention Summary: The current gold-standard for protein quantification in laboratory tests is enzyme linked immunosorbent assay (ELISA), which typically relies on optical fluorescence, and labeling of complementary molecules, resulting in lengthier and more costly testing. A team of scientists from Rutgers and U Penn has invented a nanowell array sensor system capable of performing electrochemical imped...

Biodegradable Scaffold for Advanced Stem Cell Therapy

christopher.perkins@rutgers.edu — Fri, 01 Jun 2018 08:14:31 GMT

Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet Invention Summary: While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation. Researchers at Rutgers University developed a biodegradable manganese oxide-polymer hybrid scaffold designed to selectively guide stem cell differentiation while acting as a controlled drug delivery system. The biodegradable manganese oxide layer allows for drug loading a...

Drug Candidate for the Treatment of Dilated Cardiomyopathy

christopher.perkins@rutgers.edu — Thu, 17 May 2018 08:52:22 GMT

Invention Summary: Dilated cardiomyopathy (DCM) is the most common cause of heart failure. About 5.7 million adults in the United States have heart failure, and approximately half million new cases are diagnosed annually. Patients with DCM can lead to arrhythmias, and about half of people who develop heart failure die within 5 years of diagnosis. Current treatments for DCM are focused on symptom relief. There is a need for new drug to improve the heart condition and to treat arrhythmias and myocardial fibrosis of DCM patients. This invention provides a method to promote angiogenesis (f...

Treatment for Neuropsychiatric Disorders by Intravitreal Injection of DREADD Followed by Eye Drops or Pills Containing DREADD agonist

christopher.perkins@rutgers.edu — Mon, 07 May 2018 06:52:29 GMT

Figure 1. DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like behavior as measured by the forced swim test (FST). Abbreviations: chronic dark rearing (DD); chronic dark rearing with a control virus expressed in retinal cells (DD-GFP); DREADD receptors-mediated activation of retinal cells during chro...

Metallic Nanosheets-Based Electrochemical Actuator

christopher.perkins@rutgers.edu — Wed, 18 Apr 2018 06:53:00 GMT

a, Scanning electron microscope image of restacked 1T phase 2D MoS2 film. b, The electrochemical system consists of a working electrode (the actuator) along with a counter electrode (Pt) and a reference electrode (standard calomel electrode, SCE) submerged in 0.5 M H2SO4. c, Images of curvature induced by charge intercalation in free-standing (that is, no Kapton beam) 1T MoS2 film on gold (scale bar, 1 cm). d, e, Diagram (d) and photograph (e) of actuation in forward and backward directions by modulation of the electrode potential between -0.3 V and + 0.3 V. Invention Summary: Actuators...

Small Molecule Fluorescent Probe

christopher.perkins@rutgers.edu — Tue, 17 Apr 2018 06:45:51 GMT

Sensitivity of detection method with ROC, comparison of NIR probe with conventional Invention Summary: Fluorophores in the near infrared (NIR) range, where body tissue is transparent, are promising alternatives to radioactive labels. Conjugation of NIR dyes to targeting agents enables specific detection of molecules of interest. However, conventional NIR probes are bulky, resulting in interference with the activity of the targeting molecule and limited cell uptake. In response to these challenges, Rutgers researchers have developed a small, DDAO-derived, near infrared fluorophore that...

Rapid Molecular Assays for Fungal Infections

christopher.perkins@rutgers.edu — Tue, 17 Apr 2018 06:21:07 GMT

Sensitivity of real-time NASBA assay for fungi. B: pan-Candida probe, C: pan-Aspergillus probe Invention Summary: Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. However, the current standard of care for diagnosis is blood culture, a method limited by the time to diagnosis (1-2 days), frequency of false negatives, and the difficulty in culturing certain fungi. The emergence of drug-resistant fungi adds an additional obstacle to effective treatment. While molecular assays have enabled rapid, sensitive diagnosis of bacterial ...

Fluorescent Detection of Fungal Pathogens

christopher.perkins@rutgers.edu — Mon, 16 Apr 2018 12:44:08 GMT

Mice infected intrastromally with three different strains of Aspergillus (A. fumigatus, A. flavus, A. niger). Labeling of infected area using caspofungin-conjugated fluorescent probe. Invention Summary: Diagnostic imaging could provide important spatial information about fungal infections, but current imaging modalities lack specificity for fungal pathogens. Imaging in the near infrared (NIR) range, where body tissue is transparent, is particularly promising, but conventional NIR probes are to large to enter cells and access fungal pathogens. In response to these challenges, Rutgers r...

Molecular Assays for Identification of Echinocandin Resistant Fungi

christopher.perkins@rutgers.edu — Mon, 16 Apr 2018 11:48:52 GMT

Representative melting profiles for C. Glabrata after amplification of clinical isolates A) FKS1 HS1 primers B) FKS2 HS1 primers. DNA sequencing was used to confirm predicted genotypes (indicated by markers) Invention Summary: Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. Echinocandin antifungal drugs are fist-line therapy for infections due to Candida species, but the emergence of drug-resistant fungi during therapy limits the ability of physicians to effectively treat fungal infections. Rutgers researchers have developed...

Biosensor for Therapeutic Drug Monitoring of Fungal Drugs

christopher.perkins@rutgers.edu — Mon, 16 Apr 2018 10:57:21 GMT

Aptamer-based GFET devices show a detectable threshold Dirac voltage shift between 0.1 mg/mL and 0.1 µg/mL with posconazole, but no shift with caspofungin (echinocandin). Invention Summary: To safely and effectively treat patients with anti-fungal drugs, physicians must understand the pharmacokinetics (PK) of those drugs In patients. However, the PK of azole antifungal drugs are patient dependent. If physicians can monitor levels of drug in real time, then they can better optimize dosages for an individual patient. Researchers at Rutgers have developed an aptamer-based graphene ...

Versatile Biodegradable, Bioactive-Based Polymers for Topical, Cosmetic and Personal Care Applications

christopher.perkins@rutgers.edu — Thu, 29 Mar 2018 12:01:01 GMT

A. Structure of salicylic acid-based polymer and its degradation products. B. Polymer degradation rates with different linker molecules. C. Free ferulic acid in aqueous solution is unstable and turns brown after 10 days (left). Ferulic acid-based polymers are stable and aesthetically more pleasing in solution under the same condition (right). Invention Summary: Many cosmetically relevant bioactive molecules, such as salicylic acid, kojic acid, ferulic acid, p-coumaric acid, and sinapic acid, have been successfully incorporated into the polymers. These polymers are easy to synthesize, ...

Novel Bronchodilator Therapy for Asthma, Chronic Obstructive Pulmonary Disease and Cystic Fibrosis by Gα12 Inhibitors and Rho Inhibitors

christopher.perkins@rutgers.edu — Tue, 27 Mar 2018 10:36:51 GMT

Figure 1 Gα12 signaling and RhoA-dependent activation of the PI3K/ROCK axis Figure 2 Gα12 siRNA attenuates carbachol-induced MLC (myosin light chain) phosphorylation in vivo. Reduced MLC phosphorylation indicates human airway smooth muscle relaxation. Carbachol activates Gα12 -coupled M3 muscarinic receptors in human airway smooth muscle. Invention Summary: Airway Hyperresponsiveness (AHR), a hallmark of asthma, represents exaggerated airway narrowing in response to contractile agonists such as acetylcholine. Human airway smooth muscle cells (HASMCs) mediate AHR by s...

Detection, Diagnosis, & Prediction of Dental Periapical Diseases Using Image Processing Techniques (Digital pixel intensity software/technology)

christopher.perkins@rutgers.edu — Mon, 26 Mar 2018 13:43:16 GMT

Overlaid pixels allow determination of issues, location, courses of treatment, progression. Invention Summary: Incorrect diagnosis of periapical lesions may lead to either progression of the disease of unnecessary surgical procedures. This new method and adapted software provides DIFFERENTIAL DIAGNOSIS, EARLY DETECTION and information not obtainable via visual (eyeball) inspection radiography for treatment of periapical pathologies. By quantifying and digitally locating changes in bony density of periapical regions, and categorization into discrete groups, more thorough diagnosis affec...

Rutgers Scarlet Fire® Dogwood – Cornus Kousa Rutpink

christopher.perkins@rutgers.edu — Fri, 23 Mar 2018 14:41:14 GMT

Rutgers first C. kousa in 45 years of breeding, featuring bright fuchsia/deep pink-red colorations during a long season. Invention Summary: Award winning tree. First-ever dark-pink blooming kousa dogwood. Newest Rutgers release, now becoming widely available from retail garden centers. This new cultivar, 'Rutpink', tradenamed Scarlet Fire® dogwood, is a consistently pink-bracted selection, with deep pink to fuchsia coloration at its peak. This new cultivar is the product of a long standing program of hybridization and selection of bi...

A New Method of Thin Film Patterning for Electronic and Medical Devices

christopher.perkins@rutgers.edu — Wed, 14 Mar 2018 11:33:55 GMT

Microscopic image of engineered patterns created on Bismuth thin film Invention Summary: The need to easily pattern thin film materials is widespread among the electronic and biomedical communities. However, the main approaches currently used face challenges of adapting to rapid processing and design change of patterned films, reducing material loss and high cost, or dealing with harmful chemicals. Rutgers researchers have developed a new method of patterning thin films, which applies a relatively low powered focused beam to dewet the metal from the substrate and effectively writes ...

Electrode Compositions and Methods

christopher.perkins@rutgers.edu — Wed, 14 Mar 2018 11:25:23 GMT

A Platform Approach for Free Radical-Mediated Targeted Therapeutic Delivery

christopher.perkins@rutgers.edu — Tue, 06 Mar 2018 13:56:35 GMT

Invention Summary: Various pathological states including tissue injuries, inflammation, degenerative diseases and cancer are frequently associated with elevated free radicals, such as reactive oxygen and nitrogen species. These locally-generated free radicals are extremely reactive and are known to damage cells and tissues to exacerbate the pathology. Rutgers scientists have developed a novel strategy that aims to harness the reactivity of these free radicals to target and sustain the delivery of therapeutics. The therapeutic is conjugated to a biomaterial that reacts with free radica...

Portable Exhaled Breath Condensate (EBC) Analyzer for Asthma Diagnosis and Monitoring

christopher.perkins@rutgers.edu — Mon, 22 Jan 2018 08:05:16 GMT

Invention Summary: Asthma, an increasingly important global health problem that affects ~ 300 million people worldwide, is characterized by variable airway inflammation and air flow obstruction. Currently available non-invasive methods for diagnosing and monitoring asthma involve measurements of exhaled nitric oxide (NO). Apart from the transient nature of NO, these methods are limited by low sensitivity and an inability to identify the nature and extent of airway inflammation. Measurement of alternative biomarkers in exhaled breath condensate (EBC) that can facilitate molecular phenoty...

Novel Fusion Polypeptides as Antiviral and Cancer Therapeutics

christopher.perkins@rutgers.edu — Wed, 17 Jan 2018 08:24:47 GMT

Antitumor and antiviral effects of the fusion IFN-β-IFN-λ in vivo Invention Summary: Type I and Type III interferons (IFNs) are well known for their potent broad-spectrum antiviral activities. In addition, these pluripotent cytokines can also regulate cell growth and differentiation, tissue homeostasis, angiogenesis, as well as immune and inflammatory responses in various physiological and pathophysiological conditions. Due to their diverse functions, clinical applications for IFNs include treatment of chronic and acute viral infections, various malignancies, inflammatory and...

Novel Phosphatidylserine-Targeting Immunobiologicals for Cancer and Viral Treatment

christopher.perkins@rutgers.edu — Tue, 02 Jan 2018 12:16:19 GMT

PS-targeting biological inhibits tumor growth and virus infection Invention Summary: Phosphatidylserine (PS) is a phospholipid that is restricted to the inner plasma membrane in healthy cells but is externalized in apoptotic or stressed cells abundantly present in tumor microenvironment or in sites of virus infection. PS is also present on the surface of enveloped viruses such as influenza, corona and hepatitis B viruses, facilitating virus entry into the cells and immune evasion. Rutgers scientists have developed unique multifunctional PS-targeting immunobiological that blocks PS-me...

Improved Eastern Oysters

christopher.perkins@rutgers.edu — Tue, 02 Jan 2018 10:22:40 GMT

Triploid oysters (right, 3N) produced from improved tetraploids vs. normal diploid controls (left, 2N). Invention Summary: Rutgers University has been breeding eastern oysters (Crassostrea virginica Gmelin) since 1960. Rutgers oyster strains have shown strong to moderate resistance to two diseases (MSX and Dermo). Rutgers also invented tetraploid oysters (with 4 sets of chromosomes) and a new type of triploid oysters (with 3 sets of chromosomes) by crossing diploid and tetraploid oysters. Because of their sterility, superior growth, and improved summer meat quality, new triploid oysters ...

Liquid Membrane for Separation and Filtration

christopher.perkins@rutgers.edu — Tue, 12 Dec 2017 12:48:48 GMT

Schematic view of the liquid membrane filter, showing multiple layers of liquid columns. Each layer contains liquid columns between two parallel plates Invention Summary: Separation and filtration devices have been widely used in numerous applications. Deterministic lateral displacement (DLD) systems are designed to separate biological samples and particulates of different sizes by forcing them through a periodic lattice of obstacles. DLD systems have been utilized to separate blood cells, circulating tumor cells and nanoscale particles. All obstacle lattices used in known DLD systems ...

Synthesis of p-Xylene by Dehydroaromatization of 3-Methyleneheptane obtained from Ethylene

christopher.perkins@rutgers.edu — Mon, 04 Dec 2017 12:54:33 GMT

Invention Summary: p-Xylene is mostly produced from cracking of naphtha, but there is a need for new and cost-effective methods for the production. Indeed, conventional p-xylene synthesis requires toluene separation from refinery gasoline streams; performing a disproportionation reaction to yield a benzene fraction and a mixed xylene fraction; and finally an isomerization step over a zeolite catalyst which converts ortho- and meta- xylenes to the para isomer. p-Xylene is then separated in a costly crystallization step from the unconverted ortho and meta isomers which are recycled...

VSTEP: Balance, Mobility, and Fitness Rehabilitation Game

christopher.perkins@rutgers.edu — Wed, 22 Nov 2017 12:18:30 GMT

Clinician (left) working with patient (right) within the VSTEP digital health platform Invention Summary: Restoring balance is critical for patients recovering from stroke, trauma, or joint surgery, as well as patients with other neurologic conditions. Virtual reality provides an opportunity to gamify rehabilitation and improve outcomes. Researchers at Rutgers have developed VSTEP, a digital health platform that addresses balance, mobility, and fitness. Infrared (IR), motion-sensing cameras track the movement of the lower extremities, providing feedback for balance movement training. Si...

Biomimetic, Bioactive Dental Implants

christopher.perkins@rutgers.edu — Fri, 15 Sep 2017 10:21:59 GMT

Left: 3D printed mold; Center: prototype bioactive implant; Right: prototype lateral incisor implant restored with acrylic temporary crown (after implantation). Invention Summary: While titanium dental implants are the current state of the art for tooth replacement, they involve an invasive surgical procedure and significant risks. Aside from intraoperative surgical risks, a high incidence of titanium implant failures has been reported after placement due to a variety of reasons including prosthetic material failures, improper surgical placement resulting in damage to adjacent tee...

Stable phosphorescent OLEDs for lighting applications

christopher.perkins@rutgers.edu — Mon, 28 Aug 2017 12:27:01 GMT

Novel OLEDs with higher photoluminescence stability Invention Summary: Organic light-emitting diodes (OLEDs) are an emerging display and lighting technology, especially for large area and architectural lighting. Phosphorescent OLEDs are very energy efficient, besides, they don’t suffer from the “green gap” in their emitting spectra Thus, they can generate diffuse light sources that more closely resemble natural light. Rutgers researchers have invented a novel technique to employ extensive rate engineering provided by photonic and plasmonic nanostructures to increas...

Novel Quantitative & Objective Analytical Tool for Detecting Neurodevelopmental Delays in Infants

christopher.perkins@rutgers.edu — Mon, 14 Aug 2017 12:32:55 GMT

Invention Summary: Neurodevelopmental disorders (e.g. autism) are on the rise. They are the byproduct of a lengthy maturation process that starts at conception and manifests disarray with high certainty during infancy, when dysfunction of the child’s nervous systems becomes apparent to the naked eye. By three years of age, observational diagnoses are in place; but no objective tools exist for earlier detection of risk for the improper development of the nervous systems. Pediatricians rely on charts of physical growth to sporadically track absolute changes in weight, body length...

An Underwater Acoustic Lens

christopher.perkins@rutgers.edu — Mon, 14 Aug 2017 12:10:32 GMT

Invention Summary: Sending and receiving information below the water surface is important but challenging. Techniques such as Sonar use acoustic waves in water to transmit information. Acoustic metamaterials enable Sonar devices to control, direct and manipulate sound waves for increased functionality and higher efficiency. Specifically, acoustic lens has been developed as a transmissive device designed to refract and focus sound waves. Traditional underwater acoustic lenses only operate at high frequencies greater than 300 KHz, which limits their use in secure underwater communications...

Novel Quantitative Analytical Tool for Assessing Neurological Functions in Human Subjects

christopher.perkins@rutgers.edu — Fri, 11 Aug 2017 09:16:26 GMT

Tracking statistical signals from both mental and physical activities Invention Summary: Cognitive Neuroscience research uses cortical-related activity to infer various functional and anatomical aspects of the brain. However, this is done in a rather disembodied way, discounting the feedback from bodily biorhythms. In contrast, fields like Behavioral Neuroscience examine bodily biorhythms without considering brain-related activity reflecting cognitive states. As such, we have either a ‘disembodied’ notion of the brain, or a ‘headless’ notion of the body in action...

New Non-Membrane Feeding Device And Diet Formulation For Mosquito Colony Production

christopher.perkins@rutgers.edu — Tue, 25 Jul 2017 05:20:32 GMT

Efficacy of artificial diets (BSA 10% and BSA 20%) for 10 generations of Aedes albopictus mosquito. These diets were prepared with distilled water and used in the new dietary system. For the blood feeding, the live guinea pig was used as a control. Mosquito feeding status on the new dietary system. (A) unfed, (B) half fed and (C) full fed. Arrow shows abdominal bulging after feeding on new dietary system. Invention Summary: Rutgers scientists have developed an artificial feeding system for the maintenance and growth of mosquitoes that exploits their sugar feeding be...

Autism Screener for Young Children

christopher.perkins@rutgers.edu — Mon, 24 Jul 2017 11:11:32 GMT

Invention Summary: Effective screening during the toddler period may lead to timely detection of Autism Spectrum Disorder (ASD). The Autism Screener for Young Children is a Psychological Development Questionnaire. It is a brief parent-report questionnaire designed to represent the expression of social attention, communication and reciprocity in young children and inversely to detect children at-risk for ASD. Details: Researchers at Rutgers University have created a screening instrument comprised of a ten-item parent-report questionnaire. Parents, medical or educational personnel answ...

A Dual Cell Therapy for Wound Healing

christopher.perkins@rutgers.edu — Fri, 21 Jul 2017 09:13:55 GMT

Invention Summary: This method is a combinatorial therapy for chronic wound treatment. Insulin creams increase wound healing but require constant reapplication. Mesenchymal stem cells release growth factors to speed up regeneration but are incompatible with topically applied insulin. Dr. Olabisi has developed a novel therapy of coencapsulated insulin-producing cells (IPCs) and MSCs in a hydrogel dressing to expedite wound healing and decrease scar formation. Dr. Olabisi’s coencapsulated IPCs and MSCs release growth and regenerative factors including insulin, VEGF and TGF-&b...

Hierarchical Computer-Aided Detection of Abnormal Regions in Medical Images

christopher.perkins@rutgers.edu — Mon, 17 Apr 2017 06:15:22 GMT

Receiver operator characteristic curves for detection of prostate cancer at various weights (T) in histological (top) and MRI (bottom) images. Classification is based on multiplicative weighted maximum a posteriori (MWMAP) estimation with iterated conditional modes (ICM). The regions labeled as malignant at three weights are highlighted in green (histology) or red (MRI) Invention Summary: Detection of abnormal features in medical images is a time-consuming task performed by pathologists. Although computer analysis can increase throughput, the size of the images often limits processing ...

Stem Cell Growth Matrices with Enhanced Homogeneity, Stemness & Proliferation and Reduced Need for Feeding

christopher.perkins@rutgers.edu — Fri, 24 Mar 2017 13:38:00 GMT

Invention Summary: There is currently no universal platform or widely accepted technique to efficiently and reproducibly grow stem and progenitor cells (SPCs) in vitro. Stem cells require contact with extracellular matrices as well as signals from growth factors to proliferate and to retain their stemness (preventing their differentiation towards progenitors). Rutgers researchers Dr. Steven Levison and Dr. Nolan Skop have developed a multi-functional scaffold that supports the expansion of neural stem cells and neural progenitors. This scaffold can be adhered to tissue culture plates (S...

High Voltage TFT On Glass For Solar Inverters

christopher.perkins@rutgers.edu — Tue, 24 Jan 2017 05:46:18 GMT

(a) Transfer Characteristics of MZO HVTFTs. (b) Blocking capability and ON-performance of HVTFTs Schematic diagrams of a ring structure are shown. Invention Summary: Various materials have been tried for fabricating high voltage thin film transistors (HVTFTs), including amorphous-Si, poly-Si, and organic materials. However, these TFTs all have certain limitations, ranging from low blocking voltage, low ON-current, high cost, high process temperature, poor uniformity and stability, to complex fabrication process. These issues prevent the existing technologies being used as HVTFT on...

Therapeutics for Drug-Resistant Bacterial Infections - Myxopyronins

christopher.perkins@rutgers.edu — Wed, 04 Jan 2017 08:43:54 GMT

Treatments for tuberculosis and non-tuberculous mycobacterial infections: N-aroyl-N-aryl-phenylalaninamides (AAPs)

christopher.perkins@rutgers.edu — Wed, 04 Jan 2017 07:49:48 GMT

Invention Summary: AAPs are novel orally available compounds for treatment for treatment of tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections--including drug-resistant, multi‑drug‑resistant (MDR), and extensively-drug-resistant (XDR) strains. Researchers indicate that AAPs potently inhibit mycobacterial RNA polymerase through a novel binding site and novel mechanism. AAPs exhibit potent in vitro antibacterial activity against Mycobacterium tuberculosis and non-tuberculous mycobacteria--including drug-susceptible, drug-resistant, and multidrug-resist...

New RNAi-mediated method for resistance to soybean cyst nematode

christopher.perkins@rutgers.edu — Wed, 07 Sep 2016 12:56:25 GMT

Homozygous siRNA-transgenic soybean plants are 40-80% (approx.) more resistant to soybean cyst nematode as compared to the wild type plants (wt). The percentage of reduction in egg number is shown above the bar for each transgenic soybean line. Invention Summary: Rutgers scientists have developed a new method for inducing resistance to soybean cyst nematode (SCN) by using root-specific RNA interference (RNAi) technology. Specifically, RNAi was used to express small RNAs targeting a critical SCN ribosomal gene under the root-specific promoter in soybean plants. Homozygous transgenic soyb...

High Efficiency Isotope Enriched Protein Production Systems

christopher.perkins@rutgers.edu — Fri, 12 Aug 2016 12:26:33 GMT

Isotopic Enrichment of Tryptic Fragments Invention Summary: Rutgers scientists have developed two Single Protein Production (SPP)-based systems to obtain high levels of specific isotopically enriched proteins: an independently inducible system (cSPP(tet)) and an amino acid auxotroph-based dual inducible system. The SPP system essentially turns living E. coli cells into a bioreactor for producing a single protein of interest at high levels. The system utilizes an E. coli endoribonuclease, MazF, to selectively cleave cellular mRNAs at the ACA sequences and thus completely inhibit prot...

Rutgers Venus® Dogwoods

christopher.perkins@rutgers.edu — Wed, 15 Jun 2016 13:19:00 GMT

Invention Summary: Venus® is a distinct variety of dogwood tree that it is the result of crossing two varieties (Cornus kousa x Cornus nuttallii hybrid and Cornus kousa). Its large, creamy white flowers almost completely cover the tree and develop bracts in excess of 6 inches in size. Attractive, strawberry-like fruit are also produced and leaf colors range from a glossy dark green in the summer months to extensive yellow, green, and red coloring during the fall months. Exceptionally large, profuse, large creamy white flowers (bracts...

Passive Bioaerosol Sampler using Ferroelectric Polymer

christopher.perkins@rutgers.edu — Fri, 20 May 2016 09:16:52 GMT

Invention Summary: This is the first air sampler for airborne viruses, bacteria, mold or pollen (i.e. bioaerosol) that does not need an air mover or power source of any kind (i.e. passive). It can be easily applied anywhere in indoor and outdoor environments providing representative data on ambient levels of bioaerosols and also other particulate matter. The sampler can be used in any area and for personal applications, where it can be worn by clipping it onto a shirt collar for applications such as widespread airport bioterrorism monitoring or for asthma or allergy sufferers ...

Novel Diagnostic Tool to Quantify Signatures of Movement in Subjects with Neurological Disorders, Autism and Autism Spectrum Disorders

christopher.perkins@rutgers.edu — Wed, 16 Mar 2016 10:52:19 GMT

Invention Summary: Developmental disorders such as Autism, Autism Spectrum Disorders (ASD) and neurological disorders such as Parkinson’s disease are conditions that involve both cognitive and motor impairments. Currently there is a pressing need for tools that will help to measure objectively the severity of the person’s motor deficits, relative to their normal counterparts. Scientists at Rutgers in collaboration with researchers at Indiana University have recently developed a sophisticated measurement tool and statistical metric to classify and diagnose individuals with ASD ...

New Class of Biofertilizer Promoting Growth and Stress Tolerance

christopher.perkins@rutgers.edu — Wed, 18 Nov 2015 08:39:39 GMT

Invention Summary: Rutgers scientists have identified ACC-deaminase-producing bacterial strains that have advantageous effects on overall plant growth, in particular, turfgrass. Plants infected with ACC-deaminase-producing bacteria are exposed to less ethylene, and thus exhibit better overall growth. Indeed, plants inoculated with these bacteria species and strains were found to have better growth and quality levels and exhibit enhanced resistance to environmental stressors. Market Applications: Agriculture Turfgrass Horticulture BioFertilizer Advantages: Natural biofer...

Advanced Personal Electrostatic Bioaerosol Sampler (PEBS)

christopher.perkins@rutgers.edu — Wed, 14 Oct 2015 08:17:17 GMT

Invention Summary: Identification and assessment of personal exposures to airborne biological contaminants (bioaerosols) are vital in medical, security, and industrial and many other applications. Safety and security systems require the development of advanced personal devices capable of collecting and detecting aerosol agents at low levels; however today’s sampling devices are ill suited to the current challenges because they require cumbersome sampling pumps and tubing which limits their operation time and deployment. In addition, most of the personal devices operate at low flow r...

A Novel Method for Diagnosing and Monitoring Brain Trauma Patients

christopher.perkins@rutgers.edu — Tue, 28 Jul 2015 08:43:32 GMT

A schematic illustrating brain trauma Invention Summary: Brain trauma encompasses both traumatic brain injury — an external penetrating or non-penetrating force to the skull that results in brain damage and swelling — and trauma associated with disease states such as brain tumors, stroke, seizures, and infections. Initial brain trauma may result in a loss of consciousness (coma) followed by a prolonged period of recovery with lingering cognitive, emotional, social, and motor impairments. Current methods for assessing the effectiveness of therapies rely primarily on subjective...

A Humanized Yeast System for mTOR Kinase Inhibitor Screening and Studies

christopher.perkins@rutgers.edu — Tue, 28 Jul 2015 07:16:42 GMT

Invention Summary: mTOR kinase is a highly conserved central regulator of cell growth and metabolism, and a key cancer drug target. Numerous mTOR kinase inhibitors have been developed but have not been approved by FDA. A new screening tool for mTOR kinase inhibitors will facilitate mTOR therapeutic development and related pharmacology studies. Rutgers scientists have developed a novel humanized yeast model by engineering a yeast TOR2 kinase-human TOR kinase (yTOR2-mTOR) fusion. TOR2-mTOR fusion genes are expressed in the tor2-dg strain whose growth is dependent on an active mTOR k...

A Novel Diagnostic Assay for Predicting Patients’ Resistance to mTOR Kinase Inhibitors

christopher.perkins@rutgers.edu — Tue, 28 Jul 2015 06:17:22 GMT

Invention Summary: Mechanistic Target of Rapamycin (mTOR) is a highly conserved serine/thereonine protein kinase that plays a crucial role as part of two distinct kinase complexes, mTOR1C and mTOR2C, to regulate cell growth and metabolism. Abnormal activation of mTOR has been implicated in the pathogenesis of several cancers, type 2 diabetes, obesity, and neurodegeneration. Numerous mTOR kinase inhibitors are currently in development with several currently be evaluated as anticancer therapy in clinical trials. However, given recent clinical experience with target therapeutics, acquired dr...

Growth Promoting Properties of Newly Identified Root Fungi A. panicicola for Agricultural Applications

christopher.perkins@rutgers.edu — Fri, 24 Apr 2015 12:56:07 GMT

Invention Summary: Rutgers scientists identified a new root endophytic fungal species, Acidomelania panicicola, which significantly increases growth and stress tolerance of different plant species. A. panicicola was identified from switchgrass and other grass roots from the New Jersey Pine Barrens, where the soil content is nutrient poor, acidic, dry and has high levels of toxic soluble aluminum. Functional studies showed that A. panicicola significantly increased the root hair growth in switchgrass, rice and lettuce seedlings under acidic and poor nutrient conditions. In addition, inoc...

Plant-derived Nutraceutical Compositions containing Phenethylisothiocyanate and their Uses as Anti-Inflammatory Agents

christopher.perkins@rutgers.edu — Mon, 23 Feb 2015 11:18:14 GMT

Rat paw edema anti-inflammatory assays demonstrated that treatment with PEITC essential oil (PEO) was as quick and effective as treatment with aspirin. Invention Summary: Rutgers scientists have developed proprietary and unique methods for obtaining high yields of phenethyl isothiocyanate (PEITC), a natural glucosinolate derivative known for its cancer preventive and antiinflammatory properties, from plant tissues (e.g., seeds). After evaluating various plant species and tissues for their PEITC content, it was found that the seeds of Barbarea verna (also known as early winter cress or ...

Diagnostic Methods for Protein Profiling

christopher.perkins@rutgers.edu — Wed, 02 Jul 2014 11:41:27 GMT

Invention Summary: The ubiquitin/proteasome system is the major intracellular non-lysosomal proteolytic system that catalyzes the degradation of many regulatory proteins. Ubiquitin is a highly conserved 76 amino acid residue protein present in all eukaryotes. Conjugation of ubiquitin molecules to proteins marks them for degradation via the ubiquitin/proteasome pathway. Critical regulators of cell growth, differentiation, apoptosis and tumor suppression are targets of this proteolytic pathway, and include p53, β-catenin, c-Jun, c-Myc, IκBα and Bcl2. The presence of ubiquitina...

Erythropoietin-Derived Short Peptide and Its Mimics as Immuno/Inflammatory Modulators

christopher.perkins@rutgers.edu — Fri, 09 May 2014 11:36:20 GMT

Invention Summary: Erythropoeitin (Epo) is a hematopoietic growth factor widely used in the treatment of anemia and has been claimed to have direct neuroprotective effects. However, long-term Epo therapy can lead to the excessive elevation of platelets and red blood cells in non-anemic individuals. A short Epo-derived peptide has recently been shown to induce differentiation and prevent cell death in rodent and human neuronal cell lines while lacking the erythro-proliferative effects. The present invention is a method for treating inflammatory disorders and traumatic brain injury w...

Novel anti HER-WL antibodies against cancer-associated antigens

christopher.perkins@rutgers.edu — Tue, 25 Feb 2014 08:19:25 GMT

Invention Summary: Human endogenous retroviruses (HERVs) constitute 8% human genome and are inherited remnants of retroviral integrations in the human genome. Despite being evolutionarily dysfunctional, some cells can code proteins due to epigenetic dysregulation during malignant transformation in cancer or during HIV infection, autoimmune and multi-factorial diseases. Thus, implying to be a useful asset leading to cancer cell recognition. Rutgers researchers have cloned Human endogenous retroviral protein (HERV-WL) from human B cell lymphoma cells and expressed in E....

Efficient and Easily Recyclable Heterogeneous Nanocatalysts

christopher.perkins@rutgers.edu — Fri, 07 Feb 2014 11:20:28 GMT

Invention Summary: The use of metal nanoparticles (MNPs) in catalysis has rapidly increased in recent years because of their efficient and intrinsic size dependent catalytic properties as well as their ability to catalyze a range of chemical reactions. For many MNPs to catalyze reactions and result in efficient catalysis, the reacting substrates must directly interact with the metal surface. This metal-substrate interaction could be greater if the MNPs were synthesized “naked”. Unfortunately, atoms of a “naked” MNP have a greater tendency to aggregate into a b...

Metallic and Partially-Oxidized Metallic Plasmonic Electrodes for Inverted Bulk Heterojunction Photovoltaics

christopher.perkins@rutgers.edu — Thu, 06 Feb 2014 12:24:41 GMT

Invention Summary: The demand to find novel sources of clean, renewable energy has grown significantly over the past several decades. One promising source of renewable energy is in the form of photovoltaic (PV) cells - devices that convert sunlight into electricity. Traditionally, inorganic semiconducting materials are used to create the p-n junction necessary to achieve the photovoltaic effect; these types of materials, however, are rather difficult to process due to the sensitivity of inorganic semiconductors to impurities. Traditional photovoltaics are limited in the structural flexibi...

Electrostatic Screen Battery for Emission Control

christopher.perkins@rutgers.edu — Tue, 04 Feb 2014 06:55:15 GMT

Fig. (a) Comparison of collection efficiency between ESBEC and a commercial DPF as a function of sampling time when challenged with diesel exhaust for 13 hours. (b) Photos of the latest version of ESBEC. Invention Summary: Diesel combustion engines are widely used in heavy-duty trucks, stationary engines and for power generation. With the advent of common rail injection systems and many performance-enhancing modifications, modern diesel engines have decreased their emissions, but still emit relatively high concentrations of particulate matter within a wide range of pa...

Novel Airborne Contaminant Collector: Very High Concentration Rate and Low Power Consumption

christopher.perkins@rutgers.edu — Tue, 04 Feb 2014 06:55:08 GMT

Concentration rate: a ratio of particle concentration in collection liquid versus the airborne particle concentration per time unit. Invention Summary: Airborne contaminant exposure assessment is a vital component of the protection of civil, governmental and military establishments. Safety and security applications require the development of advanced devices capable of collecting and detecting biological and non-biological agents at low levels in difficult circumstances. Today’s devices are ill suited to the current challenges because they require high concentrations of co...

Single Sensor Radio Scene Analysis for Packet Based Radio Signals Using 2nd and 4th Order Statistics

christopher.perkins@rutgers.edu — Thu, 09 Jan 2014 10:15:46 GMT

Invention Summary: Most existing wireless systems use static allocation of the radio spectrum with each system operating in a predefined fixed frequency band. Since the allocated spectrum is not used at all locations and at all times, this static allocation leads to creation of spectrum holes, which implies inefficient utilization of the available radio spectrum. Dynamic spectrum allocation offers a much more optimal spectrum utilization scheme. However, dynamic systems must have a completely new feature embedded in them, spectrum sensing capability. Spectrum sensing can be defined as RF ...

Nano-Electrokinetic Actuator Array Technology for Propulsion, and Flow Control for Underwater Vehicles

christopher.perkins@rutgers.edu — Mon, 23 Dec 2013 05:45:33 GMT

Invention Summary: Nano Electrokinetic actuators are a novel propulsion method for underwater vehicles. Of significant relevance is the ability to create faster more maneuverable underwater vehicles. These novel actuators operate on a fundamentally different principle from the traditional actuator technologies used to date. The technology takes advantage of electro-osmosis to enable fluid pumping using electric fields. The application is extensively used in micro fluidic devices. Researchers at Rutgers University have developed a new class of fluid micro/nano actuators with superior per...

Autodissemination of an Insect-Growth Regulator for Mosquito Management

christopher.perkins@rutgers.edu — Mon, 01 Jul 2013 06:06:07 GMT

Invention Summary: Container mosquitoes are prime public and veterinary health threats. They are the primary vectors of mosquito-borne viruses such as chikungunya, dengue, and zika which can cause illness among the humans. Stagnant water collected in small, squalid spaces form the habitat of these container mosquitoes. Conventional control methods focus on treating or eliminating larval habitats. However, the limitations of traditional insecticide-based strategies, particularly imprecise habitat treatments and the development of insecticide resistance, have resulted in signific...

Rutgers University Mullica Queen® Cranberries

christopher.perkins@rutgers.edu — Mon, 01 Jul 2013 06:05:56 GMT

Invention Summary: Mullica Queen® is a new and distinct variety of cranberry distinguished in that it is the result of crossing two varieties (Lemunyon and #35), produces significantly higher yields, higher anthocyanin (red pigment) content, higher stolon vigor, and earlier flowering phenology compared to other commercial varieties. Established test plots in NJ y ielded an average of 456 barrels/acre, which compares favorably to the ‘Stevens’ variety, which produced 270 barrels/ acre under the same conditions in the same location. The fruit size was also significantly larg...

Rutgers Red Beauty® Holly

christopher.perkins@rutgers.edu — Mon, 01 Jul 2013 06:05:50 GMT

Invention Summary: Red Beauty® is a new and distinct variety of evergreen holly distinguished in that it combines from three species (Ilex aquifolium, Ilex rugosa, and Ilex pernyi), and has desirable landscape and production traits which distinguish it from all other forms of Ilex. These plants have a moderate growth rate, and will typically reach 7 to 10 feet tall and 4 to 5 feet wide in 7 to 9 years. Leaves do not become lighter green when bearing a heavy crop of fruit as do the leaves of many varieties of Ilex. A plant in the mature phase (flowering) can be achieved in one year f...

Methods to Produce Hepatitis C Virus E2 Protein

christopher.perkins@rutgers.edu — Tue, 18 Jun 2013 12:02:21 GMT

Invention Summary: Rutgers scientists have developed methods to produce and purify the ectodomain of HCV E2, a critical structural protein of the virus that has potential to serve as a vaccine candidate to prevent HCV infection. Efforts to study HCV, and to develop vaccines, have been impaired in part by the inability to produce sufficient quantities of high quality protein due to the complexity of the mature form of E2. The technology developed at Rutgers has overcome this limitation and may provide the critical step towards developing a variety of therapeutic options including vaccines ...

Dimeric Diagnostic DNA Arrays for Pathogen Detection and Identification

christopher.perkins@rutgers.edu — Tue, 11 Jun 2013 11:09:47 GMT

A 7 times higher signal intensity was obtained for the dimeric probes D and the dimeric probes with a 10-adenine spacer DA compared to conventional monomeric probes M. Invention Summary: Rutgers scientists have developed a unique and pioneering technology for detection and identification of important pathogens in the form of a macroarray diagnostic technology with enhanced detection sensitivity and small reduction in specificity using repeat sequence probes (dimers). We continue to have positive results and improvements, and believe the next stage will focus on refinement, development of...

Rutgers Variegated Stellar Pink Dogwoods

christopher.perkins@rutgers.edu — Tue, 11 Jun 2013 09:42:45 GMT

Invention Summary: Variegated Stellar PinkTM is a stable mutation of the popular Stellar Pink® variety of dogwood tree that is the result of crossing two varieties (Cornus Kousa and Cornus Florida). Its abundant flowers almost completely cover the tree in an overlapping manner. The leaves have a white margin and dispersed green, and mottled hues of green and white in several shades. In the fall, leaves are multi-colored and are more brilliant than the Stellar Pink® variety. Has sold over one million trees since being introduced in the early 1990s and are coveted by ornamenta...

Rutgers University Scarlet Knight™ Cranberries

christopher.perkins@rutgers.edu — Fri, 31 May 2013 11:22:13 GMT

Invention Summary: Scarlet Knight™ is a new and distinct variety of cranberry distinguished in that it is the result of crossing two varieties (Stevens and NJS98-37), produces high yields, higher anthocyanin (red pigment) content, lower titratable acidity, and larger fruit size. Additionally, the high TAcy values that are exhibited in September allow for an earlier harvest window for processed fruit, particularly compared to the primary commercial variety, ‘Stevens’. Established test plots in NJ yielded an average of 214 barrels/acre, which is comparable to production ...

Nanotechnology Approach for Inhalation Treatment of Pulmonary (Lung) Fibrosis

christopher.perkins@rutgers.edu — Wed, 08 May 2013 06:29:40 GMT

Inhalation Treatment Invention Summary: Idiopathic Pulmonary Fibrosis (IPF), the spontaneous development of scar tissue within the lungs, is a progressive fibrotic disease that impairs the lung’s ability to get oxygen. To date, its pathogenesis remains elusive and the survival time of patients is between three and five years. Pirfenidone, an orally active small molecule drug, has been granted the Orphan Drug and Fast Track designation by the FDA and is approved and marketed in Europe as Esbriet® for mild to moderate IPF in adults. It is currently awaiting approval in the U.S. H...

Probiotics for Food and Health Use

christopher.perkins@rutgers.edu — Mon, 06 May 2013 07:25:04 GMT

Our major research and product development areas include: (i) probiotic-derived natural antimicrobials for human health (ii) novel probiotics for traditional and non-dairy applications. We isolated and characterized antimicrobial proteins from the known strain of Lactobacillus sporogenes (Bacillus coagulans) and from a novel strain of Bacillus amyloliquefaciens. The antimicrobial peptide subtilosin produced by B. amyloliquefaciens is active against vaginal pathogens, has spermicidal activity and kills herpes viruses 1 and 2. It also kills foodborne pathogen Listeria monocytogenes, including...

ANIMAL MODEL FOR MALIGNANT MELANOMA AND USES THEREOF

christopher.perkins@rutgers.edu — Thu, 07 Mar 2013 13:33:11 GMT

Invention Summary: Advances in translational research are very closely linked to the rational design and selection of animal models. Patients with advanced melanoma have very low 5-year survival rates of 1%-2% and there is a critical need for clinically relevant discoveries and development of therapeutic treatment approaches. Metabotropic Glutamate receptor-1 (Grm1) has been implicated in the development of melanocytic neoplasms. Therefore developing inhibitors/antagonists against Grm1 could potentially arrest the progression of this pathway. Scientists at Rutgers have developed a n...

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