Anti-Diabetic Agents from Leaves of Combretum micranthum (Kinkeliba)

Invention Summary 

Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties.

Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-Saharan Africa, the fresh and brewed leaves of kinkeliba have a long established history as being safe multi-functional agents that are consumed regularly for a broad range of health, prophylactic, curative, and anti-disease benefits. Kinkeliba herbal teas are a readily available niche specialty consumer product.

Our scientists have identified and isolated specific compounds from kinkeliba leaves that result in a significant glucose-lowering functionality and can be administered in efficacious dosages as a dietary supplement or food additive. Animal studies have shown that the isolated compounds:

  • decrease fasting plasma glucose levels
  • increase glucose tolerance
  • lower plasma insulin levels, and
  • decrease liver expression of the PEPCK gene, which indicates antidiabetic activity.


Further experiments have demonstrated an anti-inflammatory action of the compounds. An effective preparation method has also been developed.

Market Application 

  • Diabetes, metabolic disorders, weight loss, diuretics
  • Can be blended into existing formulations (food, beverage, or nutraceutical) to boost efficacy and broaden application and efficacy profile

Advantages 

  • Kinkeliba tea has a well documented traditional and safe medicinal use
  • Established safety profile
  • Readily available source
  • Rich in potent antioxidants
  • Distinct attributes and functionality as compared to other common tea (e.g., green tea or black tea) derivatives.

Intellectual Property & Development Status 

US 8,642,769

 

  
Rutgers ID 2010-087
Category(s):
Agriculture
Food, Nutrition and Nutraceuticals
For Information, Contact:
Deborah Perez
Rutgers the State University of New Jersey
deborah.perez@rutgers.edu
Inventors:
James Simon
Keywords:
Beverage
Diabetes
Metabolic disorders
weight loss