Anti-Diabetic Agents from Leaves of Combretum micranthum (Kinkeliba)

At 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group.


Invention Summary:

Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties.

Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-Saharan Africa, the fresh and brewed leaves of kinkeliba have a long established history as being safe multi-functional agents that are consumed regularly for a broad range of health, prophylactic, curative, and anti-disease benefits. Kinkeliba herbal teas are a readily available niche specialty consumer product.

Our scientists have identified and isolated specific compounds from kinkeliba leaves that result in a significant glucose-lowering functionality and can be administered in efficacious dosages as a dietary supplement or food additive. Animal studies have shown that the isolated compounds:

  • decrease fasting plasma glucose levels
  • increase glucose tolerance
  • lower plasma insulin levels, and
  • decrease liver expression of the PEPCK gene, which indicates antidiabetic activity 

Further experiments have demonstrated an anti-inflammatory action of the compounds. An effective preparation method has also been developed.

Market Applications:

  • Diabetes, metabolic disorders, weight loss, diuretics
  • Can be blended into existing formulations (food, beverage, or nutraceutical) to boost efficacy and broaden application and efficacy profile

Advantages:

  • Kinkeliba tea has a well documented traditional and safe medicinal use
  • Established safety profile
  • Readily available source
  • Rich in potent antioxidants
  • Distinct attributes and functionality as compared to other common tea (e.g., green tea or black tea) derivatives

Intellectual Property & Development Status:

US 8,642,769

Rutgers ID: 2010-087
Category(s):
Agriculture
Food, Nutrition and Nutraceuticals
Contact:
Deborah Perez
Senior Licensing Manager
848-932-4467
deborah.perez@rutgers.edu
Inventors:
James Simon
Keywords:
Beverage
Diabetes
Metabolic disorders
weight loss