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DNA Nanodevices for Point-of-Care Testing
DNA nanodevice can detect 0.1 nm microRNAInvention Summary: Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid and low-cost medical diagnosis that can be used by non-specialists at home, in the field or on an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and ...
Published: 7/9/2018   |   Inventor(s): Jinglin Fu, Sung Won Oh, Adriana Pereira
Category(s): Life Sciences, Diagnostics
Rapid and Efficient Production of High Lysine and High Methionine Quality Protein Maize
Lysine and methionine content of novel Quality Protein Maize lines, the opaque high lysine line W64A o2, and non-transgenic AxB. Observe that PE5, α-γ- kernels have the highest lysine and methionine levels, but are opaque. PE5, γ- has high lysine and methionine levels and a vitreous kernel, making it the best candidate for QPM a...
Published: 7/5/2018   |   Inventor(s): Joachim Messing
Category(s): Agriculture, Plants, Berries, Fruit
Wearable Transcutaneous Microsensor for Continuous “in situ” Monitoring of Biomarkers
A schematic view of the label-free flexible microsensor and its insertion into the skin.Invention Summary: The ability to measure peptide/protein biomarkers in bodily fluids “in situ” can enable continuous health monitoring. The current gold-standard for protein quantification in laboratory tests is enzyme linked immunosorbent assay (EL...
Published: 6/20/2018   |   Inventor(s): Mehdi Javanmard, Pengfei Xie, Mark Allen, Wen Shen, Naixin Song
Category(s): Physical Sciences, Medical Devices, Diagnostics
An Accurate Method for mRNA 3'End Identification and Gene Expression Analysis
3′READS+ protocol with optimized RNase H digestion and ligation stepsInvention Summary: Most mRNA genes in eukaryotes contain multiple cleavage and polyadenylation sites (PAS), resulting in alternative cleavage and polyadenylation isoforms with different coding sequences and/or variable 3' untranslated regions. Alternative polyadenylation (AP...
Published: 6/15/2018   |   Inventor(s): Bin Tian, Dinghai Zheng
Category(s): Life Sciences, Research Tools
Biodegradable Hybrid Organic-Inorganic Scaffold for Drug Delivery and Stem Cell Differentiation
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheetInvention Summary: While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation. Researchers at Rutgers University ...
Published: 6/1/2018   |   Inventor(s): KI-Bum Lee, Letao Yang
Category(s): Life Sciences, Biomaterials, Therapeutics
Graphene-Nanofiber Hybrid Scaffold for Stem Cell Differentiation
Schematic diagram of the graphene-nanofiber hybrid scaffold, from fabrication to cell differentiation.Invention Summary: Stem cell regenerative medicine has been a promising approach to tissue restoration and cell based therapies. However, there are challenges in transplantation survival and mimicking the complexity of the cellular microenvironment...
Published: 6/1/2018   |   Inventor(s): Kibum Lee, Shreyas Shah
Category(s): Life Sciences, Research Tools
Drug Candidate for the Treatment of Dilated Cardiomyopathy
Invention Summary: Dilated cardiomyopathy (DCM) is the most common cause of heart failure. About 5.7 million adults in the United States have heart failure, and approximately half million new cases are diagnosed annually. Patients with DCM can lead to arrhythmias, and about half of people who develop heart failure die within 5 years of diagnosis. C...
Published: 5/17/2018   |   Inventor(s): Diego Fraidenraich, Qingshi Zhao
Category(s): Life Sciences, Therapeutics
Transparent Watermarking for Physical Authentication
Invention Summary: Physical watermarks such as raised seals and standard watermark labels enable the authentication of important financial and legal documents, identification cards and art work. Many of the known methods like using barcodes, infrared inks and standard watermarks can be easily copied or reverse engineered. Hence, there is a demand f...
Published: 5/9/2018   |   Inventor(s): Kristin Dana, Yicheng Lu, Gabriela Livescu
Category(s): Physical Sciences, Engineering
BMP Signaling Inhibitors for the Treatment of Cancer
BMP PathwayInvention Summary: Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. BMP signaling is required for lung development and is not active in adult lungs. However, BMP signaling was found to be reactivated in lung cancer. For exampl...
Published: 5/7/2018   |   Inventor(s): David Augeri, John Langenfeld, John Kerrigan
Category(s): Life Sciences, Therapeutics
Treatment for Neuropsychiatric Disorders by Intravitreal Injection of DREADD Followed by Eye Drops or Pills Containing DREADD agonist
Figure 1. DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depress...
Published: 5/7/2018   |   Inventor(s): Gary AstoN-Jones, Hannah Bowrey
Category(s): Life Sciences, Therapeutics
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