Latest technologies from Rutgers the State University of New Jerseyhttp://techfinder.rutgers.eduBe the first to know about the latest inventions and technologies available from Rutgers, The State University of New Jerseyen-USFri, 21 Jul 2017 07:27:25 GMTTue, 16 May 2017 06:11:17 GMT 2017, Rutgers the State University of New JerseyMulticatalyst Polyelectrolyte Membranes for Protection against Chemical Warfare Agents protect a wearer from toxic chemicals, such as chemical warfare agents (CWAs), materials must be both permeable to water vapor and impermeable to those CWAs. While developing such materials is a significant engineering challenge, those materials would provide only a physical barrier between the wearer and CWAs. Researchers at Rutgers have developed a selectively permeable polyelectrolyte membrane (PEM) that includes catalytic components which decompose CWAs. The unique nanostructure of the PEM facilitates transport of water and reactants, improving the catalytic activity of the membrane. Po...Tue, 16 May 2017 06:11:17 GMTchristopher.perkins@rutgers.edu Novel Vaccine Candidate Against Fungal Infection fungal infections kill over 1.5 million people worldwide annually. Cryptococcus neoformans, for example is a human fungal pathogen that often causes lung and brain infection in immunocompromised patients, with a high fatality rate. A vaccine against infection could significantly reduce the rate of systematic fungal infections. Rutgers scientists have identified a novel protein, deletion of which makes C. neoformans as well as several other fungal organisms hypovirulent. Infection with a mutant strain generates a robust pulmonary inflammatory response and activation of protective Th1 a...Fri, 12 May 2017 13:08:13 GMTchristopher.perkins@rutgers.edu Resolution, Real-Time Measurement of Curvature and Thermal Expansion of Small Samples manufacturing of thin films and semiconductors, it is critical to monitor the radius of curvature and thermal expansion of samples to identify and manage stresses. These parameters are currently measured optically based on the deflection of multiple parallel beams. However, this approach is limited in the size of samples that can be measured, the resolution of the measurements, and the distance between the sample and the measurement apparatus.Researchers at Rutgers have developed a novel measurement apparatus to overcome these limitations. Specifically, a wide beam is directed at the sa...Fri, 12 May 2017 12:51:16 GMTchristopher.perkins@rutgers.edu Computer-Aided Detection of Abnormal Regions in Medical Images of abnormal features in medical images is a time-consuming task performed by pathologists. Although computer analysis can increase throughput, the size of the images often limits processing speeds.This invention solves these problems using a hierarchical approach. Analysis begins at low resolution to identify abnormal regions and proceeds to higher levels of resolution for these identified regions. Morphological feature information is used to classify these abnormal structures based on probabilistic pairwise Markov models. The classification is enhanced by assigning different weights...Mon, 17 Apr 2017 06:15:22 GMTchristopher.perkins@rutgers.edu Water Purification Technology for Lead and Heavy Metals, 05 Apr 2017 11:56:12 GMTchristopher.perkins@rutgers.edu Efficient Cancer Drug Delivery Method therapies have been extensively explored in the oncology field, for its potential to improve treatment efficacy, minimize the risks of resistance, and reduce adverse effects. Rutgers researchers have developed a novel drug delivery system for the combined delivery of anti-cancer drug Erlotinib (Tarceva) and nucleic acid molecules (eg. siRNA), which may lead to synergistic treatment effect. This invention utilizes novel cyclodextrin-modified dendritic polyamines (DexAMs) as a vehicle to co-deliver Erlotinib and nucleic acids. The structure of DexAMs facilitates the uptake of Erlotin...Wed, 29 Mar 2017 12:24:00 GMTchristopher.perkins@rutgers.edu Pre-Vascularized Scaffold, 27 Mar 2017 13:01:04 GMTchristopher.perkins@rutgers.edu<![CDATA[Stem Cell Growth Matrices with Enhanced Homogeneity, Stemness & Proliferation and Reduced Need for Feeding]]>, 24 Mar 2017 13:38:00 GMTchristopher.perkins@rutgers.edu Use of Brassinosteroids for Muscle Growth, Skin, 20 Mar 2017 12:34:11 GMTchristopher.perkins@rutgers.edu Barcoding of Microparticles For Multiplexed Molecular Analysis of detecting multiple protein and nucleic acid biomarkers is crucial to disease diagnosis and precision medicine. Barcoding of microparticles is one of the most common approaches for enabling multiplexed molecular assays. Although optical and plasmonic methods for barcoding particles have been developed, instrumentations involved are often bulky and expansive, preventing portability.Dr. Javanmard at Rutgers University has developed a novel system for portable, multiplexing biosensing applications. The multiplexing capability is achieved through the use of a newly developed nanoelect...Mon, 27 Feb 2017 10:28:33 GMTchristopher.perkins@rutgers.edu HIGH THROUGHPUT, FEEDBACK-CONTROLLED ELECTROPORATION MICRODEVICE FOR EFFICIENT MOLECULAR DELIVERY INTO SINGLE CELLS, 27 Feb 2017 10:28:21 GMTchristopher.perkins@rutgers.edu Candidates for Autoimmune Diseases: Cell Penetrating Peptides that Inhibit IRF5 Activity, 27 Feb 2017 10:27:57 GMTchristopher.perkins@rutgers.edu, A Newly Identified Gene Target for Improved Plant Growth and Yield in Agricultural Applications scientists discovered a new gene Gigantus1 (Gts1) in Arabidopsis thaliana , which significantly influences seed germination, growth and biomass accumulation in plants.The protein product GIGANTUS1 (GTS1) belongs to the WD40 protein superfamily, whose members are key regulators of plant development. Under the same growth conditions, Gts1 -knockout plants germinated faster and had significantly increased growth compared to WT plants (Fig. A on top). They also flowered 5 days earlier and accumulated higher cell biomass than WT, as shown by a bigger overall rosette leaf area (Fig. B on t...Mon, 27 Feb 2017 10:27:18 GMTchristopher.perkins@rutgers.edu Organoid Culture organoid is a small three-dimensional (3-D) tissue structure that highly resembles the in vivo organ from which it originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from both normal and cancerous tissues of patients.Using this human organoid culture method, stem cell-derived organoids are generated from human primary tissues at the 80-90% of efficiency within 4 weeks. The resulting organoids are reproducibly maintained up to 3 months and comprise epithelial cells (E-cadherin) and mesenchymal cells (Vimetin), as well as a...Mon, 27 Feb 2017 10:27:15 GMTchristopher.perkins@rutgers.edu<![CDATA[Novel Cationic Amphiphiles as Antimicrobial Therapeutics & Additives in Food Packaging, Household, and Personal Care Products]]>, 27 Feb 2017 10:27:13 GMTchristopher.perkins@rutgers.edu NANOSTAR SUBSTRATES FOR SERS SENSING IN THE FEMTOMOLAR REGIME, 27 Feb 2017 10:27:08 GMTchristopher.perkins@rutgers.edu Methods for Enhanced Efficacy of Mesenchymal Stem Cells, 27 Feb 2017 10:26:41 GMTchristopher.perkins@rutgers.edu Novel Biomarker for the Early Detection of Pancreatic Cancer, 27 Feb 2017 10:26:16 GMTchristopher.perkins@rutgers.edu method for large scale production of collagen-like proteins in bacteria, 27 Feb 2017 10:25:03 GMTchristopher.perkins@rutgers.edu Genetic Tool to Identify Individuals at Increased Risk for Autism, 27 Feb 2017 10:20:39 GMTchristopher.perkins@rutgers.edu for Sintering Ultrahigh Melting Temperature Covalent Non-oxide Ceramics, 27 Feb 2017 10:20:22 GMTchristopher.perkins@rutgers.edu Array for High Density Integration with Low Crosstalk, 27 Feb 2017 10:20:02 GMTchristopher.perkins@rutgers.edu Method to Determine Number of Contributors in a DNA Mixture, 27 Feb 2017 10:19:57 GMTchristopher.perkins@rutgers.edu N- and O-Doped Mesoporous Carbon: Electrocatalysts for Oxygen Reduction Reaction (ORR), 27 Feb 2017 10:19:42 GMTchristopher.perkins@rutgers.edu, Biocompatible Nucleic Acid Delivery System, 27 Feb 2017 10:19:21 GMTchristopher.perkins@rutgers.edu LOW-PHASE-NOISE OSCILLATOR, 27 Feb 2017 10:19:19 GMTchristopher.perkins@rutgers.edu and Biodegradable Films for Effective Prevention of Postoperative Adhesions Invention Summary: Adhesions are bands of scar tissue that frequently form between tissues and organs after surgery. The scar tissue binds together internal organs that are normally separated from each other. Abdominal adhesions, for example, occur in more than 90% of patients following open abdominal surgery. Such adhesions can cause chronic abdominal or pelvic pain, as well as intestinal obstruction and female infertility.Currently, three synthetic products have been approved by the FDA that reduce postoperative adhesions. However, the clinical performance is less than satisfactory (with su...Mon, 27 Feb 2017 10:19:16 GMTchristopher.perkins@rutgers.edu Circuit Building Blocks for SOG and Wearable Electronics, 27 Feb 2017 10:19:02 GMTchristopher.perkins@rutgers.edu SILICONE FOAM FOR THE SELECTIVE ABSORPTION OF OIL FROM WATER, 27 Feb 2017 10:18:57 GMTchristopher.perkins@rutgers.edu Supplement and Feed Compositions to Reduce the Incidence of Osteochondrosis Dissecans Lesions in Genetically Predisposed Foals, 27 Feb 2017 10:18:55 GMTchristopher.perkins@rutgers.edu and Versatile Copolymers to Promote Wound Healing, 27 Feb 2017 10:18:51 GMTchristopher.perkins@rutgers.edu, Mineral-based Polymers with Ionic Crosslinks, 27 Feb 2017 10:18:45 GMTchristopher.perkins@rutgers.edu System for High-Level Production of Proteins and Protein Domains, 27 Feb 2017 10:18:40 GMTchristopher.perkins@rutgers.edu Terrain Modeling Diagnostics Software (RTMDx), 27 Feb 2017 10:18:34 GMTchristopher.perkins@rutgers.edu Indentation Method Using Scanning Probe Microscope, 27 Feb 2017 10:18:33 GMTchristopher.perkins@rutgers.edu Dual Racetrack Silicon Micro-resonators for Quadrature Amplitude Modulation parallel-coupled dual racetrack micro-resonator structure has been designed for phase-shift keying and M-ary quadrature amplitude modulation (QAM). This structure comprises two racetrack resonators that are symmetrically side-coupled in parallel to a through waveguide in the center. The carriers can be injected or removed from the racetrack resonators using a pin diode or metal-oxide-semiconductor capacitor embedded in a silicon waveguide. The plasma dispersion effect of the injected carriers causes a change of refractive index in each resonator, modifying the cross-coupled resonances of the...Mon, 27 Feb 2017 10:18:23 GMTchristopher.perkins@rutgers.edu Production of Large and Highly Conductive Amphiphilic Graphene Sheets via Controlled Oxidation, 27 Feb 2017 10:18:17 GMTchristopher.perkins@rutgers.edu Rare Earth-Based Biophotonic Composites, 27 Feb 2017 10:18:12 GMTchristopher.perkins@rutgers.edu Nanoparticle-Based Biosensor for Biomarker Detection and Its Use in Early Diagnosis of Cancer, HIV and Other Diseases, 27 Feb 2017 10:17:59 GMTchristopher.perkins@rutgers.edu ZnO Thin Film Transistor Biosensor with High Sensitivity and Selectivity, 27 Feb 2017 10:17:56 GMTchristopher.perkins@rutgers.edu Transgenic Plants as Oral Delivery Vehicles for RNA-based Therapeutics, 27 Feb 2017 10:17:51 GMTchristopher.perkins@rutgers.edu Synthesis Technology: Potential Applications in Hydrocarbon Conversion and Chemical Processing Researchers at Rutgers University have developed a new process for the synthesis of Graphene onto various substrates. The invention utilizes a multiple inverse-diffusion (non-premixed) burner where for each tiny stabilized flame, the oxidizer (e.g. air) is in the center and fuel (e.g. ethylene) surrounds it. Recently, they discovered that this technology could be used for additoinal applications. The burner configured as a Flame Catalytic Reactor is ideally suited for applications in which there is a need to convert natural gas into useful products, particularly in locations where the gas ...Mon, 27 Feb 2017 10:17:47 GMTchristopher.perkins@rutgers.edu and Apparatus for Virtualizing and Sharing UpLink Bandwidth in Wireless LANs The abundance of wireless devices and the demand for constant connection has been met with the increasing deployment of wireless hotspots. Internet Service Providers (ISPs) aiming to provide the best service, frequently locate hotspots at airports, cafes, and shopping areas. One problem they face is differentiating the quality of services they provide to different users. To address this problem, the industry is looking for a mechanism that ensures sharing works across a wide range of client hardware while providing the level of service commensurate with the user contract. Researchers at Rutge...Mon, 27 Feb 2017 10:17:46 GMTchristopher.perkins@rutgers.edu for producing jet fuel from food and non-food feedstocks A number of separate studies have shown that genome-scale flux-balance analysis (FBA) modeling can be useful for the in silico design of engineered strains of microbes that overproduce diverse targets. These engineered strains include Escherichia coli (E. coli) that overproduce lycopene, lactic acid, succinic acid, l-valine, l-threonine, and strains of Saccharomyces cerevisiae that overproduce ethanol. FBA models allow the result of various genetic manipulations strategies to be predicted. As a result, the space of possible genetic manipulations can be computationally searched for the strat...Mon, 27 Feb 2017 10:17:40 GMTchristopher.perkins@rutgers.edu Collagen Methacrylamide-Derivatized Hydrogels material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties. Rutgers scientist Dr. David Shreiber invented a process for creating type I collagen and methacrylamide (CMA)-based hydrogel, which retains the properties of collagen such as self-assembly, biodegradability, and natural bioactivity. In addition, it is photoac...Mon, 27 Feb 2017 10:17:37 GMTchristopher.perkins@rutgers.edu Flow Analysis for Cardiovascular Diagnostics Following a heart attack or the development of some cardiovascular diseases, the movement of the heart walls during the cardiac cycle may change, which affects the motion of blood through the heart. Currently, valvular blood flow can be monitored using imaging techniques such as Doppler ultrasound or time-series MRI, however, the spatial resolutions of such techniques are poor. In addition, it is not possible to observe the detailed interaction of the blood flow and the endocardial surface of the heart. Therefore, the formation of cardiac thrombus remains difficult to predict. If a physicia...Mon, 27 Feb 2017 10:17:33 GMTchristopher.perkins@rutgers.edu Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases, 27 Feb 2017 10:17:29 GMTchristopher.perkins@rutgers.edu Surface Probes and Quantitative Recognition Arrays, 27 Feb 2017 10:17:26 GMTchristopher.perkins@rutgers.edu Catalysts for Water Oxidation/Water Splitting, 27 Feb 2017 10:17:19 GMTchristopher.perkins@rutgers.edu and Manufacture of Pharmaceuticals by Impregnation onto Porous Carriers Rutgers scientists have developed a novel platform of pharmaceutical product development by utilizing fluid bed impregnation (FBI) of API solutions onto porous carriers. Impreg-nation of solutions into porous carriers allows extremely uniform distribution of small amounts of material, which can be used for drug dosage regulation. Currently, the method can be adjusted for drug content as low as 0.1% and as high as 10%, thus spanning the entire range of interest for poorly soluble, highly potent compounds in oral delivery applications. The drug release profile can also be controlled through the...Mon, 27 Feb 2017 10:17:12 GMTchristopher.perkins@rutgers.edu Bipolar Transistor for Power Switching Applications A recent GBI Research report on the Discrete Power Semiconductor device market (forecasting up to 2020) shows an increased demand from the Hybrid Electric Vehicles, Solar, and Wind Energy markets. Although the majority of the market is dominated by Silicon MOSFETs and Insulated Gate Bipolar Transistors (IGBT), Silicon Carbide (SiC) has emerged as a viable replacement due to its advantages over conventional Silicon devices. SiC is 700X better than Si for power semiconductor switching, improves efficiency of a device by more than 20%, and facilitates the production and usage of devices with ...Mon, 27 Feb 2017 10:17:12 GMTchristopher.perkins@rutgers.edu Agents from Leaves of Combretum micranthum (Kinkeliba), 27 Feb 2017 10:17:10 GMTchristopher.perkins@rutgers.edu With Controllable Size And Morphology, 27 Feb 2017 10:17:02 GMTchristopher.perkins@rutgers.edu Acute Leukemia Biomarker and Relapse Predictor University investigators have discovered a novel function for the Programmed Cell Death 2 (PDCD2) protein in cancer cell growth and its potential use as a biomarker for disease response in acute leukemia patients.PDCD2 is an evolutionarily conserved eukaryotic protein with previously unknown function. Extensive cell culture studies demonstrated near universal high PDCD2 expression in leukemia and its role in promoting cancer growth, which is further supported by clinical studies in diagnosed acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) patients. As illustrate...Mon, 27 Feb 2017 10:16:55 GMTchristopher.perkins@rutgers.edu and Compositions for Removing Carbon Dioxide from a Gaseous Mixture Rutgers researchers have developed a method for separating carbon dioxide from a mixture of gases by way of passing said mixture through a porous polymeric coordination compound. The compound is a three-dimensional network with one-dimensional channels made of Zn metal and two polyfunctional ligands with binding sites conducive to CO2 removal. Sequestration of greenhouse gases as related to combating anthropogenic climate change.The MMOFs presented are highly promising candidates for use in high selectivity capture of CO2 under low temperature or high pressure conditions. They offer a low-cos...Mon, 27 Feb 2017 10:16:53 GMTchristopher.perkins@rutgers.edu IMIDAZOLATE FRAMEWORKS FOR KINETIC SEPARATION OF PROPANE AND PROPENE, 27 Feb 2017 10:16:48 GMTchristopher.perkins@rutgers.edu Enriched Black Tea Extract to Increase Physical Performance and Reduce Recovery Time from Intense Exercise, 27 Feb 2017 10:16:41 GMTchristopher.perkins@rutgers.edu Vehicle Information Systems and Methods is a mobile system comprising vehicles that collect parking space occupancy information while driving by. Each ParkNet vehicle is equipped with a GPS receiver and a passenger-side-facing ultrasonic rangefinder to determine parking spot occupancy. The data is aggregated at a central server, which builds a real-time map of parking availability and could provide this information to clients that query the system in search of parking.Creating a spot-accurate map of parking availability challenges GPS location accuracy limits. To address this need, inventors at Rutgers University have devise...Mon, 27 Feb 2017 10:16:39 GMTchristopher.perkins@rutgers.edu of Kombo Butter Extract and Derived Compounds as Novel Neuroprotective Agents, 27 Feb 2017 10:16:33 GMTchristopher.perkins@rutgers.edu LUMINESCENT MICROPOROUS MATERIALS FOR FAST AND REVERSIBLE DETECTION OF HIGH EXPLOSIVES Investigators at Rutgers University have synthesized a microporous material made of metal (Zn) and organic molecules with strong capabilities for detecting trace vapor of high explosives. The highly luminescent material exhibits very fast response and high sensitivity towards nitroaromatic explosive DNT, and plastic explosive taggant, DMNB. Such materials lay the groundwork for developing highly sensitive and highly selective luminescent MMOF-based sensors and sensor arrays. Explosive detection, public and national security, environmental protection. Low-cost, fast-acting, simple and re...Mon, 27 Feb 2017 10:16:33 GMTchristopher.perkins@rutgers.edu COMPOUNDING IN AN INJECTION MOLDING MACHINE (JOINTLY OWNED WITH RAND CASTLE) The plastics manufacturing industry compounds one to five percent (1-5%) of pelletized additives into bulk polymer resins to fabricate plastic parts. The process of dispersing and distributing pigments, modifiers, fillers, particles, reinforcing agents, and other various compounds within a polymer matrix for injection molding is difficult. In most cases, twin screw extrusion (TSE) is commonly used for pre-compounding in order to achieve good mixing. However, single screw extrusion (SSE) offers several advantages, including lower cost, rugged machinery more resistant to abuse and easy and inex...Mon, 27 Feb 2017 10:16:20 GMTchristopher.perkins@rutgers.edu BRIGHTNESS EXCIMER LAMP, 27 Feb 2017 10:16:08 GMTchristopher.perkins@rutgers.edu ZnO Nanotips/Transparent and Conductive Films for Photovoltaic Devices Researchers at Rutgers University have invented a novel 3-D structure by integrating Zinc Oxide (ZnO) nanotips and ZnO transparent conductive oxide (TCO) film for applications in photovoltaic devices. This novel 3-D structure has multifunctionality with in-situ doping: the ZnO film is heavily doped, acting as the transparent and conductive electrode, while the undoped or less heavily doped single crystalline ZnO nanotips provide n-type semiconductor with nanostructure morphology, acting for anchoring dye and/or polymer molecules. The ZnO nanotips and ZnO TCO film can be grown in the same MO...Mon, 27 Feb 2017 10:15:36 GMTchristopher.perkins@rutgers.edu SHEET FOLDING MACHINE WITH MICROFOLDING TECHNOLOGY, 27 Feb 2017 10:15:01 GMTchristopher.perkins@rutgers.edu<![CDATA[Nanostructured RE-doped SiO2-base Fluorescent Materials & Methods for Production of Same]]> A new class of nanostructured RE-doped SiO2-base materials that display superior fluorescence properties with high gain combined with a broad and flat spectral band with. Such enhanced fluorescence properties have been observed in heat treated nanopowders prepared by vapor-phase, sol-gel and spray-pyrolysis methods. The expectation is that similar effects will be observed in monolithic materials, when known bulk glass processing methods, such as glass-ceramic processing, incorporate an intermediate heat treatment step to generate preferred nanocomposite structures. In addition to optical am...Mon, 27 Feb 2017 10:14:03 GMTchristopher.perkins@rutgers.edu Butter Extract and Derivatives as Novel Anti-Inflammatory Agents, 27 Feb 2017 10:13:36 GMTchristopher.perkins@rutgers.edu Agents from Artemisia Plants, 27 Feb 2017 10:12:36 GMTchristopher.perkins@rutgers.edu Conversion Coatings For Ferrous Substrate Coatings that provide a passivating barrier of very low solubility through a conversion of the metal surface into a corrosion-resistant, non reactive form, play an important role in coating technology. Conversion coatings are often absorbent, providing an ideal base for protective oils, waxes or dyes. They are also used for high-tempera- ture applications and provide properties such as hard- ness, abrasion resistance, and adhesion and thermal stability. Chromate and phosphate conversion coat- ings have poor abrasion resistance and thermal stabil- ity, and preparation process requires the use ...Mon, 27 Feb 2017 10:10:36 GMTchristopher.perkins@rutgers.edu Doped Nanocomposite Materials for Photonics Applications, 27 Feb 2017 10:10:31 GMTchristopher.perkins@rutgers.edu Thermostable Alpha-Galactosidase for Use as a Flatulence-Reducing Agent, 27 Feb 2017 10:10:11 GMTchristopher.perkins@rutgers.edu Voltage TFT On Glass For Solar Inverters, 24 Jan 2017 05:46:18 GMTchristopher.perkins@rutgers.edu for Drug-Resistant Bacterial Infections - Myxopyronins, 04 Jan 2017 08:43:54 GMTchristopher.perkins@rutgers.edu for Drug-Resistant Bacterial Infections: Inhibitors of Bacterial RNA Polymerase, 04 Jan 2017 08:24:58 GMTchristopher.perkins@rutgers.edu for Tuberculosis: Novel Inhibitors of Mycobacterial RNA Polymerase, 04 Jan 2017 07:49:48 GMTchristopher.perkins@rutgers.edu Quantitative Assays, 10 Nov 2016 10:53:39 GMTchristopher.perkins@rutgers.edu FISH probes for the prognosis of malignant transformation in Barrett’s epithelium have reported that patients suffering from BE have a 120-fold higher risk of developing EA. Moreover, most BE patients currently undergo rigorous therapeutic and surgical procedure to alleviate progression to EA. Currently, there are no available methods or tests to predict the progression of BE to EA. It is estimated that the esophageal cancer therapeutics market will grow at a CAGR of 14% to reach $594.7m by 2017.The current standard of care is to treat each high grade BE case as a potential cancer patient. The surgical intervention and aggressive acid suppressive therapies that are ...Thu, 27 Oct 2016 13:13:09 GMTchristopher.perkins@rutgers.edu Virus/Cell Based Assay for Discovery of Anti-HIV Drugs Persistence of HIV-1 in latently infected CD4+ T-cells prevents eradication of virus in patients. The half-life of the latently infected population is quite long. To fully eliminate virus, small molecules that can reach and activate latent viral reservoirs could potentially be utilized to eliminate the latent arm of the infection by the combination with current antiretroviral therapy.Invention: This technology is a cell-based assay for high-throughput screening for novel compounds that can activate latent HIV-1. It provides an isolated, latently infected T cell line. Upon treatment...Thu, 27 Oct 2016 10:56:48 GMTchristopher.perkins@rutgers.edu<![CDATA[Highly Selective & Rapid Separation of iPSCs from Differentiated Cells]]> induced pluripotent stem cells (iPSCs) hold great promises for disease modeling and drug discovery. However, a rate-limiting step in iPSCs derivation is their separation from differentiated cells. It takes about 10 separations and passages for an iPSC clone to become stable, with minimal differentiation. Traditionally, at every passage, the researchers need to either manually pick the iPSCs from differentiated cells or mechanically scrape the differentiated cells from the plate. As such, for one 6-well plate, an experienced lab researcher typically spends 6-7 hours scraping the different...Wed, 26 Oct 2016 12:14:49 GMTchristopher.perkins@rutgers.edu Molecule Extracellular Inhibitors of TAM Receptors for Cancer Therapy TAM receptors (Tyro3, Axl, and Mertk) are a family of three homologous receptor tyrosine kinases (RTKs) that play important roles in tissue homeostasis, immune response, and the resolution of inflammation. Besides the intracellular catalytic kinase domain common to all kinases, the TAMs uniquely contain an extracellular domain that distinguishes them among all known kinases.TAMs are overexpressed in many human cancers, thereby promoting tumor proliferation, migration, survival, and immune escape. TAM dysregulation tracks with more aggressive cancers, poorer predicted patient survival, and ...Wed, 14 Sep 2016 07:53:17 GMTchristopher.perkins@rutgers.edu RNAi-mediated method for resistance to soybean cyst nematode scientists have developed a new method for inducing resistance to soybean cyst nematode (SCN) by using root-specific RNA interference (RNAi) technology. Specifically, RNAi was used to express small RNAs targeting a critical SCN ribosomal gene under the root-specific promoter in soybean plants. Homozygous transgenic soybean plants were then selected and tested against SCN. These transgenic plants demonstrated approximately 40 to 80% more resistance to SCN relative to control plants lacking the RNAi molecules. The SCN infection assay showed that the high expression of siRNA in the T1 and...Wed, 07 Sep 2016 12:56:25 GMTchristopher.perkins@rutgers.edu Efficiency Isotope Enriched Protein Production Systems scientists have developed two Single Protein Production (SPP)-based systems to obtain high levels of specific isotopically enriched proteins: an independently inducible system (cSPP(tet)) and an amino acid auxotroph-based dual inducible system. The proprietary SPP system, developed at Rutgers and currently licensed to Takara Bio Inc., essentially turns living E. coli cells into a bioreactor for producing a single protein of interest at high levels. The system utilizes an E. coli endoribonuclease, MazF, to selectively cleave cellular mRNAs at the ACA sequences and thus completely inhibi...Fri, 12 Aug 2016 12:26:33 GMTchristopher.perkins@rutgers.edu Biosensors for Rapid Determination of Antimicrobial Resistance resistance (AMR) is becoming a major global-health concern. Traditional assays available for monitoring bacterial and fungal growth require time-consuming and labor-intensive efforts. There is thus urgent need for developing rapid and highly sensitive tools for diagnosis and surveillance of AMR.A research team led by Professors Yicheng Lu and Steven Zheng at Rutgers University has developed a highly sensitive, dynamic, rapid, compact and low cost diagnostic sensor technology for monitoring antimicrobial resistance (AMR) and screening antimicrobials that work against resistant str...Fri, 12 Aug 2016 12:04:37 GMTchristopher.perkins@rutgers.edu and Cost-effective Method for Quantifying Nucleic Acid Binding Strength, 21 Jun 2016 11:04:49 GMTchristopher.perkins@rutgers.edu Methionine, Enhanced Protein Corn with a Sturdy Kernel, 15 Jun 2016 13:41:31 GMTchristopher.perkins@rutgers.edu of Field Performance in Woody Perennials Resulting from Engineered Nitrogen Use Efficiency (NUE), 15 Jun 2016 13:32:08 GMTchristopher.perkins@rutgers.edu Venus® Dogwood, 15 Jun 2016 13:19:00 GMTchristopher.perkins@rutgers.edu Bioaerosol Sampler using Ferroelectric Polymer, 20 May 2016 09:16:52 GMTchristopher.perkins@rutgers.edu Diagnostic Tool to Quantify Signatures of Movement in Subjects with Neurological Disorders, Autism and Autism Spectrum Disorders, 16 Mar 2016 10:52:19 GMTchristopher.perkins@rutgers.edu Bug Seizer Attractant and Monitoring System scientists have developed an economical and effective attractant, trapping device and monitoring system (Bed Bug SeizerTM) for detecting low levels of bed bug infestations.The proprietary bed bug monitoring system consists of a highly effective trapping device, an attractant, and a carbon dioxide source. The system can be used both in occupied and unoccupied infested places to detect bed bugs early, evaluate treatment effectiveness, and reduce control cost.In field studies, the trapping device was found to be significantly more effective than ClimbupTM Insect Interceptor, the most effe...Fri, 11 Mar 2016 10:52:09 GMTchristopher.perkins@rutgers.edu Chiral Biphosphine Metallorganocatalysts for Asymmetric Reactions, 10 Mar 2016 12:06:35 GMTchristopher.perkins@rutgers.edu Synthetic Transcription Factor for Enhanced Gene Expression, 18 Feb 2016 08:19:01 GMTchristopher.perkins@rutgers.edu Class of Biofertilizer Promoting Growth and Stress Tolerance, 18 Nov 2015 08:39:39 GMTchristopher.perkins@rutgers.edu Personal Electrostatic Bioaerosol Sampler (PEBS), 14 Oct 2015 08:17:17 GMTchristopher.perkins@rutgers.edu and Biocompatible Bioactive-based Polymers for Dental Applications Uhrich group at Rutgers University has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), and antibiotics (e.g., amoxicillin). Bioactive molecules are incorporated into polymer backbones through labile linkages, enabling high bioactive loading and sustained and controlled release upon degradation (e.g., hydrolysis). The release profile is well controlled based on the polymer chemical compositions and can be adjusted to desired release time frame (from hours, days, to months). The pol...Tue, 18 Aug 2015 13:06:59 GMTchristopher.perkins@rutgers.edu Novel Method for Diagnosing and Monitoring Brain Trauma Patients, 28 Jul 2015 08:43:32 GMTchristopher.perkins@rutgers.edu Humanized Yeast System for mTOR Kinase Inhibitor Screening and Studies, 28 Jul 2015 07:16:42 GMTchristopher.perkins@rutgers.edu Novel Diagnostic Assay for Predicting Patients’ Resistance to mTOR Kinase Inhibitors Target of Rapamycin (mTOR) is a highly conserved serine/thereonine protein kinase that plays a crucial role as part of two distinct kinase complexes, mTOR1C and mTOR2C, to regulate cell growth and metabolism. Abnormal activation of mTOR has been implicated in the pathogenesis of several cancers, type 2 diabetes, obesity, and neurodegeneration. Numerous mTOR kinase inhibitors are currently in development with several currently be evaluated as anticancer therapy in clinical trials. However, given recent clinical experience with target therapeutics, acquired drug resistance in mTOR is...Tue, 28 Jul 2015 06:17:22 GMTchristopher.perkins@rutgers.edu™ Botanical-derived Functional Ingredients for Food, Beverages, Nutrition, 10 Jul 2015 09:22:40 GMTchristopher.perkins@rutgers.edu<![CDATA[Nutrasorb™ Botanical Functional Ingredients for Cosmetic, Personal & Skin Care]]>, 10 Jul 2015 09:16:00 GMTchristopher.perkins@rutgers.edu and Biocompatible Bioactive-based Polymers - Versatile Platform Technology Uhrich group at Rutgers University has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones through labile linkages, enabling high bioactive loading and sustained and controlled release upon degradation (e.g., hydrolysis). The release profile is well controlled based on the polymer chemical compositions, and can be adjusted to the desired release time fram...Tue, 07 Jul 2015 12:12:45 GMTchristopher.perkins@rutgers.edu Bracket with Dual-Width Arch-Wire and Slot, 06 Jul 2015 07:16:34 GMTchristopher.perkins@rutgers.edu Flow Deflector, 15 May 2015 06:41:14 GMTchristopher.perkins@rutgers.edu Promoting Properties of Newly Identified Root Fungi A. panicicola for Agricultural Applications, 24 Apr 2015 12:56:07 GMTchristopher.perkins@rutgers.edu Device For Effective Vein Punctuation, 24 Apr 2015 12:05:24 GMTchristopher.perkins@rutgers.edu Nutraceutical Compositions containing Phenethylisothiocyanate and their Uses as Anti-Inflammatory Agents, 23 Feb 2015 11:18:14 GMTchristopher.perkins@rutgers.edu Adaptor: Demonstrated In Vivo Potency and Low Toxicity Provide Clear Advantages for a Next-Generation Gene Silencing Technology in Life Science Research Rutgers scientists have developed compositions of single-stranded oligonucleotides that inhibit RNA biosynthesis by a novel mechanism of action. This enables the development of highly efficient gene silencing agents that have shown unprecedented inhibitory levels both in vitro and in vivo. The U1 adaptor consists of two parts, a target-gene binding domain and a U1 domain that attracts and inhibits the cellular polyA-tail addition apparatus. By combining both capabilities in the same molecule, the U1 adaptor can specifically inhibit the pre-mRNA maturation step of polyA-tail addition of a targ...Fri, 13 Feb 2015 13:17:46 GMTchristopher.perkins@rutgers.edu NEUROTROPHIC FACTOR A MARKER OF REPRODUCTIVE POTENTIAL IN WOMEN Infertility affects about 5.3 million people in the United States. For women turning to in vitro fertilization (IVF) to aid the conception process, the treatment is expensive and only has about a 30% success rate with the current state of the art. IVF is the foundation of a multibillion dollar industry. Any technique that can decrease the cost and increase its success rate would be highly useful in the market. Neurotrophins represent a family of soluble polypeptide growth factors originally identified in the mammalian nervous system. In recent years, some neurotrophins such as nerve growth...Mon, 04 Aug 2014 12:50:11 GMTchristopher.perkins@rutgers.edu TAT proteins and methods for use thereof The human immunodeficiency virus (HIV) Tat protein stimulates the expression of early genes of the virus. Tat protein also interacts with cellular transcriptional factors and cytokines and alters the expression of a variety of genes in HIV-1-infected and noninfected cells. Tat function requires its binding to (P-TEFb), a cellular positive transcription elongation factor b. Tat protein is secreted by HIV infected cells and extracellular Tat has been implicated in the progression of AIDS. Also, extracellular Tat exerts a variety of pleiotropic effects on target cells by binding to cell surface...Wed, 30 Jul 2014 14:00:15 GMTchristopher.perkins@rutgers.edu Beacons, 30 Jul 2014 13:35:14 GMTchristopher.perkins@rutgers.edu PERCUTANEOUS VENTRICULAR ASSIST DEVICE (DUPLICATE 2004-052), 30 Jul 2014 13:35:11 GMTchristopher.perkins@rutgers.edu Diagnostics of Tick-borne Diseases, 28 Jul 2014 06:45:59 GMTchristopher.perkins@rutgers.edu FOR DIAGNOSING, PREVENTING, AND TREATING DEVELOPMENTAL DISORDERS DUE TO A COMBINATION OF GENETIC AND ENVIRONMENTAL FACTORS, 10 Jul 2014 09:13:46 GMTchristopher.perkins@rutgers.edu Unmanned Vehicle Operational in Air and Underwater, 10 Jul 2014 06:56:58 GMTchristopher.perkins@rutgers.edu MORPHOGENETIC PROTEIN-2 AND BONE MORPHOGENETIC PROTEIN-4 IN THE TREATMENT AND DIAGNOSIS OF CANCER BMP-2 expression is linked to cancer invasion and. BMPs are synthesized as inactive proteins of variable length. The precursor BMP-2 and BMP-4 proteins are proteolytically cleaved, producing mature C-terminal proteins of a little more than 100 residues. BMP-2 and BMP-4 interact with the same binding sites: mature BMP-2 and BMP-4 protein signaling is mediated by transmembrane serine/threonine kinases called type IA, IB, and type II receptors. The receptor phosphorylates cytoplasmic targets, which include the Smad family of proteins. In addition, the same molecules including noggin, chordin,...Mon, 07 Jul 2014 11:44:10 GMTchristopher.perkins@rutgers.edu GROWTH FACTOR INDUCIBLE NEUROKININ-1 GENE, 07 Jul 2014 11:44:09 GMTchristopher.perkins@rutgers.edu for Nkx3.1 in prostate development and cancer Relatively little is known about the molecular mechanisms involved in prostate carcinogenesis due to the lack of animal models that mimic human prostate carcinoma. Mutant mouse models lacking genes critical for prostate development could be utilized to understand the molecular pathways involved in prostate cancer initiation and progression. Also, very few tumor suppressor genes have been definitively shown to be lost during prostate cancer progression. Thus, the identification of prostate-specific tumor suppressor genes would be extremely valuable in studying prostate carcinogenesis. The pr...Mon, 07 Jul 2014 11:44:07 GMTchristopher.perkins@rutgers.edu and protection against glucocorticoid induced cell death in bone cells, 02 Jul 2014 13:57:30 GMTchristopher.perkins@rutgers.edu and Therapeutic uses of Topors, a possible Tumor Suppressor Gene, 02 Jul 2014 13:56:36 GMTchristopher.perkins@rutgers.edu methods for protein profiling, 02 Jul 2014 11:41:27 GMTchristopher.perkins@rutgers.edu Isoform and Diagnostic and Therapeutic Uses Therefor, 02 Jul 2014 11:41:26 GMTchristopher.perkins@rutgers.edu Safety Syringe, 02 Jul 2014 11:41:25 GMTchristopher.perkins@rutgers.edu access needle Medical instruments used for diagnostic or therapeutic purposes such as micropuncture, catheterization, and arteriography are often introduced into subjects through vascular vessels using various types of needle assemblies. However, one problem associated with the use of such needles is inadvertent needle sticks. Thus, what is needed, but has not yet been provided, is a vascular access needle which allows the insertion of instruments of varying or increasing diameter into a blood vessel without requiring the insertion of multiple guide wires, and which protects against inadvertent needle...Wed, 02 Jul 2014 11:41:24 GMTchristopher.perkins@rutgers.edu intervention of chlamydial infection Chlamydial infection is caused by Chlamydia trachomatis bacterium and is one of the most common sexually transmitted infections worldwide. As per U.S. Centers for Disease Control and Prevention estimates, there are 4 million new cases of Chlamydial infections each year. Chlamydial infection often results in abnormal discharge from female and male sexual organs and pain while urinating. If left untreated, the infection may spread to other organs of the body causing pelvic inflammatory disease (PID) in women and epidydimitis in men, inflamed rectum and inflammation of the eye. Approximate...Wed, 14 May 2014 06:17:20 GMTchristopher.perkins@rutgers.edu A-4 ANALOGUES FOR CANCER THERAPY Cancer is one of the most common human diseases, and leads to about 12% of all deaths worldwide. Mitotic inhibitors such as paclitaxel, which is a tubulin-binding compound that disrupts the formation of mitotic spindles, are widely used for the treatment of cancer, and have achieved great commercial successes. However, these clinically used anti-tubulin drugs often face severe limitations such as neural and systemic toxicity, multiple side effects, induction of drug resistance, and complex synthetic pathways and isolation methods. Combretastatin A-4 (CA-4) is a potent tubulin inhibitor wit...Wed, 14 May 2014 06:17:19 GMTchristopher.perkins@rutgers.edu Derived from Human Mesenchymal Stem Cells, 14 May 2014 06:17:18 GMTchristopher.perkins@rutgers.edu BLOCKING AGENTS FOR THE TREATMENT OF CANCER Glutamate signaling was once thought to only participate in synaptic transmission and neuronal excitability, however, recent evidence suggests that inappropriate expression of glutamate receptors in non-neuronal cells plays a role in cellular transformation. Drs. James Goydos and Suzie Chen, researchers at Rutgers University, were the first to report on the oncogenic role of metabotropic glutamate receptor 1 (GRM1) in melanoma development and progression. This group demonstrated the presence of excess levels of extracellular glutamate in GRM1 expressing melanoma cells. Given that malign...Fri, 09 May 2014 11:36:21 GMTchristopher.perkins@rutgers.edu Short Peptide and Its Mimics as Immuno/Inflammatory Modulators, 09 May 2014 11:36:20 GMTchristopher.perkins@rutgers.edu of Thermal Stability of Collagen Triple Helix, 09 May 2014 08:53:36 GMTchristopher.perkins@rutgers.edu and System for Transcutaneous Monitoring of Endotracheal tube placement Invention Summary Intubating a patient always poses a challenge due to the anatomy of the throat. Most often the tube is inserted into the esophagus by mistake. Insertion of an endotracheal tube into the trachea requires a skilled practitioner and direct visualization that requires the use of a laryngoscope. After the insertion of the laryngoscope into the mouth, the neck of the patient needs to be extended so the inlet of the trachea can be visualized to navigate the tube directly toward it. The procedure is cumbersome and poses a serious risk for patients with neck injury. Researchers at...Wed, 12 Mar 2014 11:55:30 GMTchristopher.perkins@rutgers.edu for modulating inflammatory responses, 12 Mar 2014 11:55:30 GMTchristopher.perkins@rutgers.edu OF TREATING AUTISM (JOINTLY OWNED WITH ROWAN), 10 Mar 2014 07:33:55 GMTchristopher.perkins@rutgers.edu to Modulate the Immune System Using Mesenchymal Stem Cells, Cytokines and Chemokines, 05 Mar 2014 09:03:24 GMTchristopher.perkins@rutgers.edu (JOINTLY OWNED W/NJIT), 05 Mar 2014 08:27:57 GMTchristopher.perkins@rutgers.edu and methods for the treatment and prevention of infections caused by Staphylococcus Aureus Bacteria, 05 Mar 2014 08:27:53 GMTchristopher.perkins@rutgers.edu Cancer Therapy Based On A Telomerase Reverse Transcriptase Variant, 05 Mar 2014 08:27:51 GMTchristopher.perkins@rutgers.edu METHOD TO MEASURE IGF TYPE I RECEPTOR AND INSULIN RECEPTOR ISOFORM EXPRESSION, 05 Mar 2014 08:27:50 GMTchristopher.perkins@rutgers.edu glutathione S-transferease P1 haplotype acting in mothers during pregnancy may increase risk of autistic disorder in her affected offspring, 05 Mar 2014 08:27:49 GMTchristopher.perkins@rutgers.edu OF GSTM1 WITH AUTISM AND ASSAYS AND METHODS BASED THEREON, 05 Mar 2014 06:56:09 GMTchristopher.perkins@rutgers.edu of Human Endogenous Retrovirus Expression in Cancer and Normal Cells Summary  Approximately 8% of the human genome consists of sequences classified as Human endogenous retroviruses (HERVs), which are remnants of ancient retroviral integrations in the human genome. While HERV elements have degenerated over millions of years of evolution and most of them can no longer encode complete proteins, some HERV genes still have open reading frames (ORFs) and thus can potentially code for protein. HERV genes have been implicated in cancer development and linked to HIV infection, autoimmune, and other multi-factorial diseases. Although considerable advances have ...Tue, 25 Feb 2014 08:19:25 GMTchristopher.perkins@rutgers.edu Gold Catalyzed Oxidation of Alkyl-Substituted Benzenes and n-Alkanes and Selective Oxidation to Ketones technology relates to the preparation of mesoporous silica-supported nanosized gold particles that are efficient catalysts for the selective oxidation of alkyl-substituted benzenes and n-alkanes to the corresponding ketones. The gold nanoparticles were synthesized by reducing gold ions in situ with the hemiaminal groups of hemiaminal-functionalized mesoporous silica. The size of the nanoparticles was controlled by changing the concentration of Au(III) used in the synthesis. The resulting gold nanoparticles were shown to be efficient catalysts for the oxidation of various alkyl-substituted...Fri, 21 Feb 2014 10:26:44 GMTchristopher.perkins@rutgers.edu and Easily Recyclable Heterogeneous Nanocatalysts, 07 Feb 2014 11:20:28 GMTchristopher.perkins@rutgers.edu and Partially-Oxidized Metallic Plasmonic Electrodes for Inverted Bulk Heterojunction Photovoltaics, 06 Feb 2014 12:24:41 GMTchristopher.perkins@rutgers.edu to Reduce the Computational Cost of Bayesian Indoor Positioning Systems, 06 Feb 2014 12:24:07 GMTchristopher.perkins@rutgers.edu<![CDATA[SAFE AND EFFECTIVE TOPICAL MEDICATION (SOLUTION, CREAM & PATCH) TO TREAT CUTANEOUS HEMANGIOMA]]> Summary           Capillary hemangioma is the most common benign tumor of the eyelid/orbit in children and affects up to 2% of infants, over 1.7 million children in USA and over 10 million children worldwide. If not treated promptly, it can cause blindness. Overall, the incidence of cutaneous hemangioma is widely prevalent resulting in physically disfiguring and psychologically disturbing lesions in all age groups affected. Systemic or intra-lesional corticosteroids are commonly used as first line treatment. Alternative treatments include laser photocoagulation, surgical excision and...Thu, 06 Feb 2014 11:58:52 GMTchristopher.perkins@rutgers.edu VANILLOID CARBAMATES, 06 Feb 2014 11:51:37 GMTchristopher.perkins@rutgers.edu Reconstruction Magnetic Resonance (MR) imaging has been widely used in medical diagnostics because of its non-invasive manner and excellent depiction of soft tissue changes. Image reconstruction methodologies are vital to many applications in medical imaging. Recent developments in compressive sensing theory show that it is possible to accurately reconstruct the Magnetic Resonance (MR) images from highly undersampled K-space data and therefore significantly reduce the scanning duration. Researchers at Rutgers University have developed a sparsity technique for efficient MR image segmentation and reconstruc...Tue, 04 Feb 2014 06:55:29 GMTchristopher.perkins@rutgers.edu SCREEN BATTERY FOR EMISSION CONTROL Electrostatic Screen Battery for Emission Control (ESBEC) is a device for capturing airborne particulate matter emissions from a variety of mobile and stationary sources, such as diesel engines used in automobiles, marine engines, agricultural equipment, power generation equipment, etc. The ESBEC collects and allows for subsequent removal of collected airborne particulate matter using a wire mesh screen coated with superhydrophobic material and supplied with high voltage. The superhydrophobic coating on the screen surface enables easy removal of the collected particles using liquid medium and...Tue, 04 Feb 2014 06:55:15 GMTchristopher.perkins@rutgers.edu BASED SILICONE/GLASS FIBER COMPOSITES FOR THE PROTECTION OF SUBSTRATES FROM HEAT FLUX AND FIRE (RELATED TO 2009-018) Thermal barrier coatings(TBC)s insulate and protect a substrate from prolonged or excessive heat flux and enable the substrate material to retain its mechanical property integrity during service. Selection of the type of system and its components depends upon the application. Heat may be dissipated away from a substrate by several methods, including heat sinks, active cooling, transpiration cooling, radiation cooling, and intumescence. Researchers at Rutgers have built upon earlier work in designing coating for Heat Flux and Fire protection to further enhance their materials. The proposed t...Tue, 04 Feb 2014 06:55:11 GMTchristopher.perkins@rutgers.edu Airborne Contaminant Collector: Very High Concentration Rate and Low Power Consumption, 04 Feb 2014 06:55:08 GMTchristopher.perkins@rutgers.edu Causes Accumulation of Amyloid Beta Oligomers in a New Animal Model of Alzheimer's Disease Neuropathology, 22 Jan 2014 11:46:03 GMTchristopher.perkins@rutgers.edu to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics, or Other Agents, 22 Jan 2014 11:38:30 GMTchristopher.perkins@rutgers.edu method to improve retinal viability, 22 Jan 2014 11:34:26 GMTchristopher.perkins@rutgers.edu Nucleic Acid (PNA) Conjugates as Antiviral Agents, 22 Jan 2014 11:31:19 GMTchristopher.perkins@rutgers.edu METHOD FOR MAPPING 3' ENDS OF TRANSCRIPTS AND QUANTITATIVE ANALYSIS OF ALTERNATIVE POLYADENYLATION ISOFORM AND GENE EXPRESSION, 22 Jan 2014 11:24:05 GMTchristopher.perkins@rutgers.edu POLYADENYLATION ISOFORMS AS A BIOMARKER TO DETERMINE THE CELL PROLIFERATION AND DIFFERENTIATION STATE, 22 Jan 2014 11:23:35 GMTchristopher.perkins@rutgers.edu RNA Restriction Enzymes, 22 Jan 2014 11:21:48 GMTchristopher.perkins@rutgers.edu and Extracts thereof as Anti-HCV inhibitors Summary   Hepatitis C Virus (HCV) is an RNA virus causing persistent liver infections that can progress to chronic hepatitis, cirrhosis, and in some cases cancer of the liver. With an estimated 170-200 million people infected with HCV worldwide, HCV infection has become a major public health concern both in developed and developing countries. Current therapies against HCV with their adverse side effects, are not only expensive and limited in efficacy against the various HCV genotypes, but also give rise to mutant viruses. Therefore, there is an urgent need for developing improved ant...Wed, 22 Jan 2014 11:19:27 GMTchristopher.perkins@rutgers.edu SENSOR RADIO SCENE ANALYSIS FOR PACKET BASED RADIO SIGNALS USING 2ND AND 4TH ORDER STATISTICS existing wireless systems use static allocation of the radio spectrum with each system operating in a predefined fixed frequency band. Since the allocated spectrum is not used at all locations and at all times, this static allocation leads to creation of spectrum holes, which implies inefficient utilization of the available radio spectrum. Dynamic spectrum allocation offers a much more optimal spectrum utilization scheme. However, dynamic systems must have a completely new feature embedded in them, spectrum sensing capability. Spectrum sensing can be defined as RF signal analysis with a g...Thu, 09 Jan 2014 10:15:46 GMTchristopher.perkins@rutgers.edu Engineered Algae Strains with Highly Elevated Lipid Production, 08 Jan 2014 07:40:32 GMTchristopher.perkins@rutgers.edu Biomaterials Portfolio Hydroxyapatite, HAp, chemical formula Ca10 (PO4)6(OH)2 has attracted the attention of researchers over the past thirty years as an implant material because of its excellent biocompatibility and bioactivity. HAp has been used extensively in medicine for implant fabrication. It is commonly the material of choice for fabricating dense and porous bioceramics. Its general uses include biocompatible phase-reinforcement in composites, coatings on metal implants and granular all for direct incorporation into human tissue. Other potential nonmedical applications include a packing material/support for ...Mon, 06 Jan 2014 13:23:44 GMTchristopher.perkins@rutgers.edu Actuator Array Technology for Propulsion, and Flow Control for Underwater Vehicles, 23 Dec 2013 05:45:33 GMTchristopher.perkins@rutgers.edu to Prepare and Apply Flame-retardant Coating Composed of Polyurethane, Isopropyl Alcohol and Magnesium Hydroxide Suspension, 29 Oct 2013 10:22:04 GMTchristopher.perkins@rutgers.edu Quartz Crystal Microbalance-based Biosensor for Dynamic and Non-invasive Cellular Monitoring, 18 Sep 2013 10:09:07 GMTchristopher.perkins@rutgers.edu Probe Photocurrent Measurement Device Photocurrent action spectra or external quantum efficiency (EQE) measurement of semiconductor thin films is an important parameter for solar cell development. Values higher than 80% photon to electron conversion efficiency over a broad range of wavelengths are necessary (but not sufficient) condition for the development of highly efficient solar cells. However, this measurement is usually performed on the actual solar cells, meaning the knowledge occurs once the final device is assembled which makes this important measurement burdensome and time consuming. It would be very desirable to gain ...Wed, 18 Sep 2013 10:09:05 GMTchristopher.perkins@rutgers.edu Stellar Pink® Dogwood, 19 Jul 2013 05:41:20 GMTchristopher.perkins@rutgers.edu RECOGNITION BIOFEEDBACK, 13 Jul 2013 11:21:16 GMTchristopher.perkins@rutgers.edu of an Insect-Growth Regulator for Mosquito Management, 01 Jul 2013 06:06:07 GMTchristopher.perkins@rutgers.edu University Mullica Queen® Cranberries, 01 Jul 2013 06:05:56 GMTchristopher.perkins@rutgers.edu for Enhancing Anaerobic Degradation of Methyl Tert-butyl Ether (MTBE) and Structurally Related Fuel Oxygenates, 01 Jul 2013 06:05:55 GMTchristopher.perkins@rutgers.edu Red Beauty® Holly, 01 Jul 2013 06:05:50 GMTchristopher.perkins@rutgers.edu Magneto-Plasmonic Nanoparticles for Biomolecule Delivery and Imaging, 18 Jun 2013 12:02:32 GMTchristopher.perkins@rutgers.edu to Produce Hepatitis C Virus E2 Protein, 18 Jun 2013 12:02:21 GMTchristopher.perkins@rutgers.edu Sodium Benzoate: a Novel Agent for Inhibiting Sunlight-Induced Skin Cancer, 18 Jun 2013 12:02:18 GMTchristopher.perkins@rutgers.edu Myxopyronin Analogs for Broad Spectrum Antibacterial Applications, 18 Jun 2013 12:02:14 GMTchristopher.perkins@rutgers.edu A Controlled Drug Delivery System for Extended Analgesia, 13 Jun 2013 11:34:57 GMTchristopher.perkins@rutgers.edu Surface Design of Tyrosine-Derived Polycarbonates for Attachment of Biomolecules in Medical Polymers, 13 Jun 2013 11:34:55 GMTchristopher.perkins@rutgers.edu Peak Tilting/Tracking Solar Arrays, 13 Jun 2013 06:11:31 GMTchristopher.perkins@rutgers.edu FACIAL FEATURES USING CLUSTER OF POINT DISTRIBUTION MODELS Investigators at Rutgers have developed a technology for real time tracking of facial feature shapes and expressions on a non-linear manifold applied to pose prediction, expression recognition and eye tracking. The technology proposes a novel framework for tracking faces across large head rotations at near real time processing rate. It also provides an integration of shape registration and tracking frameworks for shapes lying on any manifold by approximating non-linearities as piece¬wise linear surfaces. Monitoring driver alertness; homeland security applications; medical applications; ga...Thu, 13 Jun 2013 06:11:20 GMTchristopher.perkins@rutgers.edu Diagnostic DNA Arrays for Pathogen Detection and Identification, 11 Jun 2013 11:09:47 GMTchristopher.perkins@rutgers.edu Variegated Stellar Pink Dogwood Variegated Stellar PinkTM is a stable mutation of the popular Stellar Pink® variety of dogwood tree that is the result of crossing two varieties (Cornus Kousa and Cornus Florida). Its abundant flowers almost completely cover the tree in an overlapping manner. The leaves have a white margin and dispersed green, and mottled hues of green and white in several shades. In the fall, leaves are multi-colored and are more brilliant than the Stellar Pink® variety. Besides leaf color, all other attributes are identical to the Stellar Pink® variety. Growth is very vigorous with dense and upright branch...Tue, 11 Jun 2013 09:42:45 GMTchristopher.perkins@rutgers.edu TOUCH COMMUNICATION: A TECHNIQUE TO INPUT DATA TO CAPACITIVE TOUCHSCREEN DEVICES, 04 Jun 2013 12:41:24 GMTchristopher.perkins@rutgers.edu Versatile Biodegradable, Bioactive-Based Polymers for Cosmetic Applications Rutgers scientists have prepared various biodegradable polymers that chemically incorporate bioactive molecules, such as antioxidants and antimicrobials, in the backbone of the polymers. One such example, salicylic acid, has been widely used in cosmetic and personal care products due to its keratolytic and anti-inflammatory effects. The Uhrich group at Rutgers University has invented these novel polymers, called PolyAspirin, by linking together salicylic acid molecules via a biocompatible linker molecule (Fig 1). The polymers are fully biodegradable, and upon hydrolytic degradation release sa...Tue, 04 Jun 2013 12:40:38 GMTchristopher.perkins@rutgers.edu Diagnostic Tool to Quantify Signatures of Novel Diagnostic Tool to Quantify Signatures of Movement in Subjects with Neurological Disorders, Autism and Autism Spectrum Disorders, 04 Jun 2013 12:40:37 GMTchristopher.perkins@rutgers.edu Penetration for Topical Treatment of Fungal Nail Infections, 04 Jun 2013 08:06:32 GMTchristopher.perkins@rutgers.edu Novel Clearing Agent and Mounting Medium to replace Chloral Hydrate Solution for use in Microscopy, Forensics, Quality Control, Education, and Biological, Food, and Earth Sciences, 31 May 2013 11:22:21 GMTchristopher.perkins@rutgers.edu University Scarlet Knight™ Cranberries, 31 May 2013 11:22:13 GMTchristopher.perkins@rutgers.edu Microbead-Based Microfluidic Platform for Point-of-Care Analyte Detection Lab-on-a-chip (LOC) devices are designed to perform sample processing and analyte detection in a single microfluidic device. Typically, LOC assays are faster, require smaller sample volumes, and cost less than their conventional counterparts. Further, because LOC devices are designed to work without external equipment, they can be used in point-of-care and resource-limited settings. However, it remains a challenge to incorporate all the sample processing steps required by many clinical assays into one microfluidic device. In order to address the need for more sophisticated LOC devices, the in...Fri, 31 May 2013 11:22:12 GMTchristopher.perkins@rutgers.edu Spartan Holly, 31 May 2013 11:22:11 GMTchristopher.perkins@rutgers.edu and Methods for Generating Three-Dimensional Images from Two-Dimensional Bioluminescence Images and Visualizing Tumor Shapes and Locations Bioluminescence imaging (BLI) is an emerging technique for sensitive and non-invasive imaging, which can be used for monitoring molecular events in living animals. Important applications of this technique include gene therapy and cell trafficking studies. Recent research has focused on bioluminescence tomography (BLT) in an effort to extract depth information from 2D bioluminescence images. Such efforts, however, have been largely ineffective in generating useful 3D images with high resolution. As such, although BLI is a useful imaging modality for generating 2D images, currently no practica...Wed, 22 May 2013 08:34:43 GMTchristopher.perkins@rutgers.edu Magnetic Nanoparticle as Multimodal Imaging Probes and Cooperative Therapeutic Agents for Cancer, 15 May 2013 08:38:39 GMTchristopher.perkins@rutgers.edu Stem Cell Gene Expression and Behaviors by Nanotopography-Mediated siRNA/DNA Delivery, 15 May 2013 08:38:24 GMTchristopher.perkins@rutgers.edu Stem Cell Differentiation by Light-Responsive Hydrogel, 15 May 2013 08:37:43 GMTchristopher.perkins@rutgers.edu Proanthocyanidin Extract Effective at Inhibiting Adherence of Bacteria with P-type Fimbriae to Surfaces, 15 May 2013 08:32:21 GMTchristopher.perkins@rutgers.edu Phase Selective Sorbent Xenogels for Oil Spill Containment, 08 May 2013 06:29:56 GMTchristopher.perkins@rutgers.edu Approach for Inhalation Treatment of Pulmonary (Lung) Fibrosis, 08 May 2013 06:29:40 GMTchristopher.perkins@rutgers.edu Compounds for Treatment and Prevention of Cystinuria (Cystine Kidney Stones), 08 May 2013 06:29:24 GMTchristopher.perkins@rutgers.edu for Food and Health Use Our major research and product development areas include: (i) probiotic-derived natural antimicrobials for human health (ii) novel probiotics for traditional and non-dairy applications. We isolated and characterized antimicrobial proteins from the known strain of Lactobacillus sporogenes (Bacillus coagulans) and from a novel strain of Bacillus amyloliquefaciens. The antimicrobial peptide subtilosin produced by B. amyloliquefaciens is active against vaginal pathogens, has spermicidal activity and kills herpes viruses 1 and 2. It also kills foodborne pathogen Listeria monocytogenes, including ...Mon, 06 May 2013 07:25:04 GMTchristopher.perkins@rutgers.edu Model for Malignant Melanoma and Uses Thereof, 07 Mar 2013 13:33:11 GMTchristopher.perkins@rutgers.edu